Research Topics
Genomes and Genes | Eric WhiteSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Current and emerging strategies for the management of sarcoidosisEric S White
University of Michigan Medical Center, Division of Pulmonary and Critical Medicine, Department of Internal Medicine, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Expert Opin Pharmacother 8:1293-311. 2007..Agents commonly used to treat patients with sarcoidosis and emerging therapeutic options are discussed...
Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigationAdam J Booth
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III SPC 5642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5642 e mail
Am J Respir Crit Care Med 186:866-76. 2012..Conclusions: This methodology is expected to allow investigation of important ECM-based hypotheses in human tissues and permits future scientific exploration in an organ- and disease-specific manner...- Pharmacological therapy for Wegener's granulomatosisEric S White
Division of Pulmonary and Critical Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Drugs 66:1209-28. 2006..However, the current data are conflicting and difficult to interpret. As a result, these newer agents cannot be recommended for routine use until vigorous clinical study confirms their efficacy... - Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)Eric S White
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Crit Care Med 173:112-21. 2006..Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the development of novel therapeutic agents... - Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activityEric S White
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Cell Mol Biol 32:135-41. 2005..Collectively, these data describe the novel mechanistic finding that PGE(2), via the EP2 receptor, decreases tyrosine phosphorylation on PTEN, resulting in increased PTEN enzyme activity and inhibition of fibroblast migration... - Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosisEric S White
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
J Pathol 201:343-54. 2003..This review focuses on evolving concepts of cellular and molecular mechanisms in the pathogenesis of UIP/IPF... - Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathwayEric S White
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Exp Cell Res 316:2644-53. 2010..Thus, our results demonstrate that the PI3K/Akt/mTOR axis is instrumental in FN transcription and alternative splicing, which regulates cell behavior... - Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10Eric S White
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Crit Care Med 168:436-42. 2003..Furthermore, this study implicates a loss of PTEN function in the pathophysiology of idiopathic pulmonary fibrosis... - Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expressionRommel L Sagana
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 284:32264-71. 2009..This is the first description, to our knowledge, of PI3K/PTEN balance directing GPCR expression, and provides a novel mechanism for cellular effects of PTEN... - The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and miceKristy A Bauman
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Clin Invest 120:1950-60. 2010..These studies demonstrate crosstalk between plasminogen activation and PGE2 generation in the lung and provide a mechanism for the well-known antifibrotic actions of the fibrinolytic pathway... - PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signalingPeedikayil E Thomas
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007..Taken together, our results demonstrate that PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways... - Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblastsGuo Qiang Cai
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Exp Cell Res 316:1600-9. 2010..These data for the first time provide evidence that downregulation of endogenous FRNK plays a role in promoting cell migration through FAK and Rho GTPase in fibrotic IPF lung fibroblasts... - Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathwaysSteven K Huang
Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
FASEB J 23:4317-26. 2009..They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease... - Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblastsJeffrey C Horowitz
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, Ann Arbor, MI 48109, USA
Cell Signal 19:761-71. 2007..Activation of these pro-survival/anti-anoikis pathways in myofibroblasts likely contributes to essential roles of TGF-beta1 in tissue fibrosis and tumour-promotion... - An essential role for fibronectin extra type III domain A in pulmonary fibrosisAndres F Muro
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Am J Respir Crit Care Med 177:638-45. 2008..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen... - Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and miceSteven K Huang
Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
Am J Pathol 177:2245-55. 2010.... - Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidiaBenjamin J Murdock
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5642, USA
Infect Immun 79:125-35. 2011..fumigatus conidia... - The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantationGregory A Yanik
Department of Pediatrics, University of Michigan, Ann Arbor, USA
Blood 112:3073-81. 2008..The combination of etanercept and corticosteroids is safe and is associated with high response rates and improved survival in patients with IPS... - Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosisThomas H Sisson
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 5642, USA
Am J Respir Crit Care Med 181:254-63. 2010..Although these findings are compelling, there are no studies that demonstrate a direct role for the alveolar epithelium or, more specifically, type II cells in the scarring process... - Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophagesClaudio Canetti
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109, USA
J Immunol 179:8350-6. 2007..We suggest that this mechanism contributes to the ability of PGE2 to inhibit PI3K-dependent innate immune signaling in primary macrophages... - Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectinMichael H Lazar
Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
Am J Respir Cell Mol Biol 31:672-8. 2004..The significant effect of uPA and PAI-1 on epithelial repair suggests a mechanism by which the plasminogen system may modulate pulmonary fibrosis... - Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinaseVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Biol Chem 278:12384-9. 2003.... - Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2Bethany B Moore
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 174:5644-9. 2005..Our results for the first time link EP2 receptor loss on fibroblasts following fibrotic lung injury to altered suppression by PGE(2) and thus identify a novel fibrogenic mechanism... - Mechanisms of pulmonary fibrosisVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Annu Rev Med 55:395-417. 2004.... - Pneumocystis pneumonia increases the susceptibility of mice to sublethal hyperoxiaJames M Beck
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School Medical Service, Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105, USA
Infect Immun 71:5970-8. 2003..We conclude that Pneumocystis pneumonia leads to increased mortality following a normally sublethal hyperoxic insult, accompanied by alveolar epithelial cell injury and increased pulmonary inflammation... - Diversity of the angiogenic phenotype in non-small cell lung cancerMarc R McClelland
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
Am J Respir Cell Mol Biol 36:343-50. 2007..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway... - Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosisEric S White
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
Clin Cancer Res 9:853-60. 2003..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis... - Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniaeSharlene I Moore
Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA
Infect Immun 71:4182-5. 2003..These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria... - Pulmonary sarcoidosisJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 28:53-74. 2007..Lung transplantation is a viable option for patients with life-threatening disease failing medical therapy... - Usual interstitial pneumoniaJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 27:634-51. 2006..This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future)... - Infliximab in sarcoidosis: more answers or more questions?Eric S White
Am J Respir Crit Care Med 174:732-3. 2006
Research Grants
- Role of EIIIA fibronectin in pulmonary fibrosisEric S White; Fiscal Year: 2010..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
- Role of Integrins in Pulmonary FibrosisEric White; Fiscal Year: 2006....
- Role of EIIIA fibronectin in pulmonary fibrosisEric White; Fiscal Year: 2007..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
- Role of EIIIA fibronectin in pulmonary fibrosisEric White; Fiscal Year: 2009..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..