C Roger White

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4F
    C Roger White
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Lipid Res 53:1576-87. 2012
  2. ncbi request reprint L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia
    C Roger White
    Department of Medicine, Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 1046 Zeigler Research Building, 703 South 19th St, Birmingham, AL 35294 0007, USA
    FEBS Lett 561:94-8. 2004
  3. ncbi request reprint HDL therapy for cardiovascular diseases: the road to HDL mimetics
    C Roger White
    Vascular Biology and Hypertension Program, University of Alabama, Birmingham, 1046 Zeigler Research Building, 703 South 19th Street, Birmingham, AL 35294, USA
    Curr Atheroscler Rep 10:405-12. 2008
  4. ncbi request reprint Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F
    C Roger White
    University of Alabama at Birmingham, Department of Medicine, Boshell Diabetes Bldg, Room 650, 1808 7th Ave S Birmingham, AL 35294, USA
    Arterioscler Thromb Vasc Biol 32:2631-9. 2012
  5. ncbi request reprint Atherosclerosis and vascular disease: effects of peptide mimetics of apolipoproteins
    David W Garber
    Department of Medicine, The University of Alabama at Birmingham, Birmingham AL 35294, USA
    Curr Pharm Biotechnol 7:235-40. 2006
  6. pmc Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2)
    Geeta Datta
    Department of Medicine, Atherosclerosis Research Unit, Division of Gerontology, Geriatrics and Palliative Medicine, University of Alabama at Birmingham, 1808 Seventh Avenue South, Birmingham, AL 35294, USA
    Atherosclerosis 208:134-41. 2010
  7. ncbi request reprint Apolipoprotein E mimetic Peptide dramatically lowers plasma cholesterol and restores endothelial function in watanabe heritable hyperlipidemic rabbits
    Himanshu Gupta
    Department of Medicine, University of Alabama at Birmingham, AL, USA
    Circulation 111:3112-8. 2005
  8. doi request reprint ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity
    Geeta Datta
    Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Exp Med Biol 660:1-4. 2010
  9. pmc Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages
    Lesley E Smythies
    University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Cell Physiol 298:C1538-48. 2010
  10. pmc Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
    Nicholas K H Khoo
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Free Radic Biol Med 49:339-47. 2010

Collaborators

Detail Information

Publications34

  1. pmc Preservation of biological function despite oxidative modification of the apolipoprotein A-I mimetic peptide 4F
    C Roger White
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Lipid Res 53:1576-87. 2012
    ..Neither property was altered by HOCl. These results suggest that 4F serves as a reactive substrate for HOCl, an antioxidant response that does not influence the lipid binding and cholesterol effluxing capacities of the peptide...
  2. ncbi request reprint L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia
    C Roger White
    Department of Medicine, Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 1046 Zeigler Research Building, 703 South 19th St, Birmingham, AL 35294 0007, USA
    FEBS Lett 561:94-8. 2004
    ..These results reveal that the principal action of L-arginine is to protect against the XO-dependent inactivation of NO in arteries of HC rabbits...
  3. ncbi request reprint HDL therapy for cardiovascular diseases: the road to HDL mimetics
    C Roger White
    Vascular Biology and Hypertension Program, University of Alabama, Birmingham, 1046 Zeigler Research Building, 703 South 19th Street, Birmingham, AL 35294, USA
    Curr Atheroscler Rep 10:405-12. 2008
    ..The goal of this review is to discuss the current status of HDL therapeutics, with emphasis on a novel class of agent, the apolipoprotein A-I mimetic peptides, which improve the functional properties of HDL cholesterol...
  4. ncbi request reprint Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F
    C Roger White
    University of Alabama at Birmingham, Department of Medicine, Boshell Diabetes Bldg, Room 650, 1808 7th Ave S Birmingham, AL 35294, USA
    Arterioscler Thromb Vasc Biol 32:2631-9. 2012
    ..We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages...
  5. ncbi request reprint Atherosclerosis and vascular disease: effects of peptide mimetics of apolipoproteins
    David W Garber
    Department of Medicine, The University of Alabama at Birmingham, Birmingham AL 35294, USA
    Curr Pharm Biotechnol 7:235-40. 2006
    ..The use of peptide mimetics to study apolipoprotein function has proved to be a powerful tool, and may lead to novel therapeutic agents in the prevention of atherosclerosis and other vascular diseases...
  6. pmc Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2)
    Geeta Datta
    Department of Medicine, Atherosclerosis Research Unit, Division of Gerontology, Geriatrics and Palliative Medicine, University of Alabama at Birmingham, 1808 Seventh Avenue South, Birmingham, AL 35294, USA
    Atherosclerosis 208:134-41. 2010
    ..Such a peptide has great potential as a therapeutic agent in the management of atherosclerosis and other inflammatory diseases...
  7. ncbi request reprint Apolipoprotein E mimetic Peptide dramatically lowers plasma cholesterol and restores endothelial function in watanabe heritable hyperlipidemic rabbits
    Himanshu Gupta
    Department of Medicine, University of Alabama at Birmingham, AL, USA
    Circulation 111:3112-8. 2005
    ....
  8. doi request reprint ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity
    Geeta Datta
    Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Adv Exp Med Biol 660:1-4. 2010
    ..It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties...
  9. pmc Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages
    Lesley E Smythies
    University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Cell Physiol 298:C1538-48. 2010
    ..These data provide evidence that 4F, similar to apoA-I, induces profound functional changes in MDMs, possibly due to differentiation to an anti-inflammatory phenotype...
  10. pmc Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
    Nicholas K H Khoo
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Free Radic Biol Med 49:339-47. 2010
    ....
  11. pmc The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic rats
    Lijun Dai
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Lipid Res 51:2695-705. 2010
    ..It is proposed that 4F promotes the localization of LPS to the HDL fraction, resulting in endotoxin neutralization. 4F may thus prevent LPS-induced hemodynamic changes associated with NOS2 induction...
  12. pmc Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats
    Zhenghao Zhang
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 297:H866-73. 2009
    ..Increased plasma HDL in 4F-treated CLP rats was associated with an improvement in CO and reduced mortality. It is proposed that protective effects of 4F are related to its ability to prevent the sepsis-induced reduction in plasma HDL...
  13. pmc Anti-inflammatory mechanisms of apolipoprotein A-I mimetic peptide in acute respiratory distress syndrome secondary to sepsis
    Oleg F Sharifov
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    PLoS ONE 8:e64486. 2013
    ..The main protective mechanisms of L-4F are due to direct inhibition of endotoxin activity and preservation of HDL anti-oxidant activity...
  14. ncbi request reprint Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptide
    Himanshu Gupta
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, USA
    Circ Res 97:236-43. 2005
    ..The current studies demonstrate that L-4F reduces the expression of inflammatory markers induced by LPS and lipid A and suggest that apoAI peptide mimetics may be useful in the treatment of inflammation associated with endotoxemia...
  15. ncbi request reprint Synthetic peptides: managing lipid disorders
    Gm Anantharamaiah
    Departments of Medicine, Biochemistry, and Molecular Genetics and the Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham Alabama, USA
    Curr Opin Lipidol 17:233-7. 2006
    ..Recent publications related to the potential use of synthetic peptides for the management of lipid disorders and their vascular complications are reviewed...
  16. pmc Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
    Gin C Chuang
    Department of Pathology, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 297:L209-16. 2009
    ..Consequently, inhaled ozone, in the absence of other environmental toxicants, promotes increased vascular dysfunction, oxidative stress, mitochondrial damage, and atherogenesis...
  17. pmc Potential for chlorine gas-induced injury in the extrapulmonary vasculature
    Andrey Samal
    Department of Pathology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Proc Am Thorac Soc 7:290-3. 2010
    ..This article discusses these two areas with the view of providing a framework in which potential extrapulmonary toxic effects of Cl(2) gas exposure may be considered...
  18. ncbi request reprint Evidence of cardiovascular protection by moderate alcohol: role of nitric oxide
    Laila H Abou-Agag
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Free Radic Biol Med 39:540-8. 2005
    ..An increase in *NO may explain, at least in part, the cardioprotective benefits of moderate alcohol consumption...
  19. ncbi request reprint Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid
    C Zhang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Heart Circ Physiol 281:H1469-75. 2001
    ..The reduction in total NO metabolite production in bovine aortic endothelial cells was also reversed by addition of L-arginine. These data suggest that HOCl induces endothelial dysfunction via modification of L-arginine...
  20. ncbi request reprint Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states
    Jack H Crawford
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Blood 101:4408-15. 2003
    ..This suggests that oxygen-dependent modulation of SNOHb vasoactivity does not occur by controlling the allosteric state of Hb but is a property of vessel responsiveness to nitrosovasodilators at low oxygen tensions...
  21. ncbi request reprint Estrogen restores endothelial cell function in an experimental model of vascular injury
    C R White
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology, and Hypertension Program, 35294 0007, USA
    Circulation 96:1624-30. 1997
    ..The goal of the present study was to determine whether estrogen restores endothelial cell function in balloon-injured rat carotid arteries...
  22. ncbi request reprint Captopril treatment and its withdrawal prevents impairment of endothelium-dependent responses in the spontaneously hypertensive rat
    A K Keaton
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294 0005, USA
    Clin Exp Hypertens 20:847-66. 1998
    ..05). These data suggest that early, long-term treatment with captopril can prevent alterations in endothelial function observed in SHR even after ACE-inhibitor therapy has been stopped...
  23. ncbi request reprint Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation
    M M Tarpey
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Circ Res 84:1203-11. 1999
    ..Study of enzyme and vascular systems indicated that coelenterazine chemiluminescence is a sensitive marker for detecting both superoxide and peroxynitrite...
  24. pmc Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity
    Dong Gun Lim
    Departments of Anesthesiology, Biochemistry and Molecular Genetics, Medicine, and UAB Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Proc Natl Acad Sci U S A 99:15941-6. 2002
    ..g., linoleate), can transduce vascular signaling actions of *NO...
  25. pmc Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
    M Aslan
    Department of Anesthesiology, Center for Free Radical Biology, Imaging Facility and Comprehensive Sickle Cell Disease Center, University of Alabama, Birmingham, AL 35233, USA
    Proc Natl Acad Sci U S A 98:15215-20. 2001
    ..This circulating XO can then bind avidly to vessel luminal cells and impair vascular function by creating an oxidative milieu and catalytically consuming (*)NO via O(2)( small middle dot-)-dependent mechanisms...
  26. ncbi request reprint The neointimal response to endovascular injury is increased in obese Zucker rats
    J Shelton
    Departments of Medicine, Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Diabetes Obes Metab 5:415-23. 2003
    ..Restenosis after revascularization procedures is accelerated in persons with type 2 diabetes...
  27. ncbi request reprint Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats
    Ning Peng
    Dept of Cell Biology, University of Alabama at Birmingham, 1900 Univ Blvd THT 950, Birmingham, AL 35294 0006, USA
    Am J Physiol Regul Integr Comp Physiol 289:R771-5. 2005
    ..These results indicate that grape seed polyphenols decrease arterial pressure in SHR, probably via an antioxidant mechanism...
  28. pmc Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system
    Boglarka Laczy
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Am J Physiol Heart Circ Physiol 296:H13-28. 2009
    ..In addition, we also explore the parallels between O-GlcNAc signaling and redox signaling, as an alternative paradigm for understanding the role of O-GlcNAcylation in regulating cell function...
  29. ncbi request reprint L-arginine chlorination products inhibit endothelial nitric oxide production
    C Zhang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 276:27159-65. 2001
    ..Reaction of HOCl with D-arginine (D-Arg) did not result in the formation of inhibitory products. These results suggest that HOCl reacts with L-Arg to form chlorinated products that act as nitric-oxide synthase inhibitors...
  30. ncbi request reprint Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensions
    T Scott Isbell
    Department of Pathology, University of Alabama at Birmington, Birmingham, AL 35294 2180, USA
    Methods Enzymol 396:553-68. 2005
    ....
  31. ncbi request reprint Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolics
    B J Boersma
    UAB Botanicals Research Group, University of Alabama at Birmingham, 35233, USA
    Biofactors 15:79-81. 2001
    ..Thus the in situ metabolism at sites of inflammation is unique and generates novel pharmacophores with potentially distinct modes of action from the parent compounds...
  32. pmc Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration
    S Baldus
    Department of Anesthesiology, and. The Center for Free Radical Biology, University of Alabama at Birmingham, 35233, USA
    J Clin Invest 108:1759-70. 2001
    ..These data indicate that MPO significantly contributes to NO(2)Tyr formation in vivo. Moreover, transcytosis of MPO, occurring independently of leukocyte emigration, confers specificity to nitration of vascular matrix proteins...
  33. ncbi request reprint Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acid
    R Binsack
    Department of Anesthesiology, University of Alabama at Birmingham, 35233, USA
    Alcohol Clin Exp Res 25:434-43. 2001
    ..g., inflammation), flavonols may be converted to chlorinated derivates, which exhibit an enhanced antioxidant potential and thereby play a role in cardioprotection...
  34. ncbi request reprint Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...

Research Grants8

  1. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2001
    ..The HOCI-dependent modification of L-arginine may represent a common pathogenic mechanism underlying endothelial dysfunction in diverse cardiovascular diseases. ..
  2. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2002
    ..The HOCI-dependent modification of L-arginine may represent a common pathogenic mechanism underlying endothelial dysfunction in diverse cardiovascular diseases. ..
  3. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2002
    ..The HOCI-dependent modification of L-arginine may represent a common pathogenic mechanism underlying endothelial dysfunction in diverse cardiovascular diseases. ..
  4. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2003
    ..The HOCI-dependent modification of L-arginine may represent a common pathogenic mechanism underlying endothelial dysfunction in diverse cardiovascular diseases. ..
  5. Myeloperoxidase and NO signaling in the vasculature
    C White; Fiscal Year: 2004
    ..The HOCI-dependent modification of L-arginine may represent a common pathogenic mechanism underlying endothelial dysfunction in diverse cardiovascular diseases. ..
  6. HDL and Vascular Injury in Type 2 Diabetes
    C White; Fiscal Year: 2006
    ....
  7. HDL and Vascular Injury in Type 2 Diabetes
    C White; Fiscal Year: 2007
    ....