R C Wester

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects of heat-separation and freezing
    R C Wester
    Department of Dermatology, University of California, San Francisco 94143, USA
    Pharm Res 15:82-4. 1998
  2. ncbi request reprint Human in vivo and in vitro hydroquinone topical bioavailability, metabolism, and disposition
    R C Wester
    Department of Dermatology, University of California, San Francisco 94143 0989, USA
    J Toxicol Environ Health A 54:301-17. 1998
  3. ncbi request reprint In vivo percutaneous absorption of arsenic from water and CCA-treated wood residue
    Ronald C Wester
    University of California, San Francisco, Dermatology Department, PO Box 0989, San Francisco, California 94143 0989, USA
    Toxicol Sci 79:287-95. 2004
  4. ncbi request reprint Polymers effect on estradiol partition coefficient between powdered human stratum corneum and water
    Ronald C Wester
    Dermatology Department, University of California, San Francisco, California 94143 0989, USA
    J Pharm Sci 91:2642-5. 2002
  5. ncbi request reprint In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Box 0989, 90 Medical Center Way, San Francisco, California 94143, USA
    J Pharm Sci 96:2622-31. 2007
  6. ncbi request reprint Ciclopirox delivery into the human nail plate
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, CA 94143, USA
    J Pharm Sci 93:2545-8. 2004
  7. doi request reprint In vitro percutaneous absorption of benzene in human skin
    Xiaoying Hui
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Cutan Ocul Toxicol 28:65-70. 2009
  8. ncbi request reprint Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Surge pound 110, Box 0989, 90 Medical Center Way, San Francisco, California 94143 0989, USA
    J Pharm Sci 92:142-8. 2003
  9. ncbi request reprint Enhanced human nail drug delivery: nail inner drug content assayed by new unique method
    Xiaoying Hui
    Department of Dermatology, University of California, San Francisco, California 94143, USA
    J Pharm Sci 91:189-95. 2002
  10. ncbi request reprint Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine
    S D Gilman
    Department of Entomology, University of California, Davis 95616, USA
    Anal Chem 70:3463-9. 1998

Detail Information

Publications15

  1. ncbi request reprint Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects of heat-separation and freezing
    R C Wester
    Department of Dermatology, University of California, San Francisco 94143, USA
    Pharm Res 15:82-4. 1998
    ..Skin storage maintenance and confirmation of skin viability is important for both uses, especially for the absorption process where the in vivo situation is simulated...
  2. ncbi request reprint Human in vivo and in vitro hydroquinone topical bioavailability, metabolism, and disposition
    R C Wester
    Department of Dermatology, University of California, San Francisco 94143 0989, USA
    J Toxicol Environ Health A 54:301-17. 1998
    ..Risk assessment should not only involve the bioavailability of intact topical hydroquinone, but also consider phase I and phase II metabolism in both humans and any animal for which toxicity potential was assessed...
  3. ncbi request reprint In vivo percutaneous absorption of arsenic from water and CCA-treated wood residue
    Ronald C Wester
    University of California, San Francisco, Dermatology Department, PO Box 0989, San Francisco, California 94143 0989, USA
    Toxicol Sci 79:287-95. 2004
    ..Additionally, the results show that arsenic is poorly absorbed from CCA-treated wood residues (i.e., does not result in urinary arsenic excretion above background levels)...
  4. ncbi request reprint Polymers effect on estradiol partition coefficient between powdered human stratum corneum and water
    Ronald C Wester
    Dermatology Department, University of California, San Francisco, California 94143 0989, USA
    J Pharm Sci 91:2642-5. 2002
    ..01) in log PC for estradiol concentrations. Thus, a macromolecular chemical has the potential to alter the partitioning of chemical into the outer layers of skin, the first step in percutaneous absorption...
  5. ncbi request reprint In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Box 0989, 90 Medical Center Way, San Francisco, California 94143, USA
    J Pharm Sci 96:2622-31. 2007
    ..AN2690 has superior penetration compared to ciclopirox, and achieves levels within and under the nail plate that suggest it has the potential to be an effective topical treatment for onychomycosis...
  6. ncbi request reprint Ciclopirox delivery into the human nail plate
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, CA 94143, USA
    J Pharm Sci 93:2545-8. 2004
    ..The formulation plays an important role in the enhancement of ciclopirox permeation into and through the human nail plate, and the concentration of ciclopirox in the formulation was not a factor in determining penetration...
  7. doi request reprint In vitro percutaneous absorption of benzene in human skin
    Xiaoying Hui
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Cutan Ocul Toxicol 28:65-70. 2009
    ..6 times. These data place into partial perspective the role of occlusion in benzene flux, but should not be generalized until other volatile substances are studied in the experimental system and further validated with in vivo systems...
  8. ncbi request reprint Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Surge pound 110, Box 0989, 90 Medical Center Way, San Francisco, California 94143 0989, USA
    J Pharm Sci 92:142-8. 2003
    ..In a subsequent study, [(14)C]-dioxolane did not penetrate the nail well. Therefore, the mechanism of enhancement of econazole penetration is at the formulation/nail interface...
  9. ncbi request reprint Enhanced human nail drug delivery: nail inner drug content assayed by new unique method
    Xiaoying Hui
    Department of Dermatology, University of California, San Francisco, California 94143, USA
    J Pharm Sci 91:189-95. 2002
    ..The assay system has the unique characteristic of being able to assay the inner part of the nail where the disease resides...
  10. ncbi request reprint Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine
    S D Gilman
    Department of Entomology, University of California, Davis 95616, USA
    Anal Chem 70:3463-9. 1998
    ..7%, and the day-to-day reproducibility of the AMS measurements is 3.9%. Factors limiting AMS detection limits for these samples and ways in which these can be improved are examined...
  11. ncbi request reprint In vivo human transfer of topical bioactive drug between individuals: estradiol
    Ronald C Wester
    Department of Dermatology, School of Medicine, University of California San Francisco, 94143, USA
    J Invest Dermatol 126:2190-3. 2006
    ..It is important for prescribing physicians and patients to understand that clinically significant transfer of topical bioactive drugs can occur. This may be particularly important for substances which may produce inadvertent effects...
  12. ncbi request reprint Percutaneous absorption of arsenic from environmental media
    Yvette W Lowney
    Exponent, 4940 Pearl East Circle, Suite 300, Boulder, CO 80301, USA
    Toxicol Ind Health 21:1-14. 2005
    ..We conclude that there are likely to be many site- or sample-specific factors that will control the absorption of arsenic, and matrix-specific analyses may be required to understand the degree of percutaneous absorption...
  13. ncbi request reprint Dermal absorption of arsenic from soils as measured in the rhesus monkey
    Yvette W Lowney
    Exponent, Boulder, CO, USA
    Toxicol Sci 100:381-92. 2007
    ..Our findings suggest that dermal absorption of arsenic from soil is truly negligible, and that EPA's current default assumption of 3% dermal absorption of arsenic from soils results in significant overestimates of exposure...
  14. ncbi request reprint PBPK modeling of the percutaneous absorption of perchloroethylene from a soil matrix in rats and humans
    Torka S Poet
    Battelle, Pacific Northwest Division, P O Box 999, Richland, Washington 99352, USA
    Toxicol Sci 67:17-31. 2002
    ..In real-world situations, percutaneous absorption of PCE is likely to be minimal...
  15. ncbi request reprint Partition coefficients for benzene in human skin
    Georgia C Sinclair
    Deakin University, P O Box 210, Glen Iris, Victoria 3146, Australia
    AIHA J (Fairfax, Va) 63:685-8. 2002
    ..2), benzene : water (109/126), and benzene : blood substitute (55/59) also were determined for the purposes of validating the blood substitute: viable epidermis and blood substitute : dermis partition coefficients...