Eric M Wexler

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Clinical neurogenetics: behavioral management of inherited neurodegenerative disease
    Eric Wexler
    Department of Psychiatry, Center for Neurobehavioral Genetics, Semel Institute, University of California Los Angeles School of Medicine, 695 Charles Young Drive South, Gonda Room 2309, Los Angeles, CA 90024 1759, USA Electronic address
    Neurol Clin 31:1121-44. 2013
  2. doi DISC1: a schizophrenia gene with multiple personalities
    Eric M Wexler
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Neuron 72:501-3. 2011
  3. ncbi Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
    E M Wexler
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 13:285-92. 2008
  4. pmc Out FOXing Parkinson disease: where development meets neurodegeneration
    Eric M Wexler
    Division of Geriatric Psychiatry and the Program in Neurobehavioral Genetics, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 5:e334. 2007
  5. pmc Endogenous Wnt signaling maintains neural progenitor cell potency
    Eric M Wexler
    Department of Psychiatry, The Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
    Stem Cells 27:1130-41. 2009
  6. pmc Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways
    Eric M Wexler
    Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA
    Sci Signal 4:ra65. 2011
  7. pmc Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 22:302-11. 2006
  8. pmc Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling
    Ezra Y Rosen
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 71:1030-42. 2011

Research Grants

Collaborators

Detail Information

Publications8

  1. doi Clinical neurogenetics: behavioral management of inherited neurodegenerative disease
    Eric Wexler
    Department of Psychiatry, Center for Neurobehavioral Genetics, Semel Institute, University of California Los Angeles School of Medicine, 695 Charles Young Drive South, Gonda Room 2309, Los Angeles, CA 90024 1759, USA Electronic address
    Neurol Clin 31:1121-44. 2013
    ..The goal of this article is to provide the neurologist with a concise primer that can be applied in a busy clinic or private practice. ..
  2. doi DISC1: a schizophrenia gene with multiple personalities
    Eric M Wexler
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Neuron 72:501-3. 2011
    ..These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field...
  3. ncbi Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
    E M Wexler
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 13:285-92. 2008
    ....
  4. pmc Out FOXing Parkinson disease: where development meets neurodegeneration
    Eric M Wexler
    Division of Geriatric Psychiatry and the Program in Neurobehavioral Genetics, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 5:e334. 2007
  5. pmc Endogenous Wnt signaling maintains neural progenitor cell potency
    Eric M Wexler
    Department of Psychiatry, The Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
    Stem Cells 27:1130-41. 2009
    ..In sum, this study establishes that autonomous Wnt signaling is a conserved feature of the neurogenic niche that preserves the delicate balance between NSC maintenance and differentiation...
  6. pmc Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways
    Eric M Wexler
    Department of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90024, USA
    Sci Signal 4:ra65. 2011
    ..These unbiased and genome-wide analyses provide evidence for a connection between Wnt signaling and the transcriptional regulation of neurodegenerative disease genes...
  7. pmc Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 22:302-11. 2006
    ..The identification of a core set of genes changing early in the FRDA pathogenesis can be a useful tool in both clarifying the disease process and in evaluating new therapeutic strategies...
  8. pmc Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling
    Ezra Y Rosen
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 71:1030-42. 2011
    ..Together, these in vitro and in vivo data point to an adaptive role for altered Wnt signaling in GRN deficiency-mediated FTD, representing a potential therapeutic target...

Research Grants2