KEITH WHARTON

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling
    K A Wharton
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, B300, Stanford School of Medicine, 279 Campus Drive, Stanford, California 94305, USA
    Dev Biol 234:93-106. 2001
  2. ncbi Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    Keith A Wharton
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 9072, USA
    Dev Biol 253:1-17. 2003
  3. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
  4. ncbi naked cuticle encodes an inducible antagonist of Wnt signalling
    W Zeng
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, California 94305, USA
    Nature 403:789-95. 2000
  5. pmc Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd)
    Chih Chiang Chan
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Dev Biol 311:538-53. 2007
  6. pmc Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2
    Shu Zhang
    Laboratory of Molecular Pathology, Department of Pathology, Dallas, TX 75390 9072, USA
    Mol Cell Biol 27:4454-64. 2007
  7. pmc Regulation of wingless signaling by the CKI family in Drosophila limb development
    Lei Zhang
    Center for Developmental Biology, Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Biol 299:221-37. 2006
  8. pmc An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle
    Sharon Waldrop
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Genetics 174:331-48. 2006
  9. ncbi Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle
    Raphaël Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 277:49019-26. 2002
  10. pmc Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling
    Chih Chiang Chan
    Laboratory of Molecular Pathology, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Dev Biol 318:17-28. 2008

Research Grants

  1. Feedback Regulation of Wnt signaling
    KEITH WHARTON; Fiscal Year: 2007

Collaborators

  • Jin Jiang
  • J A Mack
  • R Nusse
  • K Wang
  • Jeffrey D Axelrod
  • L Zhang
  • Chih Chiang Chan
  • Shu Zhang
  • Raphaël Rousset
  • Tolga Cagatay
  • Manami Amanai
  • Mei Zhang
  • Sharon Waldrop
  • R Rousset
  • M P Scott
  • W Zeng
  • Janine Kline
  • Raheela Ashfaq
  • Orhan K Oz
  • Diego H Castrillon
  • Wenlin Zeng
  • Matt Fish
  • Gregor Zimmermann
  • Matthew P Scott
  • K M Cadigan
  • M P Fish
  • M Gadbaw
  • K Suyama
  • P S Klein

Detail Information

Publications10

  1. ncbi Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling
    K A Wharton
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, B300, Stanford School of Medicine, 279 Campus Drive, Stanford, California 94305, USA
    Dev Biol 234:93-106. 2001
    ..Misexpression of mouse nkd1 in Drosophila antagonizes Wg function. The data suggest that the vertebrate Nkd-related proteins, similar to their fly counterpart, may act as inducible antagonists of Wnt signals...
  2. ncbi Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    Keith A Wharton
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 9072, USA
    Dev Biol 253:1-17. 2003
    ..The biochemical and cell biological mechanisms by which Dsh/Dvl proteins accomplish these remarkable tasks remain obscure...
  3. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes...
  4. ncbi naked cuticle encodes an inducible antagonist of Wnt signalling
    W Zeng
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, California 94305, USA
    Nature 403:789-95. 2000
    ..Nkd may therefore link ion fluxes to the regulation of the potency, duration or distribution of Wnt signals. Signal-inducible feedback antagonists such as nkd may limit the effects of Wnt proteins in development and disease...
  5. pmc Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd)
    Chih Chiang Chan
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Dev Biol 311:538-53. 2007
    ..In conjunction with our recent observation that Nkd requires nuclear localization for function, our data suggest that Nkd acts at more than one subcellular location within signal-receiving cells to attenuate Wg signaling...
  6. pmc Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2
    Shu Zhang
    Laboratory of Molecular Pathology, Department of Pathology, Dallas, TX 75390 9072, USA
    Mol Cell Biol 27:4454-64. 2007
    ..Our data show that nkd function in the mouse is dispensable for embryonic development...
  7. pmc Regulation of wingless signaling by the CKI family in Drosophila limb development
    Lei Zhang
    Center for Developmental Biology, Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Biol 299:221-37. 2006
    ..Finally, we provide evidence that several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway...
  8. pmc An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle
    Sharon Waldrop
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Genetics 174:331-48. 2006
    ..Our studies suggest that Nkd targets Dsh-dependent signal transduction steps in both cytoplasmic and nuclear compartments of cells receiving the Wnt signal...
  9. ncbi Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle
    Raphaël Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 277:49019-26. 2002
    ..The results further clarify how Nkd may antagonize Wnt signaling via interaction with Dsh, and identify a novel zinc-binding domain in Drosophila Nkd that collaborates with the conserved EFX domain to bind Dsh...
  10. pmc Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling
    Chih Chiang Chan
    Laboratory of Molecular Pathology, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Dev Biol 318:17-28. 2008
    ..Our results provide further support for the hypothesis that Nkd inhibits nuclear step(s) in Wnt/beta-catenin signaling and broaden our understanding of signaling pathways that engage the nuclear import machinery...

Research Grants5

  1. Feedback Regulation of Wnt signaling
    KEITH WHARTON; Fiscal Year: 2007
    ..The potential health relevance of this project to developmental biology, stem cell biology, and disease-related research is substantial considering the wide employment of Wnt signaling throughout metazoan biology. ..