B J Whalen

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes
    B J Whalen
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Diabetes 50:972-9. 2001
  2. ncbi request reprint Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture
    B J Whalen
    Diabetes Division, University of Massachusetts Medical Center, Worcester, MA, USA
    J Immunol 162:4003-12. 1999
  3. ncbi request reprint Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat
    R Bortel
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Autoimmunity 33:199-211. 2001
  4. ncbi request reprint Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture
    D Zipris
    Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Cell Mol Biol (Noisy-le-grand) 47:65-74. 2001
  5. ncbi request reprint The BB rat as a model of human insulin-dependent diabetes mellitus
    B J Whalen
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Immunol . 2001

Collaborators

  • D Todd
  • A A Rossini
  • R Bortel
  • D Zipris
  • D L Greiner
  • J P Mordes
  • J Moss
  • J Leif
  • J H Leif
  • E Lesma
  • D J Waite
  • M Y Lin
  • D Deluca

Detail Information

Publications5

  1. ncbi request reprint BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes
    B J Whalen
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Diabetes 50:972-9. 2001
    ..Exposure of ATOCs to exogenous islets may lead to deletion or anergy of diabetogenic T-cells or to the positive selection of regulatory T-cells...
  2. ncbi request reprint Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture
    B J Whalen
    Diabetes Division, University of Massachusetts Medical Center, Worcester, MA, USA
    J Immunol 162:4003-12. 1999
    ..Such cultures should facilitate identification of the underlying pathological processes that lead to immune dysfunction and autoimmunity in BB rats...
  3. ncbi request reprint Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat
    R Bortel
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Autoimmunity 33:199-211. 2001
    ..The source of the soluble ART2 protein in the rat appeared to be the gut. The results suggest that ART2+ T cells and soluble ART2 protein may subserve different immunomodulatory functions...
  4. ncbi request reprint Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture
    D Zipris
    Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
    Cell Mol Biol (Noisy-le-grand) 47:65-74. 2001
    ..The data demonstrate that BBDP thymocytes fail to generate mature ART2+ T-cells in rat FTOC, a system that can now be used to study the mechanism of this process...
  5. ncbi request reprint The BB rat as a model of human insulin-dependent diabetes mellitus
    B J Whalen
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Immunol . 2001
    ..Support protocols are also given for diagnosis of insulitis, treatment of diabetic rats with insulin, and serological analysis of blood samples from sentinel rats to monitor the pathogen status of the colony...