Martina Wiedau-Pazos

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
    Milan Fiala
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
    J Neuroinflammation 7:76. 2010
  2. pmc Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice
    Martina Wiedau-Pazos
    Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Neurobiol Aging 30:14-21. 2009
  3. ncbi request reprint Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    George R Jackson
    Neurogenetics Program, Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, 90095, USA
    Neuron 34:509-19. 2002
  4. doi request reprint Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis
    Lili C Kudo
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:3233-53. 2010
  5. ncbi request reprint A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 51:549-60. 2006
  6. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
  7. pmc Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Dis Model Mech 2:189-95. 2009

Research Grants

  1. Gsk-3beta & beta-Catenin in pathophysiology of FTDP-17
    Martina Wiedau Pazos; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. pmc IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
    Milan Fiala
    Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
    J Neuroinflammation 7:76. 2010
    ..Immune modulation of chronic inflammation may be a new approach to sALS...
  2. pmc Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice
    Martina Wiedau-Pazos
    Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Neurobiol Aging 30:14-21. 2009
    ..We demonstrate that this induces downstream Wnt signaling via the activation of nuclear transcription factors associated with beta-catenin, suggesting that Wnt-pathway activation is an early feature of the neurodegenerative process...
  3. ncbi request reprint Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    George R Jackson
    Neurogenetics Program, Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, 90095, USA
    Neuron 34:509-19. 2002
    ..The genetic system we have established provides a powerful reagent for identification of novel modifiers of tau-induced neurodegeneration that may serve as future therapeutic targets...
  4. doi request reprint Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis
    Lili C Kudo
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:3233-53. 2010
    ....
  5. ncbi request reprint A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 51:549-60. 2006
    ..Further investigation is warranted in defining the role of PSA and other genes identified here as potential therapeutic targets in tauopathy...
  6. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
    ..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found...
  7. pmc Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Dis Model Mech 2:189-95. 2009
    ..These genetically manipulated hESC-derived motor neurons can facilitate and advance the study of disease-specific cellular pathways, and serve as a model system to test new therapeutic approaches...

Research Grants2

  1. Gsk-3beta & beta-Catenin in pathophysiology of FTDP-17
    Martina Wiedau Pazos; Fiscal Year: 2007
    ..Once correlative studies have provided information regarding potential interactions of mutant tau, GSK-3-beta and beta-catenin, functional studies of these interactions are planned. ..