Genomes and Genes
Kevin J Whitehead
Affiliation: University of Utah
- The pathogenetic features of cerebral cavernous malformations: a comprehensive review with therapeutic implicationsKhaled M Krisht
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
Neurosurg Focus 29:E2. 2010..The remaining challenges to creating a more faithful CCM animal model as well as future clinical and research implications are reviewed...
- Arteriovenous malformations and other vascular malformation syndromesKevin J Whitehead
Molecular Medicine Program, University of Utah, Salt Lake City, Utah 84112, USA
Cold Spring Harb Perspect Med 3:a006635. 2013..Here we review the vascular malformations and pathways involved in hereditary hemorrhagic telangiectasia, capillary malformation-arteriovenous malformation, cerebral cavernous malformations, and mucocutaneous venous malformations...
- The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPasesKevin J Whitehead
Division of Cardiology, Department of Medicine, 30 North 1900 East, Room 4A100, University of Utah, Salt Lake City, Utah 84132, USA
Nat Med 15:177-84. 2009..These data offer the prospect for pharmacological treatment of a human vascular dysplasia with a widely available and safe drug...
- Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in miceAubrey C Chan
Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA
J Clin Invest 121:1871-81. 2011..These results suggest that CCM may be more effectively treated by directing therapies based on the underlying genetic mutation rather than treating the condition as a single clinical entity...
- Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathySankaranarayanan Kannan
Cardiac Aging and Redox Signaling Laboratory, Rm 4A100, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Cardiovasc Res 100:63-73. 2013....
- Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotypeAubrey C Chan
Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA
FEBS J 277:1076-83. 2010..Challenges and progress towards developing a faithful model of CCM biology are reviewed...
- Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformationChristopher C Gibson
From the Program in Molecular Medicine C C G, W Z, C T D, J A B K, A C C, J L, A H G, K R T, K J W, D Y L, Department of Bioengineering C C G, Y T E S, Department of Medicine C C G, W Z, K R T, D Y L, Department of Human Genetics C T D, Department of Oncological Sciences A C C, D Y L, Division of Geriatrics, Department of Medicine A E W, A J D, L A L, Division of Nephrology and Hypertension, Department of Medicine Y T E S, Department of Pathology A H G, Division of Cardiology, and Department of Medicine K J W, D Y L, University of Utah, Salt Lake City, UT Recursion Pharmaceuticals, LLC, Salt Lake City, Minneapolis 55455
Circulation 131:289-99. 2015..A subset of patients have a hereditary form of the disease due primarily to loss-of-function mutations in KRIT1, CCM2, or PDCD10. We sought to identify known drugs that could be repurposed to treat CCM...
- Mechanisms of vascular stability and the relationship to human diseaseMatthew C P Smith
Molecular Medicine Program, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
Curr Opin Hematol 17:237-44. 2010..The genetic basis for a variety of vascular malformation syndromes have been described, with an increasing functional understanding of the associated genes...
- Endogenous endothelial cell signaling systems maintain vascular stabilityNyall R London
Department of Medicine, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112 5330, USA
Angiogenesis 12:149-58. 2009....
- Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heartStavros G Drakos
Cardiovascular Department and Utah Artificial Heart Program, Intermountain Medical Center, Salt Lake City, Utah, USA
J Am Coll Cardiol 56:382-91. 2010..This study investigates alterations in myocardial microvasculature, fibrosis, and hypertrophy before and after mechanical unloading of the failing human heart...
- The netrin receptor UNC5B promotes angiogenesis in specific vascular bedsSutip Navankasattusas
Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
Development 135:659-67. 2008....
- Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise trainingSellamuthu S Gounder
Divisions of Cardiology and Pulmonary, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
PLoS ONE 7:e45697. 2012..These observations suggest that enhancing Nrf2 function and endogenous cytoprotective mechanisms by MET, may combat age-induced ROS/RNS and protect the myocardium from oxidative stress diseases...
- Evaluating strategies for the treatment of cerebral cavernous malformationsDean Y Li
Department of Medicine, University of Utah, Salt Lake City, Utah 84112 5330, USA
Stroke 41:S92-4. 2010....