Jay Whelan

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. doi request reprint The health implications of changing linoleic acid intakes
    Jay Whelan
    Department of Nutrition, University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996 1920, USA
    Prostaglandins Leukot Essent Fatty Acids 79:165-7. 2008
  2. doi request reprint Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
    E Chu Huang
    Department of Nutrition, University of Tennessee, 1215 West Cumberland Avenue, Room 229 Jessie Harris Building, Knoxville, TN 37996, USA
    BMC Complement Altern Med 14:68. 2014
  3. doi request reprint Effects of dietary stearidonic acid on biomarkers of lipid metabolism
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN, USA
    J Nutr 142:630S-634S. 2012
  4. pmc Allometric scaling of dietary linoleic acid on changes in tissue arachidonic acid using human equivalent diets in mice
    Kylie A Weldon
    Department of Nutrition, 1215 West Cumberland Avenue, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996 1920, USA
    Nutr Metab (Lond) 8:43. 2011
  5. pmc Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review
    Brian S Rett
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 1900, USA
    Nutr Metab (Lond) 8:36. 2011
  6. doi request reprint Docosahexaenoic acid: measurements in food and dietary exposure
    Jay Whelan
    Department of Nutrition, The University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996 1920, USA
    Prostaglandins Leukot Essent Fatty Acids 81:133-6. 2009
  7. doi request reprint Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1920, USA
    J Nutr 139:5-10. 2009
  8. doi request reprint (n-6) and (n-3) Polyunsaturated fatty acids and the aging brain: food for thought
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1920, USA
    J Nutr 138:2521-2. 2008
  9. ncbi request reprint Innovative dietary sources of n-3 fatty acids
    Jay Whelan
    Department of Nutrition, The University of Tennessee, Knoxville, Tennessee 37996 1920, USA
    Annu Rev Nutr 26:75-103. 2006
  10. ncbi request reprint Dietary (n-6) PUFA and intestinal tumorigenesis
    Jay Whelan
    Department of Nutrition and the Tennessee Agricultural Experiment Station, University of Tennessee, Knoxville, USA
    J Nutr 134:3421S-3426S. 2004

Collaborators

Detail Information

Publications20

  1. doi request reprint The health implications of changing linoleic acid intakes
    Jay Whelan
    Department of Nutrition, University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996 1920, USA
    Prostaglandins Leukot Essent Fatty Acids 79:165-7. 2008
    ..The authors addressed changes in tissue arachidonic acid content and eicosanoid formation, cardiovascular disease, inflammation, and psychiatric disorders...
  2. doi request reprint Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
    E Chu Huang
    Department of Nutrition, University of Tennessee, 1215 West Cumberland Avenue, Room 229 Jessie Harris Building, Knoxville, TN 37996, USA
    BMC Complement Altern Med 14:68. 2014
    ..The current experiments were designed to investigate the effects of Zyflamend on the expression of class I and II histone deacetylases, a family of enzymes known to be over expressed in a variety of cancers...
  3. doi request reprint Effects of dietary stearidonic acid on biomarkers of lipid metabolism
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN, USA
    J Nutr 142:630S-634S. 2012
    ..Although many lipolytic and lipogenic genes remained unchanged, several lipogenic genes were downregulated and a number of other biomarkers considered atheroprotective, such as C-reactive protein and paraoxonase, were favorably modified...
  4. pmc Allometric scaling of dietary linoleic acid on changes in tissue arachidonic acid using human equivalent diets in mice
    Kylie A Weldon
    Department of Nutrition, 1215 West Cumberland Avenue, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996 1920, USA
    Nutr Metab (Lond) 8:43. 2011
    ..abstract:..
  5. pmc Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review
    Brian S Rett
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 1900, USA
    Nutr Metab (Lond) 8:36. 2011
    ..abstract:..
  6. doi request reprint Docosahexaenoic acid: measurements in food and dietary exposure
    Jay Whelan
    Department of Nutrition, The University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996 1920, USA
    Prostaglandins Leukot Essent Fatty Acids 81:133-6. 2009
    ..This value and those presented for women and men at various ages appear reasonable and should be used as the basis for establishing an Adequate Intake (AI) for DHA...
  7. doi request reprint Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1920, USA
    J Nutr 139:5-10. 2009
    ..Therefore, although SDA may not replace fish as a major dietary source of (n-3) LCPUFA, it could become a prominent surrogate for EPA in the commercial development of foods fortified with (n-3) PUFA...
  8. doi request reprint (n-6) and (n-3) Polyunsaturated fatty acids and the aging brain: food for thought
    Jay Whelan
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1920, USA
    J Nutr 138:2521-2. 2008
    ....
  9. ncbi request reprint Innovative dietary sources of n-3 fatty acids
    Jay Whelan
    Department of Nutrition, The University of Tennessee, Knoxville, Tennessee 37996 1920, USA
    Annu Rev Nutr 26:75-103. 2006
    ..All of this is possible because of newer technologies (microencapsulation) and improved processing techniques that ensure stability and preserve the integrity of these unstable fatty acids...
  10. ncbi request reprint Dietary (n-6) PUFA and intestinal tumorigenesis
    Jay Whelan
    Department of Nutrition and the Tennessee Agricultural Experiment Station, University of Tennessee, Knoxville, USA
    J Nutr 134:3421S-3426S. 2004
    ..It is the relative contributions of the different dietary PUFA that may determine overall risk for and progression of the disease...
  11. ncbi request reprint Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect
    Jay Whelan
    Department of Nutrition, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996 1900, USA
    Adv Exp Med Biol 507:579-84. 2002
  12. ncbi request reprint Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice
    Carol C Ziegler
    Department of Nutrition, University of Tennessee, Knoxville, TN, USA
    J Nutr 134:5-10. 2004
    ..However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in Apc(Min/+) mice...
  13. doi request reprint Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer
    E Chu Huang
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 1920, USA
    Nutr Cancer 63:1287-96. 2011
    ..In conclusion, Zyflamend decreased cell proliferation and inhibited IGF-1R and androgen receptor expression in a phosphatidylinositol 3-kinase/pAKT independent manner...
  14. doi request reprint Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer
    E Chu Huang
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 192, USA
    Nutr Cancer 64:749-60. 2012
    ....
  15. pmc Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer
    Michael F McEntee
    Department of Pathobiology, University of Tennessee, 2407 River Dr, Rm A201, Knoxville, TN 37996 4542, USA
    Am J Pathol 173:229-41. 2008
    ..In conclusion, dietary n-3 PUFA may enhance the response of prostate cancer to ablation therapy and retard progression to androgen-independent growth by altering tumor PUFA content...
  16. ncbi request reprint Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice
    Melissa B Hansen-Petrik
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer Res 62:403-8. 2002
    ..Overall, our results suggest that NSAIDs exert their antitumorigenic effects, in part, via interference with PGE(2) biosynthesis, and these effects may be mediated through changes in intracellular calcium levels...
  17. doi request reprint Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes
    Jaanki S Purohit
    a Department of Nutrition, University of Tennessee, 1215 W Cumberland Ave, Knoxville, TN, USA
    Biochem Cell Biol 91:428-34. 2013
    ..Taken together, our results demonstrate a novel role of NOD1 activation, via NF-κB/PKA lipolytic activation, in inducing lipolysis in adipocytes and suggest that NOD1 activation may contribute to dyslipidemia in obesity. ..
  18. pmc n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes
    Patrick Wortman
    University of Tennessee UT, Department of Animal Science, Knoxville, TN, USA
    Nutr Metab (Lond) 6:5. 2009
    ..COX-2 inhibition significantly decreased PGE2 production resulting in a decrease in FAS activity and expression that was not reversed with the addition of exogenous PGE2, suggesting an additional mechanism that is independent of COX-2...
  19. ncbi request reprint Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism
    Suyeon Kim
    Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, TN 37996, USA
    J Nutr 132:1135-40. 2002
    ..In conclusion, although Ang II stimulates both leptin and PG secretion by adipocytes, regulation of leptin secretion by Ang II in adipocytes is not mediated by a PG-dependent mechanism...
  20. ncbi request reprint Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis
    Melissa B Hansen-Petrik
    Department of Nutrition, University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996 1900, USA
    Cancer Lett 175:157-63. 2002
    ....