ANDREW WEYRICH

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint The evolving role of platelets in inflammation
    A S Weyrich
    Department of Internal Medicine and the Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Thromb Haemost 1:1897-905. 2003
  2. pmc Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets
    Hansjorg Schwertz
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 203:2433-40. 2006
  3. pmc Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis
    S Lindemann
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 154:485-90. 2001
  4. ncbi request reprint Change in protein phenotype without a nucleus: translational control in platelets
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Semin Thromb Hemost 30:491-8. 2004
  5. ncbi request reprint Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
    Circulation 111:633-42. 2005
  6. pmc Protein synthesis by platelets: historical and new perspectives
    A S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Thromb Haemost 7:241-6. 2009
  7. doi request reprint Targeting the inflammatory response in secondary stroke prevention: a role for combining aspirin and extended-release dipyridamole
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Am J Ther 16:164-70. 2009
  8. ncbi request reprint New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 16:75-80. 2006
  9. pmc Translational control in endothelial cells
    Peter B Brant-Zawadzki
    Division of Vascular Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Vasc Surg 45:A8-14. 2007
  10. pmc mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    Andrew S Weyrich
    Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Blood 109:1975-83. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The evolving role of platelets in inflammation
    A S Weyrich
    Department of Internal Medicine and the Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Thromb Haemost 1:1897-905. 2003
    ..Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases...
  2. pmc Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets
    Hansjorg Schwertz
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 203:2433-40. 2006
    ..We propose that platelet-derived TF contributes to the propagation and stabilization of a thrombus...
  3. pmc Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis
    S Lindemann
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 154:485-90. 2001
    ....
  4. ncbi request reprint Change in protein phenotype without a nucleus: translational control in platelets
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Semin Thromb Hemost 30:491-8. 2004
    ..We highlight the molecular machinery and pathways used by platelets to translate mRNA into protein and offer insight into how these synthesized products may regulate thrombotic and inflammatory events...
  5. ncbi request reprint Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
    Circulation 111:633-42. 2005
    ..Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems...
  6. pmc Protein synthesis by platelets: historical and new perspectives
    A S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Thromb Haemost 7:241-6. 2009
    ..Here, we chronologically review our increased understanding of protein synthetic responses in platelets and discuss how the field may evolve over the next decade...
  7. doi request reprint Targeting the inflammatory response in secondary stroke prevention: a role for combining aspirin and extended-release dipyridamole
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Am J Ther 16:164-70. 2009
    ..The added benefit without worsening bleeding may be attributable, in part, to the antiinflammatory actions of this combination therapy...
  8. ncbi request reprint New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 16:75-80. 2006
    ..Recent evidence indicates that dipyridamole, an old drug with a diverse history, differentially inhibits gene expression in platelet-leukocyte aggregates by exerting its effect at distinct molecular checkpoints...
  9. pmc Translational control in endothelial cells
    Peter B Brant-Zawadzki
    Division of Vascular Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Vasc Surg 45:A8-14. 2007
    ..We discuss some of the fundamental concepts of translational control, tools for studying it and its relevance to vascular cells, in particular the endothelium...
  10. pmc mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    Andrew S Weyrich
    Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Blood 109:1975-83. 2007
    ....
  11. ncbi request reprint Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility
    Huimiao Jiang
    Departments of Pathology, Human Molecular Biology and Genetics, and Medicine, University of Utah, Salt Lake City, UT 84112 5330, USA
    J Biol Chem 279:55905-13. 2004
    ....
  12. ncbi request reprint Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function
    Spencer W Galt
    Departments of Vascular Surgery, Internal Medicine, Program in Human Molecular Genetics, University of Utah, Salt Lake City, USA
    Circ Res 90:1093-9. 2002
    ..The finding that MMP-1 is rapidly activated in platelets and controls functional responses identifies a new role for this metalloproteinase as a signaling molecule that regulates thrombotic events...
  13. pmc Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events
    Christian C Yost
    Department of Pediatrics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 200:671-80. 2004
    ..Rapid expression of a transcription factor under translational control is a previously unrecognized mechanism in human PMNs that indicates unexpected diversity in gene regulation in this critical innate immune effector cell...
  14. pmc Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function
    Guy A Zimmerman
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arterioscler Thromb Vasc Biol 28:s17-24. 2008
    ..Signal-dependent translation and consequent protein synthesis are examples of a diverse group of posttranscriptural mechanisms in activated platelets that are now being revealed...
  15. pmc Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates
    Christian C Yost
    Department of Pediatrics Neonatology, University of Utah, Salt Lake City, USA
    Blood 113:6419-27. 2009
    ..Impaired NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection...
  16. ncbi request reprint Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation
    Larry W Kraiss
    Division of Vascular Surgery, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City UT, 84112 5330, USA
    J Vasc Surg 37:161-8. 2003
    ..The purpose of this study was to determine the mechanism with which fluid flow inhibits endothelial E-selectin expression...
  17. pmc Amicus or adversary: platelets in lung biology, acute injury, and inflammation
    Fernando A Bozza
    University of Utah, Program in Human Molecular Biology and Genetics, 15 North 2030 East, Room 4220, Salt Lake City, UT 84112 5330, USA
    Am J Respir Cell Mol Biol 40:123-34. 2009
    ..These issues are considered in a translational approach, with an emphasis on acute lung injury and the acute respiratory distress syndrome...
  18. pmc Anucleate platelets generate progeny
    Hansjorg Schwertz
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Blood 115:3801-9. 2010
    ..Because this new function of platelets occurs outside of the bone marrow milieu, it raises the possibility that thrombopoiesis continues in the bloodstream...
  19. pmc PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids
    Jason M Foulks
    Department of Experimental Pathology, University of Utah, Salt Lake City, UT 84112, USA
    Blood 113:6699-706. 2009
    ..Together these data suggest that megakaryocytes generate PAF-AH to modulate the accumulation of intracellular phospholipid mediators that may detrimentally affect megakaryocyte development and function...
  20. pmc Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke
    Zechariah G Franks
    Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1207:11-7. 2010
    ..In addition to mitigating thrombosis, antiplatelet drugs have direct and indirect effects on inflammation, which may translate to enhanced clinical efficacy...
  21. ncbi request reprint Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles
    Junji Watanabe
    Department of Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    J Biol Chem 278:33161-8. 2003
    ..Leukocytes can couple endotoxic challenge to the widespread circulatory and inflammatory effects of endotoxin...
  22. pmc Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs
    Stephan W Lindemann
    Program in Human Molecular Biology and Genetics, University of Utah, 15 North, 20230 East, Building 533, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 101:7076-81. 2004
    ..Signal-dependent translation in activated neutrophils may be a critical mechanism for alteration of the inflammatory milieu and a therapeutic target...
  23. ncbi request reprint Platelets: signaling cells in the immune continuum
    Andrew S Weyrich
    Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, 15 North 2030 East, Room 4220, Salt Lake City, Utah 84112, USA
    Trends Immunol 25:489-95. 2004
    ..This Review is the third in a series on interactions between haemostasis and inflammation...
  24. ncbi request reprint Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells
    Stephan W Lindemann
    Department of Internal Medicine and the Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 15:9-17. 2005
    ..These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets...
  25. ncbi request reprint Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets
    Melvin M Denis
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Cell 122:379-91. 2005
    ..While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells...
  26. ncbi request reprint Cell-cell interactions: leukocyte-endothelial interactions
    Thomas M McIntyre
    Huntsman Cancer Institute, Program in Human Molecular Biology and Genetics and Departments of Internal Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Curr Opin Hematol 10:150-8. 2003
    ..Neutrophil-endothelial encounters illustrate a multistep paradigm for inflammatory cell-cell interactions and provide the basis for multiple variations on the central themes...
  27. pmc The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses
    Christian C Yost
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
    Biochimie 92:692-7. 2010
    ....
  28. pmc Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections
    Yasunari Miyazaki
    Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, Department of Internal Medicine, University of Utah, Salt Lake City 84112, USA
    J Immunol 180:590-600. 2008
    ..These studies identify previously unrecognized and unique activities of alphaDbeta2, and macrophages that express it, in host defense and injury...
  29. ncbi request reprint Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation
    Michael J Feldhaus
    Department of Medicine, University of Utah, Salt Lake City, Utah 8411, USA
    J Biol Chem 277:4285-93. 2002
    ..We conclude that ceramide affects F-actin rearrangement, leading to massive degranulation, and reveals differences in beta(2)-integrin-mediated adhesive events...
  30. ncbi request reprint Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book
    Andrew S Weyrich
    Circulation 106:1433-5. 2002
  31. pmc Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    Dan A Dixon
    Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
    J Clin Invest 116:2727-38. 2006
    ..These checkpoints may be altered in disease and therefore useful as targets for antiinflammatory intervention...
  32. ncbi request reprint Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis
    Jiawei Chen
    Department of Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    J Lipid Res 48:2365-76. 2007
    ....
  33. ncbi request reprint Evaluating the relevance of the platelet transcriptome
    Andrew S Weyrich
    Blood 102:1550-1. 2003

Research Grants2

  1. Novel Thrombotic & Inflammatory Mechanisms of Venous Thromboembolism in Elderly
    ANDREW WEYRICH; Fiscal Year: 2007
    ..Together these studies will provide new information on how platelets influence the pathogenesis of VTE. ..