Genomes and Genes
Luke J Whitesell
Affiliation: University of Arizona
- The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agentL Whitesell
Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
Mol Cell Biol 18:1517-24. 1998..GA did not, however, appear to restore wild-type transcriptional activating activity to mutant p53 proteins in either A1-5 cells or human breast cancer cell lines...
- Inhibition of oncogene expression using vector-generated RNA antisenseL Whitesell
Department of Pediatrics, University of Arizona, Tucson, Arizona 85724, USA
Methods 18:296-303. 1999..Lastly, using specific examples, the limitations and potential artifacts associated with antisense vector use in the study of tumorigenesis are discussed...
- The stress response: implications for the clinical development of hsp90 inhibitorsLuke Whitesell
Steele Memorial Children s Research Center, University of Arizona, Tucson, AZ 85724, USA
Curr Cancer Drug Targets 3:349-58. 2003..Lastly, stress response induction by Hsp90 inhibitors may have therapeutic benefits in non-neoplastic disorders such as heart disease, stroke and neurodegenerative diseases. These benefits are just beginning to be explored...