Max S Wicha

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc B4 androgen ablation: attacking the prostate cancer stem cell
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Room 6302, Ann Arbor, Michigan 48109, USA
    J Clin Invest 123:563-5. 2013
  2. ncbi request reprint PSA lo and behold: prostate cancer stem cells
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 5942, USA
    Cell Stem Cell 10:482-3. 2012
  3. pmc Mammary stem cell number as a determinate of breast cancer risk
    Christophe Ginestier
    Breast Cancer Res 9:109. 2007
  4. pmc Cancer stem cell heterogeneity in hereditary breast cancer
    Max S Wicha
    Breast Cancer Res 10:105. 2008
  5. ncbi request reprint Breast cancer stem cells: the other side of the story
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Stem Cell Rev 3:110-2; discussion 113. 2007
  6. pmc Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis
    Max S Wicha
    Comprehensive Cancer Center, University of Michigan, E, Medical Center Drive, Ann Arbor, MI 48109 0942, USA
    Breast Cancer Res 8:109. 2006
  7. ncbi request reprint Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
  8. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
  9. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
  10. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009

Collaborators

Detail Information

Publications55

  1. pmc B4 androgen ablation: attacking the prostate cancer stem cell
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Room 6302, Ann Arbor, Michigan 48109, USA
    J Clin Invest 123:563-5. 2013
    ..demonstrates that PCSCs are regulated by a pathway in which α6β4 integrin amplifies signaling through ErbB2 and c-Met receptors. Targeting this pathway provides a novel therapeutic strategy for hormone refractory prostate cancer...
  2. ncbi request reprint PSA lo and behold: prostate cancer stem cells
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 5942, USA
    Cell Stem Cell 10:482-3. 2012
    ..In this issue of Cell Stem Cell, Qin et al. (2012) show that PSA(-/lo) cells are enriched for cells with tumor-initiating characteristics and may participate in resistance to androgen-ablative therapies...
  3. pmc Mammary stem cell number as a determinate of breast cancer risk
    Christophe Ginestier
    Breast Cancer Res 9:109. 2007
    ..The growth hormone/insulin-like growth factor-1 axis may play an important role in regulating breast stem cell number during these developmental windows, suggesting an important link between this signaling pathway and breast cancer risk...
  4. pmc Cancer stem cell heterogeneity in hereditary breast cancer
    Max S Wicha
    Breast Cancer Res 10:105. 2008
    ..Despite this heterogeneity, cancer stem cells may share common characteristics that can be used for their identification and for therapeutic targeting...
  5. ncbi request reprint Breast cancer stem cells: the other side of the story
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Stem Cell Rev 3:110-2; discussion 113. 2007
  6. pmc Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis
    Max S Wicha
    Comprehensive Cancer Center, University of Michigan, E, Medical Center Drive, Ann Arbor, MI 48109 0942, USA
    Breast Cancer Res 8:109. 2006
    ..In addition, an understanding of the biology of these cells including the pathways that regulate their self-renewal and differentiation may suggest new approaches for the prevention and treatment of breast cancer...
  7. ncbi request reprint Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
    ..The development of more effective cancer therapies may thus require targeting this important cell population...
  8. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
    ..In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism...
  9. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
    ..Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs...
  10. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ....
  11. pmc Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds
    Yanyan Li
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    J Nutr Biochem 22:799-806. 2011
    ..This may enable us to discover more preventive strategies for cancer management by reducing cancer resistance and recurrence and improving patient survival...
  12. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  13. ncbi request reprint Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  14. pmc Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
    Khaled A Hassan
    Department of Internal Medicine and Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 19:1972-80. 2013
    ..The purpose of this study is to determine the role of Notch activity in identifying lung cancer stem cells...
  15. pmc Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
    Madhuri Kakarala
    Division of Hematology Oncology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, 2150 Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 122:777-85. 2010
    ..Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials...
  16. pmc Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy
    Madhuri Kakarala
    University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109 5942, USA
    J Clin Oncol 26:2813-20. 2008
    ..Furthermore, because breast cancer stem cells may be highly resistant to radiation and chemotherapy, the development of more effective therapies for this disease may require the effective targeting of this cell population...
  17. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
    ..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
  18. ncbi request reprint Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
    ..Furthermore, the concept of cancer as a disease of stem and progenitor cells has profound implications for the development of new strategies for cancer prevention and therapy...
  19. pmc MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Genet 8:e1002751. 2012
    ..These studies demonstrate that miRNAs can regulate the states and fates of normal and malignant mammary stem cells, findings which have important biological and clinical implications...
  20. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013
    ..We suggest that targeting these distinct functions may tailor therapeutic strategies to address breast cancer heterogeneity more effectively...
  21. pmc Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    Ming Luo
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:466-74. 2009
    ..Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression...
  22. pmc Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    Suling Liu
    Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:614-24. 2011
    ..Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population...
  23. doi request reprint Targeting breast cancer stem cells
    Suling Liu
    Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 28:4006-12. 2010
    ..The effective targeting of breast cancer stem cells has the potential to significantly improve outcome for women with both early-stage and advanced breast cancer...
  24. ncbi request reprint Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
    ..This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model...
  25. pmc HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab
    Suthinee Ithimakin
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Cancer Res 73:1635-46. 2013
    ..Furthermore, these studies support a CSC model in which maximal clinical benefit is achieved when CSC targeting agents are administered in the adjuvant setting. Cancer Res; 73(5); 1635-46. ©2012 AACR...
  26. pmc Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Gabriela Dontu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R605-15. 2004
    ..The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors...
  27. pmc Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Int J Cancer 130:29-39. 2012
    ..Altogether, the data suggest that ALDH+ and CD133+ cells are enriched with ovarian cancer-initiating (stem) cells and that ALDH and CD133 may be widely used as reliable markers to investigate ovarian cancer stem cell biology...
  28. pmc Mammary stem cells, self-renewal pathways, and carcinogenesis
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 7:86-95. 2005
    ..If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment...
  29. ncbi request reprint [The cancer stem cell: the breast cancer driver]
    Christophe Ginestier
    University of Michigan Medical Center, Comprehensive Cancer Center, Int Med Hematology Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA
    Med Sci (Paris) 23:1133-9. 2007
    ..This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future...
  30. pmc Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells
    Sudha Krishnamurthy
    Angiogenesis Research Laboratory, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 70:9969-78. 2010
    ..Collectively, these findings indicate that endothelial cell-initiated signaling can enhance the survival and self-renewal of head and neck CSC...
  31. pmc Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 121:3804-9. 2011
    ..Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development...
  32. doi request reprint HER2 and breast cancer stem cells: more than meets the eye
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Cancer Res 73:3489-93. 2013
    ..Furthermore, these studies suggest that effective adjuvant therapies may need to target the CSC population...
  33. doi request reprint Role of microRNAs in the regulation of breast cancer stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    J Mammary Gland Biol Neoplasia 17:15-21. 2012
    ..In addition, since CSC states are regulated by miRNAs, these small non-coding RNAs may be useful therapeutic agents to target CSCs...
  34. pmc Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    Sarah J Conley
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:2784-9. 2012
    ....
  35. pmc Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots
    Hasan Korkaya
    Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:6125-9. 2011
    ..By blocking signals from the tumor microenvironment, these agents have the potential to target CSCs. Future clinical trials using these compounds will be needed to determine whether targeting the CSC population has clinical benefit...
  36. ncbi request reprint Breast cancer stem cells-research opportunities utilizing mathematical modeling
    Rina Ashkenazi
    Department of Mathematics, University of Michigan, 530 Church St, Ann Arbor, MI 48109, USA
    Stem Cell Rev 3:176-82. 2007
    ....
  37. ncbi request reprint Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Mammary Gland Biol Neoplasia 10:75-86. 2005
    ....
  38. pmc Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
    Hasan Korkaya
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5942, USA
    Mol Cell 47:570-84. 2012
    ..These studies demonstrate that trastuzumab resistance may be mediated by an IL6 inflammatory loop and suggest that blocking this loop may provide alternative strategy to overcome trastuzumab resistance...
  39. pmc Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
    Anne F Schott
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 19:1512-24. 2013
    ..The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy...
  40. ncbi request reprint Cancer stem cells: implications for cancer treatment and prevention
    Madhuri Kakarala
    Division of Hematology Oncology, University of Michigan Cancer Center, Ann Arbor, MI 48104, USA
    Cancer J 13:271-5. 2007
  41. pmc Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    Ines A Silva
    Division of Hematology Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:3991-4001. 2011
    ..Taken together, our findings define ALDH and CD133 as a functionally significant set of markers to identify ovarian CSCs...
  42. doi request reprint HER-2, notch, and breast cancer stem cells: targeting an axis of evil
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
    Clin Cancer Res 15:1845-7. 2009
    ..Recent studies suggest that the remarkable clinical efficacy of trastuzumab may relate to its ability to target cancer stem cell populations...
  43. doi request reprint Breast cancer stem cells: we've got them surrounded
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 19:511-3. 2013
    ..New evidence suggests that an important interaction between the interleukin (IL)-8 receptor CXCR1/2 and HER2 is involved in this regulation. Simultaneous targeting of these pathways provides a novel therapeutic approach...
  44. ncbi request reprint Breast cancer, stem/progenitor cells and the estrogen receptor
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Endocrinol Metab 15:193-7. 2004
    ..Furthermore, the concept of breast cancer as a disease of mammary stem and progenitor cells has profound implications for the development of new strategies for breast cancer prevention and therapy...
  45. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
    ..The isolation and characterization of these stem cells should help elucidate the molecular pathways that govern normal mammary development and carcinogenesis...
  46. pmc Cancer stem cell vaccination confers significant antitumor immunity
    Ning Ning
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 72:1853-64. 2012
    ..Together, these proof-of-concept results provide a rationale for a new type of cancer immunotherapy based on the development of CSC vaccines that can specifically target CSCs...
  47. doi request reprint Stem cells in normal development and cancer
    Rosemarie Chirco D'Angelo
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
    Prog Mol Biol Transl Sci 95:113-58. 2010
    ..Finally, we highlight the therapeutic implications of targeting stem cells by inhibiting these pathways for the treatment and prevention of cancer...
  48. pmc Targeting breast cancer stem cells
    Sean P McDermott
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, 6303 Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Mol Oncol 4:404-19. 2010
    ..Here, we review both approaches and their potential to effectively target breast CSC...
  49. pmc Prospective identification of tumorigenic breast cancer cells
    Muhammad Al-Hajj
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:3983-8. 2003
    ..Furthermore, because these cells drive tumor development, strategies designed to target this population may lead to more effective therapies...
  50. ncbi request reprint Selective targeting of cancer stem cells: a new concept in cancer therapeutics
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    BioDrugs 21:299-310. 2007
    ....
  51. ncbi request reprint New organizational and funds flow models for an academic cancer center
    David A Spahlinger
    University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Acad Med 79:623-7. 2004
    ..A unified budget aligned financial incentive among all stakeholders to increase efficiency, revenue, and margin. The authors report preliminary financial evidence of the success of the new managerial structure...
  52. pmc An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma
    Khaled A Hassan
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:6386-90. 2009
    ..An embryonic stem cell (ESC) profile correlates with poorly differentiated breast, bladder, and glioma cancers. In this article, we assess the correlation between the ESC profile and clinical variables in lung cancer...
  53. doi request reprint Cancer stem cells: a step toward the cure
    Bruce M Boman
    J Clin Oncol 26:2795-9. 2008
  54. pmc Cancer stem cells in breast: current opinion and future challenges
    Emmanuelle Charafe-Jauffret
    Département d Oncologie Moléculaire, Centre de Recherche en Cancerologie de Marseille, Marseille, France
    Pathobiology 75:75-84. 2008
    ..Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative...
  55. ncbi request reprint Cancer stem cells and metastasis: lethal seeds
    Max S Wicha
    Clin Cancer Res 12:5606-7. 2006

Research Grants11

  1. Stem Cell Self-Renewal mammary Carcinogenesis
    Max S Wicha; Fiscal Year: 2010
    ..Since breast cancer may originate in normal breast stem cells, understanding the earliest changes in these cells during cancer formation is critical for the development of novel strategies to detect and prevent this cancer. ..
  2. Isolation & Characterization of Human Mammary Stem Cells
    Max Wicha; Fiscal Year: 2007
    ..This should provide important insights into the processes that regulate normal mammary development, processes that may be altered during mammary carcinogenesis. ..
  3. Regulation of Breast Stem Cells by the Microenvironment
    Max S Wicha; Fiscal Year: 2010
    ....