Cara J Westmark

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
  2. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
  3. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
  4. pmc Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e26549. 2011
  5. ncbi request reprint HuR mRNA ligands expressed after seizure
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neuropathol Exp Neurol 64:1037-45. 2005
  6. ncbi request reprint Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 27:787-96. 2006
  7. pmc Soy-based diet exacerbates seizures in mouse models of neurological disease
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 33:797-805. 2013
  8. pmc Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, USA
    J Vis Exp . 2011
  9. pmc The regulation of AβPP expression by RNA-binding proteins
    Cara J Westmark
    University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705, USA
    Ageing Res Rev 11:450-9. 2012
  10. pmc Pin1 and PKMzeta sequentially control dendritic protein synthesis
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Sci Signal 3:ra18. 2010

Collaborators

  • J S Malter
  • Corinna Burger
  • Pamela R Westmark
  • Stephane Esnault
  • Athavi Jeevananthan
  • Jonathan Levenson
  • Kenneth J O'Riordan
  • Suqing Wang
  • Ronald L Sorkness
  • Zhong Jian Shen
  • Louis A Rosenthal
  • Hyun C Shin
  • Syrus R Soltaninassab
  • Emily K Reinke

Detail Information

Publications12

  1. pmc FMRP mediates mGluR5-dependent translation of amyloid precursor protein
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 5:e52. 2007
    ..Our data indicate that postsynaptic FMRP binds to and regulates the translation of APP mRNA through metabotropic glutamate receptor activation and suggests a possible link between Alzheimer disease and fragile X syndrome...
  2. pmc Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 20:1009-13. 2010
    ..Our data strongly implicates AbetaPP or a catabolite in seizure susceptibility and suggests that mGluR5 mediates this response...
  3. pmc MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta
    Cara J Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Int J Clin Exp Pathol 3:56-68. 2009
    ..These data suggest that Abeta contributes to seizure incidence and may be an appropriate therapeutic target to lessen seizure pathology in FXS, Alzheimer's disease (AD) and Down syndrome (DS) patients...
  4. pmc Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e26549. 2011
    ..Evolving therapies directed at reducing Aβ in AD may be applicable to FXS and Aβ may serve as a plasma-based biomarker to facilitate disease diagnosis or assess therapeutic efficacy...
  5. ncbi request reprint HuR mRNA ligands expressed after seizure
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neuropathol Exp Neurol 64:1037-45. 2005
    ..These results demonstrate a biochemical approach to identify and characterize the diverse repertoire of ligands for HuR and other regulatory mRNA-binding proteins...
  6. ncbi request reprint Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Neuroscience Training Program, Waisman Center for Developmental Disabilities and Institute on Aging, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Neurobiol Aging 27:787-96. 2006
    ....
  7. pmc Soy-based diet exacerbates seizures in mouse models of neurological disease
    Cara J Westmark
    Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 33:797-805. 2013
    ..Thus, the soy isoflavone daidzein recapitulated seizure induction in vivo and altered AβPP expression in vitro. These results have important implications for individuals on soy-based diets as well as for rodent model research...
  8. pmc Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, USA
    J Vis Exp . 2011
    ..The Percoll-sucrose gradient method is quick and gentle as it employs isotonic conditions, has fewer and shorter centrifugation spins and avoids centrifugation steps that pellet SNs and cause mechanical damage...
  9. pmc The regulation of AβPP expression by RNA-binding proteins
    Cara J Westmark
    University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705, USA
    Ageing Res Rev 11:450-9. 2012
    ....
  10. pmc Pin1 and PKMzeta sequentially control dendritic protein synthesis
    Pamela R Westmark
    Department of Pathology and Laboratory Medicine and Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Sci Signal 3:ra18. 2010
    ..PKMzeta interacted with and inhibited Pin1 by phosphorylating serine 16. Therefore, glutamate-induced, dendritic protein synthesis is sequentially regulated by Pin1 and PKMzeta signaling...
  11. ncbi request reprint RhoB mRNA is stabilized by HuR after UV light
    Cara J Westmark
    Department of Pathology and Laboratory Medicine, Waisman Center for Developmental Disabilities, University of Wisconsin, Madison, WI 53705, USA
    Oncogene 24:502-11. 2005
    ..Therefore, we propose a model in which UVL induces stress-activated signal transduction leading to nuclear/cytoplasmic shuttling of HuR and subsequent stabilization of RhoB mRNA...
  12. doi request reprint Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent
    Stephane Esnault
    J Allergy Clin Immunol 121:1289-90. 2008