Richard Whitley

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Oncolytic HSV-1 for the treatment of brain tumours
    James M Markert
    Division of Neurosurgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
    Herpes 13:66-71. 2006
  2. ncbi request reprint Prevention and treatment of influenza in high-risk groups: children, pregnant women, immunocompromised hosts, and nursing home residents
    Richard J Whitley
    University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S133-8. 2006
  3. doi request reprint Global assessment of resistance to neuraminidase inhibitors, 2008-2011: the Influenza Resistance Information Study (IRIS)
    Richard J Whitley
    Department of Pediatrics, Microbiology, Medicine and Neurosurgery, University of Alabama at Birmingham, 303 CHB, 1600 Seventh Ave S, Birmingham, AL 35233, USA
    Clin Infect Dis 56:1197-205. 2013
  4. pmc The use of antiviral drugs during the neonatal period
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, 1600 7th Avenue South, Birmingham, AL 35233 1711, USA
    Clin Perinatol 39:69-81. 2012
  5. ncbi request reprint Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63
    Richard J Whitley
    Department of Medicine, University of Alabama at Birmingham, Alabama 35233 0011, USA
    J Infect Dis 190:1360-7. 2004
  6. ncbi request reprint Herpes simplex encephalitis: children and adolescents
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
    Semin Pediatr Infect Dis 16:17-23. 2005
  7. ncbi request reprint Seasonal and pandemic influenza preparedness: a global threat
    Richard J Whitley
    Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery and Center for Biodefense and Emerging Infections, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S65-9. 2006
  8. ncbi request reprint Herpes simplex encephalitis: adolescents and adults
    Richard J Whitley
    Department of Pediatrics, Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue, CHB 303, Birmingham, AL 35233, United States
    Antiviral Res 71:141-8. 2006
  9. ncbi request reprint Single-day famciclovir therapy for recurrent genital herpes
    Richard Whitley
    Department of Pediatrics, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Curr Med Res Opin 22:1307-10. 2006
  10. ncbi request reprint Seasonal and pandemic influenza: recommendations for preparedness in the United States
    Richard J Whitley
    Department of Pediatric, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S155-61. 2006

Detail Information

Publications68

  1. ncbi request reprint Oncolytic HSV-1 for the treatment of brain tumours
    James M Markert
    Division of Neurosurgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 3410, USA
    Herpes 13:66-71. 2006
    ..In this review, the background of this approach will be discussed, followed by a discussion of the clinical trials, as well as potential directions for future trials...
  2. ncbi request reprint Prevention and treatment of influenza in high-risk groups: children, pregnant women, immunocompromised hosts, and nursing home residents
    Richard J Whitley
    University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S133-8. 2006
    ..The development of additional antiviral drugs is an important recommendation for the future, so that antiviral resistance can be circumvented. Similarly, availability of drugs for children <1 year of age is mandatory...
  3. doi request reprint Global assessment of resistance to neuraminidase inhibitors, 2008-2011: the Influenza Resistance Information Study (IRIS)
    Richard J Whitley
    Department of Pediatrics, Microbiology, Medicine and Neurosurgery, University of Alabama at Birmingham, 303 CHB, 1600 Seventh Ave S, Birmingham, AL 35233, USA
    Clin Infect Dis 56:1197-205. 2013
    ....
  4. pmc The use of antiviral drugs during the neonatal period
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, 1600 7th Avenue South, Birmingham, AL 35233 1711, USA
    Clin Perinatol 39:69-81. 2012
    ..This article reviews the use of acyclovir and ganciclovir in the treatment of neonatal HSV and congenital CMV infections. A brief summary precedes a detailed discussion of available established and alternative therapeutics...
  5. ncbi request reprint Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63
    Richard J Whitley
    Department of Medicine, University of Alabama at Birmingham, Alabama 35233 0011, USA
    J Infect Dis 190:1360-7. 2004
  6. ncbi request reprint Herpes simplex encephalitis: children and adolescents
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
    Semin Pediatr Infect Dis 16:17-23. 2005
    ..Recent investigative efforts are assessing the value of PCR detection of viral DNA at the completion of therapy and the value of prolonged antiviral therapy...
  7. ncbi request reprint Seasonal and pandemic influenza preparedness: a global threat
    Richard J Whitley
    Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery and Center for Biodefense and Emerging Infections, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S65-9. 2006
    ....
  8. ncbi request reprint Herpes simplex encephalitis: adolescents and adults
    Richard J Whitley
    Department of Pediatrics, Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue, CHB 303, Birmingham, AL 35233, United States
    Antiviral Res 71:141-8. 2006
    ....
  9. ncbi request reprint Single-day famciclovir therapy for recurrent genital herpes
    Richard Whitley
    Department of Pediatrics, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Curr Med Res Opin 22:1307-10. 2006
    ....
  10. ncbi request reprint Seasonal and pandemic influenza: recommendations for preparedness in the United States
    Richard J Whitley
    Department of Pediatric, University of Alabama at Birmingham, Birmingham, AL, 35233 1711, USA
    J Infect Dis 194:S155-61. 2006
    ....
  11. ncbi request reprint Incidence of neonatal herpes simplex virus infections in a managed-care population
    Richard Whitley
    Department of Pediatrics, Microbiology, Medicine and Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Sex Transm Dis 34:704-8. 2007
    ....
  12. ncbi request reprint The role of oseltamivir in the treatment and prevention of influenza in children
    Richard J Whitley
    University of Alabama at Birmingham, Department of Pediatrics, CHB 303, 1600 Seventh Avenue South, Birmingham, AL 35294 0011, USA
    Expert Opin Drug Metab Toxicol 3:755-67. 2007
    ..In the event of an influenza pandemic, oseltamivir is expected to be at the forefront of containment strategies. This article reviews the pharmacology, efficacy and tolerability of oseltamivir as treatment and prophylaxis in children...
  13. doi request reprint A 70-year-old woman with shingles: review of herpes zoster
    Richard J Whitley
    Department of Pediatrics, University of Alabama at Birmingham, CHB 303, 1600 Seventh Ave S, Birmingham, AL 35294 0011, USA
    JAMA 302:73-80. 2009
    ..Using her case as a springboard, the diagnosis, natural history, and treatment of herpes zoster and postherpetic neuralgia in immunocompetent older adults are reviewed, in addition to the effectiveness of the herpes zoster vaccine...
  14. doi request reprint Therapy of herpes virus infections in children
    Richard J Whitley
    The University of Alabama at Birmingham, AL 35233, USA
    Adv Exp Med Biol 609:216-32. 2008
    ..However, and notably so, numerous viral diseases of children represent unmet medical needs and warrant dedicated drug discovery efforts, including hepatitis B and C, and respiratory syncytial virus, among others...
  15. doi request reprint Management of herpes zoster and post-herpetic neuralgia now and in the future
    Richard J Whitley
    University of Alabama at Birmingham, CHB 303, 1600 Seventh Avenue South, Birmingham, AL 35233, USA
    J Clin Virol 48:S20-8. 2010
    ..The role of translational neuroscience in moving towards a goal of finding disease-modifying treatments will be examined...
  16. ncbi request reprint Cytomegalovirus and HIV: inextricably entwined pathogens
    Richard J Whitley
    Departments of Pediatrics, Microbiology, Medicine, and Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Lancet 363:2101-2. 2004
  17. ncbi request reprint Neonatal herpes simplex virus infection
    Richard Whitley
    University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Curr Opin Infect Dis 17:243-6. 2004
    ..This review considers recent advances that impact on disease management...
  18. ncbi request reprint Herpes simplex virus infection
    Richard J Whitley
    Department of Pediatrics, University of Alabama at Birmingham, USA
    Semin Pediatr Infect Dis 13:6-11. 2002
    ..Its prodrug, valaciclovir, and the prodrug of penciclovir, famciclovir, have not been used in practice as long and, therefore, less is known about these agents; however, neither is available as a pediatric formulation...
  19. pmc Herpes simplex viruses: is a vaccine tenable?
    Richard J Whitley
    Department of Pediatrics, Microbiology and Medicine, University of Alabama at Birmingham, 35233, USA
    J Clin Invest 110:145-51. 2002
  20. ncbi request reprint Immunologic approach to herpes simplex virus
    R J Whitley
    University of Alabama at Birmingham, Department of Pediatrics, Microbiology and Medicine, Children s Hospital, 35233, USA
    Viral Immunol 14:111-8. 2001
    ..Finally, the potential benefit of immune response modifiers (IRMs), which have shown promise in early clinical studies, is discussed...
  21. ncbi request reprint Smallpox: a potential agent of bioterrorism
    Richard J Whitley
    Department of Pediatrics, Microbiology and Medicine Children s Hospital, The University of Alabama at Birmingham, ACC 616, 1600 7th Avenue South, Birmingham, AL 35233, USA
    Antiviral Res 57:7-12. 2003
    ..The availability of a vaccine and antiviral drugs that are safe would significantly remove any major threat of smallpox deployment by a terrorist...
  22. ncbi request reprint Herpes simplex virus infections
    R J Whitley
    Department of Pediatrics, Microbiology, and Medicine, University of Alabama at Birmingham, Children s Hospital, 1600 7th Avenue South, Birmingham, AL 35233, USA
    Lancet 357:1513-8. 2001
    ..This review provides a contemporary interpretation of the biological properties, function, epidemiology, and treatment of HSV diseases...
  23. ncbi request reprint Oral oseltamivir treatment of influenza in children
    R J Whitley
    University of Alabama, Birmingham, USA
    Pediatr Infect Dis J 20:127-33. 2001
    ..Oral oseltamivir administration is effective treatment for influenza in adults. This study was conducted to determine the efficacy, safety and tolerability of oseltamivir in children with influenza...
  24. ncbi request reprint The identification of risk factors associated with persistent pain following herpes zoster
    R J Whitley
    Department of Pediatrics, Microbiology, and Medicine, University of Alabama at Birmingham 35233, USA
    J Infect Dis 178:S71-5. 1998
    ..When two or more of these factors were present, the risk of persistent pain was increased...
  25. ncbi request reprint Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel. International AIDS Society-USA
    R J Whitley
    University of Alabama at Birmingham School of Medicine, 35233, USA
    Arch Intern Med 158:957-69. 1998
    ..To provide recommendations for the treatment of acquired immunodeficiency syndrome-related cytomegalovirus (CMV) end-organ diseases, including retinitis, colitis, pneumonitis, and neurologic diseases...
  26. ncbi request reprint Herpes zoster: risk categories for persistent pain
    R J Whitley
    Department of Pediatrics, University of Alabama at Birmingham, USA
    J Infect Dis 179:9-15. 1999
    ..0; 95% confidence interval [CI], 6. 6-48.6, and RR, 5.3; 95% CI, 4.2-17.2, respectively). These analyses identify the subgroups of patients for whom aggressive interventions are most strongly indicated...
  27. ncbi request reprint Valacyclovir therapy to reduce recurrent genital herpes in pregnant women
    William W Andrews
    Department of Obstetrics and Gynecology, Center for Research in Women s Health, University of Alabama, Birmingham, AL, USA
    Am J Obstet Gynecol 194:774-81. 2006
    ..The purpose of this study was to estimate the efficacy of valacyclovir suppressive therapy in pregnant women with recurrent genital herpes...
  28. pmc Serial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors
    Amish C Shah
    Division of Neurosurgery, University of Alabama at Birmingham, 510 20th Street South, Birmingham, AL 35294 3410, USA
    J Virol 80:7308-15. 2006
    ..This finding emphasizes the contribution of the in vivo tumor environment for selecting novel oncolytic HSV specifically adapted for tumor cell destruction in vivo...
  29. ncbi request reprint The spectrum of genital herpes simplex virus infection in men attending a sexually transmitted disease clinic
    James M Sizemore
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
    J Infect Dis 193:905-11. 2006
    ..The spectrum of genital herpes (GH) has been understudied in men, especially African American men...
  30. ncbi request reprint Viral encephalitis: familiar infections and emerging pathogens
    Richard J Whitley
    Department of Pediatrics, Microbiology and Medicine, University of Alabama at Birmingham, USA
    Lancet 359:507-13. 2002
    ..We review current understanding of viral encephalitides with particular reference to emerging viral infections and the availability of existing treatment regimens...
  31. pmc Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM
    James M Markert
    Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 3410, USA
    Mol Ther 17:199-207. 2009
    ..Evidence of viral replication was demonstrated. G207 appears safe for multiple dose delivery, including direct inoculation into the brain surrounding tumor resection cavity...
  32. doi request reprint Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Infect Dis 197:836-45. 2008
    ..Intravenous ganciclovir administered for 6 weeks improves hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system...
  33. pmc Oseltamivir dosing for influenza infection in premature neonates
    Edward P Acosta
    Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    J Infect Dis 202:563-6. 2010
    ..0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population...
  34. pmc Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system
    Sara E Oliver
    Department of Pediatrics, University of Alabama at Birmingham, United States
    J Clin Virol 46:S22-6. 2009
    ..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)...
  35. ncbi request reprint Varicella-zoster vaccine for the prevention of herpes zoster
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    N Engl J Med 356:1338-43. 2007
  36. pmc Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides
    Mark N Prichard
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA
    Antimicrob Agents Chemother 53:5251-8. 2009
    ....
  37. pmc Safety of oseltamivir compared with the adamantanes in children less than 12 months of age
    David W Kimberlin
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA
    Pediatr Infect Dis J 29:195-8. 2010
    ..To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine...
  38. ncbi request reprint Current non-AIDS antiviral chemotherapy
    Scott T Rottinghaus
    Infectious Diseases, The University of Alabama at Birmingham, Department of Medicine, 1530 Third Avenue South, Birmingham, AL 35294 0006, USA
    Expert Rev Anti Infect Ther 5:217-30. 2007
    ..Notably, considerable progress remains to be made in these areas. Moreover, a variety of additional viral diseases currently require the development of specific therapies...
  39. ncbi request reprint Recurrent benign lymphocytic meningitis
    Marwan Shalabi
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Clin Infect Dis 43:1194-7. 2006
    ..This therapy is thought to be beneficial, although there is no controlled trial data to support efficacy and safety...
  40. ncbi request reprint Neonatal herpes: what have we learned
    David W Kimberlin
    Department of Pediatrics, The University of Alabama Birmingham, AL 35233, USA
    Semin Pediatr Infect Dis 16:7-16. 2005
    ..In the longer term, development of a bedside nucleic acid detection kit for real-time detection of HSV DNA in the maternal genital tract at the time of delivery could identify which babies are at risk of developing neonatal HSV disease...
  41. ncbi request reprint Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12
    Jacqueline N Parker
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294 3410, USA
    Cancer Gene Ther 12:359-68. 2005
    ..Our results demonstrate that combinatorial cytokine/chemokine gamma(1)34.5(-) HSV therapies can provide superior antitumor effects in experimental tumors as a model for malignancies arising in the brain...
  42. ncbi request reprint Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates
    Jacqueline N Parker
    Department of Pediatrics, Division of Infectious Diseases, The University of Alabama at Birmingham, CHB 118B, 1600 6th Avenue South, Birmingham, AL 35233, USA
    Vaccine 24:1644-52. 2006
    ..These data suggest that conditionally replicating, cytokine-expressing HSV are able to elicit protective immune responses while retaining safety in an experimental murine model...
  43. ncbi request reprint Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 143:16-25. 2003
    ..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease...
  44. ncbi request reprint Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system
    Russell D Bradford
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Infect Dis 191:227-33. 2005
    ....
  45. doi request reprint Predictors of undiagnosed herpes simplex virus type 2 seropositivity among persons attending an HIV care clinic
    Nicholas J Van Wagoner
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    Sex Transm Dis 39:857-9. 2012
    ..We demonstrate that although the seroprevalence of HSV-2 is higher in this HIV-infected population, predictors of HSV-2 seropositivity are similar to those in the general population...
  46. pmc Treatment of congenital cytomegalovirus infection: implications for future therapeutic strategies
    Lauren Nassetta
    Department of Pediatrics, The University of Alabama at Birmingham, USA
    J Antimicrob Chemother 63:862-7. 2009
    ..Notably, only intravenous ganciclovir and orally administered valganciclovir have been used to treat congenital CMV infection. Hopefully, other drugs such as maribavir will be available for evaluation in this population...
  47. ncbi request reprint Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis
    Mark J Abzug
    Pediatric Infectious Disease, Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 1056 E Nineteenth Avenue, Denver, CO 80218, USA
    Pediatr Infect Dis J 22:335-41. 2003
    ..Treatment of older children and adults with pleconaril has been associated with reduced severity and duration of symptoms. This study evaluated the pharmacokinetics, safety and efficacy of pleconaril in infants with EV meningitis...
  48. doi request reprint Herpes simplex virus in African American heterosexual males: the roles of age and male circumcision
    Nicholas J Van Wagoner
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham, AL, USA
    Sex Transm Dis 37:217-22. 2010
    ..Male circumcision is protective against human immunodeficiency virus (HIV) and select other STIs. The protective role of male circumcision in genital herpes simplex virus (HSV) infection and disease, however, remains controversial...
  49. pmc HIV-1(89.6) Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in mice
    Scott D Parker
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Vaccine 25:6764-73. 2007
    ..These data highlight the potential utility of neuroattenuated, replication competent HSV-1 vectors for delivery of HIV-1 immunogens...
  50. ncbi request reprint Regulatory challenges: lessons from recent West Nile virus trials in the United States
    Penelope M Jester
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Contemp Clin Trials 27:254-9. 2006
    ....
  51. pmc Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection
    Scott H James
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
    Antiviral Res 83:207-13. 2009
    ..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments...
  52. ncbi request reprint Effect of adenine arabinoside on severe Herpesvirus hominis infections in man. 1973
    Lawrence T Ch'ien
    Department of Pediatrics, School of Medicine, The University of Alabama in Birmingham, USA
    J Infect Dis 190:1362-7. 2004
  53. doi request reprint The new age of molecular diagnostics for microbial agents
    Richard Whitley
    University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 358:988-9. 2008
  54. ncbi request reprint Congenital cytomegalovirus infection: epidemiology and treatment
    Richard J Whitley
    University of Alabama at Birmingham, USA
    Adv Exp Med Biol 549:155-60. 2004
    ..Ideally, the best approach would be the development of an efficacious vaccine. Regardless, current clinical efforts define a new era for the treatment of congenital infections...
  55. ncbi request reprint Clinical practice. Herpes zoster
    John W Gnann
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Ala 35294 2170, USA
    N Engl J Med 347:340-6. 2002
  56. ncbi request reprint Clinical applications for change-point analysis of herpes zoster pain
    Renee A Desmond
    Medical Statistics Section, Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Pain Symptom Manage 23:510-6. 2002
    ..This model verifies three phases of zoster pain and delineates the impact of treatment and other factors on the phase-specific rates of pain cessation...
  57. ncbi request reprint Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America
    Gregory J Mertz
    Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Clin Infect Dis 39:1307-13. 2004
    ..BACKGROUND. Ribavirin is active in vitro against hantaviruses, but the findings of an open trial of the use of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome (HCPS) were inconclusive...
  58. doi request reprint Seasonal and pandemic influenza: a 2007 update on challenges and solutions
    Arnold S Monto
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, USA
    Clin Infect Dis 46:1024-31. 2008
    ..These initiatives will also help control outbreaks of seasonal influenza...
  59. ncbi request reprint Neonatal herpes should be a reportable disease
    H Hunter Handsfield
    University of Washington, Center for AIDS and STD, Harborview Medical Center, Seattle, Washington 98104, USA
    Sex Transm Dis 32:521-5. 2005
    ..Neonatal herpes should be a reportable condition...
  60. ncbi request reprint The incidence and severity of herpes simplex encephalitis in Sweden, 1990-2001
    Richard J Whitley
    Clin Infect Dis 45:881-2. 2007
  61. ncbi request reprint Review of recent HSV recurrent-infection treatment studies
    Raj Patel
    Southampton University Hospitals, University of Southampton, UK
    Herpes 14:23-6. 2007
    ..This article reports on presentations given at the IHMF Annual Meeting and International Congress of Antimicrobial Agents and Chemotherapy, both of which took place in late 2006...
  62. pmc Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model
    Elizabeth K Hellums
    Brain Tumor Research Laboratories, Division of Neurosurgery, Department of Surgery, University of Alabama School of Medicine, Birmingham AL 35294, USA
    Neuro Oncol 7:213-24. 2005
    ..We conclude that the 4C8/B6D2F1 syngeneic glioma model is suitable for preclinical evaluation of HSV-based therapies and that M002 is a superior virus for the treatment of murine glioma in this model...
  63. ncbi request reprint Changing dynamics of varicella-zoster virus infections in the 21st century: the impact of vaccination
    Richard J Whitley
    J Infect Dis 191:1999-2001. 2005
  64. ncbi request reprint Human herpesvirus 6 infection of the central nervous system: is it just a case of mistaken association?
    Richard J Whitley
    Clin Infect Dis 40:894-5. 2005
  65. ncbi request reprint Recommendations for the management of herpes zoster
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 44:S1-26. 2007
    ..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ...
  66. doi request reprint Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia
    Robert H Dworkin
    Department of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Pain 9:S37-44. 2008
    ..PERSPECTIVE: Comprehensive assessments of pain are necessary for clinical research on the epidemiology, natural history, pathophysiologic mechanisms, treatment, and prevention of pain in herpes zoster and PHN...
  67. ncbi request reprint A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients
    Gary L Davis
    Division of Hepatology, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 11:941-9. 2005
    ..Further studies are required to determine whether the drug has beneficial effects in this group of patients...
  68. ncbi request reprint Lessons learned from reconstructing the 1918 influenza pandemic
    Adolfo Garcia-Sastre
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, 10029, USA
    J Infect Dis 194:S127-32. 2006
    ..Monitoring the sequences of avian influenza viruses for genetic changes and diversity may help us to predict the risks that these viruses pose of causing a new pandemic...