Adam Whaley-Connell

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint The importance of early identification of chronic kidney disease
    Adam Whaley-Connell
    Department of Internal Medicine, Division of Nephrology, University of Missouri School of Medicine, USA
    Mo Med 108:25-8. 2011
  2. pmc Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)
    Subhasish Bose
    Department of Nephrology, Temple University Hospital, Philadelphia, PA, USA
    BMC Nephrol 13:104. 2012
  3. pmc Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
    Adam Whaley-Connell
    Research Service, Harry S Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, USA
    Metabolism 62:861-72. 2013
  4. pmc Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Harry S Truman VA Medical Center, University of Missouri Columbia School of Medicine, Columbia, MO 65211, USA
    Regul Pept 176:36-44. 2012
  5. pmc Awareness of kidney disease and relationship to end-stage renal disease and mortality
    Adam Whaley-Connell
    Division of Nephrology and Hypertension, Harry S Truman VA Medical Center, Columbia, Missouri, USA
    Am J Med 125:661-9. 2012
  6. pmc Oxidative stress in the cardiorenal metabolic syndrome
    Adam Whaley-Connell
    Diabetes and Cardiovascular Center, Harry S Truman VA Medical Center and the University of Missouri Columbia School of Medicine, Columbia, MO 65213, USA
    Curr Hypertens Rep 14:360-5. 2012
  7. pmc Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway
    Adam T Whaley-Connell
    Harry S Truman VA Medical Center, Columbia, MO, USA
    Am J Nephrol 35:90-100. 2012
  8. pmc Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Department of Internal Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Hypertension 51:474-80. 2008
  9. doi request reprint Dysglycemia predicts cardiovascular and kidney disease in the Kidney Early Evaluation Program
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    J Clin Hypertens (Greenwich) 12:51-8. 2010
  10. ncbi request reprint Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Am J Nephrol 28:67-75. 2008

Detail Information

Publications77

  1. ncbi request reprint The importance of early identification of chronic kidney disease
    Adam Whaley-Connell
    Department of Internal Medicine, Division of Nephrology, University of Missouri School of Medicine, USA
    Mo Med 108:25-8. 2011
    ..Herein, we will review screening and detection strategies for CKD as well as the importance of intervention in early stages to reduce progression and the burden of CKD...
  2. pmc Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)
    Subhasish Bose
    Department of Nephrology, Temple University Hospital, Philadelphia, PA, USA
    BMC Nephrol 13:104. 2012
    ..We sought to investigate the association of dyslipidemia and glycemic control with levels of albuminuria in the National Kidney Foundation (NKF) Kidney Early Evaluation Program (KEEP) participants with DM and CKD stage 3 or higher...
  3. pmc Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
    Adam Whaley-Connell
    Research Service, Harry S Truman Memorial Veterans Hospital, 800 Hospital Drive, Columbia, MO 65201, USA
    Metabolism 62:861-72. 2013
    ....
  4. pmc Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Harry S Truman VA Medical Center, University of Missouri Columbia School of Medicine, Columbia, MO 65211, USA
    Regul Pept 176:36-44. 2012
    ..Further, combination therapy did not improve markers of oxidative stress and podocyte and proximal tubule integrity in this transgenic model of RAAS-mediated kidney damage despite greater reductions in serum aldosterone and BP levels...
  5. pmc Awareness of kidney disease and relationship to end-stage renal disease and mortality
    Adam Whaley-Connell
    Division of Nephrology and Hypertension, Harry S Truman VA Medical Center, Columbia, Missouri, USA
    Am J Med 125:661-9. 2012
    ..Often, patients with chronic kidney disease are reported to be unaware of it. We prospectively evaluated the association between awareness of kidney disease to end-stage renal disease and mortality...
  6. pmc Oxidative stress in the cardiorenal metabolic syndrome
    Adam Whaley-Connell
    Diabetes and Cardiovascular Center, Harry S Truman VA Medical Center and the University of Missouri Columbia School of Medicine, Columbia, MO 65213, USA
    Curr Hypertens Rep 14:360-5. 2012
    ....
  7. pmc Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway
    Adam T Whaley-Connell
    Harry S Truman VA Medical Center, Columbia, MO, USA
    Am J Nephrol 35:90-100. 2012
    ..Recent data indicate aldosterone signaling through the mineralocorticoid receptor (MR) can activate the mTOR pathway. Further, antagonism of the MR has beneficial effects on proteinuria that occur independent of hemodynamics...
  8. pmc Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Department of Internal Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Hypertension 51:474-80. 2008
    ....
  9. doi request reprint Dysglycemia predicts cardiovascular and kidney disease in the Kidney Early Evaluation Program
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    J Clin Hypertens (Greenwich) 12:51-8. 2010
    ..However, prevalent CVD increased at >140 mg/dL and prevalent CKD at >180 mg/dL. Therefore, data support that increasing metabolic components and dysglycemia are strongly associated with an increased prevalence of CKD and CVD...
  10. ncbi request reprint Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Am J Nephrol 28:67-75. 2008
    ..The glomerular filtration barrier is emerging as a critical determinant of albumin filtration. We investigated the effects of insulin resistance and rosuvastatin or placebo on the glomerular filtration barrier...
  11. doi request reprint CKD in the United States: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Adam T Whaley-Connell
    University of Missouri Columbia School of Medicine and the Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Am J Kidney Dis 51:S13-20. 2008
    ..CKD is silent and undetected until advanced stages. The study of populations with earlier stages of kidney disease may improve outcomes of CKD...
  12. doi request reprint Diabetes mellitus in CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition and Examination Survey (NHANES) 1999-2004
    Adam T Whaley-Connell
    University of Missouri Columbia School of Medicine and Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Am J Kidney Dis 51:S21-9. 2008
    ..Early diabetes identification through targeted screening programs is important for the development of preventive strategies...
  13. pmc Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat
    Adam Whaley-Connell
    The University of Missouri School of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension CE417, DC043 0, Five, Hospital Dr, Columbia, MO 65212, USA
    Am J Nephrol 30:354-60. 2009
    ..Thereby, we hypothesized that in vivo nebivolol therapy in a rodent model of activated RAAS would attenuate glomerular damage and proteinuria through its actions to reduce NADPH oxidase activity/ROS and increase bioavailable NO...
  14. doi request reprint Diabetes mellitus and CKD awareness: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES)
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine and Harry S Truman VA Medical Center, Columbia, MO 65212, USA
    Am J Kidney Dis 53:S11-21. 2009
    ..We sought to describe CKD awareness and identify factors associated with optimal glycemic control in diabetic and nondiabetic individuals both aware and unaware of CKD...
  15. pmc Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat
    Adam Whaley-Connell
    Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 296:F1013-22. 2009
    ..Thus, in this model of RAAS activation, MR antagonism attenuates glomerular/podocyte remodeling and albuminuria, in part through reductions in redox-mediated impairment of insulin metabolic signaling...
  16. doi request reprint Renin-angiotensin-aldosterone system intervention in the cardiometabolic syndrome and cardio-renal protection
    Adam Whaley-Connell
    Division of Nephrology, Department of Internal Medicine, University of Missouri Health Sciences Center, One Hospital Dr, MA436, DC 043 0, Columbia, MO 65212, USA
    Ther Adv Cardiovasc Dis 1:27-35. 2007
    ..g. ACE inhibitors and Angiotensin type 1 receptor blockers) have been shown to reduce proteinuria, CKD progression, and CVD events. Herein, we will examine the relationship between RAAS intervention and reductions in CKD and CVD events...
  17. ncbi request reprint Relapsing peritonitis in continuous ambulatory peritoneal dialysis and an unconventional approach to treatment
    Adam Whaley-Connell
    Division of Nephrology, University of Missouri Columbia Health Sciences Center, Columbia, Missouri 65212, USA
    Adv Perit Dial 20:71-3. 2004
    ..Removal of the peritoneal dialysis (PD) catheter frequently is curative. We describe here a case in which partial removal of a presternal catheter resulted in resolution of relapsing peritonitis...
  18. ncbi request reprint Rates of continuous ambulatory peritoneal dialysis-associated peritonitis at the University of Missouri
    Adam Whaley-Connell
    School of Medicine, Department of Internal Medicine, Division of Nephrology, University of Missouri, Columbia, Missouri 65212, USA
    Adv Perit Dial 21:72-5. 2005
    ..Many factors have contributed to the reduction of PD-associated peritonitis rates at our center Improved connectology, catheter care, and patient education play key roles in the reduction of peritonitis...
  19. ncbi request reprint Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Am J Physiol Endocrinol Metab 293:E355-63. 2007
    ..05). Collectively, these data suggest cardiac oxidative stress-induced structural and functional changes are driven, in part, by AT(1)R-mediated increases in NADPH oxidase activity...
  20. ncbi request reprint Obesity and insulin resistance as risk factors for chronic kidney disease
    Adam Whaley-Connell
    Department of Internal Medicine, Division of Nephrology, University of Missouri School of Medicine, Columbia, MO, USA
    J Cardiometab Syndr 1:209-14; quiz 215-6. 2006
    ..Hence, aggressive management of risk factors for the metabolic syndrome, nonpharmacologic and pharmacologic, is essential to prevent or delay the progressive loss of renal function and chronic kidney disease...
  21. ncbi request reprint Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells
    Adam T Whaley-Connell
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Nephrol 27:15-23. 2007
    ..Thus in states of albumin overload, Rac1 activation could lead to NOX activation and ROS formation in the PTC. Furthermore, accumulating evidence supports that HMG-CoA reductase inhibition may reduce oxidative stress and albuminuria...
  22. pmc Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Renal Physiol 298:F655-61. 2010
    ..Our results highlight both the importance of pressor-related reductions on podocyte integrity and albuminuria as well as RAS-mediated oxidant stress largely comparable between ARB and renin inhibition treatment...
  23. ncbi request reprint Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance
    Shawna A Cooper
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Heart Circ Physiol 293:H2009-23. 2007
    ..This review examines currently understood mechanisms underlying the development of resistance to the metabolic actions of insulin in cardiovascular as well as skeletal muscle tissue...
  24. ncbi request reprint Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats
    Javad Habibi
    University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 148:2181-8. 2007
    ..05). These results suggest that in vivo statin treatment through its direct actions on the heart reduces oxidative stress and remodeling including ventricular mass regression in the Ang-II-dependent Ren2 model...
  25. pmc Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat
    Adam Whaley-Connell
    The University of Missouri School of Medicine, Department of Medicine, Columbia, Missouri, USA
    Am J Physiol Endocrinol Metab 295:E103-9. 2008
    ..Collectively, these data suggest that both reduce changes driven, in part, by Ang II-mediated increases in NADPH oxidase and, in part, increases in blood pressure...
  26. ncbi request reprint Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling
    Sameer Stas
    Division of Endocrinology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 148:3773-80. 2007
    ....
  27. pmc Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat
    Camila Manrique
    Diabetes Cardiovascular Center of Excellence, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Metabolism 60:1757-66. 2011
    ....
  28. pmc Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat
    Xinli Zhou
    Department of Internal Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA
    Hypertension 55:880-8. 2010
    ....
  29. pmc Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese rats
    Javad Habibi
    Diabetes and Cardiovascular Center, the University of Missouri ColumbiaSchool of Medicine, Columbia, Missouri 65211, USA
    Endocrinology 152:659-68. 2011
    ....
  30. pmc Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, USA
    Am J Nephrol 31:262-72. 2010
    ..Accordingly, we hypothesized that nebivolol therapy would attenuate PTC damage and tubulointerstitial fibrosis...
  31. pmc Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat
    Lixin Ma
    Department of Radiology, University of Missouri School of Medicine, Columbia, USA
    Am J Physiol Heart Circ Physiol 302:H2341-51. 2012
    ..These results support that targeting NO with nebivolol treatment improves diastolic dysfunction through reducing myocardial oxidative stress by enhancing 5'-AMP-activated protein kinase and Akt activation of NO biosynthesis...
  32. pmc Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat
    Javad Habibi
    Departments of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 149:5643-53. 2008
    ....
  33. pmc Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat
    Guido Lastra
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Am J Physiol Endocrinol Metab 295:E110-6. 2008
    ..05). Our findings suggest that aldosterone contributes to insulin resistance in the transgenic Ren2, in part, by increasing NADPH oxidase activity in skeletal muscle tissue...
  34. ncbi request reprint Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri, Columbia, USA
    Am J Physiol Renal Physiol 292:F861-7. 2007
    ..These data indicate that PTC structural damage in the Ren2 rat is related to the oxidative stress response to ANG II and/or albuminuria...
  35. doi request reprint Obesity is associated with increased parathyroid hormone levels independent of glomerular filtration rate in chronic kidney disease
    Georges Saab
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 59:385-9. 2010
    ....
  36. doi request reprint Is there a future for direct renin inhibitors?
    Kunal Chaudhary
    Harry S Truman VA Medical Center, Columbia, MO 65211, USA
    Expert Opin Investig Drugs 19:653-61. 2010
    ..Thereby, aliskiren - alone or in combination - might offer a novel therapeutic intervention to improve suppression of the RAAS, with potential to translate to improved CVD and CKD outcomes...
  37. pmc Aldosterone: role in the cardiometabolic syndrome and resistant hypertension
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Prog Cardiovasc Dis 52:401-9. 2010
    ..In summary, aldosterone excess exerts detrimental metabolic effects that contribute to the development of the CMS and resistant hypertension as well as CVD and CKD...
  38. ncbi request reprint The cardiometabolic syndrome as a cardiovascular risk factor
    Gurushankar Govindarajan
    University of Missouri Columbia, School of Medicine, Department of Internal Medicine and Physiology, Harry S Truman VA Medical Center, Columbia, Missouri 65212, USA
    Am J Med Sci 330:311-8. 2005
    ..We will review how the varying components of the CMS relate to an increased CVD and renal disease risk...
  39. pmc Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket
    Ravi Nistala
    Division of Nephrology, Department of Internal Medicine, University of Missouri Columbia, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 304:F1105-13. 2013
    ..These observations highlight the potential utility of evaluating AT(1)R polymorphisms within the ARB-binding pocket in various hypertensive populations...
  40. pmc Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
    James R Sowers
    University of Missouri, Columbia, Missouri, USA
    Ann Intern Med 150:776-83. 2009
    ....
  41. ncbi request reprint Dual renin-angiotensin system blockade in the ONTARGET study: clinically relevant risk for the kidney?
    Kunal Chaudhary
    Department of Internal Medicine, Division of Nephrology and Hypertension, Harry S Truman Veterans Administration Medical Center, 800 Hospital Drive, Columbia, MO 65211, USA
    Curr Hypertens Rep 11:375-81. 2009
    ..Therefore, this review explores data from ONTARGET in relation to other available evidence on the use of combination therapies...
  42. ncbi request reprint Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyte
    Melvin R Hayden
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Diabetes and Cardiovascular Disease Center, University of Missouri School of Medicine, Columbia, 65212, USA
    Am J Nephrol 25:553-69. 2005
    ....
  43. ncbi request reprint Diabetic hypertension
    Khurshid A Khan
    University of Missouri Columbia, Columbia, MO 65212, USA
    Heart Fail Clin 2:25-36. 2006
  44. doi request reprint Obesity and heart failure as a mediator of the cerebrorenal interaction
    Ankur Jindal
    Department of Internal Medicine, University of Missouri, Columbia, MO, USA
    Contrib Nephrol 179:15-23. 2013
    ..g. stroke). Whether the relationship between obesity, heart disease/failure and risk for chronic kidney disease and stroke is direct or a confluence of risk factors is poorly understood...
  45. ncbi request reprint Insights into the emerging cardiometabolic prevention and management of diabetes mellitus
    Guido Lastra-Gonzalez
    Division of Endocrinology, Harry S Truman VA Medical Center, University of Missouri Columbia, School of Medicine, MO, USA
    Expert Opin Pharmacother 6:2209-21. 2005
    ..In the near future, ongoing trials should provide data that will allow us to better treat patients with the cardiometabolic syndrome and diabetes in order to reduce CVD morbidity and mortality...
  46. doi request reprint The emerging role of biomarkers in diabetic and hypertensive chronic kidney disease
    Kunal Chaudhary
    Department of Internal Medicine, Division of Nephrology and Hypertension, University of Missouri Columbia School of Medicine, CE417, DC043 0, Five Hospital Drive, Columbia, MO 65212, USA
    Curr Diab Rep 10:37-42. 2010
    ..In this article, we focus on the applications of these biomarkers in disease...
  47. pmc Angiotensin receptor blockers for the reduction of proteinuria in diabetic patients with overt nephropathy: results from the AMADEO study
    Prasad Bichu
    Division of Nephrology and Endocrinology, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Vasc Health Risk Manag 5:129-40. 2009
    ..In this review, we discuss the pathophysiology of diabetic kidney disease and implications of the AMADEO trial in the context of current understanding from recent outcome trials...
  48. ncbi request reprint A 9-year survival analysis of the presternal Missouri swan-neck catheter
    Preethi Yerram
    University of Missouri Columbia School of Medicine, Department of Internal Medicine, Division of Nephrology, Columbia, Missouri 65212, USA
    Adv Perit Dial 23:90-3. 2007
    ..That trend is partly explained by repeated episodes of peritonitis in 11 catheters; 8.5% of the patients experienced 40% of the peritonitis episodes...
  49. pmc Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats
    Annayya R Aroor
    Department of Internal Medicine, University of Missouri School of Medicine, and Diabetes and Cardiovascular Center, Columbia, MO 65212, USA
    Endocrinology 154:2501-13. 2013
    ....
  50. doi request reprint Nebivolol in obese and non-obese hypertensive patients
    Camila Manrique
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, USA
    J Clin Hypertens (Greenwich) 11:309-15. 2009
    ..5 mg in obese patients. These findings and nebivolol's neutral effects on lipid and carbohydrate metabolism suggest that it is one option for blood pressure control in the moderately obese population...
  51. pmc Renin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease
    Ravi Nistala
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Transl Res 153:102-13. 2009
    ..Thus, the focus of current research is on understanding the pathophysiology of chronic kidney disease in the context of an increased RAAS and unbalanced redox mechanisms...
  52. ncbi request reprint Hypertension and the cardiometabolic syndrome
    Camila Manrique
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Clin Hypertens (Greenwich) 7:471-6. 2005
    ..The notion that hypertension is a metabolic as well as a vascular disease opens a new paradigm for the treatment of this disorder...
  53. pmc Redox control of renal function and hypertension
    Ravi Nistala
    University of Missouri Columbia School of Medicine, Department of Internal Medicine, Columbia, Missouri 65212, USA
    Antioxid Redox Signal 10:2047-89. 2008
    ..The imbalance of redox homeostasis within the kidney is integral in hypertension and the progression of kidney disease. An emerging paradigm exists for renal redox contribution to hypertension...
  54. pmc Resistance to insulin and kidney disease in the cardiorenal metabolic syndrome; role for angiotensin II
    Ravi Nistala
    University of Missouri School of Medicine, Diabetes and Cardiovascular Center, Departments of Internal Medicine, Divisions of Nephrology and Hypertension, United States Dialysis Clinics Inc, Lemone Industrial Blvd, Columbia MO, United States Electronic address
    Mol Cell Endocrinol 378:53-8. 2013
    ..Evidence is also emerging for the role of insulin signaling in the glomerulus both epithelial and endothelial. Central to the mechanism of injury is inappropriate activation of the RAAS. ..
  55. doi request reprint Outcomes of carotid revascularization in patients with chronic kidney disease
    Gurushankar Govindarajan
    Department of Internal Medicine, Division of Cardiology, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Adv Chronic Kidney Dis 15:347-54. 2008
    ..There is an urgent need to conduct large clinical trials in patients with CKD to enable better understanding and to improve techniques of various carotid revascularization therapies in CKD patients...
  56. pmc Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities
    Lakshmi Pulakat
    University of Missouri School of Medicine, Department of Internal Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Regul Integr Comp Physiol 301:R885-95. 2011
    ..We posit that such a lack of activation of the mTOR↔AT2R integrative pathway in cardiac tissue under conditions of obesity-induced diabetes may be a metabolic switch associated with INS deficiency and clinical diabetes...
  57. doi request reprint The role of oxidative stress in the metabolic syndrome
    Adam Whaley-Connell
    Diabetes and Cardiovascular Center, Harry S Truman VA Medical Center, Columbia, MO, USA
    Rev Cardiovasc Med 12:21-9. 2011
    ....
  58. pmc Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65121 0001, USA
    J Cardiometab Syndr 3:234-43. 2008
    ....
  59. ncbi request reprint The key role of insulin resistance in the cardiometabolic syndrome
    Harvinder Gill
    Department of Internal Medicine, School of Medicine, University of Missouri Columbia, Harry S Truman VA Medical Center, Columbia, Missouri 65212, USA
    Am J Med Sci 330:290-4. 2005
    ..Effective management of the cardiometabolic syndrome will ultimately depend on our understanding of the underlying molecular mechanisms of key components of this disorder, such as insulin resistance...
  60. doi request reprint Resistant hypertension in the high-risk metabolic patient
    Kunal Chaudhary
    Harry S Truman Hospital, University of Missouri Health Sciences Center, 800 Hospital Drive, Columbia, MO 65201, USA
    Curr Diab Rep 11:41-6. 2011
    ..The management of hypertension in such patients can be challenging and generally requires nonpharmacologic as well as pharmacologic interventions...
  61. doi request reprint Novel role for the incretins in blood pressure regulation
    Preethi Yerram
    Division of Nephrology and Hypertension, Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Curr Opin Nephrol Hypertens 21:463-8. 2012
    ..This article will review the origins of incretins, the incretin axis, possible mechanisms of antihypertensive effect of these agents, as well as the recent evidence...
  62. ncbi request reprint Hypertension management in type 2 diabetes mellitus: recommendations of the Joint National Committee VII
    Adam Whaley-Connell
    Department of Internal Medicine, Health Sciences Center, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Endocrinol Metab Clin North Am 34:63-75. 2005
    ..Early and aggressive antihypertensive therapy pays off;it is hoped that the insights in this article enable clinicians to meet the challenge more successfully...
  63. pmc Inhibition of nitric oxide synthase evokes central sympatho-excitation in healthy humans
    Colin N Young
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    J Physiol 587:4977-86. 2009
    ..These findings indicate that pharmacological inhibition of NOS causes sympathetic activation and support a role of nitric oxide in central sympathetic control in humans...
  64. ncbi request reprint A series of unusual complications of the presternal peritoneal dialysis catheter
    Brian S Pavey
    University of Missouri Columbia, School of Medicine, Department of Internal Medicine, Division of Nephrology, Columbia, Missouri 65212, USA
    Adv Perit Dial 24:113-6. 2008
    ..In this report, we review four cases of rare complications associated with presternal PD catheters and a brief review of the Tenckhoff, Toronto Western Hospital, and Missouri swan-neck abdominal and presternal PD catheters...
  65. ncbi request reprint Hyponatremia, arginine vasopressin dysregulation, and vasopressin receptor antagonism
    Amit Rai
    Departments of Internal Medicine, Division of Nephrology, University of Missouri Columbia School of Medicine, Columbia, MO, USA
    Am J Nephrol 26:579-89. 2006
    ..Agents that antagonize V(2) receptors promote aquaresis and can lead to increased serum sodium. Dual-receptor antagonism, in which both V(2) and V(1A) receptors are blocked, may provide additional benefits in patients with hyponatremia...
  66. ncbi request reprint Chronic kidney disease and cardiovascular risk
    Preethi Yerram
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA
    J Am Soc Hypertens 1:178-84. 2007
    ..This review will elaborate on the pathophysiology of CVD in CKD and will discuss the role of microalbuminuria (MAU)-proteinuria as a potential diagnostic and prognostic tool for CVD in CKD risk assessment...
  67. ncbi request reprint Atherosclerotic renovascular hypertension: current trends in diagnosis and management
    Kunal Chaudhary
    Department of Internal Medicine, Division of Nephrology, University of Missouri School of Medicine, USA
    Mo Med 108:37-41. 2011
    ..In managing such patients, clinicians need to consider the risk-benefit of expensive and invasive workup and interventions...
  68. ncbi request reprint HMG CoA reductase inhibitors and renoprotection: the weight of the evidence
    L Romayne Kurukulasuriya
    University of Missouri Columbia School of Medicine, Diabetes Center, D109 HSC, One Hospital Dr, Columbia, MO 65212, USA
    Ther Adv Cardiovasc Dis 1:49-59. 2007
    ..This review examines the role of statins for reno-protection as well as cardiovascular benefit in patients with CKD...
  69. doi request reprint Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat
    Vincent G Demarco
    Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65210, USA
    Am J Physiol Heart Circ Physiol 294:H2659-68. 2008
    ..05). Collectively, the results of this investigation support a seminal role for enhanced tissue RAS/oxidative stress as factors in development of PH and pulmonary vascular remodeling...
  70. doi request reprint Trends in mineral metabolism: Kidney Early Evaluation Program (KEEP) and the National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Joseph A Vassalotti
    National Kidney Foundation, Mount Sinai School of Medicine, One Gustave L Levy Pl, Nephrology Box 1243, New York, NY 10029 6574, USA
    Am J Kidney Dis 51:S56-68. 2008
    ..No study specifically examined mineral metabolism trends in a generalizable sample of patients at increased CKD risk...
  71. doi request reprint Prevalence and associations of anemia of CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Samy I McFarlane
    Division of Endocrinology, SUNY Downstate and Kings County Hospital Centers, Brooklyn, NY 11203, USA
    Am J Kidney Dis 51:S46-55. 2008
    ..We compared anemia prevalence and characteristics in the National Kidney Foundation Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004 populations...
  72. ncbi request reprint Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Regul Integr Comp Physiol 294:R673-80. 2008
    ..This review is focused on the effects of inflammatory cytokines and oxidative stress on insulin signaling in skeletal muscle and consequent development of insulin resistance...
  73. ncbi request reprint NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat
    Yongzhong Wei
    University of Missouri Columbia, Harry S Truman VA Medical Center, Columbia, MO, USA
    Hypertension 50:384-91. 2007
    ..Collectively, these data suggest that increased angiotensin type 1 receptor/NADPH oxidase activation/reactive oxygen species contribute to vascular insulin resistance, endothelial dysfunction, apoptosis, and inflammation...
  74. doi request reprint CKD and cardiovascular disease in screened high-risk volunteer and general populations: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004
    Peter A McCullough
    Department of Medicine, Divisions of Cardiology, Nutrition, and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Kidney Dis 51:S38-45. 2008
    ..Chronic kidney disease (CKD) is recognized as an independent cardiovascular disease risk state. The relationship between CKD and cardiovascular disease in volunteer and general populations has not been explored...
  75. ncbi request reprint Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat
    Adam T Whaley-Connell
    Department of Internal Medicine, University of Missouri School of Medicine, 1 Hospital Dr, MA410 Medical Science Bldg, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 291:F1308-14. 2006
    ..Thus reductions in blood pressure, albuminuria, and tissue oxidative stress with AT1R blockade were associated with improved indexes of glomerular filtration barrier integrity and renal RAS in Ren2 rats...
  76. doi request reprint CKD awareness in the United States: the Kidney Early Evaluation Program (KEEP)
    Georges Saab
    Am J Kidney Dis 52:382-3. 2008
  77. doi request reprint Chronic kidney disease, prevalence of premature cardiovascular disease, and relationship to short-term mortality
    Peter A McCullough
    Department of Medicine, Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am Heart J 156:277-83. 2008
    ..The relationship between CKD and CVD in younger and middle-aged adults has not been fully explored...