D C Whitcomb

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint A gene for hereditary pancreatitis maps to chromosome 7q35
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 110:1975-80. 1996
  2. ncbi request reprint Distribution of pancreatic polypeptide receptors in the rat brain
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, PA 15261, USA
    Brain Res 760:137-49. 1997
  3. ncbi request reprint Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats
    H S Li
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15216, USA
    Pancreas 23:117-24. 2001
  4. ncbi request reprint Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis
    M C Gorry
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Gastroenterology 113:1063-8. 1997
  5. pmc Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis
    R Pfutzer
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15101, USA
    Gut 50:271-2. 2002
  6. ncbi request reprint PYY inhibits CCK-stimulated pancreatic secretion through the area postrema in unanesthetized rats
    X Deng
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 281:R645-53. 2001
  7. ncbi request reprint PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats
    X Deng
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Dig Dis Sci 46:156-65. 2001
  8. pmc Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins
    S T Amann
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Gut 48:542-7. 2001
  9. pmc Genetics of pancreatitis with a focus on the pancreatic ducts
    J Larusch
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 58:299-308. 2012
  10. ncbi request reprint The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA
    A Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Diabet Med 22:744-8. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint A gene for hereditary pancreatitis maps to chromosome 7q35
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 110:1975-80. 1996
    ..A genetic linkage study was designed to identify the HP gene...
  2. ncbi request reprint Distribution of pancreatic polypeptide receptors in the rat brain
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, PA 15261, USA
    Brain Res 760:137-49. 1997
    ..We speculate, based on the patterns of binding in the olfactory and limbic systems, that PP receptors might be involved in positive reinforcement of ingestion behavioral as well as modulation of gastrointestinal function...
  3. ncbi request reprint Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats
    H S Li
    Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15216, USA
    Pancreas 23:117-24. 2001
    ..Because MP stimulates cholecystokinin release and cholecystokinin is an important stimulant of pancreatic secretion, the enhanced MP gene expression may contribute to pancreatic hypersecretion...
  4. ncbi request reprint Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis
    M C Gorry
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Gastroenterology 113:1063-8. 1997
    ..However, not all families studied have this mutation. The aim of this study was to determine the disease-causing mutation in kindreds with hereditary pancreatitis that lack the previously identified mutation...
  5. pmc Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis
    R Pfutzer
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15101, USA
    Gut 50:271-2. 2002
    ..The N29T mutation may also enhance intrapancreatic trypsin activity as has been demonstrated in vitro. Identification of these new mutations requires special attention as commonly used detection methods may fail...
  6. ncbi request reprint PYY inhibits CCK-stimulated pancreatic secretion through the area postrema in unanesthetized rats
    X Deng
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 281:R645-53. 2001
    ..9 vs. 68.9%) secretion in APX rats. Our findings demonstrate that PYY inhibits CCK-8-secretin-stimulated pancreatic secretion through an AP-dependent mechanism in sham-operated rats. The AP also contributes to basal pancreatic secretion...
  7. ncbi request reprint PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats
    X Deng
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Dig Dis Sci 46:156-65. 2001
    ..Therefore, the site of PYY's inhibitory action on pancreatic secretion appears to be primarily on the CCK-stimulated pathway at a site proximal to the convergence of the CCK and 2-DG pathways...
  8. pmc Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins
    S T Amann
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610 0214, USA
    Gut 48:542-7. 2001
    ....
  9. pmc Genetics of pancreatitis with a focus on the pancreatic ducts
    J Larusch
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 58:299-308. 2012
    ..A simple duct cell model is given to illustration the relationship between CFTR, CASR, aquaporins, claudins, and SPINK1, and how they interact. The role of CFTR variants in pancreatic diseases is then discussed...
  10. ncbi request reprint The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA
    A Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Diabet Med 22:744-8. 2005
    ..Therefore, we determined the frequency of SPINK1 N34S mutations in patients with Type 2 diabetes mellitus from the USA...
  11. ncbi request reprint The area postrema lesions alter the inhibitory effects of peripherally infused pancreatic polypeptide on pancreatic secretion
    X Deng
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Room 571, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Brain Res 902:18-29. 2001
    ..p. injection of PP activates c-fos expression in DVC neurons. Thus, PP and PYY may regulate different components of the pancreatic secretory control system through unique pathways...
  12. ncbi request reprint Genetic predispositions to acute and chronic pancreatitis
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Med Clin North Am 84:531-47, vii. 2000
    ....
  13. ncbi request reprint Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study
    S E Applebaum-Shapiro
    Department of Medicine, University of Pittsburgh, Center for Genomic Sciences, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Pancreatology 1:439-43. 2001
    ..The etiology of HP can be identified in a small majority of HP families through genetic testing. However, family history alone is not a good predictor of finding a mutation in the cationic trypsinogen (PRSS1) gene...
  14. ncbi request reprint A systems biology approach to genetic studies of pancreatitis and other complex diseases
    D C Whitcomb
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cell Mol Life Sci 64:1763-77. 2007
    ....
  15. ncbi request reprint Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    D C Whitcomb
    Dept of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Nat Genet 14:141-5. 1996
    ..Cleavage at this site is probably part of a fail-safe mechanism by which trypsin, which is activated within the pancreas, may be inactivated; loss of this cleavage site would permit autodigestion resulting in pancreatitis...
  16. ncbi request reprint Lessons from hereditary pancreatitis
    D C Whitcomb
    Department of Medicine, University of Pittsburgh and the Veterans Affairs Pittsburgh Health Care System, PA, USA
    Croat Med J 42:484-7. 2001
    ..This newly acquired knowledge is setting the stage for new preventive and management strategies for hereditary and sporadic acute and chronic pancreatitis...
  17. ncbi request reprint Motivations and concerns of patients with access to genetic testing for hereditary pancreatitis
    S E Applebaum-Shapiro
    Center for Genomic Sciences, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Gastroenterol 96:1610-7. 2001
    ..These results suggest that a mechanism to disclose results to research participants should be considered, and effective ways to protect at-risk individuals from insurance discrimination must remain a genetics health care priority...
  18. ncbi request reprint Clinical characterization of patients with idiopathic chronic pancreatitis and SPINK1 Mutations
    A Schneider
    Department of Medicine, VA Pittsburgh Health Care System, Pittsburgh, PA 15101, USA
    Scand J Gastroenterol 39:903-4. 2004
  19. ncbi request reprint Hereditary pancreatitis: a model for understanding the genetic basis of acute and chronic pancreatitis
    D C Whitcomb
    Departments of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh, VA Pittsburgh Health Care System, Pittsburgh, PA, USA
    Pancreatology 1:565-70. 2001
    ..The availability of new genetic information and genomic tools should produce a revolution in our understanding of pancreatic diseases...
  20. pmc Value of genetic testing in the management of pancreatitis
    D C Whitcomb
    GI Administration, Mezzanine Level, C Wing, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gut 53:1710-7. 2004
  21. ncbi request reprint SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    R H Pfützer
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 119:615-23. 2000
    ..Loss of trypsin inhibitor function may have similar effects. We investigated the prevalence of SPINK1 (PSTI) mutations in familial pancreatitis, idiopathic chronic pancreatitis, and controls...
  22. ncbi request reprint Area postrema lesion alters the effects of peptide YY on 2-DG-stimulated pancreatic exocrine secretion
    X Deng
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Dig Dis Sci 46:2460-9. 2001
    ....
  23. ncbi request reprint Obesity and the risk of severe acute pancreatitis
    A C Evans
    College of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 56:169-79. 2010
    ....
  24. ncbi request reprint Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding
    H S Li
    Department of Medicine, Center for Genomic Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Physiol Genomics 6:91-8. 2001
    ..The cellular response to mitochondrial damage and metabolic stress may reflect an adaptive process for mitochondrial repair in pancreatic acinar cells during chronic ethanol ingestion...
  25. pmc A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance
    A Khalid
    Division of Gastroenterology, Hepatology, and Nutrition, M2, C Wing, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Gut 55:728-31. 2006
    ..HP twins study suggests that modifier genes influence severity but not penetrance...
  26. ncbi request reprint Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
    M Tschop
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
    Nature 430:1 p following 165; discussion 2 p following 165. 2004
    ..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36...
  27. ncbi request reprint SPINK1 mutations are associated with multiple phenotypes
    R H Pfützer
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Germany
    Pancreatology 1:457-60. 2001
    ..The possible role of SPINK1 mutations and polymorphisms in pancreatic disease is discussed...
  28. ncbi request reprint SPINK1/PSTI mutations are associated with tropical pancreatitis in Bangladesh. A preliminary report
    L Rossi
    Department of Gastroenterology, Kantonsspital, Luzern, Switzerland
    Pancreatology 1:242-5. 2001
    ....