Research Topics
Genomes and GenesSpecies | Brian W WhitcombSummaryAffiliation: University of Massachusetts Country: USA Publications
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Publications
Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birthBrian W Whitcomb
Epidemiology Branch, DESPR, NICHD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland
J Womens Health (Larchmt) 18:73-8. 2009..G-CSF, a hematopoietic cytokine, mediates the increase in leukocytes in pregnancy and may play a role in placentation. We evaluated the association between maternal serum G-CSF in the first and second trimesters and PTB...
Assessment of skewed exposure in case-control studies with poolingBrian W Whitcomb
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA
Stat Med 31:2461-72. 2012....
Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inferencePatrick F McArdle
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, RM, 492, Baltimore, MD 21201, USA
BMC Cardiovasc Disord 12:16. 2012..In this report, we demonstrate its use in assessing direct causal relations between serum bilirubin levels and CVD risk factors, including obesity, cholesterol, measures of vascular function and blood pressure...
Quantification of collider-stratification bias and the birthweight paradoxBrian W Whitcomb
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
Paediatr Perinat Epidemiol 23:394-402. 2009..The simulations demonstrate the conditions necessary to give rise to empirical evidence of the paradox...
Ovarian function and cigarette smokingBrian W Whitcomb
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, MA, USA
Paediatr Perinat Epidemiol 24:433-40. 2010..These phase-specific differences in levels of LH and FSH in healthy, regularly menstruating women who are current smokers compared with non-smokers reflect one mechanism by which smoking may influence fertility and reproductive health...
Treatment of batch in the detection, calibration, and quantification of immunoassays in large-scale epidemiologic studiesBrian W Whitcomb
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
Epidemiology 21:S44-50. 2010..Immunoassays, polymerase chain reaction, and chromatographic approaches are among assays performed in this manner...
Realignment and multiple imputation of longitudinal data: an application to menstrual cycle dataSunni L Mumford
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
Paediatr Perinat Epidemiol 25:448-59. 2011..Our method has applications in settings where missing data may occur over time, where daily blood sampling for hormonal measurements is not feasible, and in other areas where timing is essential...
Endogenous reproductive hormones and C-reactive protein across the menstrual cycle: the BioCycle StudyAudrey J Gaskins
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Am J Epidemiol 175:423-31. 2012..4, 31.5). These results support the hypothesis that endogenous estradiol might have antiinflammatory effects and highlight the need for standardization of CRP measurement to menstrual cycle phase in reproductive-aged women...
Effect of daily fiber intake on reproductive function: the BioCycle StudyAudrey J Gaskins
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
Am J Clin Nutr 90:1061-9. 2009..The influence of fiber on aspects of reproduction, which include ovulation, has not been well studied in premenopausal women...
The use of follicle flushing during oocyte retrieval in assisted reproductive technologies: a systematic review and meta-analysisGary Levy
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Hum Reprod 27:2373-9. 2012..STUDY FUNDING/COMPETING INTEREST(S): This work was supported, in part, by the Program in Reproductive and Adult Endocrinology, NICHD, NIH, Bethesda, MD. The authors have no competing interests to declare. TRIAL REGISTRATION NUMBER: N/A...
Z-scores and the birthweight paradoxEnrique F Schisterman
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Paediatr Perinat Epidemiol 23:403-13. 2009....
Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriageBrian W Whitcomb
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Insttutes of Health, Bethesda, Maryland 20852, USA
Fertil Steril 89:1795-802. 2008..To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage...
Circulating chemokine levels and miscarriageBrian W Whitcomb
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA
Am J Epidemiol 166:323-31. 2007..The observation regarding ENA-78, which has roles in regulation of angiogenesis and leukocyte recruitment, suggests a possible role for this chemokine as an early indicator of miscarriage risk...
Perceived stress and severity of perimenstrual symptoms: the BioCycle StudyAudra L Gollenberg
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Womens Health (Larchmt) 19:959-67. 2010..To examine the longitudinal relation between perceived stress in the previous month and perimenstrual symptom severity across two cycles among regularly menstruating, healthy women (n = 259)...
The limitations due to exposure detection limits for regression modelsEnrique F Schisterman
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rm 7B03, Rockville, MD 20852, USA
Am J Epidemiol 163:374-83. 2006..These results may inform decisions regarding analytical plans for future studies and provide a possible explanation for some amount of the discordance seen in extant literature...
The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review and meta-analysisMicah J Hill
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Fertil Steril 97:1108-14.e1. 2012..To evaluate the effect of recombinant LH in assisted reproduction technology (ART) cycles in patients of advanced reproductive age...
Assays with lower detection limits: implications for epidemiological investigationsBrian W Whitcomb
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
Paediatr Perinat Epidemiol 22:597-602. 2008....
Lipid adjustment in the analysis of environmental contaminants and human health risksEnrique F Schisterman
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Environ Health Perspect 113:853-7. 2005..g., nonfasting blood samples), laboratory measurement, and other underlying modeling assumptions when devising a statistical plan for assessing health outcomes in relation to environmental exposures...
Physical activity of pregnant Hispanic womenKristine E Lynch
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA
Am J Prev Med 43:434-9. 2012..However, factors influencing activity in pregnant Hispanic women, who have high rates of sedentary activity as compared to non-Hispanic whites, are not well characterized...
Effects of low-dose aspirin in in-vitro fertilizationEnrique F Schisterman
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Curr Opin Obstet Gynecol 21:275-8. 2009..It is hypothesized that this effect on blood flow will improve success rates...
