Eric White

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Current and emerging strategies for the management of sarcoidosis
    Eric S White
    University of Michigan Medical Center, Division of Pulmonary and Critical Medicine, Department of Internal Medicine, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Expert Opin Pharmacother 8:1293-311. 2007
  2. pmc Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation
    Adam J Booth
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5642, USA
    Am J Respir Crit Care Med 186:866-76. 2012
  3. ncbi request reprint Pharmacological therapy for Wegener's granulomatosis
    Eric S White
    Division of Pulmonary and Critical Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Drugs 66:1209-28. 2006
  4. pmc Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 173:112-21. 2006
  5. pmc Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 32:135-41. 2005
  6. pmc Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis
    Eric S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    J Pathol 201:343-54. 2003
  7. pmc Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway
    Eric S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Exp Cell Res 316:2644-53. 2010
  8. pmc Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 168:436-42. 2003
  9. pmc Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression
    Rommel L Sagana
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:32264-71. 2009
  10. pmc The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice
    Kristy A Bauman
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 120:1950-60. 2010

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Current and emerging strategies for the management of sarcoidosis
    Eric S White
    University of Michigan Medical Center, Division of Pulmonary and Critical Medicine, Department of Internal Medicine, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Expert Opin Pharmacother 8:1293-311. 2007
    ..Agents commonly used to treat patients with sarcoidosis and emerging therapeutic options are discussed...
  2. pmc Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation
    Adam J Booth
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5642, USA
    Am J Respir Crit Care Med 186:866-76. 2012
    ..In the lung, fibroblasts exist in ECM-rich interstitial spaces and are key effectors of lung fibrogenesis...
  3. ncbi request reprint Pharmacological therapy for Wegener's granulomatosis
    Eric S White
    Division of Pulmonary and Critical Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Drugs 66:1209-28. 2006
    ..However, the current data are conflicting and difficult to interpret. As a result, these newer agents cannot be recommended for routine use until vigorous clinical study confirms their efficacy...
  4. pmc Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 173:112-21. 2006
    ..Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the development of novel therapeutic agents...
  5. pmc Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 32:135-41. 2005
    ..Collectively, these data describe the novel mechanistic finding that PGE(2), via the EP2 receptor, decreases tyrosine phosphorylation on PTEN, resulting in increased PTEN enzyme activity and inhibition of fibroblast migration...
  6. pmc Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis
    Eric S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    J Pathol 201:343-54. 2003
    ..This review focuses on evolving concepts of cellular and molecular mechanisms in the pathogenesis of UIP/IPF...
  7. pmc Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway
    Eric S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Exp Cell Res 316:2644-53. 2010
    ..Thus, our results demonstrate that the PI3K/Akt/mTOR axis is instrumental in FN transcription and alternative splicing, which regulates cell behavior...
  8. pmc Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 168:436-42. 2003
    ..Furthermore, this study implicates a loss of PTEN function in the pathophysiology of idiopathic pulmonary fibrosis...
  9. pmc Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression
    Rommel L Sagana
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:32264-71. 2009
    ..This is the first description, to our knowledge, of PI3K/PTEN balance directing GPCR expression, and provides a novel mechanism for cellular effects of PTEN...
  10. pmc The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice
    Kristy A Bauman
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 120:1950-60. 2010
    ..These studies demonstrate crosstalk between plasminogen activation and PGE2 generation in the lung and provide a mechanism for the well-known antifibrotic actions of the fibrinolytic pathway...
  11. pmc PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    Peedikayil E Thomas
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007
    ..Taken together, our results demonstrate that PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways...
  12. pmc Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts
    Guo Qiang Cai
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 316:1600-9. 2010
    ..These data for the first time provide evidence that downregulation of endogenous FRNK plays a role in promoting cell migration through FAK and Rho GTPase in fibrotic IPF lung fibroblasts...
  13. pmc Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways
    Steven K Huang
    Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
    FASEB J 23:4317-26. 2009
    ..They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease...
  14. pmc Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts
    Jeffrey C Horowitz
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, Ann Arbor, MI 48109, USA
    Cell Signal 19:761-71. 2007
    ..Activation of these pro-survival/anti-anoikis pathways in myofibroblasts likely contributes to essential roles of TGF-beta1 in tissue fibrosis and tumour-promotion...
  15. pmc An essential role for fibronectin extra type III domain A in pulmonary fibrosis
    Andres F Muro
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 177:638-45. 2008
    ..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen...
  16. pmc Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice
    Steven K Huang
    Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Pathol 177:2245-55. 2010
    ....
  17. pmc Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia
    Benjamin J Murdock
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5642, USA
    Infect Immun 79:125-35. 2011
    ..fumigatus conidia...
  18. pmc The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
    Gregory A Yanik
    Department of Pediatrics, University of Michigan, Ann Arbor, USA
    Blood 112:3073-81. 2008
    ..The combination of etanercept and corticosteroids is safe and is associated with high response rates and improved survival in patients with IPS...
  19. pmc Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
    Thomas H Sisson
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 5642, USA
    Am J Respir Crit Care Med 181:254-63. 2010
    ..Although these findings are compelling, there are no studies that demonstrate a direct role for the alveolar epithelium or, more specifically, type II cells in the scarring process...
  20. ncbi request reprint Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages
    Claudio Canetti
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109, USA
    J Immunol 179:8350-6. 2007
    ..We suggest that this mechanism contributes to the ability of PGE2 to inhibit PI3K-dependent innate immune signaling in primary macrophages...
  21. ncbi request reprint Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin
    Michael H Lazar
    Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 0642, USA
    Am J Respir Cell Mol Biol 31:672-8. 2004
    ..The significant effect of uPA and PAI-1 on epithelial repair suggests a mechanism by which the plasminogen system may modulate pulmonary fibrosis...
  22. ncbi request reprint Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:12384-9. 2003
    ....
  23. ncbi request reprint Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
    ..Our results for the first time link EP2 receptor loss on fibroblasts following fibrotic lung injury to altered suppression by PGE(2) and thus identify a novel fibrogenic mechanism...
  24. ncbi request reprint Mechanisms of pulmonary fibrosis
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Annu Rev Med 55:395-417. 2004
    ....
  25. pmc Pneumocystis pneumonia increases the susceptibility of mice to sublethal hyperoxia
    James M Beck
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School Medical Service, Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    Infect Immun 71:5970-8. 2003
    ..We conclude that Pneumocystis pneumonia leads to increased mortality following a normally sublethal hyperoxic insult, accompanied by alveolar epithelial cell injury and increased pulmonary inflammation...
  26. pmc Diversity of the angiogenic phenotype in non-small cell lung cancer
    Marc R McClelland
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 36:343-50. 2007
    ..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway...
  27. ncbi request reprint Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis
    Eric S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Clin Cancer Res 9:853-60. 2003
    ..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis...
  28. pmc Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae
    Sharlene I Moore
    Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA
    Infect Immun 71:4182-5. 2003
    ..These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria...
  29. ncbi request reprint Pulmonary sarcoidosis
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 28:53-74. 2007
    ..Lung transplantation is a viable option for patients with life-threatening disease failing medical therapy...
  30. ncbi request reprint Usual interstitial pneumonia
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 27:634-51. 2006
    ..This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future)...
  31. ncbi request reprint Infliximab in sarcoidosis: more answers or more questions?
    Eric S White
    Am J Respir Crit Care Med 174:732-3. 2006

Research Grants5

  1. Role of EIIIA fibronectin in pulmonary fibrosis
    Eric S White; Fiscal Year: 2010
    ..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
  2. Role of Integrins in Pulmonary Fibrosis
    Eric White; Fiscal Year: 2006
    ....
  3. Role of EIIIA fibronectin in pulmonary fibrosis
    Eric White; Fiscal Year: 2007
    ..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..
  4. Role of EIIIA fibronectin in pulmonary fibrosis
    Eric White; Fiscal Year: 2009
    ..Successful completion of these experiments may also identify novel, potentially therapeutic, agents to combat lung fibrosis. ..