David C Whitcomb

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Human pancreatic digestive enzymes
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Dig Dis Sci 52:1-17. 2007
  2. pmc ABO blood group and chronic pancreatitis risk in the NAPS2 cohort
    Julia B Greer
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Pancreas 40:1188-94. 2011
  3. ncbi request reprint Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15101, USA
    Pancreatology 4:490-4. 2004
  4. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
  5. doi request reprint Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, 3708 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Intern Med 169:1035-45. 2009
  6. doi request reprint Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Dig Dis Sci 55:2676-80. 2010
  7. doi request reprint Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis
    Arun Sharma
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreas 38:907-12. 2009
  8. pmc Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2003. 2008
  9. pmc Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 140:162-71. 2011
  10. pmc Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis
    Harrison Brand
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 42:836-40. 2013

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Human pancreatic digestive enzymes
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Dig Dis Sci 52:1-17. 2007
    ..This report updates our understanding of human pancreatic digestive enzymes with a focus on new insights into the biology of human proteases, lipases and amylases...
  2. pmc ABO blood group and chronic pancreatitis risk in the NAPS2 cohort
    Julia B Greer
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Pancreas 40:1188-94. 2011
    ..Our goal was to determine whether ABO blood group may affect the risk of chronic pancreatitis...
  3. ncbi request reprint Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15101, USA
    Pancreatology 4:490-4. 2004
    ..Cytokines participate in the immunological progression of pancreatic inflammation and may play an important role in the development of pancreatic fibrosis...
  4. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
    ..We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP...
  5. doi request reprint Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, 3708 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Intern Med 169:1035-45. 2009
    ..We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers...
  6. doi request reprint Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Dig Dis Sci 55:2676-80. 2010
    ..In animal models, EGF protects against pancreatic injury and prevents septic complications. The role of EGF in human AP is unknown...
  7. doi request reprint Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis
    Arun Sharma
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreas 38:907-12. 2009
    ..We tested the hypothesis that serum adiponectin, the primary anti-inflammatory adipokine, is associated with functional polymorphisms in the adiponectin gene (ADIPOQ) and inversely associated with SAP...
  8. pmc Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2003. 2008
    ..We tested this hypothesis by evaluating the differences in effect size of the high risk SPINK1 N34S haplotype on CP from multiple etiologies after combining clinical reports of SPINK1 N34S frequency using meta-analysis...
  9. pmc Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 140:162-71. 2011
    ..We investigated whether sequence variants in the gene encoding the pancreatic secretory trypsin inhibitor SPINK1 further increase the risk of pancreatitis in these patients...
  10. pmc Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis
    Harrison Brand
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 42:836-40. 2013
    ....
  11. doi request reprint Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis
    Rawad Mounzer
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Gastroenterology 142:1476-82; quiz e15-6. 2012
    ..We head-to-head compared the accuracy of these systems in predicting persistent organ failure, developed rules that combined these scores to optimize predictive accuracy, and validated our findings in an independent cohort...
  12. ncbi request reprint Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?
    Georgios I Papachristou
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 3:475-81. 2005
    ..Our aim was to determine whether the MCP-1 -2518 A/G polymorphism affects the severity of AP...
  13. ncbi request reprint The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 6:297-300. 2006
    ..Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP...
  14. pmc Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol
    Venkata Muddana
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA
    World J Gastroenterol 14:4486-91. 2008
    ....
  15. doi request reprint TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis
    Faraz Bishehsari
    Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 12:113-8. 2012
    ..Small genetic cohort studies of the TNFA promoter in AP produced ambiguous results. We performed a comprehensive evaluation of TNFA promoter variants to assess both susceptibility to AP and risk of progression to MODS...
  16. doi request reprint SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:446-51. 2010
    ..Our aim was to study the prevalence of the SPINK1 N34S polymorphism in patients with sentinel and recurrent AP (RAP)...
  17. ncbi request reprint Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    J Gastroenterol 39:783-7. 2004
    ..It has been suggested that oxidative stress contributes to pancreatic damage. The glutathione s-transferases (GSTs) represent major detoxification enzymes that protect cells from oxidative stress...
  18. ncbi request reprint Keratin 8 mutations are not associated with familial, sporadic and alcoholic pancreatitis in a population from the United States
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreatology 6:103-8. 2006
    ..We determined whether mutations in the keratin 8 gene are associated with familial, sporadic and alcoholic recurrent acute or chronic pancreatitis in a population from the United States...
  19. pmc Whole exome sequencing identifies multiple, complex etiologies in an idiopathic hereditary pancreatitis kindred
    Jessica Larusch
    Department of Medicine, University of Pittsburgh Pittsburgh, PA, USA
    JOP 13:258-62. 2012
    ....
  20. ncbi request reprint Rapid adaptation of pancreatic exocrine function to short-term alcohol feeding in rats
    Xiaoying Deng
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreatology 5:183-95. 2005
    ..However, the origin, nature and timing of hyperstimulation/hypersecretion are unknown...
  21. ncbi request reprint The functional angiotensin converting enzyme gene I/D polymorphism does not alter susceptibility to chronic pancreatitis
    Nevin Oruc
    Department of Medicine, Division of Gastroenterology, and the Center for Genomic Sciences, University of Pittsburgh Pittsburgh, PA, USA
    JOP 5:457-63. 2004
    ..The pancreatic renin-angiotensin system plays a role in the development of pancreatic fibrosis and ACE inhibitors decrease pancreatic fibrosis in experimental models...
  22. ncbi request reprint Genetic issues in pediatric pancreatitis
    Leena Kandula
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, 2nd Floor DeSoto Bldg, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 8:248-53. 2006
    ..These findings, along with the advances in cell biology, have contributed to a better understanding of the pathophysiology of pancreatic diseases...
  23. pmc Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats
    Xiaoying Deng
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Pathol 166:93-106. 2005
    ..Pancreatic fibrosis develops after repeated episodes of AP and is potentiated by alcohol. Expression of fibrosis-associated genes was associated with expression of anti-inflammatory cytokines in alcohol-fed rats...
  24. ncbi request reprint Functional polymorphisms of the GSTT-1 gene do not predict the severity of acute pancreatitis in the United States
    Yasser M Bhat
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pancreatology 7:180-6. 2007
    ..Our aim was to determine whether the same GSTT-1 polymorphism affects the severity of AP in a population from Pittsburgh, Pa., USA...
  25. ncbi request reprint Genetic polymorphisms in alcoholic pancreatitis
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Dig Dis 23:247-54. 2005
    ..Growing evidence suggests that environmental and possibly genetic cofactors must also be present to overcome the redundant mechanisms protecting the pancreas from pancreatitis and facilitating complete recovery...
  26. ncbi request reprint Risk and markers of severe acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Gastroenterol Clin North Am 36:277-96, viii. 2007
    ....
  27. pmc Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nat Genet 44:1349-54. 2012
    ..These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07)...
  28. ncbi request reprint Rapid evolution from the first episode of acute pancreatitis to chronic pancreatitis in human subjects
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    JOP 8:573-8. 2007
    ..The sentinel acute pancreatitis event hypothesis suggests that an initial episode of acute pancreatitis is the first step in a complicated series of events ultimately leading to chronic pancreatitis...
  29. doi request reprint Current management and novel insights in acute pancreatitis
    Venkata Muddana
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, PA 15219, USA
    Expert Rev Gastroenterol Hepatol 3:435-44. 2009
    ..The lack of scientific advancements in the management of AP reflects the limited understanding of the early pathogenetic mechanisms and our moderate-to-poor ability to predict severe course at the time of admission...
  30. ncbi request reprint Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis
    Veronique D Morinville
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 35:308-12. 2007
    ..Because of the potential importance of hyperstimulation in triggering episodes of AP in HP, we designed a pilot study to evaluate the safety and potential benefit of CCB use in HP...
  31. ncbi request reprint Genetic polymorphisms in alcoholic pancreatitis
    Christoph Hanck
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, PUH, University of Pittsburgh, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Best Pract Res Clin Gastroenterol 17:613-23. 2003
    ..However, the major cofactor associated with alcoholic chronic pancreatitis is yet to be identified...
  32. doi request reprint Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study
    Daniel K Mullady
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gut 60:77-84. 2011
    ..To compare patients with chronic pancreatitis (CP) with constant pain patterns to patients with CP with intermittent pain patterns...
  33. doi request reprint Elevated serum creatinine as a marker of pancreatic necrosis in acute pancreatitis
    Venkata Muddana
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, UPMC Presbyterian Hospital, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Gastroenterol 104:164-70. 2009
    ..This study focuses on the association between routine laboratory tests and the development of pancreatic necrosis in patients with acute pancreatitis...
  34. doi request reprint Serum immunoglobulin G fraction 4 levels in pancreatic cancer: elevations not associated with autoimmune pancreatitis
    Amit Raina
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Pathol Lab Med 132:48-53. 2008
    ..A previous Japanese study reported that serum IgG4 greater than 135 mg/dL was 97% specific and 95% sensitive in predicting autoimmune pancreatitis...
  35. ncbi request reprint Serum proteomic patterns as a predictor of severity in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Cancer Institute Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 7:317-24. 2007
    ....
  36. doi request reprint Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany
    David C Whitcomb
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Gastroenterol 105:2287-92. 2010
    ..The aim of this study was to determine whether Ang-1 and/or Ang-2 levels are predictive biomarkers of persistent organ failure (>48 h) and prolonged hospital course...
  37. doi request reprint MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer
    Lauren M Smith
    School of Arts and Sciences, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Pancreatology 9:793-6. 2009
    ..The purpose of this study was to determine if a similar association exists between exon 7 and 13 MUTYH mutations and pancreatic cancer...
  38. pmc Smoking is underrecognized as a risk factor for chronic pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreatology 10:713-9. 2010
    ..Smoking is an established risk factor for chronic pancreatitis (CP). We sought to identify how often and in which CP patients physicians consider smoking to be a risk factor...
  39. doi request reprint Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:435-41; quiz 442. 2010
    ....
  40. pmc Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2)
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreatology 8:520-31. 2008
    ..We developed the North American Pancreatitis Study 2 (NAPS2) to be sufficiently powered to understand the complex environmental, metabolic and genetic mechanisms underlying RAP and CP...
  41. pmc Genetics of alcoholic and nonalcoholic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh and UPMC, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Gastroenterol 28:501-6. 2012
    ..To provide an expert review and expert perspective on important advances related to the genetics of acute and chronic pancreatitis...
  42. pmc Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis
    Gregory A Cote
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Gastroenterol Hepatol 9:266-73; quiz e27. 2011
    ..We investigated the epidemiology of alcohol-related CP at tertiary US referral centers...
  43. pmc Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism
    Kay L Pogue-Geile
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 3:e516. 2006
    ..In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene...
  44. ncbi request reprint Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreatology 6:279-85. 2006
    ..Obese patients appear to be at risk for complications of acute pancreatitis (AP). APACHE-O score has been suggested to improve APACHE-II accuracy in predicting severe outcome in AP...
  45. doi request reprint The role of alcohol and smoking in pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, Room 401 4, 3708 Fifth Avenue, Pittsburgh, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 7:131-45. 2010
    ..In humans, aggressive interventional counseling against alcohol use may reduce the frequency of recurrent attacks of disease and smoking cessation may help to slow the progression of acute to chronic pancreatitis...
  46. doi request reprint Evaluation and management of autoimmune pancreatitis: experience at a large US center
    Amit Raina
    Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Gastroenterol 104:2295-306. 2009
    ..Systematic evaluation and management of AIP in the United States is reported only from one center. Our aim was to review the evaluation and management of AIP at a large tertiary center...
  47. ncbi request reprint Genetic predisposition to alcoholic chronic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, and the VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    Pancreas 27:321-6. 2003
    ..New genetic, environmental, and triggering factors must be considered to gain further insight into the mechanisms leading to alcoholic chronic pancreatitis so that strategies for treatment and prevention can be developed...
  48. doi request reprint DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma
    Kenneth E Fasanella
    Department of Medicine, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 10:429-33. 2010
    ..Preoperative distinction between pancreatic cancer (PC) and extrahepatic cholangiocarcinoma (CC) is desirable due to diverging management options, and to optimize enrollment into neoadjuvant trials...
  49. doi request reprint Low penetrance pancreatitis phenotype in a Venezuelan kindred with a PRSS1 R122H mutation
    Sheila Solomon
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA 15232, USA
    JOP 14:187-9. 2013
    ....
  50. pmc Endoscopic therapy is effective for patients with chronic pancreatitis
    Bridger Clarke
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Gastroenterol Hepatol 10:795-802. 2012
    ..We evaluated use and long-term effectiveness of ET in a well-defined cohort of patients with CP...
  51. pmc Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis
    Brenda Diergaarde
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Pancreatology 10:194-200. 2010
    ..Knowledge regarding genetic factors that influence pancreatic cancer risk is currently limited. To identify novel pancreatic cancer susceptibility loci, we conducted a two-stage genome-wide association study...
  52. pmc Significant association between ABO blood group and pancreatic cancer
    Julia B Greer
    The Institute For Transfusion Medicine, 3636 Blvd of the Allies, Pittsburgh, PA 15213, USA
    World J Gastroenterol 16:5588-91. 2010
    ..To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States...
  53. ncbi request reprint Genetic counseling for nonsyndromic pancreatitis
    Erin N Fink
    Department of Medicine, University of Pittsburgh, 1218 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:325-33, ix. 2007
    ..This article focuses on the approach to genetic counseling for pancreatitis and implications of recent advances...
  54. pmc Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
    Mark Lazarev
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pain 4:58. 2008
    ....
  55. pmc Genetics of pancreatitis
    Jessica Larusch
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Gastroenterol 27:467-74. 2011
    ..This review highlights recent advances and future directions in genetic research...
  56. ncbi request reprint Analysis of tumor necrosis factor-alpha, transforming growth factor-beta 1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Alcohol 32:19-24. 2004
    ..05). We did not find an association between the different genotypes and the clinical course of the disease. Therefore, we assume that these genetic variants do not play a dominant role in alcoholic chronic pancreatitis...
  57. doi request reprint Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis
    Elie Aoun
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 9:777-85. 2009
    ..We conducted a meta-analysis to assess the accuracy of IL-6 and IL-8 at predicting SAP...
  58. ncbi request reprint Alcoholic pancreatitis
    Christoph Hanck
    Department of Medicine, University of Pittsburgh, UPMC Presbyterian, Mezzanine Level C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 33:751-65. 2004
    ..If alcohol-associated pancreatitis is detected, then limitation of pancreatic damage, limitation of progression, or preventative intervention should become the major concern...
  59. pmc Genetic risk factors for pancreatic disorders
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 144:1292-302. 2013
    ..Learning how various genetic factors affect pancreatic cells and systems could lead to etiology-based therapies rather than treatment of symptoms...
  60. doi request reprint Genetics of pancreatitis: an update for clinicians and genetic counselors
    Sheila Solomon
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 14:112-7. 2012
    ..This chapter addresses the intricate medical and psychosocial issues that can arise in the setting of treating patients with hereditary pancreatitis...
  61. ncbi request reprint Inflammatory markers of disease severity in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Lab Med 25:17-37. 2005
    ..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP, are needed for a quantum step forward...
  62. ncbi request reprint Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link?
    Leena Kandula
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    JOP 7:482-5. 2006
    ..For instance, studies show that mutations in the cystic fibrosis transmembrane conductance regulator gene increase the susceptibility for acute and chronic pancreatitis...
  63. ncbi request reprint Chronic alcohol consumption is a major risk factor for pancreatic necrosis in acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 101:2605-10. 2006
    ..Early diagnosis of PNEC in high-risk patients is critical to management. Hemoconcentration is one risk factor for PNEC, but additional risk factors are likely implicated...
  64. pmc Serum biomarker panels for the detection of pancreatic cancer
    Randall E Brand
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:805-16. 2011
    ..Serum-biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations...
  65. ncbi request reprint Predictors of severity and necrosis in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 33:871-90. 2004
    ..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP or other approaches are needed for a quantum step forward...
  66. ncbi request reprint Acute pancreatitis: molecular biology update
    David C Whitcomb
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and Pittsburgh VA Health Care System, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Gastrointest Surg 7:940-2. 2003
  67. ncbi request reprint Conference report for APA postgraduate course: clinical controversies in pancreatobiliary diseases
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    Pancreas 31:218-20. 2005
  68. ncbi request reprint Alcohol-associated pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:219-38, vii. 2007
    ..Newer developments in the understanding of complex disorders allow clinicians to understand better the role of cofactors and interactions between known and yet unknown environmental and genetic factors in causing alcoholic pancreatitis...
  69. ncbi request reprint Pain in chronic pancreatitis and pancreatic cancer
    Kenneth E Fasanella
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Mezzanine Level 2, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:335-64, ix. 2007
    ..Updates of established therapies, as well as new techniques used in addressing pain from chronic pancreatitis, are reviewed. Lastly, outcome measures, which have been highly variable in this field over the years, are addressed...
  70. ncbi request reprint Genetic predisposition to pancreatic cancer: a brief review
    Julia B Greer
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 102:2564-9. 2007
  71. ncbi request reprint Gene-environment factors that contribute to alcoholic pancreatitis in humans
    David C Whitcomb
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Gastroenterol Hepatol 21:S52-5. 2006
    ..Human studies suggest that PRSS1 and SPINK1 mutation increase the pancreas' susceptibility to alcohol-associated pancreatitis, and that tobacco smoking, and some factors, affect disease progression...
  72. ncbi request reprint Pancreatitis as a risk for pancreatic cancer
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, UPMC Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 31:663-78. 2002
    ..g., long-standing HP), then screening for cancers must be considered. Inclusion in multicenter trials is recommended, and information on ongoing studies can be obtained through the office of Dr. Whitcomb, or as posted on www.pancreas.org...
  73. ncbi request reprint Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer
    David C Whitcomb
    UPMC Presbyterian, GI Div, Mezzanine 2, C Wing, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 287:G315-9. 2004
    ....
  74. ncbi request reprint A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, UPMC Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Pancreas 29:e30-40. 2004
    ..To develop a simple, physiologically based mathematical model of pancreatic duct cell secretion using experimentally derived parameters that generates pancreatic fluid bicarbonate concentrations of >140 mM after CFTR activation...
  75. ncbi request reprint Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology, Center for Genomic Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 48:1110-5. 2003
    ..The N34S mutation is uncommon in patients with alcoholic chronic pancreatitis in the United States; its prevalence is similar to other countries and appears not to alter the onset or the severity of alcoholic chronic pancreatitis...
  76. doi request reprint Genetic aspects of pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Med 61:413-24. 2010
    ..Multiple studies are reporting new polymorphisms, as well as complex gene x gene and gene x environmental interactions...
  77. ncbi request reprint Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments for the motion
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pennsylvania, USA
    Can J Gastroenterol 17:47-52. 2003
    ..In the future, increased knowledge of the myriad genetic causes of pancreatitis, as well as advances in the diagnosis and treatment of early chronic pancreatitis, should enhance the utility of genetic testing...
  78. ncbi request reprint Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 50:2195-202. 2005
    ..Instead, systems biology-based approaches should be developed to integrate multiple, focused, and mechanistic association studies with the goal of assisting in the risk assessment of patients on a person-by-person basis...
  79. ncbi request reprint SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 123:1026-30. 2002
    ..A more extensive investigation of patients with pancreatic diseases in Bangladesh, including non-insulin-dependent diabetes mellitus, was undertaken...
  80. ncbi request reprint Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA
    Nat Clin Pract Gastroenterol Hepatol 1:46-52. 2004
    ....
  81. ncbi request reprint Conference report: Pittsburgh Pancreasfest 2005
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreatology 6:138-40. 2006
  82. ncbi request reprint Polygenetic traits in pancreatic disorders
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, GI Administration, UPMC Presbyterian, Mezzanine Level 2, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Endocrinol Metab Clin North Am 35:255-69, viii. 2006
    ..Instead, systems biology-based approaches should be developed to integrate multiple, focused, and mechanistic association studies, with the goal of assisting in the risk assessment of patients on a person-by-person basis...
  83. doi request reprint Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:2276-86. 2010
    ..Our objective was to assess the efficacy and safety of a new formulation of pancrelipase (pancreatin) delayed-release 12,000-lipase unit capsules (CREON) in patients with EPI due to CP or PS...
  84. ncbi request reprint Clinical practice. Acute pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    N Engl J Med 354:2142-50. 2006
  85. ncbi request reprint Hereditary, familial, and idiopathic chronic pancreatitis are not associated with polymorphisms in the tumor necrosis factor alpha (TNF-alpha) promoter region or the TNF receptor 1 (TNFR1) gene
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Genet Med 5:120-5. 2003
    ..Genetic alterations that are associated with acute and chronic pancreatitis remain to be identified...
  86. ncbi request reprint Hereditary pancreatitis: a model for inflammatory diseases of the pancreas
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA 15101, USA
    Best Pract Res Clin Gastroenterol 16:347-63. 2002
    ..Finally, the major independent theories on development of chronic pancreatitis are reviewed with respect to the SAPE hypothesis of chronic pancreatitis pathogenesis...
  87. pmc Role of BRCA1 and BRCA2 mutations in pancreatic cancer
    Julia B Greer
    Department of Medicine, University of Pittsburgh, Division of Gastroenterology, Hepatology and Nutrition, Presbyterian University Hospital, Mezzanine 2, C Wing, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Gut 56:601-5. 2007
    ..We are just beginning to elucidate what these factors are...
  88. ncbi request reprint Challenges of examining complex genetic disorders like GERD
    Susan R Orenstein
    University of Pittsburgh School of Medicine, Pittsburgh, USA
    J Pediatr Gastroenterol Nutr 41:S17-9. 2005
  89. ncbi request reprint Molecular and genetic aspects of gastrointestinal and pancreatic disease
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, Director, Center for Genomic Sciences, University of Pittsburgh, UPMC Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Lab Med 25:xi-xii. 2005
  90. ncbi request reprint Conservative treatment of chronic pancreatitis
    Asif Khalid
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Eur J Gastroenterol Hepatol 14:943-9. 2002
    ..The good news is that the understanding of the underlying pathophysiological mechanisms is now advancing rapidly, and hopefully patient-specific and highly effective therapies will become available in the near future...
  91. ncbi request reprint Acute pancreatitis in children
    John R DeBanto
    Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, USA
    Am J Gastroenterol 97:1726-31. 2002
    ..Our intent was to evaluate the performance of existing scoring systems in children, to develop a system for children, and to examine the etiology of acute pancreatitis in children...
  92. ncbi request reprint Genetically defined models of chronic pancreatitis
    Roland M Schmid
    Gastroenterology 131:2012-5. 2006
  93. pmc SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent
    Zahid Hassan
    Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 71:964-8. 2002
    ..02 compared with the ethnically matched control group). These results suggest that the N34S variant of SPINK1 is a susceptibility gene for FCPD in the Indian subcontinent, although, by itself, it is not sufficient to cause disease...
  94. pmc Advances in counselling and surveillance of patients at risk for pancreatic cancer
    Randall E Brand
    Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Gut 56:1460-9. 2007
  95. ncbi request reprint Clinical and genetic characteristics of hereditary pancreatitis in Europe
    Nathan Howes
    Department of Surgery, University of Liverpool, United Kingdom
    Clin Gastroenterol Hepatol 2:252-61. 2004
    ..Hereditary pancreatitis is an autosomal dominant disease that is mostly caused by cationic trypsinogen (PRSS1) gene mutations. The aim was to determine phenotype-genotype correlations of families in Europe...
  96. ncbi request reprint Genetics of gastroesophageal reflux disease: a review
    Susan R Orenstein
    Pediatric Gastroenterology, Children s Hospital of Pittsburgh, PA 15213 2583, USA
    J Pediatr Gastroenterol Nutr 34:506-10. 2002
  97. ncbi request reprint How to think about SPINK and pancreatitis
    David C Whitcomb
    Am J Gastroenterol 97:1085-8. 2002
  98. ncbi request reprint The 5th International Symposium on Inherited Diseases of the Pancreas
    Markus M Lerch
    Department of Gastroenterology, Endocrinology and Nutrition, Ernst Moritz Arndt University, Greifswald, Germany
    Pancreatology 6:414-6. 2006
  99. ncbi request reprint Pancreatic cholesterol esterase, ES-10, and fatty acid ethyl ester synthase III gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats
    Roland H Pfutzer
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Pancreas 25:101-6. 2002
    ..Chronic alcohol consumption predisposes susceptible individuals to both acute and chronic pancreatitis...
  100. ncbi request reprint Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes
    L Rossi
    University Hospital, Department of Medicine, Basel, Switzerland
    Pancreatology 4:461-7. 2004
    ..Testing pancreatic function, we investigated whether selective beta-cell impairment triggers diabetes associated with tropical pancreatitis...
  101. ncbi request reprint Animal models in alcoholic pancreatitis--what can we learn?
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology and Hepatology, Human Genetics, Cell Biology and Physiology, University of Pittsburgh, PA, USA
    Pancreatology 2:189-203. 2002
    ....