Research Topics
Species | Deric L WheelerSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
The role of Src in solid tumorsDeric L Wheeler
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Oncologist 14:667-78. 2009..This review discusses the role of SFKs in solid tumors and the recent therapeutic advances aimed at targeting this family of tyrosine kinases in cancer...- Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximabDeric L Wheeler
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Cancer Biol Ther 8:696-703. 2009.... - Understanding resistance to EGFR inhibitors-impact on future treatment strategiesDeric L Wheeler
Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53705, USA
Nat Rev Clin Oncol 7:493-507. 2010..A greater understanding of the mechanisms that lead to EGFR resistance may provide valuable insights to help design new strategies that will enhance the impact of this promising class of inhibitors for the treatment of cancer... - Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cellsSergio Benavente
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 0600, USA
Clin Cancer Res 15:1585-92. 2009..Many tumors, however, eventually manifest resistance to treatment. Efforts to better understand the underlying mechanisms of acquired resistance to EGFR inhibitors, and potential strategies to overcome resistance, are greatly needed... - Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyondPaul M Harari
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Semin Radiat Oncol 19:63-8. 2009.... - Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancerTim J Kruser
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Int J Radiat Oncol Biol Phys 72:534-42. 2008..To examine the interaction between panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, and radiation in head-and-neck squamous cell carcinoma and non-small-cell lung cancer cell lines and xenografts... - Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptorsTim J Kruser
Department of Human Oncology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Clin Cancer Res 16:3639-47. 2010..In this report we examine the interaction between motesanib and radiation in vitro and in head and neck squamous cell carcinoma (HNSCC) xenograft models... - Erlotinib is a viable treatment for tumors with acquired resistance to cetuximabToni M Brand
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI USA
Cancer Biol Ther 12:436-46. 2011.... - Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinomaChunrong Li
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Radiother Oncol 97:330-7. 2010..In this report we sought to determine how to block cetuximab- and radiation-induced translocation of EGFR to the nucleus in HNSCC cell lines... - p53 modulates acquired resistance to EGFR inhibitors and radiationShyhmin Huang
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
Cancer Res 71:7071-9. 2011.... 
Mechanisms of resistance to HER family targeting antibodiesTim J Kruser
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Exp Cell Res 316:1083-100. 2010..In this review, we discuss resistance to antibody-based therapies against the EGFR and HER2, similarities between these resistance profiles, and strategies to overcome resistance to HER family targeting monoclonal antibody therapy...- The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patientsTim J Kruser
University of Wisconsin Comprehensive Cancer Center, Department of Human Oncology, Madison, Wisconsin, WI 53705, USA
Expert Opin Investig Drugs 20:305-7. 2011..Future studies of dasatinib in NSCLC should examine the agent in combination with EGFR inhibitors and/or cytotoxic chemotherapies... - Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibitionPaul A Clark
Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
Neoplasia 14:420-8. 2012.... - The nuclear epidermal growth factor receptor signaling network and its role in cancerToni M Brand
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, WIMR 3159, Madison, Wisconsin 53705, USA
Discov Med 12:419-32. 2011.... - Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximabToni M Brand
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Cancer Biol Ther 11:777-92. 2011..Further, we provide an in depth discussion of described molecular mechanisms of resistance to cetuximab and potential strategies to circumvent this resistance... - KRAS mutant colorectal tumors: past and presentToni M Brand
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI USA
Small Gtpases 3:34-9. 2012.... 
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic miceYafan Li
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA
Toxicol Pathol 33:684-94. 2005..Prolonged hyperplasia in the hair follicle may result in the early neoplastic lesions originally described by Jansen et al. (2001) by expanding initiated cells in the hair follicles resulting in the subsequent development of SCC...- Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like diseaseDeric L Wheeler
Department of Human Oncology, Medical School, University of Wisconsin, K4 532 CSC Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
Am J Pathol 166:117-26. 2005..The susceptibility of PKC-epsilon transgenic mice to the induction of SCC and the spontaneous development of MPD are unrelated... - Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2Moammir H Aziz
Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
Cancer Res 66:713-22. 2006.... - Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomasDeric L Wheeler
Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53792, USA
Cancer Res 64:7756-65. 2004..Taken together, the results indicate that PKCepsilon signals UVR-induced TNFalpha release that is linked, at least in part, to the photosensitivity of PKCepsilon transgenic mice... - Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic miceDeric L Wheeler
Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
Cancer Res 63:6547-55. 2003.... - Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancerAjit K Verma
Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53792, USA
Mol Carcinog 45:381-8. 2006..It appears that PKCepsilon sensitizes skin to the development of SCC by UVR by transducting signals, which inhibit apoptosis on one hand, and enhances proliferation of preneoplastic cells on the other hand... - Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair lossDeric L Wheeler
Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53762, USA
Cancer Res 63:3037-42. 2003..Severe hair loss observed in PKC epsilon transgenic mice on DFMO during skin tumor promotion has not been reported before in the prevention of cancer in other animal models or in human cancer prevention trials...