Brent W Weston

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
  2. ncbi request reprint A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells
    B W Weston
    The Lineberger Comprehensive Cancer Center and the Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Eur J Haematol 63:42-9. 1999
  3. pmc Familial deficiency of vitamin K-dependent clotting factors
    B W Weston
    The Harold R Roberts Comprehensive Hemophilia Treatment Center, Department of Pediatrics, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
    Haemophilia 14:1209-13. 2008
  4. ncbi request reprint Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children
    Matthew W Richardson
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7220, USA
    Pediatr Hematol Oncol 19:129-34. 2002
  5. ncbi request reprint Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
  6. ncbi request reprint Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995

Research Grants

Collaborators

  • P E Monahan
  • M B Klein
  • J L Goodman
  • Matthew W Richardson
  • H S Cameron
  • William K Funkhouser
  • Brent Senior
  • R S McCurley
  • D Szczepaniak
  • A S Olsen
  • A Recinos
  • J C Gingrich
  • R Krauss

Detail Information

Publications6

  1. ncbi request reprint Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
    ..These results provide target validation for inhibition of carcinoma metastasis with antisense FUT sequences and confirm the primacy of alpha(1,3)fucosyltransferases in the synthesis of selectin ligands...
  2. ncbi request reprint A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells
    B W Weston
    The Lineberger Comprehensive Cancer Center and the Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Eur J Haematol 63:42-9. 1999
    ..Transcript analyses show that FUT7 and FUT4 are inversely expressed in HL60 and variant cell lines. HL60A2 cells provide a tool to study the regulation of selectin ligands and corresponding human fucosyltransferase genes...
  3. pmc Familial deficiency of vitamin K-dependent clotting factors
    B W Weston
    The Harold R Roberts Comprehensive Hemophilia Treatment Center, Department of Pediatrics, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
    Haemophilia 14:1209-13. 2008
    ..The results may also provide potential targets for molecular therapeutics and pharmacogenetics...
  4. ncbi request reprint Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children
    Matthew W Richardson
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7220, USA
    Pediatr Hematol Oncol 19:129-34. 2002
    ..These rare lesions should be part of the differential of children with a head and neck mass...
  5. ncbi request reprint Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
    ..Thus, tissue-specific post-transcriptional modifications are associated with expression patterns of FUT3, FUT5, and FUT6...
  6. ncbi request reprint Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995
    ..A P1 clone with all three 19p FUT genes in tandem orientation was isolated and used to study regions flanking FUT3, -5, and -6. Our studies provide preliminary information to study regulation of human FUT genes...

Research Grants5

  1. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..The long-term goals are to extend the use of AS-ODNs to adjunctive treatment of colon carcinoma metastasis and to contribute to the study of glycosyltransferase gene regulation. ..