William Whitehead

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO
    Miranda A L Van Tilburg
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Complement Altern Med 8:46. 2008
  2. ncbi Mindfulness for irritable bowel syndrome: protocol development for a controlled clinical trial
    SUSAN A GAYLORD
    Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Complement Altern Med 9:24. 2009
  3. ncbi Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome
    W E Whitehead
    Center for Functional Gastrointestinal and Motility Disorders and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599, USA
    Neurogastroenterol Motil 23:944-e400. 2011
  4. ncbi Fecal incontinence in US adults: epidemiology and risk factors
    William E Whitehead
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 137:512-7, 517.e1-2. 2009
  5. ncbi Conservative and behavioural management of constipation
    W E Whitehead
    Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Neurogastroenterol Motil 21:55-61. 2009
  6. ncbi The usual medical care for irritable bowel syndrome
    W E Whitehead
    Center for Functional GI and Motility Disorders and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599 7555, USA
    Aliment Pharmacol Ther 20:1305-15. 2004
  7. ncbi Validation of symptom-based diagnostic criteria for irritable bowel syndrome: a critical review
    William E Whitehead
    Center for Functional Gastrointestinal and Motility Disorders, and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 105:814-20; quiz 813, 821. 2010
  8. ncbi Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome
    W E Whitehead
    Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Aliment Pharmacol Ther 24:137-46. 2006
  9. ncbi Hypnosis for irritable bowel syndrome: the empirical evidence of therapeutic effects
    William E Whitehead
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Clin Exp Hypn 54:7-20. 2006
  10. ncbi Functional disorders of the anus and rectum
    W E Whitehead
    Committee on Functional Anorectal Disorders, Multinational Working Teams to Develop Diagnostic Criteria for Functional Gastrointestinal Disorders Rome II, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Gut 45:II55-9. 1999

Research Grants

  1. Advancing the Treatment of Fecal & Urinary Incontinence
    William Whitehead; Fiscal Year: 2003
  2. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2006
  3. Gastrointestinal Biopsychosocial Research Center
    William Whitehead; Fiscal Year: 2007
  4. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2007
  5. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2009
  6. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2009
  7. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2003
  8. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2002
  9. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William E Whitehead; Fiscal Year: 2010

Collaborators

Detail Information

Publications71

  1. ncbi Complementary and alternative medicine use and cost in functional bowel disorders: a six month prospective study in a large HMO
    Miranda A L Van Tilburg
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Complement Altern Med 8:46. 2008
    ..The aim of this study is to determine prevalence, types and costs of CAM in IBS, functional diarrhea, functional constipation, and functional abdominal pain...
  2. ncbi Mindfulness for irritable bowel syndrome: protocol development for a controlled clinical trial
    SUSAN A GAYLORD
    Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Complement Altern Med 9:24. 2009
    ..This paper describes an on-going feasibility study to assess the efficacy of mindfulness training, a behavioral treatment involving directing and sustaining attention to present-moment experience, for the treatment of IBS...
  3. ncbi Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome
    W E Whitehead
    Center for Functional Gastrointestinal and Motility Disorders and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599, USA
    Neurogastroenterol Motil 23:944-e400. 2011
    ..A secondary aim was to determine whether changes in pain sensitivity influence clinical pain independently of changes in transit time...
  4. ncbi Fecal incontinence in US adults: epidemiology and risk factors
    William E Whitehead
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 137:512-7, 517.e1-2. 2009
    ..The study aims were to estimate the prevalence of different types and frequencies of fecal incontinence (FI), describe demographic factors, and identify risk factors...
  5. ncbi Conservative and behavioural management of constipation
    W E Whitehead
    Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Neurogastroenterol Motil 21:55-61. 2009
    ....
  6. ncbi The usual medical care for irritable bowel syndrome
    W E Whitehead
    Center for Functional GI and Motility Disorders and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599 7555, USA
    Aliment Pharmacol Ther 20:1305-15. 2004
    ..To determine what constitutes usual medical care for irritable bowel syndrome, which patient characteristics influence choice of treatment and how satisfied patients are with care...
  7. ncbi Validation of symptom-based diagnostic criteria for irritable bowel syndrome: a critical review
    William E Whitehead
    Center for Functional Gastrointestinal and Motility Disorders, and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 105:814-20; quiz 813, 821. 2010
    ..There are no consistent differences in sensitivity or specificity between Manning, Rome I, and Rome II. Both study types support the validity of symptom-based IBS criteria. Tests of Rome III are needed...
  8. ncbi Utility of red flag symptom exclusions in the diagnosis of irritable bowel syndrome
    W E Whitehead
    Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Aliment Pharmacol Ther 24:137-46. 2006
    ..Studies suggest that the positive predictive value of the Rome II criteria for diagnosing irritable bowel syndrome can be enhanced by excluding red flag symptoms suggestive of organic diseases...
  9. ncbi Hypnosis for irritable bowel syndrome: the empirical evidence of therapeutic effects
    William E Whitehead
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Clin Exp Hypn 54:7-20. 2006
    ....
  10. ncbi Functional disorders of the anus and rectum
    W E Whitehead
    Committee on Functional Anorectal Disorders, Multinational Working Teams to Develop Diagnostic Criteria for Functional Gastrointestinal Disorders Rome II, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Gut 45:II55-9. 1999
    ..Some suggestions for the direction of future research on these disorders are also given...
  11. ncbi Control groups appropriate for behavioral interventions
    William E Whitehead
    Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, 27599 7080, USA
    Gastroenterology 126:S159-63. 2004
    ....
  12. ncbi Priorities for treatment research from different professional perspectives
    William E Whitehead
    Division of Gastroenterology and Hepatology, Center for Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill 27599 7080, USA
    Gastroenterology 126:S180-5. 2004
    ....
  13. ncbi Sexual and physical abuse are not associated with rectal hypersensitivity in patients with irritable bowel syndrome
    Y Ringel
    Department of Medicine, Division of Digestive Diseases and Nutrition, and the UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, 27599 7080, USA
    Gut 53:838-42. 2004
    ..This lead to a hypothesis that abuse history may sensitise patients to report pain at a lower threshold...
  14. ncbi Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception
    W E Whitehead
    Division of Digestive Diseases and Nutrition and UNC Functional Gastrointestinal Disorders Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Gastroenterology 115:1263-71. 1998
    ..Rectal pain sensitivity has been called a biological marker for irritable bowel syndrome, but this conclusion may be premature. This article is a critical review of the evidence for psychological influences on perception...
  15. ncbi Psychosocial aspects of the functional gastrointestinal disorders
    D A Drossman
    Division of Digestive Diseases, University of North Carolina, Chapel Hill 27599 7080, USA
    Gut 45:II25-30. 1999
    ..Review of treatment trials indicates clear support for psychotherapeutic treatments, especially in the long term, as well as some evidence for the benefit of antidepressants in FGID, even in the absence of improvements in mood...
  16. ncbi Factor analysis of bowel symptoms in US and Italian populations
    W E Whitehead
    UNC Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, USA
    Dig Liver Dis 35:774-83. 2003
    ..CONCLUSIONS: Empirically derived symptom clusters agree in most respects with the Rome II classification system and support their validity. These symptom clusters are independent of cultural differences in diet and behaviour...
  17. ncbi Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress
    M Grover
    Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, NC 27599 7080, USA
    Neurogastroenterol Motil 20:998-1008. 2008
    ..05) and SIBO- IBS patients (P < 0.05). SIBO is unlikely to contribute significantly to the pathogenesis of IBS. Methane production is associated with constipation...
  18. ncbi Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases and Department of Radiology and Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 124:754-61. 2003
    ..We also found that clinical and psychosocial improvement was associated with reduced cingulate activation...
  19. ncbi Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain
    K A Nyrop
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Aliment Pharmacol Ther 26:237-48. 2007
    ..To provide estimates of actual costs to deliver health care to patients with functional bowel disorders, and to assess the cost impact of symptom severity, recency of onset, and satisfaction with treatment...
  20. ncbi Treatment options for fecal incontinence
    W E Whitehead
    UNC Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dis Colon Rectum 44:131-42; discussion 142-4. 2001
    ....
  21. ncbi Selective recall of gastrointestinal-sensation words: evidence for a cognitive-behavioral contribution to irritable bowel syndrome
    N Gibbs-Gallagher
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Gastroenterol 96:1133-8. 2001
    ..CONCLUSIONS: IBS patients selectively recall words describing GI sensations; this suggests that they may selectively attend to GI sensations, thus supporting the cognitive-behavioral theory of IBS...
  22. ncbi Biofeedback treatment of fecal incontinence: a critical review
    S Heymen
    Center for Functional Gastrointestinal and Motility Disorders, Department of Medicine, The University of North Carolina, Chapel Hill 27599-7080, USA
    Dis Colon Rectum 44:728-36. 2001
    ..Recommendations are made for future investigations to 1) improve experimental design, 2) include long term follow-up data, and 3) to use an adequate sample size that allows for meaningful analysis...
  23. ncbi Bowel symptoms in women planning surgery for pelvic organ prolapse
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 195:1814-9. 2006
    ..2). CONCLUSION: Bowel symptoms and questionnaire scores do not increase with prolapse stage in women presenting for sacrocolpopexy...
  24. ncbi Validation of the Japanese version of the Rome II modular questionnaire and irritable bowel syndrome severity index
    Masae Shinozaki
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Seiryo, Aoba, Sendai, Japan
    J Gastroenterol 41:491-4. 2006
    ..86, P < 0.001). CONCLUSIONS: The RIIMQ-J and IBSSI-J are valid, reliable, and appropriate instruments for detecting and assessing the severity of IBS status in Japanese patients...
  25. ncbi Reports of "satisfactory relief" by IBS patients receiving usual medical care are confounded by baseline symptom severity and do not accurately reflect symptom improvement
    William E Whitehead
    Division of Gastroenterology and Hepatology and Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7080, USA
    Am J Gastroenterol 101:1057-65. 2006
    ..Confirmation of these findings in a clinical trial is needed...
  26. ncbi Parents' worries about recurrent abdominal pain in children
    Miranda A L Van Tilburg
    Center for Motility and Functional GI Disorders, Department of Medicine, University of North Carolina, Chapel Hill, 27599, USA
    Gastroenterol Nurs 29:50-5; quiz 56-7. 2006
    ..This study adds to our understanding of parents' view on recurrent abdominal pain and gives us tools to address cognitions that can perpetuate symptoms in children...
  27. ncbi Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI study
    Yehuda Ringel
    UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
    Gastroenterology 134:396-404. 2008
    ..These effects may be mediated by enhanced responses to aversive visceral stimuli. We investigated the effects of IBS and abuse history on pain reporting and brain activation in response to rectal distentions...
  28. ncbi Randomized, controlled trial shows biofeedback to be superior to alternative treatments for patients with pelvic floor dyssynergia-type constipation
    Steve Heymen
    UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dis Colon Rectum 50:428-41. 2007
    ....
  29. ncbi Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity
    Spencer D Dorn
    Center for Functional GI and Motility Disorders, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599 7080, USA
    Gut 56:1202-9. 2007
    ..The aim was to determine whether lower visceral pain thresholds in irritable bowel syndrome (IBS) primarily reflect physiological or psychological factors...
  30. ncbi Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment
    Douglas Drossman
    The UNC Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 102:1442-53. 2007
    ....
  31. ncbi Prevalence of symptomatic pelvic floor disorders in US women
    Ingrid Nygaard
    Department of Obstetrics and Gynecology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2209, USA
    JAMA 300:1311-6. 2008
    ..No national prevalence estimates derived from the same population-based sample exists for multiple pelvic floor disorders in women in the United States...
  32. ncbi Enhancing participation of older women in surgical trials
    Patricia S Goode
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Am Coll Surg 207:303-11. 2008
    ..Older participants are often excluded from clinical trials, precluding a representative sample...
  33. ncbi Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits
    Motoyori Kanazawa
    Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, North Carolina, USA
    Am J Gastroenterol 103:2550-61. 2008
    ..Aims were to determine whether predominant bowel habits and IBS symptom severity are related to pain sensitivity, colon motility, or smooth muscle tone...
  34. ncbi Comorbidity in irritable bowel syndrome
    William E Whitehead
    Center for Functional GI and Motility Disorders at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
    Am J Gastroenterol 102:2767-76. 2007
    ..Comorbid nongastrointestinal symptoms account for two-thirds of excess health-care costs in irritable bowel syndrome (IBS)...
  35. ncbi The role of biofeedback in the treatment of gastrointestinal disorders
    Giuseppe Chiarioni
    Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Nat Clin Pract Gastroenterol Hepatol 5:371-82. 2008
    ..For both incontinence and dyssynergic defecation, the benefits of biofeedback last at least 12 months...
  36. ncbi Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia
    Giuseppe Chiarioni
    Gastrointestinal Rehabilitation Division, Valeggio sul Mincio Hospital, Azienda Ospedaliera and University of Verona, Verona, Italy
    Gastroenterology 130:657-64. 2006
    ..Biofeedback should become the treatment of choice for this common and easily diagnosed type of constipation...
  37. ncbi Recurrent abdominal pain: what determines medical consulting behavior?
    Neeta Kiran Venepalli
    Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Dig Dis Sci 51:192-201. 2006
    ..Severity of symptoms and psychological distress did not predict consulting behavior. Only maternal fears about abdominal symptoms differentiated consulters from nonconsulters...
  38. ncbi Biofeedback treatment of constipation: a critical review
    Steve Heymen
    Center for Functional Gastrointestinal and Motility Disorders, Department of Medicine, The University of North Carolina, Chapel Hill, North Carolina, USA
    Dis Colon Rectum 46:1208-17. 2003
    ....
  39. ncbi Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina at Chapel Hill, 27599-7080, USA
    Gastroenterology 125:19-31. 2003
    ..CONCLUSIONS: For female patients with moderate to severe FBD, CBT is effective and DES may be effective when taken adequately. Certain clinical subgroups are more or less amenable to these treatments...
  40. ncbi Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress
    Motoyori Kanazawa
    Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, North Carolina 27599 7080, USA
    Dig Dis Sci 49:1046-53. 2004
    ..Moreover, patients with such a family history show more psychological distress than other patients...
  41. ncbi Biofeedback treatment for functional anorectal disorders: a comprehensive efficacy review
    Olafur S Palsson
    Department of Medicine, Center for Functional Gastrointestinal and Motility Disorders, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Appl Psychophysiol Biofeedback 29:153-74. 2004
    ..001 for both). Biofeedback treatment may therefore be viewed as a valuable adjunct to medical management of functional PFD/constipation and incontinence. A number of recommendations for future investigations are made based on the review...
  42. ncbi Increased somatic complaints and health-care utilization in children: effects of parent IBS status and parent response to gastrointestinal symptoms
    Rona L Levy
    University of Washington, Seattle, Washington 98105, USA
    Am J Gastroenterol 99:2442-51. 2004
    ....
  43. ncbi Validity and reliability of the Modified Manchester Health Questionnaire in assessing patients with fecal incontinence
    Soo Kwon
    Division of Female Pelvic Medicine and Reconstructive Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dis Colon Rectum 48:323-31; discussion 331-4. 2005
    ..The telephone-administered Fecal Incontinence Severity Index yielded lower severity scores than the written Fecal Incontinence Severity Index; however, the difference (3.66 units) was not clinically significant...
  44. ncbi Hypnosis treatment for severe irritable bowel syndrome: investigation of mechanism and effects on symptoms
    Olafur S Palsson
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7080 USA
    Dig Dis Sci 47:2605-14. 2002
    ..In conclusion, hypnosis improves IBS symptoms through reductions in psychological distress and somatization. Improvements were unrelated to changes in the physiological parameters measured...
  45. ncbi Regional brain activation in response to rectal distension in patients with irritable bowel syndrome and the effect of a history of abuse
    Yehuda Ringel
    UNC Center for Functional GI and Motility Disorders, University of North Carolina, Department of Medicine, Chapel Hill, North Carolina 27599-7080, USA
    Dig Dis Sci 48:1774-81. 2003
    ..The observations on the effect of abuse suggest a possible modulating role of abuse history on this brain response...
  46. ncbi Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?
    William E Whitehead
    Division of Digestive Diseases and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 122:1140-56. 2002
    ..The aims of this study were to (1) assess comorbidity in 3 areas: gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders; and (2) evaluate explanatory hypotheses...
  47. ncbi Hypnosis home treatment for irritable bowel syndrome: a pilot study
    Olafur S Palsson
    Division of Digestive Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Int J Clin Exp Hypn 54:85-99. 2006
    ..Although response rate was lower than previously observed in therapist-delivered treatment, hypnosis home treatment may double the proportion of IBS patients improving significantly across 6 months...
  48. ncbi Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation
    Giuseppe Chiarioni
    Divisione di Riabilitazione Gastroenterologica, Universita di Verona, Azienda Ospedaliera di Verone, Centro Ospedaliero Clinicizzato, Valeggio sul Mincio, Verona, Italy
    Gastroenterology 129:86-97. 2005
    ..We aimed to test the hypothesis that biofeedback benefits only patients with pelvic floor dyssynergia, describe the physiologic mechanism of treatment, and identify predictors of success...
  49. ncbi Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths
    Tamara D Simon
    Department of Pediatrics, Division of Inpatient Medicine, University of Utah, Salt Lake City, Utah 84113, USA
    J Neurosurg Pediatr 1:131-7. 2008
    ....
  50. ncbi Fecal incontinence: a neglected area of gastroenterology
    William E Whitehead
    Gastroenterology 122:5. 2002
  51. ncbi Does irritable bowel syndrome really exist? Reactions to the proposed motility-based classification system
    William E Whitehead
    Gastroenterology 124:598. 2003
  52. ncbi The growing case for hypnosis as adjunctive therapy for functional gastrointestinal disorders
    Olafur S Palsson
    Gastroenterology 123:2132-5. 2002
  53. ncbi Anorectal functional testing: review of collective experience
    Fernando Azpiroz
    Digestive System Research Unit, Hospital General Vall d'Hebron, Barcelona, Spain
    Am J Gastroenterol 97:232-40. 2002
    ....
  54. ncbi Duration of antibiotic therapy for the treatment of shunt infection: a surgeon and patient survey
    Adam S Arthur
    Department of Neurological Surgery, Division of Pediatric Neurosurgery, Primary Children's Medical Center, University of Utah, Salt Lake City 84113, USA
    Pediatr Neurosurg 36:256-9. 2002
    ..These data support the feasibility of a planned randomized study to determine the ideal length of antibiotic treatment for shunt infection...
  55. ncbi AGA technical review on irritable bowel syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina, Chapel Hill, USA
    Gastroenterology 123:2108-31. 2002
  56. ncbi Lactulose breath testing and irritable bowel syndrome
    Madhusudan Grover
    Am J Gastroenterol 103:2652-3; author reply 2653-4. 2008
  57. ncbi Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review
    Denesh K Chitkara
    UNC Center for Functional GI and Motility Disorders, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7555, USA
    Am J Gastroenterol 103:765-74; quiz 775. 2008
    ..The natural history of symptoms and risk factors that contribute to IBS may begin in childhood. The aim of this systematic review was to determine what early life factors contribute to the development of IBS in adolescents and adults...
  58. ncbi Introduction. Advancing the treatment of fecal and urinary incontinence through research
    William E Whitehead
    Gastroenterology 126:S1-2. 2004
  59. ncbi Effects of parent attention versus distraction on abdominal discomfort in children: a new method and new findings
    Carl L von Baeyer
    Pain 122:8-10. 2006
  60. ncbi Design of treatment trials for functional gastrointestinal disorders
    E Jan Irvine
    Division of Gastroenterology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 130:1538-51. 2006
    ..Trials should be registered in a public location, prior to initiation, and should be published even if the results are negative or inconclusive...
  61. ncbi Diagnosing and managing fecal incontinence: if you don't ask, they won't tell
    William E Whitehead
    Gastroenterology 129:6. 2005
  62. ncbi Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage
    Albena Halpert
    UNC Center for Functional GI and Motility Disorders, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 100:664-71. 2005
    ..CONCLUSIONS: Detectable blood levels of DES are associated with a clinical response in FBD. However, with dosages up to 150 mg, there is no relationship between total dose or plasma level and the clinical response...
  63. ncbi Relationship between the decision to take a child to the clinic for abdominal pain and maternal psychological distress
    Rona L Levy
    School of Social Work and School of Medicine and Department of Psychology, University of Washington, and Lakeside School, Seattle, USA
    Arch Pediatr Adolesc Med 160:961-5. 2006
    ..Among adults with functional gastrointestinal disorders, psychological distress influences who consults a physician, but little is known about predictors of consultation when the patient is a child...
  64. ncbi Management of shunt infections: a multicenter pilot study
    John R W Kestle
    Department of Neurosurgery, Primary Children s Medical Center, University of Utah, Salt Lake City, Utah 84113, USA
    J Neurosurg 105:177-81. 2006
    ..The present multicenter pilot study was undertaken to evaluate current strategies in the treatment of shunt infection...
  65. ncbi Validation of a measure of protective parent responses to children's pain
    Lynn S Walker
    Department of Pediatrics, Vanderbilt Medical Center University of Washington, USA
    Clin J Pain 22:712-6. 2006
    ..To assess the validity of the Protect Scale of the Adult Responses to Children's Symptoms (ARCS) Questionnaire with regard to mothers' responses to their children's abdominal pain...
  66. ncbi Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome
    Olafur S Palsson
    Division of Gastroenterology and Hepatology and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dig Dis Sci 49:1236-43. 2004
    ....
  67. ncbi Social learning contributions to the etiology and treatment of functional abdominal pain and inflammatory bowel disease in children and adults
    Rona L Levy
    World J Gastroenterol 13:2397-403. 2007
    ..2) Standard gastrointestinal practice should include, when appropriate, learning opportunities for patients and family members, for example, instruction regarding the encouragement of wellness behavior...
  68. ncbi Randomized controlled trial of biofeedback
    Giuseppe Chiarioni
    Clin Gastroenterol Hepatol 5:1119; author reply 1119. 2007
  69. ncbi Risk factors for sonographic internal anal sphincter gaps 6-12 months after delivery complicated by anal sphincter tear
    Catherine S Bradley
    Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
    Am J Obstet Gynecol 197:310.e1-5. 2007
    ..The objective of the study was to identify risk factors for internal anal sphincter (IAS) gaps on postpartum endoanal ultrasound in women with obstetric anal sphincter tear...
  70. ncbi Is irritable bowel syndrome an inherited disorder? Asking the question right
    William E Whitehead
    Gastroenterology 126:1655. 2004
  71. ncbi Twin studies used to prove that the comorbidity of major depressive disorder with IBS is NOT influenced by heredity
    William E Whitehead
    Am J Gastroenterol 102:2230-1. 2007
    ..This study provides precise, generalizable estimates from a large population-based study for the comorbidity of IBS with major depressive disorder, chronic widespread pain, and chronic fatigue...

Research Grants30

  1. Advancing the Treatment of Fecal & Urinary Incontinence
    William Whitehead; Fiscal Year: 2003
    ..The conference is scheduled to take place November 3-5, 2002, in Milwaukee, and half of the invitees have accepted invitations to speak. ..
  2. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2006
    ..These studies will be done in collaboration with the University of Washington, Group Health Cooperative of Puget Sound, and the Mayo Clinic in Scottsdale, AZ. ..
  3. Gastrointestinal Biopsychosocial Research Center
    William Whitehead; Fiscal Year: 2007
    ..The proposed Center is university wide and includes investigators from psychology, psychiatry, surgery (gynecology division), neuroradiology, dentistry, and the school of public health. ..
  4. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2007
    ..These studies will be done in collaboration with the University of Washington, Group Health Cooperative of Puget Sound, and the Mayo Clinic in Scottsdale, AZ. ..
  5. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2009
    ..Identifying these different phenotypes of IBS and the genetic markers associated with them may help to identify new targets for drug development and may help us to individualize treatment and thereby make it more successful. ..
  6. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2009
    ..Identifying these different phenotypes of IBS and the genetic markers associated with them may help to identify new targets for drug development and may help us to individualize treatment and thereby make it more successful. ..
  7. Psychophysiology of Irritable Bowel Synbdrome
    William Whitehead; Fiscal Year: 2003
    ..These studies will be done in collaboration with the University of Washington, Group Health Cooperative of Puget Sound, and the Mayo Clinic in Scottsdale, AZ. ..
  8. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William Whitehead; Fiscal Year: 2002
    ....
  9. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William E Whitehead; Fiscal Year: 2010
    ..Identifying these different phenotypes of IBS and the genetic markers associated with them may help to identify new targets for drug development and may help us to individualize treatment and thereby make it more successful. ..