Judith White

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Searching for the silver lining
    Judith M White
    Nat Struct Mol Biol 12:382-4. 2005
  2. pmc Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
    Judith M White
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    Crit Rev Biochem Mol Biol 43:189-219. 2008
  3. pmc Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection
    Charles J Shoemaker
    Departmentof Cell BIology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e56265. 2013
  4. pmc A new player in the puzzle of filovirus entry
    Judith M White
    Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908 20732, USA
    Nat Rev Microbiol 10:317-22. 2012
  5. pmc Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
    Matthew Brecher
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    J Virol 86:364-72. 2012
  6. pmc Conservation and divergence of ADAM family proteins in the Xenopus genome
    Shuo Wei
    Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, VA 22908, USA
    BMC Evol Biol 10:211. 2010
  7. ncbi request reprint ADAMs and cell fusion
    A P Huovila
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 439, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 8:692-9. 1996
  8. ncbi request reprint ADAMs: modulators of cell-cell and cell-matrix interactions
    Judith M White
    University of Virginia, Health System School of Medicine, Department of Cell Biology, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0732, USA
    Curr Opin Cell Biol 15:598-606. 2003
  9. ncbi request reprint Yeast mating: getting close to membrane merger
    J M White
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Biol 11:R16-20. 2001
  10. pmc Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    Kathryn Schornberg
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 80:4174-8. 2006

Collaborators

  • A C Steven
  • Sue E Delos
  • Shutoku Matsuyama
  • Amy Bouton
  • Christopher Broder
  • Scott A Coonrod
  • Shin Ichi Murase
  • D Alfandari
  • LUKAS TAMM
  • Jay C Brown
  • Cezary Marcinkiewicz
  • JOHN DAVID CASTLE
  • DEAN C SHEPPARD
  • Laurie J Earp
  • Kathryn L Schornberg
  • Matthew Brecher
  • Charles J Shoemaker
  • Robert C Netter
  • Shuo Wei
  • Jennifer A Gruenke
  • Derek Dube
  • Kathryn Schornberg
  • Alex L Lai
  • Audray Harris
  • Douglas W DeSimone
  • Paul Bates
  • Yuji Takahashi
  • Monika Tomczuk
  • Heather E Park
  • Adrian Higginbottom
  • Laura Bolling
  • Katherine M Smith
  • Christina Ochsenbauer-Jambor
  • Lisa M Johansen
  • Gene G Olinger
  • Corinne Scully
  • Hassan Pajouhesh
  • Erica Ollmann Saphire
  • Marnie L Fusco
  • Lance C Bridges
  • Charles A Whittaker
  • Anoop Shah
  • Guofeng Xu
  • Tzanko S Stantchev
  • Matthew I Bonaparte
  • J Bernard Heymann
  • Heather Park
  • Kirsten Kabsch
  • Giovanni Cardone
  • Dennis C Winkler
  • Arwen Vermeulen
  • Mark J Biscone
  • Sean M Amberg
  • John W Balliet
  • Ann Sutherland
  • Erin Klaffky
  • Peter N Monk
  • Mary Ann Stepp
  • Jing Huang
  • Lynda J Partridge
  • Marie Mistretta
  • Lorraine D Hernandez
  • A P Huovila
  • R Todd Armstrong
  • William W Newcomb
  • Alban Gaultier
  • Helene Cousin
  • Mary Ann Accavitti
  • Eric Hunter
  • E A Almeida

Detail Information

Publications27

  1. ncbi request reprint Searching for the silver lining
    Judith M White
    Nat Struct Mol Biol 12:382-4. 2005
  2. pmc Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
    Judith M White
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    Crit Rev Biochem Mol Biol 43:189-219. 2008
    ..Clearly, highly divergent proteins have converged on the same overall strategy to mediate fusion, an essential step in the life cycle of every enveloped virus...
  3. pmc Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection
    Charles J Shoemaker
    Departmentof Cell BIology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e56265. 2013
    ..47. Our findings suggest that there are minimally two ways of perturbing NPC1-dependent pathways that can block EBOV entry, increasing the attractiveness of NPC1 as an anti-filoviral therapeutic target...
  4. pmc A new player in the puzzle of filovirus entry
    Judith M White
    Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908 20732, USA
    Nat Rev Microbiol 10:317-22. 2012
    ..Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process...
  5. pmc Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change
    Matthew Brecher
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    J Virol 86:364-72. 2012
    ..Our findings also indicate that low pH and an additional endosomal factor (possibly reduction or possibly a process mimicked by reduction) act as fusion triggers...
  6. pmc Conservation and divergence of ADAM family proteins in the Xenopus genome
    Shuo Wei
    Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, VA 22908, USA
    BMC Evol Biol 10:211. 2010
    ..In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species...
  7. ncbi request reprint ADAMs and cell fusion
    A P Huovila
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 439, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 8:692-9. 1996
    ..As ADAMs are also found in both vertebrates and invertebrates, some features of cell-cell fusion reactions may be conserved throughout the animal kingdom...
  8. ncbi request reprint ADAMs: modulators of cell-cell and cell-matrix interactions
    Judith M White
    University of Virginia, Health System School of Medicine, Department of Cell Biology, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0732, USA
    Curr Opin Cell Biol 15:598-606. 2003
    ..Hence, ADAMs are emerging as key modulators of cell-cell and cell-matrix interactions. Important questions, including if and how ADAM adhesive domains promote ADAM protease function, are currently being addressed...
  9. ncbi request reprint Yeast mating: getting close to membrane merger
    J M White
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Biol 11:R16-20. 2001
    ..But now a post-genomics approach has provided a powerful wedge into this difficult problem: a pheromone-induced multimembrane spanning protein has been identified as a key part of the mating machine...
  10. pmc Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    Kathryn Schornberg
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 80:4174-8. 2006
    ..These and other results support a model in which CatB and CatL prime GP by generating a 19-kDa intermediate that can be acted upon by an as yet unidentified endosomal/lysosomal enzyme to trigger fusion...
  11. ncbi request reprint A single glycosylation site within the receptor-binding domain of the avian sarcoma/leukosis virus glycoprotein is critical for receptor binding
    Sue E Delos
    Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
    Virology 294:354-63. 2002
    ..This work has therefore identified a single N-linked glycosylation site in the SU domain of EnvA that is critical for binding between EnvA and its receptor, Tva...
  12. pmc Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex
    Christina Ochsenbauer-Jambor
    Department of Microbiology, School of Medicine, University of Alabama at Birmingham, 35294, USA
    J Virol 76:7518-27. 2002
    ..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope...
  13. pmc Cysteines flanking the internal fusion peptide are required for the avian sarcoma/leukosis virus glycoprotein to mediate the lipid mixing stage of fusion with high efficiency
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 82:3131-4. 2008
    ..These findings indicate that the cysteines flanking the internal fusion peptide of EnvA (and perhaps by analogy Ebola virus glycoprotein) are important for the foldback stage of the conformational changes that lead to membrane merger...
  14. ncbi request reprint Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3
    Monika Tomczuk
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    Exp Cell Res 290:68-81. 2003
    ....
  15. ncbi request reprint Fusion peptide of influenza hemagglutinin requires a fixed angle boomerang structure for activity
    Alex L Lai
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 281:5760-70. 2006
    ..A specific fixed angle boomerang structure is thus required to support membrane fusion...
  16. pmc Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation
    Sue E Delos
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, VA 22908 0732, USA
    J Virol 79:3488-99. 2005
    ..Low pH does not alter the off rate for the complex, further alter the secondary structure of SU-A, or induce measurable changes in tryptophan environment. The implications of these findings for fusion are discussed...
  17. pmc The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH
    Laurie J Earp
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 77:3058-66. 2003
    ..Possible roles for low pH at subsequent stages of viral entry are discussed...
  18. ncbi request reprint Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion
    Adrian Higginbottom
    Department of Neurology, University of Sheffield Medical School, UK
    Biochem Biophys Res Commun 311:208-14. 2003
    ....
  19. ncbi request reprint Leash in the groove mechanism of membrane fusion
    Heather E Park
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Struct Biol 10:1048-53. 2003
    ..Therefore, HA employs a 'leash in the groove,' rather than a helix-bundle, mechanism of membrane fusion...
  20. pmc Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion intermediate
    Robert C Netter
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 78:13430-9. 2004
    ..These experiments support a model in which receptor interaction promotes formation of an envelope conformation in which the TM subunit is stably associated with its target membrane and is able to bind a C-terminal peptide...
  21. ncbi request reprint Receptor-activated binding of viral fusion proteins to target membranes
    Laurie J Earp
    Department of Cell Biology, UVA Health System, School of Medicine, P O Box 800732, Charlottesville, Virginia 22908, USA
    Methods Enzymol 372:428-40. 2003
  22. pmc Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein
    Shutoku Matsuyama
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    J Virol 78:8201-9. 2004
    ....
  23. pmc The cysteine-rich domain regulates ADAM protease function in vivo
    Katherine M Smith
    Department of Cell Biology, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Cell Biol 159:893-902. 2002
    ..These findings are likely relevant to other membrane-anchored cell surface proteases...
  24. pmc ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb
    Shin Ichi Murase
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Eur J Neurosci 27:1585-95. 2008
    ..These experiments suggest that ADAM2 contributes to RMS migration, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint...
  25. pmc Influenza virus pleiomorphy characterized by cryoelectron tomography
    Audray Harris
    Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:19123-7. 2006
    ....
  26. pmc New insights into the spring-loaded conformational change of influenza virus hemagglutinin
    Jennifer A Gruenke
    Department of Cell Biology Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 76:4456-66. 2002
    ..Our data also indicate that the spring-loaded conformational change has another role beyond presenting the fusion peptide to the target membrane...
  27. pmc Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infection
    Derek Dube
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
    J Virol 82:7238-42. 2008
    ..Furthermore, with 293F cells the acquisition of EboV RBD binding paralleled cell spreading and did not require new mRNA or protein synthesis...

Research Grants27

  1. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2001
    ..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..
  2. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2001
    ....
  3. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2003
    ..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..
  4. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2003
    ....
  5. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2004
    ..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..
  6. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2004
    ....
  7. Fusion Mechanism of the Ebola Virus Glycoprotein
    Judith White; Fiscal Year: 2004
    ..The stage would then be set to screen for inhibitors of Ebola virus fusion and to test their efficacy in animal models. ..
  8. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2005
    ..g. influenza, West Nile, and Ebola viruses). The proposed work will aid these important efforts. ..
  9. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2006
    ..g. influenza, West Nile, and Ebola viruses). The proposed work will aid these important efforts. ..
  10. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2000
    ..The project should also provide insights into pathologies that may involve other ADAMs, for examples metastasis and certain developmental abnormalities. ..
  11. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2000
    ....
  12. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 1999
    ..The project should also provide insights into pathologies that may involve other ADAMs, for examples metastasis and certain developmental abnormalities. ..
  13. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2009
    ..g. influenza, West Nile, and Ebola viruses). The proposed work will aid these important efforts. ..
  14. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 1999
    ..In the case of HA, information on the fusion mechanism is now being coupled with structural information to rationally design fusion inhibitors. This strategy should be generalizable to other enveloped viruses. ..
  15. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2002
    ....
  16. MOLECULAR MECHANISMS OF VIRAL MEMBRANE FUSION PROTEINS
    Judith White; Fiscal Year: 2007
    ..g. influenza, West Nile, and Ebola viruses). The proposed work will aid these important efforts. ..
  17. ADAMS--ADHESION, FUSION AND SIGNALING ACTIVITIES
    Judith White; Fiscal Year: 2002
    ..For example, the dual functions of ADAMs as both adhesion molecules and as proteases suggests that they may be key players in the de-adhesive, migratory, and re-adhesive activities involved in tumor metastasis. ..