Barton Wicksteed

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain
    Barton Wicksteed
    Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
    Diabetes 59:3090-8. 2010
  2. pmc Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A
    Sindhu Rajan
    Kovler Diabetes Center, The University of Chicago, USA Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, USA
    Mol Metab 4:265-76. 2015
  3. pmc PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
    Kelly A Kaihara
    Kovler Diabetes Center, The University of Chicago, Chicago, IL Committee for Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, Chicago, IL
    Diabetes 64:1688-97. 2015
  4. pmc β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion
    Kelly A Kaihara
    Kovler Diabetes Center, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Diabetes 62:1527-36. 2013

Collaborators

Detail Information

Publications4

  1. pmc Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain
    Barton Wicksteed
    Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, llinois, USA
    Diabetes 59:3090-8. 2010
    ..The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell- or pancreas-specific recombination, also drive Cre expression in the brain...
  2. pmc Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A
    Sindhu Rajan
    Kovler Diabetes Center, The University of Chicago, USA Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, USA
    Mol Metab 4:265-76. 2015
    ..The aim of this study was to determine the mechanistic causes underlying the reduced efficacy of GLP-1R ligands...
  3. pmc PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
    Kelly A Kaihara
    Kovler Diabetes Center, The University of Chicago, Chicago, IL Committee for Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, Chicago, IL
    Diabetes 64:1688-97. 2015
    ..These data highlight that improving β-cell function through the activation of PKA has a large and underappreciated capacity to restore glucose control with minimal risk for adverse side effects. ..
  4. pmc β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion
    Kelly A Kaihara
    Kovler Diabetes Center, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Diabetes 62:1527-36. 2013
    ..Thus, β-cell PKA activity transduces the cAMP signal to dramatically increase acute-phase insulin secretion, thereby enhancing the efficiency of insulin to control circulating glucose...