P C White

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Inherited forms of mineralocorticoid hypertension
    P C White
    Department of Pediatrics, University of Texas South Western Medical Center, Dallas 75235 9063, USA
    Hypertension 28:927-36. 1996
  2. ncbi Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    P C White
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas 75390 9063, USA
    Endocr Rev 21:245-91. 2000
  3. ncbi Mutants of 11beta-hydroxysteroid dehydrogenase (11-HSD2) with partial activity: improved correlations between genotype and biochemical phenotype in apparent mineralocorticoid excess
    B S Nunez
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Tex 75235 9063, USA
    Hypertension 34:638-42. 1999
  4. ncbi Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people
    P C White
    Department of Pediatrics, University of Texas South Western Medical Center, Dallas, TX 75235 9063, USA
    Clin Endocrinol (Oxf) 55:249-52. 2001
  5. ncbi Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1)
    X L Wang
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390 9032, USA
    Endocrinology 141:3587-94. 2000
  6. ncbi 11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Endocr Rev 18:135-56. 1997
  7. ncbi Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes
    P C White
    Division of Pediatric Endocrinology, Cornell University Medical College, New York, NY 10021, USA
    J Steroid Biochem Mol Biol 43:827-35. 1992
  8. ncbi Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Endocr Res 24:797-804. 1998
  9. ncbi Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase
    A K Agarwal
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Genomics 29:195-9. 1995
  10. ncbi Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase
    A K Agarwal
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390 9063, USA
    Biochem Biophys Res Commun 279:543-7. 2000

Collaborators

Detail Information

Publications22

  1. ncbi Inherited forms of mineralocorticoid hypertension
    P C White
    Department of Pediatrics, University of Texas South Western Medical Center, Dallas 75235 9063, USA
    Hypertension 28:927-36. 1996
    ..This autosomal recessive form of severe hypertension results from mutations in the HSD11K (HSD11B2) gene...
  2. ncbi Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    P C White
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas 75390 9063, USA
    Endocr Rev 21:245-91. 2000
    ..Glucocorticoid and mineralocorticoid replacement are the mainstays of treatment, but more rational dosing and additional therapies are being developed...
  3. ncbi Mutants of 11beta-hydroxysteroid dehydrogenase (11-HSD2) with partial activity: improved correlations between genotype and biochemical phenotype in apparent mineralocorticoid excess
    B S Nunez
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Tex 75235 9063, USA
    Hypertension 34:638-42. 1999
    ..0004). Approximately 5% conversion of cortisol to cortisone is predicted in subjects with mutations that completely inactivate HSD11B2, suggesting that a low level of enzymatic activity is mediated by another enzyme, possibly 11-HSD1...
  4. ncbi Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people
    P C White
    Department of Pediatrics, University of Texas South Western Medical Center, Dallas, TX 75235 9063, USA
    Clin Endocrinol (Oxf) 55:249-52. 2001
    ..This gene is thus a logical candidate locus for risk of essential hypertension...
  5. ncbi Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1)
    X L Wang
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390 9032, USA
    Endocrinology 141:3587-94. 2000
    ..The differential effects of SF-1 on transcription of hCYP11B1 and hCYP11B2 may be one of the mechanisms controlling differential expression of these isozymes within the zonae fasciculata and glomerulosa of the human adrenal cortex...
  6. ncbi 11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Endocr Rev 18:135-56. 1997
    ..Mutations in the HSD11B2 (HSD11K) gene encoding the kidney isozyme of 11-HSD have been detected in all kindreds with AME studied thus far. This gene represents a candidate locus for the common, "essential" form of hypertension...
  7. ncbi Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes
    P C White
    Division of Pediatric Endocrinology, Cornell University Medical College, New York, NY 10021, USA
    J Steroid Biochem Mol Biol 43:827-35. 1992
    ..It is possible that mutations in this gene cause a form of childhood hypertension called apparent mineralocorticoid excess, in which the mineralocorticoid receptor is not protected from high concentrations of cortisol...
  8. ncbi Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Endocr Res 24:797-804. 1998
    ..These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males...
  9. ncbi Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase
    A K Agarwal
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Genomics 29:195-9. 1995
    ..Different transcriptional start sites are utilized in kidney and placenta. These data should be applicable to genetic analysis of the syndrome of apparent mineralocorticoid excess, which may represent a deficiency of 11 beta HSD...
  10. ncbi Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase
    A K Agarwal
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390 9063, USA
    Biochem Biophys Res Commun 279:543-7. 2000
    ..The functional significance of the proximity of these two genes remains to be established...
  11. ncbi Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene
    K M Kayes-Wandover
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 86:5379-82. 2001
    ..These results demonstrate the existence of an inherited form of hyperreninemic hypoaldosteronism distinct from aldosterone synthase deficiency. The affected gene(s) remain to be determined...
  12. ncbi Steroidogenic enzyme gene expression in the human heart
    K M Kayes-Wandover
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    J Clin Endocrinol Metab 85:2519-25. 2000
    ..1% those in the adrenal gland. These findings are consistent with autocrine or paracrine roles for corticosterone and deoxycorticosterone, but not cortisol or aldosterone, in the normal adult human heart...
  13. ncbi CA-Repeat polymorphism in intron 1 of HSD11B2 : effects on gene expression and salt sensitivity
    A K Agarwal
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Hypertension 36:187-94. 2000
    ..We conclude that polymorphisms in HSD11B2 and decreased 11-HSD2 activity are associated with sensitivity to sodium loading, but a functional explanation for these associations remains to be elucidated...
  14. ncbi Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1
    M H Bassett
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    J Mol Endocrinol 28:125-35. 2002
    ..Taken together, these data suggest that SF-1 and the Ad4 element are not major regulators of adrenal hCYP11B2 gene expression. Thus far, hCYP11B2 is the first steroid hydroxylase gene which is not positively regulated by SF-1...
  15. ncbi Steroid 11 beta-hydroxylase deficiency and related disorders
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Endocrinol Metab Clin North Am 30:61-79, vi. 2001
    ..Recombinations between these two genes cause glucocorticoid suppressible hyperaldosteronism, an autosomal dominant form of hypertension...
  16. ncbi Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain
    H Nikkila
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Mol Endocrinol 14:1351-64. 2000
    ..These results define a consensus cation binding motif employed in several widely divergent types of proteins. The ligand for VLGR1, its function, and the signaling pathway(s) it employs remain to be defined...
  17. ncbi Type 1 aldosterone synthase deficiency presenting in a middle-aged man
    K M Kayes-Wandover
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 86:1008-12. 2001
    ....
  18. ncbi 11beta-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, 75390 9063, USA
    Am J Med Sci 322:308-15. 2001
    ..This suggests that the biochemical and clinical phenotype of AME is largely determined by genotype...
  19. ncbi Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function
    P C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    J Steroid Biochem Mol Biol 69:409-12. 1999
    ..These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males...
  20. ncbi Prominent sex steroid metabolism in human lymphocytes
    Z Zhou
    Department of Pediatrics, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA
    Mol Cell Endocrinol 138:61-9. 1998
    ..One metabolite thought to be deoxycorticosterone was identified by GC/MS as 6alpha-hydroxypregnanolone. It was concluded that sex hormone metabolism, including androgen synthesis, occurs in lymphocytes, and may modulate immune response...
  21. ncbi Congenital adrenal hyperplasias
    P C White
    Division of Pediatric Endocrinology, UT Southwestern Medical Center, Dallas, TX 75235-9063, USA
    Best Pract Res Clin Endocrinol Metab 15:17-41. 2001
    ..These clinical recommendations are explained in the context of the molecular and biochemical characteristics of the diseases...
  22. ncbi Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase
    T Mune
    Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas 75235 9063, USA
    Nat Genet 10:394-9. 1995
    ..These mutations markedly affect enzymatic activity. They thus permit cortisol to occupy the renal mineralocorticoid receptor and thereby cause sodium retention and hypertension...