Brent W Weston

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
  2. ncbi A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells
    B W Weston
    The Lineberger Comprehensive Cancer Center and the Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Eur J Haematol 63:42-9. 1999
  3. ncbi Familial deficiency of vitamin K-dependent clotting factors
    B W Weston
    The Harold R Roberts Comprehensive Hemophilia Treatment Center, Department of Pediatrics, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
    Haemophilia 14:1209-13. 2008
  4. ncbi Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children
    Matthew W Richardson
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7220, USA
    Pediatr Hematol Oncol 19:129-34. 2002
  5. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
  6. ncbi Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995

Research Grants

  1. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004

Collaborators

  • P E Monahan
  • M B Klein
  • J L Goodman
  • Matthew W Richardson
  • H S Cameron
  • Brent Senior
  • William K Funkhouser
  • D Szczepaniak
  • R S McCurley
  • A Recinos
  • A S Olsen
  • J C Gingrich
  • R Krauss

Detail Information

Publications6

  1. ncbi Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
    ..These results provide target validation for inhibition of carcinoma metastasis with antisense FUT sequences and confirm the primacy of alpha(1,3)fucosyltransferases in the synthesis of selectin ligands...
  2. ncbi A cloned CD15s-negative variant of HL60 cells is deficient in expression of FUT7 and does not adhere to cytokine-stimulated endothelial cells
    B W Weston
    The Lineberger Comprehensive Cancer Center and the Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Eur J Haematol 63:42-9. 1999
    ..Transcript analyses show that FUT7 and FUT4 are inversely expressed in HL60 and variant cell lines. HL60A2 cells provide a tool to study the regulation of selectin ligands and corresponding human fucosyltransferase genes...
  3. ncbi Familial deficiency of vitamin K-dependent clotting factors
    B W Weston
    The Harold R Roberts Comprehensive Hemophilia Treatment Center, Department of Pediatrics, Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7220, USA
    Haemophilia 14:1209-13. 2008
    ..The results may also provide potential targets for molecular therapeutics and pharmacogenetics...
  4. ncbi Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children
    Matthew W Richardson
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7220, USA
    Pediatr Hematol Oncol 19:129-34. 2002
    ..These rare lesions should be part of the differential of children with a head and neck mass...
  5. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
    ..Thus, tissue-specific post-transcriptional modifications are associated with expression patterns of FUT3, FUT5, and FUT6...
  6. ncbi Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995
    ..A P1 clone with all three 19p FUT genes in tandem orientation was isolated and used to study regions flanking FUT3, -5, and -6. Our studies provide preliminary information to study regulation of human FUT genes...

Research Grants5

  1. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..The long-term goals are to extend the use of AS-ODNs to adjunctive treatment of colon carcinoma metastasis and to contribute to the study of glycosyltransferase gene regulation. ..