Ellen Whyte

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
  2. ncbi request reprint Preventing depression after stroke
    Ellen M Whyte
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA
    Int Rev Psychiatry 18:471-81. 2006
  3. ncbi request reprint Depression in late-life: shifting the paradigm from treatment to prevention
    Ellen M Whyte
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 21:746-51. 2006
  4. ncbi request reprint Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
  5. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
  6. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
  7. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
  8. ncbi request reprint Effect of cerebrovascular risk factors on depression treatment outcome in later life
    Mark D Miller
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:592-8. 2002
  9. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
  10. ncbi request reprint Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003

Research Grants

Detail Information

Publications39

  1. pmc Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD II
    Alastair J Flint
    Department of Psychiatry, University of Toronto, Toronto, Canada
    BMC Psychiatry 13:38. 2013
    ..On the other hand, premature discontinuation of antipsychotic medication has the potential risk of early relapse of a severe disorder...
  2. ncbi request reprint Preventing depression after stroke
    Ellen M Whyte
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA
    Int Rev Psychiatry 18:471-81. 2006
    ..Then, we will discuss recent research supporting the prevention of depression after stroke and the likely positive effect successful prevention may have on non-psychiatric outcomes...
  3. ncbi request reprint Depression in late-life: shifting the paradigm from treatment to prevention
    Ellen M Whyte
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 21:746-51. 2006
    ....
  4. ncbi request reprint Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1634-41. 2004
    ....
  5. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  6. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  7. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  8. ncbi request reprint Effect of cerebrovascular risk factors on depression treatment outcome in later life
    Mark D Miller
    Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:592-8. 2002
    ..This study tested the relationship of cerebrovascular risk factors (CVRF) to clinical presentation and treatment outcome in 156 subjects enrolled in a long-term maintenance treatment study of late-life recurrent major depression...
  9. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  10. ncbi request reprint Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
    ....
  11. ncbi request reprint Preventing depression in medical illness: a new lead?
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 64:884-5. 2007
  12. pmc Brain imaging findings predict blood pressure response to pharmacological treatment
    J Richard Jennings
    Departments of Psychiatry and Psychology, University of Pittsburgh, PA, USA
    Hypertension 52:1113-9. 2008
    ..The state of the brain may be an important factor in the remediation of blood pressure...
  13. ncbi request reprint Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
    ..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy...
  14. pmc The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults
    Ariel G Gildengers
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:851-8. 2010
    ..We also examine whether there are negative, synergistic effects between lifetime duration of BD and vascular disease burden on cognition...
  15. pmc Treating depression to remission in older adults: a controlled evaluation of combined escitalopram with interpersonal psychotherapy versus escitalopram with depression care management
    Charles F Reynolds
    Department of Psychiatry, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Clinical Trials Management Unit, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 25:1134-41. 2010
    ....
  16. pmc Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  17. pmc Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  18. ncbi request reprint Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...
  19. ncbi request reprint Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depression
    Eric J Lenze
    Advanced Center for Interventions and Services Research and John A Hartford Center of Excellence in Geriatric Psychiatry, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Am Geriatr Soc 55:81-6. 2007
    ..To identify predictors of onset of major depressive disorder (MDD) and of depressive symptoms in subjects who suffered a hip fracture...
  20. ncbi request reprint The relation of white matter hyperintensities to cognitive performance in the normal old: education matters
    Robert D Nebes
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:326-40. 2006
    ..This is consistent with recent concepts of cognitive reserve, but does raise a question as to the underlying source of the cognitive decrement found in the sort of well-educated elders typically used in cognitive-aging studies...
  21. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  22. ncbi request reprint Depression after stroke: a prospective epidemiological study
    Ellen M Whyte
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:774-8. 2004
    ..To elucidate the relationship between stroke and depressive symptoms and to determine whether disability or cerebrovascular risk factors mediate that relationship...
  23. ncbi request reprint Depressive symptoms in late life: associations with apathy, resilience and disability vary between young-old and old-old
    Mona Mehta
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 23:238-43. 2008
    ..We investigated the association of depression with disability, apathy and resilience across the age range of late-life...
  24. pmc Empirically derived decision trees for the treatment of late-life depression
    Carmen Andreescu
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:855-62. 2008
    ..The aim of this analysis was to develop a clinically useful algorithm that would allow clinicians to predict which patients will likely respond to treatment and thereby guide clinical decision making...
  25. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  26. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  27. ncbi request reprint Time course of response to antidepressants in late-life major depression: therapeutic implications
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 21:531-54. 2004
    ..Better understanding of factors related to such differences may suggest new intervention strategies to accelerate response...
  28. pmc Treatment of late-life depression alleviates caregiver burden
    Lynn M Martire
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Am Geriatr Soc 58:23-9. 2010
    ..To describe the burden experienced by family caregivers of older adults with depression and to examine the positive effects on caregivers of treating late-life depression...
  29. ncbi request reprint Post stroke depression: epidemiology, pathophysiology, and biological treatment
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 52:253-64. 2002
    ..The authors conclude that the available evidence supports poststroke depression as being multifactorial in origin and consistent with the biopsychosocial model of mental illness...
  30. pmc Apathy after hip fracture: a potential target for intervention to improve functional outcomes
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, USA
    J Neuropsychiatry Clin Neurosci 21:271-8. 2009
    ..Interventions to prevent or improve apathy in elderly persons deserve further attention...
  31. ncbi request reprint Differential cortical atrophy in subgroups of mild cognitive impairment
    Sandra Bell-McGinty
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Neurol 62:1393-7. 2005
    ..To compare gray matter brain volumes in patients diagnosed with subtypes of mild cognitive impairment (MCI) (those with a focal amnestic disorder and those with more diffuse cognitive dysfunction) with those of elderly controls...
  32. ncbi request reprint CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly
    Ellen M Whyte
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int J Geriatr Psychiatry 21:542-9. 2006
    ....
  33. pmc Factors associated with non-completion in a double-blind randomized controlled trial of olanzapine plus sertraline versus olanzapine plus placebo for psychotic depression
    Judith Weissman
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Psychiatry Res 197:221-6. 2012
    ....
  34. doi request reprint Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventions
    Ellen Whyte
    Department of Psychiatry, School of Medicine, WPIC BT 764, 3811 O Hara St, Pittsburgh PA 15213, USA
    PM R 3:S45-51. 2011
    ..Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes...
  35. pmc An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients
    Ellen M Whyte
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Cerebrovasc Dis 26:317-21. 2008
    ..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery...
  36. pmc Rescue pharmacotherapy with duloxetine for selective serotonin reuptake inhibitor nonresponders in late-life depression: outcome and tolerability
    Jordan F Karp
    Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 69:457-63. 2008
    ....
  37. ncbi request reprint Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features
    Carmen Andreescu
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 68:194-200. 2007
    ..We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations...
  38. pmc Cognitive and affective predictors of rehabilitation participation after stroke
    Elizabeth R Skidmore
    Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Phys Med Rehabil 91:203-7. 2010
    ..To examine associations between cognitive and affective impairments and rehabilitation participation during stroke rehabilitation...
  39. ncbi request reprint Missed diagnosis of psychotic depression at 4 academic medical centers
    Anthony J Rothschild
    Department of Psychiatry, University of Massachusetts Medical School, and UMass Memorial Healthcare, Worcester, MA 01605, USA
    J Clin Psychiatry 69:1293-6. 2008
    ..Major depressive disorder with psychotic features (psychotic depression), though occurring relatively frequently in the general population, is a commonly missed psychiatric diagnosis...

Research Grants5

  1. Donepezil to promote functional recovery post-stroke
    Ellen M Whyte; Fiscal Year: 2010
    ..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
  2. Intervention to Prevent Post-Stroke Major Depression
    Ellen Whyte; Fiscal Year: 2007
    ..The proposed activities will take place at the University of Pittsburgh under the auspices of the NIMH-funded Intervention Research Center for Late Life Mood Disorders, directed by the candidate's sponsor. ..
  3. Donepezil to promote functional recovery post-stroke
    Ellen Whyte; Fiscal Year: 2009
    ..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
  4. Donepezil to promote functional recovery post-stroke
    Ellen M Whyte; Fiscal Year: 2011
    ..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..