E John Wherry


Affiliation: University of Pennsylvania
Country: USA


  1. Wherry E. T cell exhaustion. Nat Immunol. 2011;12:492-9 pubmed
  2. Pauken K, Wherry E. TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit. Cancer Cell. 2014;26:785-787 pubmed publisher
  3. Bengsch B, Wherry E. The importance of cooperation: partnerless NFAT induces T cell exhaustion. Immunity. 2015;42:203-205 pubmed publisher
    ..In this issue of Immunity, Martinez et al. report that monomeric NFAT binding in the absence of a transcriptional partner induces a gene expression program involved in T cell exhaustion. ..
  4. Pauken K, Wherry E. Overcoming T cell exhaustion in infection and cancer. Trends Immunol. 2015;36:265-76 pubmed publisher
    ..We discuss the current understanding of the mechanisms involved in reversing T cell exhaustion, and outline critical areas of focus for future research, both basic and clinical. ..
  5. Herati R, Reuter M, Dolfi D, Mansfield K, Aung H, Badwan O, et al. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol. 2014;193:3528-37 pubmed publisher
    ..Future rational vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging. ..
  6. Attanasio J, Wherry E. Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. Immunity. 2016;44:1052-68 pubmed publisher
    ..Mechanistic insights from studies of infectious disease provide opportunities to further expand our toolkit to treat cancer and chronic infections in the clinic. ..
  7. Barnett B, Staupe R, Odorizzi P, Palko O, Tomov V, Mahan A, et al. Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection. J Immunol. 2016;197:1017-22 pubmed publisher
    ..Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages. ..
  8. Pauken K, Sammons M, Odorizzi P, Manne S, Godec J, Khan O, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 2016;354:1160-1165 pubmed
    ..These data indicate that epigenetic fate inflexibility may limit current immunotherapies. ..
  9. Kahan S, Wherry E, Zajac A. T cell exhaustion during persistent viral infections. Virology. 2015;479-480:180-93 pubmed publisher

More Information


  1. Bengsch B, Johnson A, Kurachi M, Odorizzi P, Pauken K, Attanasio J, et al. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. 2016;45:358-73 pubmed publisher
    ..These data highlight a key metabolic control event early in exhaustion and suggest that manipulating glycolytic and mitochondrial metabolism might enhance checkpoint blockade outcomes. ..
  2. Crawford A, Angelosanto J, Kao C, Doering T, Odorizzi P, Barnett B, et al. Molecular and transcriptional basis of CD4? T cell dysfunction during chronic infection. Immunity. 2014;40:289-302 pubmed publisher
    ..This study provides a framework for therapeutic interventions targeting exhausted CD4(+) T cells. ..
  3. Odorizzi P, Pauken K, Paley M, Sharpe A, Wherry E. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med. 2015;212:1125-37 pubmed publisher
    ..They also highlight a novel role for PD-1 in preserving TEX cell populations from overstimulation, excessive proliferation, and terminal differentiation. ..
  4. Bengsch B, Ohtani T, Herati R, Bovenschen N, Chang K, Wherry E. Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. J Immunol Methods. 2018;453:3-10 pubmed publisher
    ..Such comprehensive cytotoxic profiling may identify distinct patterns of cytotoxic potential relevant for specific infections, autoimmunity or tumor settings. ..
  5. Chen Z, Stelekati E, Kurachi M, Yu S, Cai Z, Manne S, et al. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Cell Rep. 2017;20:2584-2597 pubmed publisher
    ..Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit. ..