YOUNG WHANG

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
    Y Liu
    UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Oncogene 29:3208-16. 2010
  2. doi request reprint A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer
    Young E Whang
    Division of Hematology Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Urol Oncol 31:82-6. 2013
  3. doi request reprint A multidisciplinary approach to the management of urologic malignancies: does it influence diagnostic and treatment decisions?
    Raj Kurpad
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Urol Oncol 29:378-82. 2011
  4. ncbi request reprint Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:28258-63. 2003
  5. ncbi request reprint p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
    Weidong Wu
    Division of Immunology and Infectious Disease, Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 289:L883-9. 2005
  6. ncbi request reprint Estrogen-receptor-dependent regulation of telomerase activity in human endometrial cancer cell lines
    John F Boggess
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Gynecol Oncol 103:417-24. 2006
  7. doi request reprint A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: clinical and pathological results
    Raj S Pruthi
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BJU Int 106:349-54. 2010
  8. ncbi request reprint The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels
    Chunxiao Zhou
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA
    Gynecol Oncol 101:305-10. 2006
  9. pmc Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Departments of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:8438-43. 2007
  10. ncbi request reprint Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Department of Medicine and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Cancer Res 65:10514-23. 2005

Collaborators

Detail Information

Publications20

  1. pmc Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
    Y Liu
    UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Oncogene 29:3208-16. 2010
    ..These data suggest that specific tyrosine kinases phosphorylate AR at distinct sites and that dasatinib may exert antitumor activity in prostate cancer through inhibition of Ack1...
  2. doi request reprint A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer
    Young E Whang
    Division of Hematology Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Urol Oncol 31:82-6. 2013
    ..Lapatinib is an oral inhibitor of EGFR and HER-2. The objective of this study is to assess the preliminary clinical efficacy of lapatinib in the therapy of castration-resistant prostate cancer...
  3. doi request reprint A multidisciplinary approach to the management of urologic malignancies: does it influence diagnostic and treatment decisions?
    Raj Kurpad
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Urol Oncol 29:378-82. 2011
    ..We prospectively studied the effect of such a multidisciplinary approach on the diagnosis and treatment decisions of patients newly presenting with urologic malignancies...
  4. ncbi request reprint Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:28258-63. 2003
    ..In summary, exposure to Zn2+ ions causes PTEN degradation and loss of function, which is mediated by an ubiquitin-associated proteolytic process in the airway epithelium...
  5. ncbi request reprint p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
    Weidong Wu
    Division of Immunology and Infectious Disease, Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 289:L883-9. 2005
    ..These data suggest that p38 and EGFR kinase-mediated Akt activation is required for Zn2+-induced COX-2 expression and that the PI3K/Akt signaling pathway plays a central role in this event...
  6. ncbi request reprint Estrogen-receptor-dependent regulation of telomerase activity in human endometrial cancer cell lines
    John F Boggess
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Gynecol Oncol 103:417-24. 2006
    ....
  7. doi request reprint A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: clinical and pathological results
    Raj S Pruthi
    Division of Urologic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BJU Int 106:349-54. 2010
    ....
  8. ncbi request reprint The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels
    Chunxiao Zhou
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA
    Gynecol Oncol 101:305-10. 2006
    ..Given that PTEN is often absent and telomerase is overexpressed by endometrial cancers, we hypothesize that PTEN signaling is important in telomerase regulation...
  9. pmc Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Departments of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:8438-43. 2007
    ..Targeting the Ack1 kinase may be a potential therapeutic strategy in prostate cancer...
  10. ncbi request reprint Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Department of Medicine and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Cancer Res 65:10514-23. 2005
    ..Further, these findings suggest that Ack1 could be a novel therapeutic target for prostate cancer...
  11. ncbi request reprint Rapamycin inhibits hTERT telomerase mRNA expression, independent of cell cycle arrest
    Victoria L Bae-Jump
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA
    Gynecol Oncol 100:487-94. 2006
    ..Our goal was to examine the ability of rapamycin to suppress growth and regulate telomerase activity in cervical and ovarian cancer cell lines...
  12. ncbi request reprint PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway
    Xiu juan Yuan
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, NC 27599 7295, USA
    Oncogene 21:319-27. 2002
    ..Taken together, these data are consistent with the hypothesis that PTEN promotes drug-induced apoptosis by facilitating caspase-8 activation and BID cleavage through a FADD-dependent pathway...
  13. ncbi request reprint Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells
    Chunxiao Zhou
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Cancer Ther 2:789-95. 2003
    ..This work suggests that rapamycin is a potentially useful targeted therapy for endometrial cancer and that loss of telomerase activity may be a good surrogate biomarker for assessing antitumor activity of rapamycin...
  14. ncbi request reprint Regulation of sensitivity to TRAIL by the PTEN tumor suppressor
    Young E Whang
    Lineberger Comprehensive Cancer Center, Department of Medicine and Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7295, USA
    Vitam Horm 67:409-26. 2004
    ..Because PTEN loss is common in tumors, strategies to inactivate Akt may be necessary to overcome TRAIL resistance and make TRAIL-based therapy more effective...
  15. ncbi request reprint Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer
    Yuanbo Liu
    Lineberger Comprehensive Cancer Center, Department of Radiation Oncology, University of North Carolina, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Cancer Res 65:3404-9. 2005
    ..These results show that HER-2 signaling is required for optimal transcriptional activity of AR in prostate cancer cells and suggest that HER-2 inhibition may provide a novel strategy to disrupt AR function in prostate cancer...
  16. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
    ..Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB...
  17. ncbi request reprint The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells
    Chin Hui Hsiang
    Department of Urology, University of California, Irvine, California, USA
    Prostate 66:1413-24. 2006
    ..Although reduced expression levels of annexin I (ANX I) protein is a common finding in all stages of prostate cancer a causative relationship between ANX I dysregulation and prostate cancer development has yet to be established...
  18. ncbi request reprint Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability
    Samarpan Majumder
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Prostate 66:1292-301. 2006
    ..Androgen receptor (AR) may play a role in prostate cancer progression. Coactivator-associated arginine methyltransferase (CARM1) catalyzes methylation of histone H3 at Arg-17...
  19. ncbi request reprint Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth
    Christopher W Gregory
    Department of Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Clin Cancer Res 11:1704-12. 2005
    ..In these "androgen-independent" tumors, alternative means of AR activation have been invoked, including regulation by growth factors and their receptors in prostate cancer recurrence...
  20. ncbi request reprint Human epidermal receptor-2 expression in prostate cancer
    Benjamin F Calvo
    Department of Surgery, Divisions of Surgical Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 9:1087-97. 2003
    ..To clarify human tumor findings, we studied HER-2 expression at the gene (DNA), mRNA, and protein levels in well-characterized CaP specimens...

Research Grants6

  1. Targeted Therapy of Prostate Cancer
    YOUNG WHANG; Fiscal Year: 2004
    ..Successful completion of this project will validate the concept that inhibition of the EGFR family kinase signaling pathway is a rational strategy that can be rapidly translated into clinical trials in prostate cancer patients. ..
  2. FUNCTIONAL ANALYSIS OF PTEN IN PROSTATE CANCER
    YOUNG WHANG; Fiscal Year: 2005
    ....
  3. Regulation of androgen receptor by HER-2 and Ack1 tyrosine kinases
    Young E Whang; Fiscal Year: 2010
    ....
  4. Regulation of androgen receptor by HER-2 and Ack1 tyrosine kinases
    YOUNG WHANG; Fiscal Year: 2009
    ....