Research Topics
| Ellen WhyteSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Depression in late-life: shifting the paradigm from treatment to preventionEllen M Whyte
University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 21:746-51. 2006....- Preventing depression after strokeEllen M Whyte
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA
Int Rev Psychiatry 18:471-81. 2006..Then, we will discuss recent research supporting the prevention of depression after stroke and the likely positive effect successful prevention may have on non-psychiatric outcomes... - Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitorsEllen M Whyte
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 65:1634-41. 2004.... - Cardiovascular changes associated with venlafaxine in the treatment of late-life depressionEllyn M Johnson
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:796-802. 2006..Systematic monitoring of cardiovascular parameters during treatment with venlafaxine-XR should be strongly recommended, especially in the elderly... - Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorderRamin Saghafi
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Int J Geriatr Psychiatry 22:1141-6. 2007..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life... - Impact of prior treatment exposure on response to antidepressant treatment in late lifeJames D Tew
Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:957-65. 2006..Most TR and TI patients eventually respond, but TR patients may require more intensive and longer courses of treatment than TI and TN patients... - Effect of cerebrovascular risk factors on depression treatment outcome in later lifeMark D Miller
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 10:592-8. 2002..This study tested the relationship of cerebrovascular risk factors (CVRF) to clinical presentation and treatment outcome in 156 subjects enrolled in a long-term maintenance treatment study of late-life recurrent major depression... - The nature and determinants of neuropsychological functioning in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 61:587-95. 2004..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction... - Achieving long-term optimal outcomes in geriatric depression and anxietyBenoit H Mulsant
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
CNS Spectr 8:27-34. 2003.... - Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapyMary Amanda Dew
Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:892-9. 2007..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy... - Preventing depression in medical illness: a new lead?Charles F Reynolds
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 64:884-5. 2007 
Brain imaging findings predict blood pressure response to pharmacological treatmentJ Richard Jennings
Departments of Psychiatry and Psychology, University of Pittsburgh, PA, USA
Hypertension 52:1113-9. 2008..The state of the brain may be an important factor in the remediation of blood pressure...- Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patientsDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Psychiatr Serv 60:888-97. 2009..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder... - Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care managementCharles F Reynolds
Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
Int J Geriatr Psychiatry 25:1134-41. 2010.... - The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adultsAriel G Gildengers
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 12:851-8. 2010..We also examine whether there are negative, synergistic effects between lifetime duration of BD and vascular disease burden on cognition... - Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapyCharles F Reynolds
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:51-60. 2011..Cognitive impairment in late-life depression is a core feature of the illness... - Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementiaEllen M Whyte
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 10:321-7. 2002..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment... - Maintenance treatment of major depression in old ageCharles F Reynolds
Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
N Engl J Med 354:1130-8. 2006..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death... - Depression after stroke: a prospective epidemiological studyEllen M Whyte
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 52:774-8. 2004.... - The relation of white matter hyperintensities to cognitive performance in the normal old: education mattersRobert D Nebes
University of Pittsburgh Medical Center, Pennsylvania, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies... - Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depressionEric J Lenze
Advanced Center for Interventions and Services Research and John A Hartford Center of Excellence in Geriatric Psychiatry, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
J Am Geriatr Soc 55:81-6. 2007..To identify predictors of onset of major depressive disorder (MDD) and of depressive symptoms in subjects who suffered a hip fracture... - Depressive symptoms in late life: associations with apathy, resilience and disability vary between young-old and old-oldMona Mehta
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 23:238-43. 2008..We investigated the association of depression with disability, apathy and resilience across the age range of late-life... - A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)Barnett S Meyers
Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
Arch Gen Psychiatry 66:838-47. 2009..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features... - Empirically derived decision trees for the treatment of late-life depressionCarmen Andreescu
Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Am J Psychiatry 165:855-62. 2008..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making... - Medical burden in late-life bipolar and major depressive disordersAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:194-200. 2008..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder... - Post stroke depression: epidemiology, pathophysiology, and biological treatmentEllen M Whyte
Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 52:253-64. 2002..The authors conclude that the available evidence supports poststroke depression as being multifactorial in origin and consistent with the biopsychosocial model of mental illness... - Time course of response to antidepressants in late-life major depression: therapeutic implicationsEllen M Whyte
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Drugs Aging 21:531-54. 2004..Better understanding of factors related to such differences may suggest new intervention strategies to accelerate response... - Treatment of late-life depression alleviates caregiver burdenLynn M Martire
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Am Geriatr Soc 58:23-9. 2010..To describe the burden experienced by family caregivers of older adults with depression and to examine the positive effects on caregivers of treating late-life depression... - Differential cortical atrophy in subgroups of mild cognitive impairmentSandra Bell-McGinty
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Neurol 62:1393-7. 2005..These data also suggest that these structural abnormalities precede the development of Alzheimer disease... - CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderlyEllen M Whyte
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
Int J Geriatr Psychiatry 21:542-9. 2006.... - Apathy after hip fracture: a potential target for intervention to improve functional outcomesEric J Lenze
Department of Psychiatry, Washington University School of Medicine, USA
J Neuropsychiatry Clin Neurosci 21:271-8. 2009..Interventions to prevent or improve apathy in elderly persons deserve further attention... - Factors associated with non-completion in a double-blind randomized controlled trial of olanzapine plus sertraline versus olanzapine plus placebo for psychotic depressionJudith Weissman
Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
Psychiatry Res 197:221-6. 2012.... 
Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventionsEllen Whyte
Department of Psychiatry, School of Medicine, WPIC BT 764, 3811 O Hara St, Pittsburgh PA 15213, USA
PM R 3:S45-51. 2011..Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes...- An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patientsEllen M Whyte
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
Cerebrovasc Dis 26:317-21. 2008..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery... - Rescue pharmacotherapy with duloxetine for selective serotonin reuptake inhibitor nonresponders in late-life depression: outcome and tolerabilityJordan F Karp
Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 69:457-63. 2008.... - Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic featuresCarmen Andreescu
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 68:194-200. 2007..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations... - Cognitive and affective predictors of rehabilitation participation after strokeElizabeth R Skidmore
Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA
Arch Phys Med Rehabil 91:203-7. 2010..To examine associations between cognitive and affective impairments and rehabilitation participation during stroke rehabilitation... - Missed diagnosis of psychotic depression at 4 academic medical centersAnthony J Rothschild
Department of Psychiatry, University of Massachusetts Medical School, and UMass Memorial Healthcare, Worcester, MA 01605, USA
J Clin Psychiatry 69:1293-6. 2008..Major depressive disorder with psychotic features (psychotic depression), though occurring relatively frequently in the general population, is a commonly missed psychiatric diagnosis...
Research Grants
- Donepezil to promote functional recovery post-strokeEllen M Whyte; Fiscal Year: 2010..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
- Intervention to Prevent Post-Stroke Major DepressionEllen Whyte; Fiscal Year: 2007..The proposed activities will take place at the University of Pittsburgh under the auspices of the NIMH-funded Intervention Research Center for Late Life Mood Disorders, directed by the candidate's sponsor. ..
- Donepezil to promote functional recovery post-strokeEllen Whyte; Fiscal Year: 2009..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
- Donepezil to promote functional recovery post-strokeEllen M Whyte; Fiscal Year: 2011..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..