Perrin White

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids
    Perrin C White
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX Electronic address
    J Pediatr 163:761-6. 2013
  2. doi request reprint Congenital adrenal hyperplasia due to 21 hydroxylase deficiency: from birth to adulthood
    Perrin C White
    Division of Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Semin Reprod Med 30:400-9. 2012
  3. ncbi request reprint Steroid 11 beta-hydroxylase deficiency and related disorders
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Endocrinol Metab Clin North Am 30:61-79, vi. 2001
  4. pmc Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Mol Cell Endocrinol 265:89-92. 2007
  5. ncbi request reprint Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 90:5880-3. 2005
  6. doi request reprint Physiological roles of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 20:453-7. 2008
  7. ncbi request reprint Aldosterone synthase deficiency and related disorders
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Mol Cell Endocrinol 217:81-7. 2004
  8. pmc Ontogeny of adrenal steroid biosynthesis: why girls will be girls
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Invest 116:872-4. 2006
  9. doi request reprint Neonatal screening for congenital adrenal hyperplasia
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Nat Rev Endocrinol 5:490-8. 2009
  10. doi request reprint Sitagliptin treatment of patients with type 2 diabetes does not affect CD4+ T-cell activation
    Perrin C White
    Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    J Diabetes Complications 24:209-13. 2010

Research Grants

Collaborators

Detail Information

Publications46

  1. doi request reprint Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids
    Perrin C White
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX Electronic address
    J Pediatr 163:761-6. 2013
    ..To assess current rates of complications of diabetic ketoacidosis (DKA), particularly cerebral edema, in a large tertiary-care pediatric hospital with a consistent management protocol...
  2. doi request reprint Congenital adrenal hyperplasia due to 21 hydroxylase deficiency: from birth to adulthood
    Perrin C White
    Division of Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Semin Reprod Med 30:400-9. 2012
    ..Transition of care of older patients to adult physicians should be planned in advance as a structured, ongoing process...
  3. ncbi request reprint Steroid 11 beta-hydroxylase deficiency and related disorders
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Endocrinol Metab Clin North Am 30:61-79, vi. 2001
    ..Recombinations between these two genes cause glucocorticoid suppressible hyperaldosteronism, an autosomal dominant form of hypertension...
  4. pmc Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Mol Cell Endocrinol 265:89-92. 2007
    ..However, these polymorphisms do not have detectable biochemical or physiologic effects when prospectively ascertained...
  5. ncbi request reprint Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 90:5880-3. 2005
    ....
  6. doi request reprint Physiological roles of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 20:453-7. 2008
    ..This paper reviews the functional role(s) of 11 beta-hydroxysteroid dehydrogenase type 1 and examines factors influencing its activity...
  7. ncbi request reprint Aldosterone synthase deficiency and related disorders
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Mol Cell Endocrinol 217:81-7. 2004
    ..An additional form of familial hyperreninemic hypoaldosteronism has been described that is not due to mutations in CYP11B2, but its etiology remains to be elucidated...
  8. pmc Ontogeny of adrenal steroid biosynthesis: why girls will be girls
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Invest 116:872-4. 2006
    ..Thus normal sexual differentiation requires exquisite timing of fetal cortisol and androgen secretion versus placental capacity for aromatization...
  9. doi request reprint Neonatal screening for congenital adrenal hyperplasia
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Nat Rev Endocrinol 5:490-8. 2009
    ....
  10. doi request reprint Sitagliptin treatment of patients with type 2 diabetes does not affect CD4+ T-cell activation
    Perrin C White
    Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390 9063, USA
    J Diabetes Complications 24:209-13. 2010
    ..Randomized studies, preferably using several assays of immune function, should be performed to confirm and extend these findings...
  11. ncbi request reprint Aldosterone: direct effects on and production by the heart
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 88:2376-83. 2003
  12. ncbi request reprint Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people
    P C White
    Department of Pediatrics, University of Texas South Western Medical Center, Dallas, TX 75235 9063, USA
    Clin Endocrinol (Oxf) 55:249-52. 2001
    ..This gene is thus a logical candidate locus for risk of essential hypertension...
  13. ncbi request reprint 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 75390 9063, USA
    Am J Med Sci 322:308-15. 2001
    ..This suggests that the biochemical and clinical phenotype of AME is largely determined by genotype...
  14. doi request reprint Screening for type 2 diabetes in obese youth
    Shuchi Shah
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Pediatrics 124:573-9. 2009
    ..To assess available blood tests as potential screening tools for impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM)...
  15. ncbi request reprint Depression and diabetes in children and adolescents
    Sunita M Stewart
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Curr Opin Pediatr 17:626-31. 2005
    ....
  16. ncbi request reprint Insulin-like growth factor-I and fibroblast growth factor, but not growth hormone, affect growth plate chondrocyte proliferation
    Michele R Hutchison
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Endocrinology 148:3122-30. 2007
    ..These results suggest that the major regulator of chondrocyte proliferation is systemic IGF-I; FGFs may influence the actions of IGF-I at the growth plate by altering its receptor number in chondrocytes...
  17. pmc SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation
    Michele R Hutchison
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Mol Endocrinol 24:193-203. 2010
    ..IGF-I appears to be the primary proliferative signal in growth plate chondrocytes, whereas multiple factors including SCF, BDNF, and Gas6 regulate the pace of differentiation at the growth plate...
  18. ncbi request reprint Depressive symptoms predict hospitalization for adolescents with type 1 diabetes mellitus
    Sunita M Stewart
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
    Pediatrics 115:1315-9. 2005
    ..To examine the role of self-reported depressive symptoms in predicting hospitalization for complications of diabetes mellitus over a period of up to 2 years...
  19. doi request reprint Somatic items in the assessment of depressive symptoms in pediatric patients with diabetes
    Sunita M Stewart
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8589, USA
    J Behav Med 34:112-9. 2011
    ..These findings were not moderated by level of depressive symptoms. Our study suggests that the somatic items on the CES-D do not confound the measurement of depressive symptoms in young people with type 1 diabetes...
  20. pmc Institution of basal-bolus therapy at diagnosis for children with type 1 diabetes mellitus
    Soumya Adhikari
    Division of Pediatric Endocrinology, Department of Dietary Behavior, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Pediatrics 123:e673-8. 2009
    ..We studied whether the institution of basal-bolus therapy immediately after diagnosis improved glycemic control in the first year after diagnosis for children with newly diagnosed type 1 diabetes mellitus...
  21. ncbi request reprint Expression profiles for steroidogenic enzymes in adrenocortical disease
    Mary H Bassett
    Divisions of Reproductive and Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    J Clin Endocrinol Metab 90:5446-55. 2005
    ..The mechanisms leading to the autonomous hypersecretion of aldosterone or cortisol in aldosterone-producing adenoma (APA) or cortisol-producing adenoma (CPA) are unknown...
  22. ncbi request reprint The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
    Mary H Bassett
    Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 18:279-90. 2004
    ..Our results suggest that NGFIB and NURR1 are key regulators of hCYP11B2 expression and may partially mediate the regulation of hCYP11B2 by Ang II...
  23. ncbi request reprint Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase
    Daniela Rogoff
    University of Texas Southwestern Medical Center, 5223 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Endocrinology 148:5072-80. 2007
    ..Comparison with other animal models of adrenal insufficiency suggests that many of the observed abnormalities can be explained by blunted intracellular corticosterone actions, despite elevated circulating levels of this hormone...
  24. ncbi request reprint Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
    Gareth G Lavery
    Department of Internal Medicine and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 281:6546-51. 2006
    ....
  25. doi request reprint Improved glycemic control in adolescents with type 1 diabetes mellitus who attend diabetes camp
    Yu Chi A Wang
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Diabetes 9:29-34. 2008
    ..Although patients' knowledge and self-management of diabetes may improve after camp, improved glycated hemoglobin A1c (HbA1c) levels have not been consistently demonstrated...
  26. ncbi request reprint Congenital adrenal hyperplasia
    Phyllis W Speiser
    Department of Pediatrics, Schneider Children s Hospital North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
    N Engl J Med 349:776-88. 2003
  27. ncbi request reprint The regulation of aldosterone synthase expression
    Mary H Bassett
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9032, USA
    Mol Cell Endocrinol 217:67-74. 2004
    ..Both potassium and angiotensin II (ANG II) increase intracellular calcium levels, which regulate expression of CYP11B2 through transcription factors that interact with defined sites in the 5'-flanking region of the gene...
  28. ncbi request reprint Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus
    Eric I Felner
    Department of Pediatrics, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Pediatr Diabetes 6:213-20. 2005
    ..Combining the age of onset of T1DM with specific genotypes may operate to produce a single disease through different underlying causes...
  29. ncbi request reprint Long-term consequences of childhood-onset congenital adrenal hyperplasia
    Perrin C White
    Division of Pediatric Endocrinology and Professor of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Best Pract Res Clin Endocrinol Metab 16:273-88. 2002
    ..This chapter addresses issues relating to long-term consequences in adult life of CAH-21OHD diagnosed in early childhood or adolescence...
  30. ncbi request reprint Stimulated growth hormone concentrations in obese pediatric patients with mild and severe insulin resistance: a pilot study
    Jill A Radack
    Division of Pediatric Endocrinology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Pediatr Endocrinol Metab 23:355-61. 2010
    ..GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR.ŗŗ..
  31. doi request reprint Contribution of hexose-6-phosphate dehydrogenase to NADPH content and redox environment in the endoplasmic reticulum
    Daniela Rogoff
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Redox Rep 15:64-70. 2010
    ..Thus, H6PD may have additional functions in muscle...
  32. ncbi request reprint Gene expression in peripheral blood mononuclear cells from children with diabetes
    Ellen C Kaizer
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 92:3705-11. 2007
    ....
  33. doi request reprint Presentation of primary adrenal insufficiency in childhood
    Susan Hsieh
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA u
    J Clin Endocrinol Metab 96:E925-8. 2011
    ..Primary adrenal insufficiency is usually diagnosed in infancy or adulthood, and cases presenting in childhood have not been systematically reviewed...
  34. ncbi request reprint A role for the NGFI-B family in adrenal zonation and adrenocortical disease
    Mary H Bassett
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Endocr Res 30:567-74. 2004
    ..Taken together these results suggest that the NGFI-B family of transcription factors plays a role in establishing the functional zonation of the human adrenal by regulating CYP11B2 and HSD3B2 gene transcription...
  35. ncbi request reprint The endocrinologist's approach to the intersex patient
    Perrin C White
    Division of Pediatric Endocrinology, UT Southwestern Medical Center, Dallas, Texas, USA
    Adv Exp Med Biol 511:107-19; discussion 119-20. 2002
  36. ncbi request reprint Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas
    Karla Saner-Amigh
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA
    J Clin Endocrinol Metab 91:1136-42. 2006
    ..Aberrant adrenal expression of LH receptors has been shown to cause Cushing's syndrome, but the role of LH receptors in Conn's disease (hyperaldosteronism) has not been studied...
  37. ncbi request reprint Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
    Nicole Draper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Nat Genet 34:434-9. 2003
    ..CRD defines a new ER-specific redox potential and establishes H6PDH as a potential factor in the pathogenesis of PCOS...
  38. ncbi request reprint Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas
    Hiromichi Tanahashi
    Department of Diabetes and Endocrinology, Room 2S15, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    J Clin Endocrinol Metab 90:6226-31. 2005
    ..These polymorphisms have been associated with cardiovascular parameters, including hypertension, but not directly with gene expression...
  39. ncbi request reprint Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1
    Iwona J Bujalska
    Division of Medical Sciences, Endocrinology, Institute of Biomedical Research, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    J Mol Endocrinol 34:675-84. 2005
    ..In conclusion, H6PDH is a crucial determinant of 11 beta-HSD1 oxo-reductase activity in intact cells. Through its interaction with 11 beta-HSD1, H6PDH may represent a novel target in the pathogenesis and treatment of obesity...
  40. ncbi request reprint Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2
    Mako Isaji
    Department of Diabetes and Endocrinology, Gifu University School of Medicine, Yanagido, Gifu, Japan
    J Hypertens 23:1149-57. 2005
    ..However, the association of polymorphisms in the aldosterone synthase gene (CYP11B2) with hypertension or cardiac hypertrophy remains controversial...
  41. ncbi request reprint Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas
    Tomoatsu Mune
    Third Department of Internal Medicine, Gifu University School of Medicine, Gifu 500 8705, Japan
    J Clin Endocrinol Metab 88:864-70. 2003
    ..Nonfunctioning adenomas and those causing preclinical and overt Cushing's syndrome may represent a continuum with clinical manifestations depending mainly on tumor size and HSD11B2 expression levels...
  42. pmc The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles
    Joann McGee
    Developmental Auditory Physiology Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Neurosci 26:6543-53. 2006
    ..Our results indicate that Vlgr1 is required for formation of the ankle link complex and the normal development of cochlear hair bundles...
  43. ncbi request reprint Role of local 11beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) expression in determining the phenotype of adrenal adenomas
    Tomoatsu Mune
    Third Department of Internal Medicine, Gifu University School of Medicine, Gifu 500 8705, Japan
    Endocr Res 28:751-2. 2002
  44. ncbi request reprint Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity
    Perrin C White
    J Clin Endocrinol Metab 90:1252-5. 2005
  45. pmc Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Biol Chem 283:8453-61. 2008
    ..These studies thus define a novel metabolic pathway that links ER stress to skeletal muscle integrity and function...

Research Grants19

  1. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2007
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  2. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  3. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  4. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..