Ruth Westenbroek

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Altered localization of Cav1.2 (L-type) calcium channels in nerve fibers, Schwann cells, odontoblasts, and fibroblasts of tooth pulp after tooth injury
    R E Westenbroek
    Department of Pharmacology, University of Washington, Seattle, USA
    J Neurosci Res 75:371-83. 2004
  2. pmc Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry
    Ruth E Westenbroek
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA Electronic address
    J Mol Cell Cardiol 64:69-78. 2013
  3. pmc Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons
    Misty R Marshall
    Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 286:12627-39. 2011
  4. ncbi request reprint GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP mice
    Margaret R Byers
    Anesthesiology, University of Washington, Seattle, Washington 98195, USA
    Microsc Res Tech 65:295-307. 2004
  5. pmc CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:14864-8. 2003
  6. pmc Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 100:13093-8. 2003
  7. ncbi request reprint Identical phenotypes of CatSper1 and CatSper2 null sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Biol Chem 280:32238-44. 2005
  8. pmc Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 103:16574-9. 2006
  9. ncbi request reprint Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 293:H1359-70. 2007
  10. pmc Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels
    Sumiko Mochida
    Department of Physiology, Tokyo Medical University, Tokyo 160 8402, Japan
    Proc Natl Acad Sci U S A 100:2819-24. 2003

Research Grants

Collaborators

  • William A Catterall
  • Sebastian K G Maier
  • MARGARET BYERS
  • J Striessnig
  • LUIS SANTANA
  • Todd Scheuer
  • Joanne T Hulme
  • Anne E Carlson
  • Misty R Marshall
  • Manuel F Navedo
  • Bertil Hille
  • Donner F Babcock
  • Sumiko Mochida
  • Chunling Chen
  • Frank H Yu
  • John Patrick Clark
  • Gregory C Amberg
  • Martina J Sinnegger-Brauns
  • Timothy A Quill
  • Sonya M Schuh
  • Huijun Zhong
  • Scott J Myers
  • Teddy W C Lin
  • Charles T Yokoyama
  • Kanako Itoh
  • David E Clapham
  • Timothy Quill
  • David L Garbers
  • Dejian Ren
  • Christy Avery
  • Jyoti Dhar Malhotra
  • Angus Brown
  • Lori L Isom
  • Vandana Bharucha
  • Yuan Chen
  • Dorothy Jones
  • Thomas L Saunders
  • Peter Shrager
  • Kristin A Kazen-Gillespie
  • Bruce R Ransom
  • Katie Kazarinova-Noyes
  • Patrick J Gillespie
  • Robert L Macdonald

Detail Information

Publications11

  1. ncbi request reprint Altered localization of Cav1.2 (L-type) calcium channels in nerve fibers, Schwann cells, odontoblasts, and fibroblasts of tooth pulp after tooth injury
    R E Westenbroek
    Department of Pharmacology, University of Washington, Seattle, USA
    J Neurosci Res 75:371-83. 2004
    ..These findings provide new insight into the localization of Cav1.2 channels in dental pulp and sensory fibers, and demonstrate unexpected plasticity of channel distribution in response to nerve injury...
  2. pmc Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry
    Ruth E Westenbroek
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA Electronic address
    J Mol Cell Cardiol 64:69-78. 2013
    ....
  3. pmc Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons
    Misty R Marshall
    Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
    J Biol Chem 286:12627-39. 2011
    ..2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling...
  4. ncbi request reprint GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP mice
    Margaret R Byers
    Anesthesiology, University of Washington, Seattle, Washington 98195, USA
    Microsc Res Tech 65:295-307. 2004
    ..GFP transcription by some Schwann cell subtypes in oral mucosae and trigeminal nerve, but not trigeminal root was a novel finding that reveals more complexity in peripheral glia than previously recognized...
  5. pmc CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:14864-8. 2003
    ..We propose that CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization...
  6. pmc Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 100:13093-8. 2003
    ....
  7. ncbi request reprint Identical phenotypes of CatSper1 and CatSper2 null sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Biol Chem 280:32238-44. 2005
    ..Hence, stable expression of CatSper1 protein requires CatSper2 and vice versa. This co-dependent expression dictates identical loss-of-function sperm phenotypes for CatSper1 and -2 null mutants...
  8. pmc Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation
    Joanne T Hulme
    Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 103:16574-9. 2006
    ..Our results correlate phosphorylation of S1928 with beta1-adrenergic functional up-regulation of cardiac calcium channels in the presence of BAPTA in intact ventricular myocytes...
  9. ncbi request reprint Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 293:H1359-70. 2007
    ..We conclude that although Ca(v)1.3 channels can produce Ca(2+) sparklets, Ca(v)1.2 channels underlie I(Ca), Ca(2+) sparklets, and hence dihydropyridine-sensitive Ca(2+) influx in mouse arterial myocytes...
  10. pmc Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels
    Sumiko Mochida
    Department of Physiology, Tokyo Medical University, Tokyo 160 8402, Japan
    Proc Natl Acad Sci U S A 100:2819-24. 2003
    ....
  11. pmc Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits
    Chunling Chen
    Departments of Pharmacology and Neurology, and Transgenic Animal Model Core Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 99:17072-7. 2002
    ..Our observations show that beta2-subunits play an important role in the regulation of sodium channel density and function in neurons in vivo and are required for normal action potential generation and control of excitability...

Research Grants3

  1. CA CHANNELS IN TRIGEMINAL NEUROPATHIC PLASTICITY & PAIN
    Ruth Westenbroek; Fiscal Year: 2000
    ....
  2. CA CHANNELS IN TRIGEMINAL NEUROPATHIC PLASTICITY & PAIN
    Ruth Westenbroek; Fiscal Year: 2001
    ....
  3. CA CHANNELS IN TRIGEMINAL NEUROPATHIC PLASTICITY & PAIN
    Ruth Westenbroek; Fiscal Year: 2002
    ....