E John Wherry

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi T cell exhaustion
    E John Wherry
    Department of Microbiology, Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:492-9. 2011
  2. pmc A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002098. 2011
  3. pmc Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
    Charlly Kao
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:663-71. 2011
  4. pmc A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection
    Haina Shin
    Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA 19104, USA
    Immunity 31:309-20. 2009
  5. pmc Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche
    Arnob Banerjee
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 185:4988-92. 2010
  6. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
  7. pmc Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    Nobuhiro Nakamoto
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    PLoS Pathog 5:e1000313. 2009
  8. pmc Bystander chronic infection negatively impacts development of CD8(+) T cell memory
    Erietta Stelekati
    Department of Microbiology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA Institute for Immunology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA
    Immunity 40:801-13. 2014
  9. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
  10. pmc Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory
    Travis A Doering
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 37:1130-44. 2012

Detail Information

Publications64

  1. ncbi T cell exhaustion
    E John Wherry
    Department of Microbiology, Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:492-9. 2011
    ....
  2. pmc A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002098. 2011
    ..Our results demonstrate an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection...
  3. pmc Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
    Charlly Kao
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:663-71. 2011
    ..Persistent antigenic stimulation caused downregulation of T-bet, which resulted in more severe exhaustion of CD8(+) T cells. Our observations suggest therapeutic opportunities involving higher T-bet expression during chronic infection...
  4. pmc A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection
    Haina Shin
    Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA 19104, USA
    Immunity 31:309-20. 2009
    ..Thus, we identify Blimp-1 as a transcriptional regulator of CD8(+) T cell exhaustion during chronic viral infection and propose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhaustion...
  5. pmc Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche
    Arnob Banerjee
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 185:4988-92. 2010
    ....
  6. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  7. pmc Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    Nobuhiro Nakamoto
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    PLoS Pathog 5:e1000313. 2009
    ....
  8. pmc Bystander chronic infection negatively impacts development of CD8(+) T cell memory
    Erietta Stelekati
    Department of Microbiology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA Institute for Immunology, University of Pennsylvania Perelman School Medicine, Philadelphia, PA 19104, USA
    Immunity 40:801-13. 2014
    ..Thus, exposure to prolonged bystander inflammation impairs the effector to memory transition. These data have relevance for immunity and vaccination during persisting infections and chronic inflammation...
  9. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  10. pmc Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory
    Travis A Doering
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 37:1130-44. 2012
    ..These data identify pathways involved in CD8(+) T cell exhaustion, and highlight the context-dependent nature of transcription factors in exhaustion versus memory...
  11. pmc Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells
    Karla R Wiehagen
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 116:5560-70. 2010
    ..Our data are consistent with a model in which tonic TCR signals are required at multiple stages of differentiation, but are dispensable for memory CD8 T-cell persistence...
  12. doi Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection
    Vilma Decman
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 184:5151-9. 2010
    ..Thus, the poor proliferative potential of memory T cells and altered memory CD8 T cell differentiation could underlie age-related defects in antiviral immunity...
  13. pmc Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses
    Marcio O Lasaro
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:205-12. 2008
    ..The immunopotentiating effect required binding of the gD chimeric protein to HVEM. Overall, the studies demonstrate that targeting of antigen to the BTLA binding site of HVEM augments the immunogenicity of vaccines...
  14. pmc Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 204:2015-21. 2007
    ..T-bet, thus, appears to function as a molecular switch between central- and effector-memory cell differentiation. Antagonism of T-bet may, therefore, represent a novel strategy to offset dysfunctional programming of memory CD8+ T cells...
  15. pmc MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection
    Adeeb H Rahman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia PA 19104, USA
    J Immunol 181:3804-10. 2008
    ....
  16. pmc Commensal bacteria calibrate the activation threshold of innate antiviral immunity
    Michael C Abt
    Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 37:158-70. 2012
    ..Collectively, these data indicate that commensal-derived signals provide tonic immune stimulation that establishes the activation threshold of the innate immune system required for optimal antiviral immunity...
  17. pmc The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling
    Donald T Gracias
    Department of Microbiology and Immunology, Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 14:593-602. 2013
    ..We have thus identified a previously unknown role for miR-155 in regulating responsiveness to interferon and CD8(+) T cell responses to pathogens in vivo...
  18. pmc IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells
    Steven A Saenz
    Department of Microbiology, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 210:1823-37. 2013
    ....
  19. pmc Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88
    Adeeb H Rahman
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 117:3123-30. 2011
    ..Our findings clarify the importance of MyD88 during distinct phases of the antiviral T-cell response and establish differential dependence on MyD88 signaling as a novel characteristic that distinguishes naive from memory CD8 T cells...
  20. pmc Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 40:289-302. 2014
    ..This study provides a framework for therapeutic interventions targeting exhausted CD4(+) T cells...
  21. pmc Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses
    Vesselin T Tomov
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 87:7015-31. 2013
    ....
  22. pmc Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity
    Brian J Laidlaw
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    PLoS Pathog 9:e1003207. 2013
    ....
  23. pmc Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans
    Douglas V Dolfi
    Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e77164. 2013
    ..g. NP and M) over a lifetime of exposure to infection and vaccination may influence vaccine-induced CD4 T cell responses in the aged. ..
  24. ncbi Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation
    Naofumi Takemoto
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 177:7515-9. 2006
    ....
  25. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...
  26. ncbi Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation
    Surojit Sarkar
    Department of Microbiology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 179:6704-14. 2007
    ..Thus, long-lasting, Ag-independent CD8 T cell memory results from progressive differentiation of memory CD8 T cells, and the rate of memory T cell differentiation is governed by events occurring early during T cell priming...
  27. pmc Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
    Matthew R Hepworth
    Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 498:113-7. 2013
    ..These data identify that ILCs maintain intestinal homeostasis through MHCII-dependent interactions with CD4(+) T cells that limit pathological adaptive immune cell responses to commensal bacteria...
  28. pmc Dynamic T cell migration program provides resident memory within intestinal epithelium
    David Masopust
    Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 207:553-64. 2010
    ..These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation...
  29. pmc Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
    Shawn D Blackburn
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:15016-21. 2008
    ..These results have implications for predicting clinical responses to PD-1-based therapeutic interventions and for understanding T cell dynamics during persisting infections...
  30. pmc Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines
    Nia Tatsis
    Wistar Institute, Philadelphia, PA 19104, USA
    Blood 110:1916-23. 2007
    ....
  31. pmc Differential localization of T-bet and Eomes in CD8 T cell memory populations
    Laura M McLane
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 190:3207-15. 2013
    ..Together, these findings suggest a novel model for CD8 T cell differentiation in humans that is based on the localization of T-bet and Eomes...
  32. pmc Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice
    Felipe Bedoya
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 190:6115-25. 2013
    ..These studies demonstrate that thymically generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet(+) Treg phenotypes while participating in and modulating an antiviral immune response...
  33. ncbi Not-so-great expectations: re-assessing the essence of T-cell memory
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Immunol Rev 211:203-13. 2006
    ..We suggest that the ability to maintain the integrity of the T-cell repertoire, more than establishing immunity to re-infection, may represent the fundamental form of memory for the adaptive immune system...
  34. pmc Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection
    Jill M Angelosanto
    Department of Microbiology and Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 86:8161-70. 2012
    ..These studies have implications for our understanding of senescence versus exhaustion and for therapeutic interventions during chronic infection...
  35. pmc Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors
    Vilma Decman
    Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 188:1933-41. 2012
    ..Thus, a decrease in precursor frequency as well as qualitative changes of CD8 T cells during aging are directly related to impaired immunity...
  36. pmc T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool
    Jennifer E Smith-Garvin
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA
    Blood 116:5548-59. 2010
    ..Furthermore, we show that TCR signals sufficient to promote CD8(+) T-cell differentiation are different from those required to elicit inflammatory cytokine production...
  37. pmc Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
    Kerry A Casey
    Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 188:4866-75. 2012
    ....
  38. pmc Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes
    Michael A Paley
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 93:307-15. 2013
    ..Thus, the murine Eomes(gfp)-targeted allele provides a novel opportunity to explore Eomes biology in cytotoxic lymphocytes...
  39. pmc Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
    Michael A Paley
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 338:1220-5. 2012
    ..Genetic elimination of either subset resulted in failure to control chronic infection, which suggests that an imbalance in differentiation and renewal could underlie the collapse of immunity in humans with chronic infections...
  40. ncbi Plasmacytoid dendritic cells are dispensable during primary influenza virus infection
    Amaya I Wolf
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 182:871-9. 2009
    ..Taken together, our study suggests that pDC regulate the accumulation of T cells in the bronchoalveolar space during early influenza virus infection, but are dispensable for the control of this disease...
  41. pmc Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    Laurel A Monticelli
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:1045-54. 2011
    ..Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus...
  42. pmc Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
    Haina Shin
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Exp Med 204:941-9. 2007
    ..These results indicate that antigen-specific CD8 T cell responses during persisting infection are maintained by a mechanism distinct from that after acute infection...
  43. pmc The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses
    Alison Crawford
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Curr Opin Immunol 21:179-86. 2009
    ..These distinct inhibitory pathways appear to cooperate in regulating T cell function, could have distinct mechanisms of action, and are likely to provide novel therapeutic targets during persisting infections and other diseases...
  44. doi The contribution of epigenetic memory to immunologic memory
    Valerie P Zediak
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Curr Opin Genet Dev 21:154-9. 2011
    ..This gives strength to the concept of gene poising, and has shown that memory T lymphocytes are an ideal model in which to further define various mechanisms of epigenetic poising...
  45. pmc Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
    George Makedonas
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000798. 2010
    ....
  46. doi Transcription factor regulation of CD8+ T-cell memory and exhaustion
    Jill M Angelosanto
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunol Rev 236:167-75. 2010
    ..We also discuss recent innovations in genomic and computational tools that could be used to enhance the way we understand the development of T-cell responses to infectious disease...
  47. pmc Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    Nobuhiro Nakamoto
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:1927-37, 1937.e1-2. 2008
    ..As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell dysfunction in the liver and blood of HCV-infected patients...
  48. pmc Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
    Douglas V Dolfi
    Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Leukoc Biol 93:825-36. 2013
    ..Thus, our data suggest a prominent role for senescence and/or terminal differentiation for influenza virus-specific CD8 T cells in elderly subjects...
  49. pmc Enhanced T cell function in a mouse model of human glycosylation
    George Buchlis
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 191:228-37. 2013
    ..These findings in a human-like mouse model have implications for understanding the hyperimmune responses that characterize some human diseases...
  50. pmc Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status
    Valerie P Zediak
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 186:2705-9. 2011
    ..We propose that these chromatin changes poise effector genes for rapid upregulation, but are insufficient for PolII recruitment and transcription...
  51. pmc The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells
    Makoto Kurachi
    1 Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA 2 Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA 3
    Nat Immunol 15:373-83. 2014
    ..This checkpoint prevents irreversible commitment to an effector fate until a critical threshold of downstream transcriptional activity has been achieved. ..
  52. pmc Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis
    William R Lagor
    Division of Translational Medicine and Human Genetics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Atherosclerosis 233:234-41. 2014
    ..These studies implicate STAT2 as a potentially important player in atherosclerosis, and support the growing evidence that the Type I IFN pathway may contribute to this complex disease. ..
  53. pmc Chronic bystander infections and immunity to unrelated antigens
    Erietta Stelekati
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 12:458-69. 2012
    ..Further understanding of the immunological effects of coinfection should provide opportunities to enhance vaccine efficacy and control of infectious diseases...
  54. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency...
  55. pmc Inhibitory receptors on lymphocytes: insights from infections
    Pamela M Odorizzi
    Department of Microbiology, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 188:2957-65. 2012
    ..We discuss our current understanding of the molecular mechanisms for key inhibitory receptor pathways, highlight major gaps in knowledge, and explore current and future clinical applications...
  56. pmc K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation
    Tao Wang
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    J Leukoc Biol 91:449-59. 2012
    ..These results indicate that SECTM1 is a broadly expressed, IFN-γ-inducible molecule, which functions as a potent costimulatory ligand for T cell activation and is synergistic with anti-CD28...
  57. doi Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppression
    Sara Samimi
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arch Dermatol 146:1382-8. 2010
    ....
  58. pmc TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
    Mark C Siracusa
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 477:229-33. 2011
    ....
  59. ncbi IL-10, T cell exhaustion and viral persistence
    Shawn D Blackburn
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Trends Microbiol 15:143-6. 2007
    ..These insights into the role of IL-10 in the establishment of chronic infection could lead to new therapeutic opportunities during human infections with pathogens such as HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV)...
  60. ncbi Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope
    E John Wherry
    Department of Microbiology and Immunology, Jefferson Medical College and Kimmel Cancer Institute, Thomas Jefferson University, Bluemle Life Sciences Building, Philadelphia, PA 19107, USA
    J Immunol 176:2249-61. 2006
    ....
  61. pmc Differential induction of TLR3-dependent innate immune signaling by closely related parasite species
    Daniel P Beiting
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e88398. 2014
    ..gondii actively suppresses the production of type I interferon. These findings reveal that eukaryotic pathogens can be potent inducers of type I interferon and that related parasite species interact with this pathway in distinct ways. ..
  62. pmc AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells
    Lauren E Mays
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Ther 22:28-41. 2014
    ....
  63. ncbi A brief history of CD8 T cells
    David Masopust
    Department of Microbiology, University of Minnesota, Minneapolis, MN, USA
    Eur J Immunol 37:S103-10. 2007
    ..Herein, we recount the historical developments leading to the discovery of CD8 T cells, highlight a few of the important discoveries that have followed, and discuss some of the critical issues on the horizon...
  64. pmc Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 30:300-11. 2009
    ....

Research Grants1

  1. Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
    E John Wherry; Fiscal Year: 2010
    ..Our studies may provide important information for the design of prophylactic vaccines and also may uncover opportunities to develop novel therapeutic interventions for chronic diseases. ..