Mary Whooley

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Hostility, health behaviors, and risk of recurrent events in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Jonathan M Wong
    School of Medicine, University of California, Irvine, CA
    J Am Heart Assoc 2:e000052. 2013
  2. pmc Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study
    Jeffrey Krauss
    School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26983. 2011
  3. doi request reprint Depression and cardiovascular disorders
    Mary A Whooley
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Annu Rev Clin Psychol 9:327-54. 2013
  4. doi request reprint Diagnosis and treatment of depression in adults with comorbid medical conditions: a 52-year-old man with depression
    Mary A Whooley
    University of California, San Francisco, and Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    JAMA 307:1848-57. 2012
  5. ncbi request reprint To screen or not to screen? Depression in patients with cardiovascular disease
    Mary A Whooley
    Veterans Affairs Medical Center and University of California, San Francisco, California, USA
    J Am Coll Cardiol 54:891-3. 2009
  6. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
  7. pmc Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study
    Mary A Whooley
    Department of Veterans Affairs Medical Center, San Francisco, California University of California, San Francisco, CA 94121, USA
    Biol Psychiatry 62:314-20. 2007
  8. pmc Depression and cardiovascular disease: healing the broken-hearted
    Mary A Whooley
    Veterans Affairs Medical Center and University of California, San Francisco Medical Center, San Francisco, CA 94121, USA
    JAMA 295:2874-81. 2006
  9. pmc Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study
    David Singh
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Nephrol Dial Transplant 22:1087-92. 2007
  10. pmc Pulmonary regurgitation end-diastolic gradient is a Doppler marker of cardiac status: data from the Heart and Soul Study
    Bryan Ristow
    California Pacific Medical Center, San Francisco, California 94115, USA
    J Am Soc Echocardiogr 18:885-91. 2005

Collaborators

Detail Information

Publications95

  1. pmc Hostility, health behaviors, and risk of recurrent events in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Jonathan M Wong
    School of Medicine, University of California, Irvine, CA
    J Am Heart Assoc 2:e000052. 2013
    ..The purpose of this study was to evaluate potential mechanisms of association between hostility and adverse cardiovascular outcomes...
  2. pmc Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study
    Jeffrey Krauss
    School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26983. 2011
    ..Short telomere length (TL) is an independent predictor of mortality in patients with coronary heart disease (CHD). However, the relationship between physical fitness and TL has not been explored in these patients...
  3. doi request reprint Depression and cardiovascular disorders
    Mary A Whooley
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Annu Rev Clin Psychol 9:327-54. 2013
    ..We also examine current recommendations for screening, diagnosis, and management of depression. We conclude by highlighting new research areas and discussing therapeutic management of depression in patients with cardiovascular disorders...
  4. doi request reprint Diagnosis and treatment of depression in adults with comorbid medical conditions: a 52-year-old man with depression
    Mary A Whooley
    University of California, San Francisco, and Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    JAMA 307:1848-57. 2012
    ....
  5. ncbi request reprint To screen or not to screen? Depression in patients with cardiovascular disease
    Mary A Whooley
    Veterans Affairs Medical Center and University of California, San Francisco, California, USA
    J Am Coll Cardiol 54:891-3. 2009
    ..Thus, patients with cardiovascular disease should receive routine screening for depression by primary care providers in the context of a collaborative care treatment program...
  6. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  7. pmc Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study
    Mary A Whooley
    Department of Veterans Affairs Medical Center, San Francisco, California University of California, San Francisco, CA 94121, USA
    Biol Psychiatry 62:314-20. 2007
    ..However, studies investigating the link between depression and inflammation in patients with established CHD have produced inconclusive results...
  8. pmc Depression and cardiovascular disease: healing the broken-hearted
    Mary A Whooley
    Veterans Affairs Medical Center and University of California, San Francisco Medical Center, San Francisco, CA 94121, USA
    JAMA 295:2874-81. 2006
    ..This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder...
  9. pmc Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study
    David Singh
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Nephrol Dial Transplant 22:1087-92. 2007
    ..In this study, we compared the relative strengths of association of cystatin C and estimated glomerular filtration rate (eGFR) with inflammatory biomarkers...
  10. pmc Pulmonary regurgitation end-diastolic gradient is a Doppler marker of cardiac status: data from the Heart and Soul Study
    Bryan Ristow
    California Pacific Medical Center, San Francisco, California 94115, USA
    J Am Soc Echocardiogr 18:885-91. 2005
    ..Echocardiograms routinely sample pulmonary regurgitation signals from which it is possible to measure end diastolic gradients; these correlate with pulmonary artery diastolic pressures...
  11. pmc Self-efficacy as a marker of cardiac function and predictor of heart failure hospitalization and mortality in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Urmimala Sarkar
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, Box 1732, San Francisco, CA 94143 1732, USA
    Health Psychol 28:166-73. 2009
    ..The authors sought to evaluate the association of self-efficacy with objective measures of cardiac function, subsequent hospitalization for heart failure (HF), and all-cause mortality...
  12. pmc Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study
    Meyeon Park
    From the Division of Nephrology M P, C A P, and Departments of Epidemiology and Biostatistics E V, M W, M G S and Medicine P G, M W, M G S, University of California, San Francisco, CA Division of Cardiology, San Francisco General Hospital, San Francisco, CA P G and San Francisco VA Medical Center, San Francisco, CA M W, M G S
    Arterioscler Thromb Vasc Biol 34:231-6. 2014
    ..This study evaluated circulating soluble endothelial cell-selective adhesion molecule (sESAM), a marker of endothelial dysfunction, as a risk factor for kidney function decline and albuminuria...
  13. pmc Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study
    Ruth Dubin
    University of California, San Francisco, USA
    Am Heart J 163:274-9. 2012
    ..Whether PTX3 is independently associated with adverse events among persons with stable coronary heart disease (CHD), independently of CRP, and whether kidney dysfunction influences these associations are not known...
  14. doi request reprint Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: insights from the Heart and Soul Study
    S Marlene Grenon
    Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
    Vasc Med 18:176-84. 2013
    ..The increased vulnerability to CV events was partially explained by shared CV risk factors and inflammation. ..
  15. pmc Depression, stress, and quality of life in persons with chronic kidney disease: the Heart and Soul Study
    Michelle C Odden
    Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Nephron Clin Pract 103:c1-7. 2006
    ..The effect of mild chronic kidney disease (CKD) on depression, stress, quality of life (QOL), and health status is not well understood. We compared these outcomes in subjects with and without CKD...
  16. pmc C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study
    Mary S Beattie
    Department of Medicine, University of California, San Francisco, USA
    Circulation 107:245-50. 2003
    ..Elevated levels of C-reactive protein (CRP) are associated with an increased risk of coronary events, but whether inflammation is associated with inducible ischemia in patients with stable coronary disease is unknown...
  17. pmc Development of an echocardiographic risk-stratification index to predict heart failure in patients with stable coronary artery disease: the Heart and Soul study
    Steven M Stevens
    Department of Medicine, Division of Cardiology, University of California, San Francisco, California, USA
    JACC Cardiovasc Imaging 2:11-20. 2009
    ..We sought to determine which transthoracic echocardiographic (TTE) measurements most strongly predict heart failure (HF) and to develop an index for risk stratification in outpatients with coronary artery disease (CAD)...
  18. pmc Depression and cardiac function in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Heather Lett
    VA Palo Alto Health Care System, Palo Alto, California, USA
    Psychosom Med 70:444-9. 2008
    ..However, a frequent criticism of this literature is that the association between depression and adverse cardiovascular outcomes may be confounded by worse baseline cardiac disease severity in depressed patients...
  19. pmc Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study
    Mary H Zhang
    University of California, San Francisco, CA 94121, USA
    Atherosclerosis 205:233-8. 2009
    ..We sought to determine whether higher adiponectin levels are associated with exercise-induced ischemia in patients with stable CHD...
  20. pmc Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: data from the Heart and Soul Study
    David D McManus
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143, USA
    J Am Soc Echocardiogr 22:190-7. 2009
    ..The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown...
  21. pmc N-terminal pro-B-type natriuretic peptide as a diagnostic test for ventricular dysfunction in patients with coronary disease: data from the heart and soul study
    David C M Corteville
    Department of Medicine, University of California, San Francisco, CA, USA
    Arch Intern Med 167:483-9. 2007
    ..Whether NT-proBNP can be used to detect ventricular dysfunction in patients with stable coronary heart disease (CHD) and no history of heart failure is unknown...
  22. pmc Association of anemia with diastolic dysfunction among patients with coronary artery disease in the Heart and Soul Study
    Deepu Nair
    Department of Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 95:332-6. 2005
    ..6, 95% CI 0.6 to 4.6) were not significantly associated with LVH. We found anemia to be strongly associated with diastolic dysfunction but not with LVH in this community-based sample of outpatients who had established coronary disease...
  23. pmc Relation between depressive symptoms and treadmill exercise capacity in the Heart and Soul Study
    Bernice Ruo
    Section of General Internal Medicine, VA Medical Center, and Department of Medicine, University of California, San Francisco, USA
    Am J Cardiol 94:96-9. 2004
    ..8, 95% confidence interval 1.1 to 2.7, p = 0.01). Depressive symptoms should be considered in the differential diagnosis of poor exercise capacity...
  24. doi request reprint Comparison of cardiovascular prognosis by 3 serum cystatin C methods in the Heart and Soul Study
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA, USA
    Clin Chem 57:737-45. 2011
    ..Other companies, including Gentian and Roche, have developed cystatin C assays that can be used with most routine clinical chemistry analyzers...
  25. pmc Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study
    Michael G Shlipak
    Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif, USA
    Am J Med 121:50-7. 2008
    ..The study purpose was to evaluate the ability of 6 biomarkers to improve the prediction of cardiovascular events among persons with established coronary artery disease...
  26. pmc C-reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study
    Eric S Williams
    San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, CA, USA
    Eur J Heart Fail 10:63-9. 2008
    ..Whether the association of inflammation with incident HF is explained by worse baseline left ventricular dysfunction or by underlying CHD is unknown...
  27. pmc Association of African American race with elevated pulmonary artery diastolic pressure: data from the Heart and Soul Study
    Kiran K Khush
    Division of Cardiology, University of California, San Francisco, California 94143 0124, USA
    J Am Soc Echocardiogr 20:1307-13. 2007
    ..We hypothesized that African American race is associated with an elevated EDPR gradient that may partially predispose African Americans to heart failure...
  28. pmc Usefulness of noninvasive estimate of pulmonary vascular resistance to predict mortality, heart failure, and adverse cardiovascular events in Patients With stable coronary artery disease (from the Heart and Soul Study)
    Ramin Farzaneh-Far
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 101:762-6. 2008
    ..3 to 4.7). In conclusion, a noninvasive estimate of PVR (TRV/VTI RVOT ratio) predicts mortality, heart failure hospitalization, and adverse cardiovascular events in patients with stable coronary artery disease...
  29. pmc Self-efficacy and health status in patients with coronary heart disease: findings from the heart and soul study
    Urmimala Sarkar
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 1211, USA
    Psychosom Med 69:306-12. 2007
    ..We hypothesized that lower self-efficacy would predict worse health status, independent of CHD severity and depression...
  30. pmc Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:2533-9. 2007
    ..Lower serum fetuin-A concentrations are associated with valvular calcification in persons with end-stage renal disease. Whether fetuin-A is associated with valvular calcification in other patient populations is unknown...
  31. pmc Depressive symptoms and perceived doctor-patient communication in the Heart and Soul study
    Yael Schenker
    Department of Medicine, University of California, San Francisco, Box 1364, San Francisco, CA 94143, USA
    J Gen Intern Med 24:550-6. 2009
    ..Little is known about the extent to which medical comorbidities, disease severity and depressive symptoms influence perceptions of doctor-patient communication in patients with chronic disease...
  32. pmc A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study
    Ramin Farzaneh-Far
    Division of Cardiology, San Francisco General Hospital, San Francisco, California, United States of America
    PLoS ONE 5:e13496. 2010
    ..The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported...
  33. pmc Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study
    Kirsten Neudoerffer Kangelaris
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Gen Intern Med 25:1030-7. 2010
    ....
  34. pmc Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
    Ramin Farzaneh-Far
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 303:250-7. 2010
    ..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
  35. pmc Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: data from the Heart and Soul study
    Bill P C Hsieh
    Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Am Heart J 158:673-9. 2009
    ..We sought to investigate the prevalence and prognostic value of cardiac troponin T (cTnT) elevation in a population with stable CAD...
  36. pmc Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study
    Ramin Farzaneh-Far
    Department of Medicine, University of California San Francisco, 94143 0124, United States
    Atherosclerosis 205:538-43. 2009
    ..We sought to investigate the relationship between n-3 fatty acid levels in erythrocyte membranes and markers of systemic inflammation in 992 individuals with stable coronary artery disease...
  37. pmc Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study
    Ramin Farzaneh-Far
    Department of Medicine, University of California San Francisco, 94143 0124, United States
    Atherosclerosis 205:492-6. 2009
    ..We sought to compare cardiovascular structure and function in carriers and non-carriers of the risk haplotype in a cross-sectional study...
  38. pmc Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study
    Beth E Cohen
    General Internal Medicine, VA Medical Center, San Francisco, CA, United States Department of Medicine, University of California, San Francisco, CA, USA
    Psychiatry Res 175:133-7. 2010
    ..Further research is needed to determine whether addressing socioeconomic and behavioral factors in people with depression or high levels of anger or hostility could reduce the burden of the metabolic syndrome...
  39. pmc Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, General Internal Medicine, University of California, San Francisco, CA 94121, USA
    Arch Gen Psychiatry 66:1214-20. 2009
    ..In addition to its tremendous mental health burden, PTSD has been associated with worse physical health status and an increased risk of cardiovascular disease...
  40. pmc Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study
    Ramin Farzaneh-Far
    Division of Cardiology, San Francisco General Hospital, San Francisco, California, USA
    PLoS ONE 5:e8612. 2010
    ..We sought to investigate the longitudinal trajectory of telomere length, and to identify the independent predictors of telomere shortening, in persons with coronary artery disease...
  41. pmc Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Nutr 138:1135-40. 2008
    ..Our results raise the possibility that (n-3) fatty acids may be an important mediating factor in the association between low SES and CVD...
  42. pmc Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study
    Ramin Farzaneh-Far
    Department of Medicine, Box 0124, University of California San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 28:1379-84. 2008
    ..Telomere shortening has been proposed as a marker of biological aging. Whether leukocyte telomere length is associated with mortality among patients with stable coronary artery disease (CAD) is unknown...
  43. pmc Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study
    Gregory M Marcus
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, CA 94143 1354, USA
    Am Heart J 155:303-9. 2008
    ..We therefore examined several biomarkers of inflammation and ultimately genotyped IL-6 polymorphisms in patients with AF in a cohort of subjects with known CAD...
  44. pmc Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul Study
    Carmen A Peralta
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco, California 94124, USA
    Am J Hypertens 19:939-46. 2006
    ..Whether kidney function in the normal range is associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure is unclear...
  45. pmc Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the heart and soul study)
    Lindsey A Lubbock
    Department of Veterans Affairs Medical Center, San Francisco, California, USA
    Am J Cardiol 96:1506-11. 2005
    ..In conclusion, low SES is associated with high CRP levels in patients who have CHD. This observation raises the possibility that inflammation may contribute to the adverse cardiovascular outcomes associated with low SES...
  46. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
    ..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
  47. pmc Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Nephrol Dial Transplant 21:2144-51. 2006
    ..Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown...
  48. ncbi request reprint Depressive symptoms and bone mineral density in older men
    Mary A Whooley
    San Francisco Department of Veterans Affairs Medical Center, 4150 Clement Street 111A1, San Francisco, CA 94121, USA
    J Geriatr Psychiatry Neurol 17:88-92. 2004
    ..These findings suggest that depressive symptoms are not associated with BMD in community-dwelling, older men...
  49. ncbi request reprint Religious involvement and cigarette smoking in young adults: the CARDIA study (Coronary Artery Risk Development in Young Adults)study (
    Mary A Whooley
    Department of Veterans Affairs Medical Center and Department of Medicine, University of California, San Fancisco, 94121, USA
    Arch Intern Med 162:1604-10. 2002
    ..We sought to determine whether frequent attendance at religious services is associated with less smoking among young adults...
  50. pmc Is B-type natriuretic peptide a useful screening test for systolic or diastolic dysfunction in patients with coronary disease? Data from the Heart and Soul Study
    Kirsten Bibbins-Domingo
    Department of Medicine, University of California, San Francisco, USA
    Am J Med 116:509-16. 2004
    ..We examined the characteristics of a BNP test for identifying systolic and diastolic dysfunction in outpatients with stable coronary disease...
  51. pmc Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Card Fail 12:601-7. 2006
    ..We evaluate whether cystatin C is associated with left ventricular hypertrophy, diastolic dysfunction, and systolic dysfunction among 818 outpatients with coronary artery disease who were free of clinical heart failure...
  52. ncbi request reprint Central nervous system active medications and risk for fractures in older women
    Kristine E Ensrud
    Department of Medicine and Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Intern Med 163:949-57. 2003
    ..Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control of confounders...
  53. ncbi request reprint Depressive symptoms, unemployment, and loss of income: The CARDIA Study
    Mary A Whooley
    Department of Veterans Affairs Medical Center, 4150 Clement St Mail Stop 111A1, San Francisco, CA 94121
    Arch Intern Med 162:2614-20. 2002
    ..Previous studies have suggested an association between depression and low socioeconomic status, but few have empirically examined the effect of depressive symptoms on income and employment over time...
  54. pmc Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, 4150 Clement Street, Box 181G, San Francisco, CA 94121, USA
    J Gerontol A Biol Sci Med Sci 58:M461-7. 2003
    ..Our aim was to examine whether the combination of varying levels of cognitive function and depressive symptoms affect the risk of mortality in community-living elderly adults...
  55. pmc Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California at San Francisco, San Francisco, CA 94143 0532, USA
    Circulation 115:173-9. 2007
    ..Cystatin C is a novel and sensitive endogenous marker of kidney function. Whether cystatin C concentrations are associated with adverse events among ambulatory persons with CHD is unknown...
  56. pmc N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease
    Kirsten Bibbins-Domingo
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    JAMA 297:169-76. 2007
    ..Identification of individuals at high risk for cardiovascular events is important for the optimal use of primary and secondary prevention measures...
  57. pmc Elevated pulmonary artery pressure by Doppler echocardiography predicts hospitalization for heart failure and mortality in ambulatory stable coronary artery disease: the Heart and Soul Study
    Bryan Ristow
    Department of Medicine, Division of Cardiology, University of California, San Francisco, California, USA
    J Am Coll Cardiol 49:43-9. 2007
    ..We compared the predictive ability of tricuspid regurgitation (TR) and end-diastolic pulmonary regurgitation (EDPR) gradients in outpatients with coronary artery disease...
  58. pmc Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Am J Psychiatry 162:2139-45. 2005
    ..Elevated catecholamine levels may contribute to this association, but whether depressive symptoms are associated with catecholamine levels in patients with heart disease is unknown...
  59. ncbi request reprint Prognostic value of low-level cardiac troponin-I elevations in patients without definite acute coronary syndromes
    Michael X Pham
    General Internal Medicine Section, Veterans Affairs Medical Center, and the Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, Calif, USA
    Am Heart J 148:776-82. 2004
    ..However, their prognostic value in other clinical situations remains unclear...
  60. pmc Usefulness of diastolic dominant pulmonary vein flow to predict hospitalization for heart failure and mortality in ambulatory patients with coronary heart disease (from the Heart and Soul Study)
    Xiushui Ren
    Department of Cardiology, California Pacific Medical Center, San Francisco, California, USA
    Am J Cardiol 103:482-5. 2009
    ..004). In conclusion, diastolic dominant pulmonary vein flow pattern was a stand-alone predictor of adverse cardiac events, and its presence was associated with significantly higher rates of HF hospitalizations and cardiovascular death...
  61. pmc Screening for depression in patients with coronary heart disease (data from the Heart and Soul Study)
    David McManus
    Department of Medicine, University of California, San Francisco, USA
    Am J Cardiol 96:1076-81. 2005
    ..A score > or =10 on the Patient Health Questionnaire-9 was 54% sensitive and 90% specific, with a positive likelihood ratio of 5.4. Thus, a cutpoint > or =10 was virtually diagnostic for depression...
  62. pmc Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study)
    Bryan Ristow
    California Pacific Medical Center, San Francisco, CA, USA
    Am J Cardiol 102:70-6. 2008
    ..4, p = 0.02), and LAVI >40 ml/m2 was predictive of mortality (OR 1.9, p = 0.005). In conclusion, LAVI had similar predictability as LVEF for HF hospitalization and mortality in ambulatory adults with coronary artery disease...
  63. pmc Association of chronic kidney disease and anemia with physical capacity: the heart and soul study
    Michelle C Odden
    Section of General Internal Medicine, San Francisco VA Medical Center, CA 94121, USA
    J Am Soc Nephrol 15:2908-15. 2004
    ..CKD and anemia are independently associated with physical limitation and reduced exercise capacity in outpatients with coronary disease, and these effects are additive. The broad impact of these disease conditions merits further study...
  64. pmc Association between renal insufficiency and inducible ischemia in patients with coronary artery disease: the heart and soul study
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, San Francisco, California 94121, USA
    J Am Soc Nephrol 14:3233-8. 2003
    ..The greater severity of atherosclerotic disease observed in patients with CRI may in part explain the association of CRI with increased cardiovascular risk among individuals with CAD...
  65. pmc Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study
    Christian Otte
    Department of Psychiatry, University of California, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Biol Psychiatry 56:241-7. 2004
    ..However, it is not known whether depression is associated with elevated cortisol levels in patients with CHD...
  66. pmc B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the Heart and Soul study
    Kirsten Bibbins-Domingo
    Department of Medicine, University of California, San Francisco, USA
    Circulation 108:2987-92. 2003
    ..However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as myocardial ischemia may also cause elevations in BNP...
  67. pmc Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease
    Michael G Shlipak
    San Francisco VA Medical Center, CA, USA
    BMC Nephrol 12:2. 2011
    ..This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk...
  68. pmc Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study
    Nisha Bansal
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Nephrol 35:483-90. 2012
    ..Whether urine DA is associated with phosphorus homeostasis in humans is uncertain...
  69. pmc Racial differences in atrial fibrillation prevalence and left atrial size
    Gregory M Marcus
    Division of Cardiology, University of California, San Francisco, CA, USA
    Am J Med 123:375.e1-7. 2010
    ....
  70. pmc Predicting heart failure hospitalization and mortality by quantitative echocardiography: is body surface area the indexing method of choice? The Heart and Soul Study
    Bryan Ristow
    California Pacific Medical Center, San Francisco, California 94115, USA
    J Am Soc Echocardiogr 23:406-13. 2010
    ..The American Society of Echocardiography recommends dividing measurements by body surface area (BSA), but others have advocated alternative indexing methods...
  71. pmc Prevalence and prognosis of asymptomatic left ventricular diastolic dysfunction in ambulatory patients with coronary heart disease
    Xiushui Ren
    Department of Cardiology, California Pacific Medical Center, University of California, San Francisco, USA
    Am J Cardiol 99:1643-7. 2007
    ..Patients with asymptomatic LV diastolic dysfunction may benefit from more aggressive therapy to prevent or delay the development of HF...
  72. pmc Association of socioeconomic status and exercise capacity in adults with coronary heart disease (from the Heart and Soul Study)
    Beth Cohen
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Cardiol 101:462-6. 2008
    ..In conclusion, 4 indicators of low SES were strongly associated with decreased exercise capacity in patients with CHD. Differences in traditional cardiac risk factors and health behaviors did not explain this association...
  73. pmc Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study)
    Mintu P Turakhia
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Cardiol 102:1131-5. 2008
    ..004). In conclusion, in patients with stable CHD, increased LV mass index was independently associated with all-cause mortality and sudden or arrhythmic death, even in subjects with normal EF...
  74. pmc Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation
    Whittemore G Tingley
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:8461-6. 2007
    ..Our stem cell-based screen may provide a means of identifying other genes that control heart rhythm...
  75. pmc Relation of self-reported angina pectoris to inducible myocardial ischemia in patients with known coronary artery disease: the Heart and Soul Study
    Anil K Gehi
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Cardiol 92:705-7. 2003
    ..We observed no association between self-reported angina pectoris and objective evidence of inducible ischemia...
  76. pmc Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study
    Anil K Gehi
    Emory University Hospital, 1364 Clifton Rd NE, Ste 414, Atlanta, GA 30322
    Arch Intern Med 167:1798-803. 2007
    ..Whether patient self-report can provide an accurate assessment of medication adherence in outpatients with stable coronary heart disease is unknown...
  77. pmc Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Psychiatry 164:1379-84. 2007
    ..Whether the short allele increases risk for depression associated with the stress of a chronic illness has not been established...
  78. ncbi request reprint Depression predicts mortality and hospitalization in patients with myocardial infarction complicated by heart failure
    John S Rumsfeld
    Section of Cardiology, Denver VA Medical Center, Denver, Colorado 80220, USA
    Am Heart J 150:961-7. 2005
    ..To evaluate whether depressive symptoms are independently predictive of mortality and hospitalization among patients with acute myocardial infarction (AMI) complicated by heart failure...
  79. pmc Inducible ischemia and the risk of recurrent cardiovascular events in outpatients with stable coronary heart disease: the heart and soul study
    Anil K Gehi
    Division of Cardiology, Emory University Hospital, 1364 Clifton Rd NE, Ste 424, Atlanta, GA 30322, USA
    Arch Intern Med 168:1423-8. 2008
    ..Our objective was to compare the prognosis of self-reported angina symptoms, inducible ischemia, or both in patients with stable CHD...
  80. ncbi request reprint Association between anaemia and N-terminal pro-B-type natriuretic peptide (NT-proBNP): findings from the Heart and Soul Study
    Arati S Desai
    Department of Medicine, Johns Hopkins University, United States
    Eur J Heart Fail 9:886-91. 2007
    ..Anaemia is associated with elevated levels of natriuretic peptides. Whether the association of anaemia with natriuretic peptides is independent of other cardiovascular risk factors is unclear...
  81. pmc Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul study
    David McManus
    Cardiology Division, University of Massachusetts, Worcester, MA, USA
    Am J Kidney Dis 49:365-72. 2007
    ..We hypothesized that serum cystatin C concentration would have a stronger more linear association with cardiovascular functional status than creatinine-based measures in outpatients with established coronary heart disease (CHD)...
  82. ncbi request reprint Central nervous system-active medications and risk for falls in older women
    Kristine E Ensrud
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 50:1629-37. 2002
    ..To determine whether current use of central nervous system (CNS)-active medications, including benzodiazepines, antidepressants, anticonvulsants, and narcotics, increases the risk for subsequent falls...
  83. pmc Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Peter De Jonge
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Psychosom Med 69:735-9. 2007
    ....
  84. pmc Acute myocardial infarction in patients with versus without aortic valve sclerosis and effect of statin therapy (from the Heart and Soul Study)
    Sanjiv J Shah
    Division of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 99:1128-33. 2007
    ..4-fold increased rate of subsequent MI. Statins may attenuate the increased risk of future MI in patients with aortic sclerosis...
  85. pmc Depressive symptoms and health-related quality of life: the Heart and Soul Study
    Bernice Ruo
    Section of General Internal Medicine, Veterans Affairs Medical Center, San Francisco 94121, USA
    JAMA 290:215-21. 2003
    ..Little is known regarding the extent to which patient-reported health status, including symptom burden, physical limitation, and quality of life, is determined by psychosocial vs physiological factors among patients with chronic disease...
  86. pmc Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study
    Anil Gehi
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arch Intern Med 165:2508-13. 2005
    ..Medication nonadherence is a potential mechanism for the increased risk of CHD events associated with depression, but it is not known whether depression is associated with medication nonadherence in outpatients with stable CHD...
  87. doi request reprint Depression screening and patient outcomes in cardiovascular care: a systematic review
    Brett D Thombs
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    JAMA 300:2161-71. 2008
    ..Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear...
  88. ncbi request reprint Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial
    Mark A Hlatky
    Stanford University School of Medicine, HRP Redwood Bldg, Room 150, Stanford, CA 94305 5405, USA
    JAMA 287:591-7. 2002
    ..Postmenopausal hormone therapy is commonly used by women for disease prevention, but its effects on quality of life have not been well documented...
  89. pmc Relation of anemia to low heart rate variability in patients with coronary heart disease (from the Heart and Soul study)
    Anil Gehi
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 95:1474-7. 2005
    ..Thus, anemia is associated with low HRV in ambulatory patients who have stable coronary heart disease. Low HRV could potentially mediate the association of anemia with increased cardiac risk...
  90. pmc Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Anil Gehi
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arch Gen Psychiatry 62:661-6. 2005
    ..Whether depression is associated with low HRV in patients with stable coronary heart disease (CHD) is not known...
  91. pmc Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study
    Christian Spies
    Section of Cardiology, Rush University Medical Center, Chicago, Illinois, USA
    Am J Cardiol 95:1175-9. 2005
    ..Decreased exercise capacity may contribute to the adverse outcomes associated with the metabolic syndrome...
  92. ncbi request reprint Blood pressure reactivity to psychological stress and coronary calcification in the Coronary Artery Risk Development in Young Adults Study
    Karen A Matthews
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hypertension 47:391-5. 2006
    ..Blood pressure reactivity may provide useful prognostic information about future risk beyond standard risk factors...
  93. ncbi request reprint Depressive symptoms and rates of bone loss at the hip in older women
    Susan J Diem
    Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55415, USA
    J Am Geriatr Soc 55:824-31. 2007
    ..To ascertain whether depressive symptoms are associated with increased rates of bone loss at the hip...
  94. ncbi request reprint Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study
    Karen A Matthews
    University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA, USA
    Circulation 110:74-8. 2004
    ..We tested whether BP changes during psychological stress predict incident hypertension in young adults...
  95. ncbi request reprint Mind your heart
    Mary A Whooley
    Ann Intern Med 144:858-60. 2006

Research Grants6

  1. Epidemiology of Depression and Heart Failure in Aging
    Mary Whooley; Fiscal Year: 2005
    ..By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients. ..
  2. Epidemiology of Depression and Heart Failure in Aging
    Mary Whooley; Fiscal Year: 2006
    ..By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients. ..
  3. Epidemiology of Depression and Heart Failure in Aging
    Mary Whooley; Fiscal Year: 2007
    ..By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients. ..
  4. Epidemiology of Depression and Heart Failure in Aging
    Mary Whooley; Fiscal Year: 2009
    ..By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients. ..
  5. Epidemiology of Depression and Heart Failure in Aging
    Mary Whooley; Fiscal Year: 2009
    ..By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients. ..