Genomes and Genes
Affiliation: University of Washington
- Altered localization of Cav1.2 (L-type) calcium channels in nerve fibers, Schwann cells, odontoblasts, and fibroblasts of tooth pulp after tooth injuryR E Westenbroek
Department of Pharmacology, University of Washington, Seattle, USA
J Neurosci Res 75:371-83. 2004..These findings provide new insight into the localization of Cav1.2 channels in dental pulp and sensory fibers, and demonstrate unexpected plasticity of channel distribution in response to nerve injury...
- Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistryRuth E Westenbroek
Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA Electronic address
J Mol Cell Cardiol 64:69-78. 2013....
- Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neuronsMisty R Marshall
Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
J Biol Chem 286:12627-39. 2011..2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling...
- GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP miceMargaret R Byers
Anesthesiology, University of Washington, Seattle, Washington 98195, USA
Microsc Res Tech 65:295-307. 2004..GFP transcription by some Schwann cell subtypes in oral mucosae and trigeminal nerve, but not trigeminal root was a novel finding that reveals more complexity in peripheral glia than previously recognized...
- CatSper1 required for evoked Ca2+ entry and control of flagellar function in spermAnne E Carlson
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:14864-8. 2003..We propose that CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization...
- Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15Joanne T Hulme
Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
Proc Natl Acad Sci U S A 100:13093-8. 2003....
- Identical phenotypes of CatSper1 and CatSper2 null spermAnne E Carlson
Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
J Biol Chem 280:32238-44. 2005..Hence, stable expression of CatSper1 protein requires CatSper2 and vice versa. This co-dependent expression dictates identical loss-of-function sperm phenotypes for CatSper1 and -2 null mutants...
- Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulationJoanne T Hulme
Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
Proc Natl Acad Sci U S A 103:16574-9. 2006..Our results correlate phosphorylation of S1928 with beta1-adrenergic functional up-regulation of cardiac calcium channels in the presence of BAPTA in intact ventricular myocytes...
- Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscleManuel F Navedo
Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 293:H1359-70. 2007..We conclude that although Ca(v)1.3 channels can produce Ca(2+) sparklets, Ca(v)1.2 channels underlie I(Ca), Ca(2+) sparklets, and hence dihydropyridine-sensitive Ca(2+) influx in mouse arterial myocytes...
- Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channelsSumiko Mochida
Department of Physiology, Tokyo Medical University, Tokyo 160 8402, Japan
Proc Natl Acad Sci U S A 100:2819-24. 2003....
- Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunitsChunling Chen
Departments of Pharmacology and Neurology, and Transgenic Animal Model Core Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 99:17072-7. 2002..Our observations show that beta2-subunits play an important role in the regulation of sodium channel density and function in neurons in vivo and are required for normal action potential generation and control of excitability...
- CA CHANNELS IN TRIGEMINAL NEUROPATHIC PLASTICITY & PAINRuth Westenbroek; Fiscal Year: 2002....