Robert F Wideman

Summary

Affiliation: University of Arkansas
Country: USA

Publications

  1. pmc Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis
    Robert F Wideman
    Center of Excellence for Poultry Science, University of Arkansas Fayetteville, AR, USA
    Front Endocrinol (Lausanne) 3:183. 2012
  2. doi request reprint Susceptibility of 4 commercial broiler crosses to lameness attributable to bacterial chondronecrosis with osteomyelitis
    R F Wideman
    Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 92:2311-25. 2013
  3. doi request reprint Pulmonary arterial hypertension (ascites syndrome) in broilers: a review
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 92:64-83. 2013
  4. ncbi request reprint Dexamethasone triggers lameness associated with necrosis of the proximal tibial head and proximal femoral head in broilers
    R F Wideman
    University of Arkansas, Division of Agriculture, Fayetteville, AR, USA
    Poult Sci 91:2464-74. 2012
  5. doi request reprint A wire-flooring model for inducing lameness in broilers: evaluation of probiotics as a prophylactic treatment
    R F Wideman
    University of Arkansas, Division of Agriculture, Fayetteville, AR 72701, USA
    Poult Sci 91:870-83. 2012
  6. ncbi request reprint Broiler survivors of intravenous micro-particle injections: evaluation of growth, livability, meat quality, and arterial blood gas values during a cyclic heat challenge
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 82:484-95. 2003
  7. doi request reprint Broiler pulmonary hypertensive responses during lipopolysaccharide-induced tolerance and cyclooxygenase inhibition
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 88:72-85. 2009
  8. ncbi request reprint N(omega)-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to endotoxin in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 83:485-94. 2004
  9. pmc Idiopathic pulmonary arterial hypertension: an avian model for plexogenic arteriopathy and serotonergic vasoconstriction
    Robert F Wideman
    Center of Excellence for Poultry Science, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    J Pharmacol Toxicol Methods 63:283-95. 2011
  10. ncbi request reprint Influence of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on the pulmonary hypertensive response to microparticle injections in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:511-27. 2006

Detail Information

Publications68

  1. pmc Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis
    Robert F Wideman
    Center of Excellence for Poultry Science, University of Arkansas Fayetteville, AR, USA
    Front Endocrinol (Lausanne) 3:183. 2012
    ..Our new model for reliably triggering spontaneous osteomyelitis in large numbers of animals represents an important opportunity to conduct translational research focused on developing effective prophylactic and therapeutic treatments...
  2. doi request reprint Susceptibility of 4 commercial broiler crosses to lameness attributable to bacterial chondronecrosis with osteomyelitis
    R F Wideman
    Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 92:2311-25. 2013
    ..Stress-mediated immunosuppression contributes to the pathogenesis of BCO; perhaps female broilers experience less social or competitive stress when reared separately from their male hatch mates. ..
  3. doi request reprint Pulmonary arterial hypertension (ascites syndrome) in broilers: a review
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 92:64-83. 2013
    ..Ongoing immunological and genomic investigations are likely to continue generating important new knowledge regarding the fundamental biological bases for the PAH/ascites syndrome...
  4. ncbi request reprint Dexamethasone triggers lameness associated with necrosis of the proximal tibial head and proximal femoral head in broilers
    R F Wideman
    University of Arkansas, Division of Agriculture, Fayetteville, AR, USA
    Poult Sci 91:2464-74. 2012
    ..These caveats must be acknowledged when DEX is used to trigger lameness in broilers...
  5. doi request reprint A wire-flooring model for inducing lameness in broilers: evaluation of probiotics as a prophylactic treatment
    R F Wideman
    University of Arkansas, Division of Agriculture, Fayetteville, AR 72701, USA
    Poult Sci 91:870-83. 2012
    ..Rearing broilers on wire flooring provides an important new research model for investigating the etiology, pathogenesis, and treatment strategies for BCO...
  6. ncbi request reprint Broiler survivors of intravenous micro-particle injections: evaluation of growth, livability, meat quality, and arterial blood gas values during a cyclic heat challenge
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 82:484-95. 2003
    ..Overall, these observations indicate that selection for a robust cardiopulmonary capacity can confer advantages in growth and livability without affecting meat quality when broilers are exposed to a moderate heat challenge...
  7. doi request reprint Broiler pulmonary hypertensive responses during lipopolysaccharide-induced tolerance and cyclooxygenase inhibition
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 88:72-85. 2009
    ..The key vasoconstrictors responsible for the PH elicited by LPS remain to be determined...
  8. ncbi request reprint N(omega)-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to endotoxin in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 83:485-94. 2004
    ..Inhibition of NOS by L-NAME apparently reduced the modulatory influence of NO and exposed a more dramatic pulmonary hypertensive response to LPS...
  9. pmc Idiopathic pulmonary arterial hypertension: an avian model for plexogenic arteriopathy and serotonergic vasoconstriction
    Robert F Wideman
    Center of Excellence for Poultry Science, Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    J Pharmacol Toxicol Methods 63:283-95. 2011
    ..Serotonin also plays a major role in the susceptibility of broilers to IPAH. This avian model of spontaneous IPAH constitutes a new animal model for biomedical research focused on the pathogenesis of IPAH and plexogenic arteriopathy...
  10. ncbi request reprint Influence of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on the pulmonary hypertensive response to microparticle injections in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:511-27. 2006
    ..Different NOS-mediated responses among broiler populations may affect pulmonary hemodynamic characteristics of broiler lines selected using i.v. microparticle injections...
  11. ncbi request reprint An inadequate pulmonary vascular capacity and susceptibility to pulmonary arterial hypertension in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 86:984-98. 2007
    ..The contribution of TxA(2) remains to be determined. Selecting broiler lines for resistance to PHS depends upon improving both anatomical and functional components of pulmonary vascular capacity...
  12. ncbi request reprint Immune modulation of the pulmonary hypertensive response to bacterial lipopolysaccharide (endotoxin) in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 83:624-37. 2004
    ..Innate differences in the effect of LPS on the pulmonary vasculature may contribute to differences in susceptibility of broilers to pulmonary hypertension syndrome (ascites)...
  13. pmc Pulmonary vascular pressure profiles in broilers selected for susceptibility to pulmonary hypertension syndrome: age and sex comparisons
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, USA
    Poult Sci 89:1815-24. 2010
    ..Susceptibility to PHS can be attributed primarily to pulmonary arterial hypertension associated with increased precapillary (arteriole) resistance...
  14. ncbi request reprint Pulmonary and systemic hemodynamic responses to intravenous prostacyclin in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 84:442-53. 2005
    ..The consistent failure of PGI2 to elicit pulmonary vasodilation in this study suggests fundamental differences in AA metabolism or the etiology of pulmonary hypertension may exist when broilers are compared with mammals...
  15. doi request reprint Plexiform lesions in the lungs of domestic fowl selected for susceptibility to pulmonary arterial hypertension: incidence and histology
    Robert F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, USA
    Anat Rec (Hoboken) 294:739-55. 2011
    ..Broiler chickens selected for innate susceptibility to IPAH represent a new animal model for investigating the mechanisms responsible for spontaneous plexogenic arteriopathy...
  16. ncbi request reprint Nomega-nitro-L-arginine methyl ester (L-NAME) amplifies the pulmonary hypertensive response to microparticle injections in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 84:1077-91. 2005
    ..Inhibition of NOS by L-NAME exposed a more dramatic increase in PVR and pulmonary hypertension leading to enhanced mortality in response to microparticle injections...
  17. doi request reprint Differential expression of vasoactive mediators in microparticle-challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension
    Krishna R Hamal
    Dept of Poultry Science, Univ of Arkansas, POSC 420, 1260 W Maple, Fayetteville, AR 72701, USA
    Am J Physiol Regul Integr Comp Physiol 298:R235-42. 2010
    ....
  18. ncbi request reprint Dietary sodium bicarbonate, cool temperatures, and feed withdrawal: impact on arterial and venous blood-gas values in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 82:560-70. 2003
    ..gt; or = 12 h withdrawal), environmental temperature (24 vs. 16 degrees C), and the pathogenesis associated with PHS (RV:TV < 0.28 vs. > or = 0.28)...
  19. ncbi request reprint Taurine, cardiopulmonary hemodynamics, and pulmonary hypertension syndrome in broilers
    C A Ruiz-Feria
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:1607-18. 2001
    ..Overall, depleting cardiac taurine did not appear to initiate PHS, but systemic hypoxemia developing during the mid- to late-pathogenesis of PHS may expose and incipient cardiac weakness attributable to depleted taurine reserves...
  20. doi request reprint Differential gene expression of proinflammatory chemokines and cytokines in lungs of ascites-resistant and -susceptible broiler chickens following intravenous cellulose microparticle injection
    Krishna R Hamal
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Vet Immunol Immunopathol 133:250-5. 2010
    ..Higher expression of chemokines/cytokines in RES compared to SUS line lungs may explain the ability of RES line broilers to effectively counteract the MP-induced PH and resolve the vascular occlusion...
  21. ncbi request reprint Pulmonary hypertension triggered by lipopolysaccharide in ascites-susceptible and -resistant broilers is not amplified by aminoguanidine, a specific inhibitor of inducible nitric oxide synthase
    O T Bowen
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:528-36. 2006
    ....
  22. ncbi request reprint Furosemide does not facilitate pulmonary vasodilation in broilers during chronic or acute unilateral pulmonary arterial occlusion
    M F Forman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:937-43. 2001
    ..Dietary FURO at 0.015% (wt/wt) does not appear to influence the pulmonary vasculature in broilers, but it may prolong the survival of broilers during the pathophysiological progression of PHS...
  23. ncbi request reprint Pulmonary hemodynamic responses to intravenous prostaglandin E2 in broiler chickens
    S Stebel
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 87:138-45. 2008
    ....
  24. doi request reprint A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines
    Sriram Krishnamoorthy
    Program in Cell and Molecular Biology, University of Arkansas, Fayetteville 72701
    Poult Sci 93:307-17. 2014
    ..There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals. ..
  25. doi request reprint Immunohistochemical examination of plexiform-like complex vascular lesions in the lungs of broiler chickens selected for susceptibility to idiopathic pulmonary arterial hypertension
    Krishna R Hamal
    Department of Poultry Science, University of Arkansas, 1260 West Maple, Fayetteville, AR 72701, USA
    Avian Pathol 41:211-9. 2012
    ....
  26. ncbi request reprint Minimal number of chicken daily growth velocities for artificial neural network detection of pulmonary hypertension syndrome (PHS)
    W B Roush
    Department of Poultry Science, The Pennsylvania State University, University Park 16802 3501, USA
    Poult Sci 80:254-9. 2001
    ..However, these studies demonstrate that within a breed or line reared under similar selection pressures for ascites, a GRNN based on the first 14 d of growth velocity can detect, with at least 93% accuracy, broilers susceptible to PHS...
  27. ncbi request reprint Immune system and cardiac functions of progeny chicks from dams fed diets differing in zinc and manganese level and source
    W S Virden
    Department of Poultry Science, Mississippi State University, Mississippi State, Mississippi 39762, USA
    Poult Sci 83:344-51. 2004
    ..Although progeny ascites incidence did not differ between breeder mineral treatments, breeders fed supplemental Zn and Mn sired progeny with improved cardiac functional capacity and some improvements in immunity...
  28. ncbi request reprint Effect of intravenous endotoxin on blood cell profiles of broilers housed in cages and floor litter environments
    W Wang
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 82:1886-97. 2003
    ..v. LPS when compared with those of broilers reared in clean stainless steel cages. However, such desensitization of the immune system did not help broilers survive subsequent i.v. LPS challenge...
  29. doi request reprint Altered monocyte and macrophage numbers in blood and organs of chickens injected i.v. with lipopolysaccharide
    O T Bowen
    Department of Poultry Science, University of Arkansas, Division of Agriculture, Fayetteville, AR 72701, USA
    Vet Immunol Immunopathol 131:200-10. 2009
    ..Furthermore, monocyte differentiation and recruitment from the bone marrow is a likely contributor to the reconstitution and rise of monocyte concentrations in blood samples post-i.v. LPS injection...
  30. ncbi request reprint The use of vitamin A-deficient diets and jugular vein ligation to increase intracranial pressure in chickens (Gallus gallus)
    W J Kuenzel
    Poultry Science Center, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:537-45. 2006
    ..86 mmH2O. Results suggest that the chicken may be a useful animal model to investigate intracranial hypertension and its accompanying headaches known to occur in humans...
  31. ncbi request reprint Renal responses of normal and preascitic broilers to systemic hypotension induced by unilateral pulmonary artery occlusion
    M F Forman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:1773-85. 1999
    ..The differences observed between normal and preascitic broilers demonstrate that systemic hypotension can trigger renal mechanisms contributing to fluid and solute retention during development of PHS...
  32. ncbi request reprint Evaluation of the serotonin receptor blockers ketanserin and methiothepin on the pulmonary hypertensive responses of broilers to intravenously infused serotonin
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:777-86. 2006
    ....
  33. ncbi request reprint Transpulmonary pressure gradient verifies pulmonary hypertension is initiated by increased arterial resistance in broilers
    A G Lorenzoni
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 87:125-32. 2008
    ....
  34. doi request reprint Cellular component of lavage fluid from broilers with normal versus aerosol-primed airways
    A G Lorenzoni
    University of Arkansas, Department of Poultry Science, Fayetteville 72701, USA
    Poult Sci 88:303-8. 2009
    ..We propose that the increased concentration of leukocytes present within the airways was one of the components that enabled broilers pre-treated with aerosolized Red#3+PG to exhibit PH responses to intratracheal lipopolysaccharide...
  35. ncbi request reprint Variation in the pulmonary hypertensive responsiveness of broilers to lipopolysaccharide and innate variation in nitric oxide production by mononuclear cells
    O T Bowen
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:1349-63. 2006
    ....
  36. ncbi request reprint Evaluation of the serotonin receptor blocker methiothepin in broilers injected intravenously with lipopolysaccharide and microparticles
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:2222-30. 2006
    ....
  37. doi request reprint Intratracheal administration of bacterial lipopolysaccharide elicits pulmonary hypertension in broilers with primed airways
    A G Lorenzoni
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 87:645-54. 2008
    ..Common air contaminants such as LPS can result in PH leading to pulmonary hypertension syndrome (ascites) in broilers with appropriately primed airways...
  38. ncbi request reprint Plasma nitric oxide concentrations in broilers after intravenous injections of lipopolysaccharide or microparticles
    O T Bowen
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 86:2550-4. 2007
    ....
  39. ncbi request reprint Analysis of plasma serotonin levels and hemodynamic responses following chronic serotonin infusion in broilers challenged with bacterial lipopolysaccharide and microparticles
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 87:116-24. 2008
    ....
  40. ncbi request reprint Inhaling one hundred percent oxygen eliminates the systemic arterial hypoxemic response of broilers to intravenous microparticle injections
    A G Lorenzoni
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 87:146-54. 2008
    ....
  41. ncbi request reprint Evaluation of total plasma nitric oxide concentrations in broilers infused intravenously with sodium nitrite, lipopolysaccharide, aminoguanidine, and sodium nitroprusside
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:312-20. 2006
    ..Therefore, total plasma NO concentrations (assayed as NO2- + NO3-) qualitatively reflect whole-body NO synthesis, but biologically relevant quantities of NO may be produced at levels that cannot be detected by colorimetric assays...
  42. ncbi request reprint Measurements of pulmonary arterial pressure in anesthetized male broilers at two to seven weeks of age
    M F Forman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 79:1645-9. 2000
    ....
  43. ncbi request reprint Cardio-pulmonary function in broilers reared at warm or cool temperatures: effect of acute inhalation of 100% oxygen
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 79:257-64. 2000
    ..It was the elevated cardiac output rather than hypoxemic pulmonary vasoconstriction that increased the pulmonary arterial pressure in the cool group when compared with the warm group...
  44. ncbi request reprint Cardio-pulmonary function in preascitic (hypoxemic) or normal broilers inhaling ambient air or 100% oxygen
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 79:415-25. 2000
    ..A sustained reduction in cardiac output theoretically should attenuate pulmonary hypertension, but this was not observed because of the overriding influence of sustained pulmonary vascular resistance...
  45. ncbi request reprint Ascites resistance of progeny from broiler breeders selected for two generations using chronic unilateral pulmonary artery occlusion
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 79:396-401. 2000
    ....
  46. ncbi request reprint Plasma taurine levels in broilers with pulmonary hypertension syndrome induced by unilateral pulmonary artery occlusion
    C A Ruiz-Feria
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:1627-33. 1999
    ....
  47. ncbi request reprint Venous blood pressure in broilers during acute inhalation of five percent carbon dioxide or unilateral pulmonary artery occlusion
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:1443-51. 1999
    ..Central venous congestion predisposes broilers to the onset of cirrhosis and ascites by impeding the outflow of hepatic venous blood and increasing the hydrostatic pressure within hepatic sinusoids...
  48. ncbi request reprint Thromboxane mimics the pulmonary but not systemic vascular responses to bolus HCl injections in broiler chickens
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:714-21. 1999
    ..Alternatively, a direct dilatory effect of elevated hydrogen ion concentrations on the systemic vasculature may have counteracted any tendency for simultaneously evolved endogenous thromboxane to elicit systemic vasoconstriction...
  49. ncbi request reprint Broiler breeder survivors of chronic unilateral pulmonary artery occlusion produce progeny resistant to pulmonary hypertension syndrome (ascites) induced by cool temperatures
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:404-11. 1999
    ..These results support a primary role for pulmonary hypertension but not cardiomyopathy in the pathogenesis of ascites triggered by cool temperatures in both the Base and Resistant populations...
  50. ncbi request reprint Cardiac output in four-, five-, and six-week-old broilers, and hemodynamic responses to intravenous injections of epinephrine
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 78:392-403. 1999
    ....
  51. ncbi request reprint Evaluation of minimally invasive indices for predicting ascites susceptibility in three successive hatches of broilers exposed to cool temperatures
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 77:1565-73. 1998
    ..Values obtained for minimally invasive diagnostic indices on Day 42 also establish predictive thresholds that can be used to evaluate the PHS susceptibility of large and apparently healthy male and female broilers...
  52. ncbi request reprint Flow-dependent pulmonary vasodilation during acute unilateral pulmonary artery occlusion in Jungle Fowl
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 77:615-26. 1998
    ....
  53. ncbi request reprint Plasma levels of arginine, ornithine, and urea and growth performance of broilers fed supplemental L-arginine during cool temperature exposure
    C A Ruiz-Feria
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:358-69. 2001
    ..Plasma Arg was increased significantly, but no effects were observed in ascites mortality...
  54. ncbi request reprint Pulmonary wedge pressures confirm pulmonary hypertension in broilers is initiated by an excessive pulmonary arterial (precapillary) resistance
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:468-73. 2001
    ....
  55. ncbi request reprint Lung mitochondrial dysfunction in pulmonary hypertension syndrome. I. Site-specific defects in the electron transport chain
    M Iqbal
    Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:485-95. 2001
    ....
  56. ncbi request reprint Pulmonary hypertensive responses of broilers to bacterial lipopolysaccharide (LPS): evaluation of LPS source and dose, and impact of pre-existing pulmonary hypertension and cellulose micro-particle selection
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 84:432-41. 2005
    ..These findings are consistent with the hypothesis that innate rather than acquired variability may influence the profile of chemical mediators released during the inflammatory cascade...
  57. ncbi request reprint Intravenous micro-particle injections and pulmonary hypertension in broiler chickens: acute post-injection mortality and ascites susceptibility
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 81:1203-17. 2002
    ....
  58. ncbi request reprint Pulmonary and hematological inflammatory responses to intravenous cellulose micro-particles in broilers
    W Wang
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 82:771-80. 2003
    ....
  59. ncbi request reprint Effect of cage vs. floor litter environments on the pulmonary hypertensive response to intravenous endotoxin and on blood-gas values in broilers
    W Wang
    Department of Poultry Science, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Poult Sci 81:1728-37. 2002
    ..Nevertheless, the pulmonary hypertensive response to endotoxin did not differ between broilers reared on the floor and those in cages...
  60. ncbi request reprint Pulmonary hypertensive response to endotoxin in cellulose-primed and unprimed broiler chickens
    W Wang
    Poult Sci 81:1224-30. 2002
    ..Accordingly, the initiation of a preexisting inflammatory response within the lung parenchyma did not alter the timing, amplitude, or variability of the subsequent pulmonary hypertensive response to endotoxin in broilers...
  61. ncbi request reprint Intravenous micro-particle injection and pulmonary hypertension in broiler chickens: cardio-pulmonary hemodynamic responses
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 81:877-86. 2002
    ....
  62. ncbi request reprint Antioxidant enzyme activities and mitochondrial fatty acids in pulmonary hypertension syndrome (PHS) in broilers
    M Iqbal
    Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 81:252-60. 2002
    ..The increase in saturation of lung mitochondrial fatty acids with high dietary VE would presumably make them more resistant to oxidative stress and, thus, reduce the level of PHS-induced oxidative stress...
  63. ncbi request reprint Hemodynamic responses of broiler pulmonary vasculature to intravenously infused serotonin
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 81:231-8. 2002
    ..The present study provides direct evidence that serotonin can trigger pulmonary vasoconstriction and pulmonary hypertension in broilers...
  64. ncbi request reprint Lung mitochondrial dysfunction in pulmonary hypertension syndrome. II. Oxidative stress and inability to improve function with repeated additions of adenosine diphosphate
    M Iqbal
    Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:656-65. 2001
    ..Furthermore, genetic resistance to PHS was associated with more efficient oxidative phosphorylation in lung mitochondria and an inherently lower degree of oxidative stress...
  65. ncbi request reprint Intravenous endotoxin triggers pulmonary vasoconstriction and pulmonary hypertension in broiler chickens
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 80:647-55. 2001
    ..Individual differences among broilers in their susceptibility to pulmonary hypertension syndrome (ascites) may be related to innate or acquired variability in their pulmonary vascular responsiveness to vasoactive mediators...
  66. ncbi request reprint The infusion rate dependent influence of acute metabolic acidosis on pulmonary vascular resistance in broilers
    R F Wideman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 77:309-21. 1998
    ..Increments in either pulmonary vascular resistance or cardiac output induced by metabolic acidosis would be expected to contribute to the onset of pulmonary hypertension syndrome (PHS, ascites) in broilers...
  67. ncbi request reprint Growth and immunity of broiler chicks as affected by dietary arginine
    M T Kidd
    Department of Poultry Science, Mississippi State University, MS 39762, USA
    Poult Sci 80:1535-42. 2001
    ..A dietary Arg level near the NRC (1994) recommendation should support proper immune system functions in healthy chicks...
  68. ncbi request reprint Evaluation of broiler growth velocity and acceleration in relation to pulmonary hypertension syndrome
    W B Roush
    Department of Poultry Science, The Pennsylvania State University, University Park 16802 3501, USA
    Poult Sci 79:180-91. 2000
    ..In general, data in the second experiment exceeded the neural network range of training for both velocity and acceleration, which reflected increased oscillation during the second phase of growth...