HUNTER contact WESSELLS

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes
    Hunter Wessells
    Department of Urology and Diabetes Endocrinology Research Center, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 185:1828-34. 2011
  2. ncbi request reprint Melanocortinergic control of penile erection
    H Wessells
    Department of Urology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Peptides 26:1972-7. 2005
  3. ncbi request reprint Penile and genital injuries
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Urol Clin North Am 33:117-26, vii. 2006
  4. ncbi request reprint Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors
    H Wessells
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98195, USA
    Neuroscience 118:755-62. 2003
  5. ncbi request reprint Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses
    H Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, USA
    Int J Impot Res 18:438-45. 2006
  6. ncbi request reprint Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104 2499, USA
    BJU Int 97:1047-52. 2006
  7. ncbi request reprint Renal injury and operative management in the United States: results of a population-based study
    Hunter Wessells
    Department of Urology, Harborview Medical Center and University of Washington Medical School, Seattle, 98104, USA
    J Trauma 54:423-30. 2003
  8. ncbi request reprint Erectile dysfunction
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Urol 177:1675-81. 2007
  9. pmc Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function
    Hunter Wessells
    Departments of Urology, Harborview Medical Center, 325 Ninth Ave, Seattle Washington 98104, USA
    Physiol Genomics 39:100-8. 2009
  10. ncbi request reprint Ventral onlay graft techniques for urethroplasty
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Urol Clin North Am 29:381-7, vii. 2002

Collaborators

Detail Information

Publications34

  1. pmc Effect of intensive glycemic therapy on erectile function in men with type 1 diabetes
    Hunter Wessells
    Department of Urology and Diabetes Endocrinology Research Center, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 185:1828-34. 2011
    ..We determined whether intensive glycemic therapy reduces the risk of erectile dysfunction in men with type 1 diabetes enrolled in the Diabetes Control and Complications Trial...
  2. ncbi request reprint Melanocortinergic control of penile erection
    H Wessells
    Department of Urology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Peptides 26:1972-7. 2005
    ....
  3. ncbi request reprint Penile and genital injuries
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Urol Clin North Am 33:117-26, vii. 2006
    ..This article reviews the mechanism, initial evaluation, and operative management of injuries to the male and female external genitalia including the penis, scrotal skin, and vaginal structures...
  4. ncbi request reprint Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors
    H Wessells
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98195, USA
    Neuroscience 118:755-62. 2003
    ..These results provide new insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction...
  5. ncbi request reprint Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses
    H Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, USA
    Int J Impot Res 18:438-45. 2006
    ..However, our findings suggest that iNOS gene transfer may have deleterious effects on endothelial function if used as a treatment for erectile dysfunction...
  6. ncbi request reprint Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104 2499, USA
    BJU Int 97:1047-52. 2006
    ....
  7. ncbi request reprint Renal injury and operative management in the United States: results of a population-based study
    Hunter Wessells
    Department of Urology, Harborview Medical Center and University of Washington Medical School, Seattle, 98104, USA
    J Trauma 54:423-30. 2003
    ..To evaluate the extent to which nonoperative renal trauma management has been adopted, we determined the incidence of renal injury and the rate of operative management across the United States...
  8. ncbi request reprint Erectile dysfunction
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Urol 177:1675-81. 2007
    ..We characterized the burden and severity of disease, treatment patterns and economic consequences of erectile dysfunction...
  9. pmc Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function
    Hunter Wessells
    Departments of Urology, Harborview Medical Center, 325 Ninth Ave, Seattle Washington 98104, USA
    Physiol Genomics 39:100-8. 2009
    ..Contribution of the tight junction protein CLDN11 to barrier function in endothelial cells is novel and may reflect hemodynamic requirements of the corpus cavernosum...
  10. ncbi request reprint Ventral onlay graft techniques for urethroplasty
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Urol Clin North Am 29:381-7, vii. 2002
    ..3 and 85.9% respectively). Nevertheless, grafting techniques are now considered first line therapy for the majority of strictures that cannot be excised and reanastomosed...
  11. ncbi request reprint Traumatic intracorporal septal avulsion resulting in cavernous veno-occlusive dysfunction
    T Walsh
    Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Int J Impot Res 17:295-6. 2005
  12. ncbi request reprint Smoking and erectile dysfunction: evidence based analysis
    K T McVary
    Department of Urology, Northwestern University Medical School, Chicago, Illinois, USA
    J Urol 166:1624-32. 2001
    ..However, the evidence of such an association is likely due to the consistency of the relationship of smoking and endothelial disease, and the strength of the association of erectile dysfunction with other endothelial diseases...
  13. ncbi request reprint Monckeberg's calciphylaxis with necrosis of the glans penis: a case presentation
    Mathew D Sorensen
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98105, USA
    Hemodial Int 11:300-2. 2007
    ..Two months later the patient had persistent wound-healing issues with intractable pain and thus underwent a complete penectomy with ultimate resolution of his severe pain...
  14. ncbi request reprint American Association for the Surgery of Trauma Organ Injury Scale for kidney injuries predicts nephrectomy, dialysis, and death in patients with blunt injury and nephrectomy for penetrating injuries
    James K Kuan
    Department of Urology, University of Washington Medical Center, Seattle, Washington 98104, USA
    J Trauma 60:351-6. 2006
    ..We sought to validate this scheme for morbidity and mortality in a national cohort of patients with renal injury...
  15. ncbi request reprint MT-II induces penile erection via brain and spinal mechanisms
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Ann N Y Acad Sci 994:90-5. 2003
    ..These results provide insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction...
  16. ncbi request reprint Ex vivo repair and renal autotransplantation after penetrating trauma: is there an upper limit of ischemic/traumatic injury beyond which a kidney is unsalvageable?
    Michael Angelis
    Department of Surgery, Division of Transpalntation, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Trauma 54:606-9; discussion 609. 2003
  17. ncbi request reprint Predictors and prevalence of erectile dysfunction in a racially diverse population
    Christopher S Saigal
    Department of Urology, The David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1738, USA
    Arch Intern Med 166:207-12. 2006
    ..To obtain a better understanding of the national estimates of prevalence and risk factors for ED, we analyzed data from the 2001-2002 National Health and Nutrition Examination Survey...
  18. pmc Melanocortin receptors, melanotropic peptides and penile erection
    Stephen H King
    Department of Urology, University of Washington School of Medicine, University of Arizona, Arizona, USA
    Curr Top Med Chem 7:1098-1106. 2007
    ..Through their centrally mediated activity, melanocortin agonists have potential to treat erectile dysfunction as well as possible applications to the unmet medical needs of decreased sexual motivation and loss of libido...
  19. ncbi request reprint Renal injury mechanisms of motor vehicle collisions: analysis of the crash injury research and engineering network data set
    James K Kuan
    Department of Urology, University of Washington, School of Medicine, Seattle, Washington 98102, USA
    J Urol 178:935-40; discussion 940. 2007
    ..We identified possible collision patterns and vehicle interior components that may have a role in kidney injury following motor vehicle collision...
  20. ncbi request reprint Tadalafil-associated priapism
    Stephen H King
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    Urology 66:432. 2005
    ..At outpatient follow-up, the patient remained flaccid without erections. To our knowledge, this is the first report of tadalafil-associated priapism...
  21. ncbi request reprint Meshed unexpanded split-thickness skin grafting for reconstruction of penile skin loss
    Peter C Black
    Department of Urology, Harborview Medical Center and University of Washington School of Medicine, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Urol 172:976-9. 2004
    ..We report our experience with meshed, unexpanded STSGs for all penile resurfacing regardless of erectile function...
  22. ncbi request reprint Efficacy and safety of sildenafil citrate (Viagra) in black and Hispanic American men
    Jay M Young
    South Orange County Urological Medical Associates, Laguna Woods, California 92653, USA
    Urology 60:39-48. 2002
    ..These data demonstrate that despite differences in prevalence rates of comorbidities, efficacy and safety of sildenafil is maintained across different ethnic groups...
  23. ncbi request reprint Predicting urethral injury from pelvic fracture patterns in male patients with blunt trauma
    Amaya M Basta
    Department of Radiology, Harborview Injury Prevention and Research Center, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    J Urol 177:571-5. 2007
    ..We determined the specific anterior pelvic injury locations associated with urethral injury...
  24. ncbi request reprint Trauma cases from Harborview Medical Center. Rupture of a ureteropelvic junction-obstructed kidney in a 15-year-old football player
    Martin Smith
    Department of Radiology, Harborview Medical Center, University of Washington School of Medicine, 325 Ninth Ave, Box 359728, Seattle, WA 98104 2499, USA
    AJR Am J Roentgenol 180:504. 2003
  25. ncbi request reprint Urologic complications of diabetes
    Jeanette S Brown
    University of California, San Francisco, San Francisco, California 94115, USA
    Diabetes Care 28:177-85. 2005
  26. ncbi request reprint What is the most cost-effective treatment for 1 to 2-cm bulbar urethral strictures: societal approach using decision analysis
    Jonathan L Wright
    Department of Urology, Harborview Medical Center, University of Washington Medical Center, Seattle, Washington, USA
    Urology 67:889-93. 2006
    ..Using decision analysis, we determine the cost-effectiveness of different management strategies for short, bulbar urethral strictures 1 to 2 cm in length...
  27. ncbi request reprint Urethral and bladder neck injury associated with pelvic fracture in 25 female patients
    Peter C Black
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center and Harborview Injury Prevention Research Center, Seattle, Washington 98104, USA
    J Urol 175:2140-4; discussion 2144. 2006
    ..We describe the presentation, diagnostic evaluation, management and outcome of female urethral trauma...
  28. ncbi request reprint Radiographic and clinical predictors of bladder rupture in blunt trauma patients with pelvic fracture
    Greg Avey
    Department of Radiology, University of Washington School of Medicine, Box 359960, 325 Ninth Avenue, Seattle, WA 98104, USA
    Acad Radiol 13:573-9. 2006
    ..Bladder rupture is a potentially serious injury in blunt trauma patients. We determined whether location and displacement of pelvic fractures and the degree of hematuria can accurately predict bladder injury...
  29. ncbi request reprint Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia
    Hunter Wessells
    University of Washington, Seattle, Washington, USA
    Urology 61:579-84. 2003
    ..To evaluate the incidence and resolution of sexual adverse experiences (AEs) in men with benign prostatic hyperplasia treated with finasteride 5 mg compared with placebo...
  30. ncbi request reprint Renal and extrarenal predictors of nephrectomy from the national trauma data bank
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 175:970-5; discussion 975. 2006
    ..The management of renal injuries is controversial, as reflected in regional and institutional variations in treatment preferences. Using a national trauma database we identified independent risk factors for nephrectomy...
  31. ncbi request reprint Immunohistochemical comparison of vascular and sinusoidal adherens junctions in cavernosal endothelium
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104, USA
    Urology 63:201-6. 2004
    ..To characterize endothelial cell-to-cell junctions in the sinusoids and microvasculature of the corpus cavernosum...
  32. ncbi request reprint Microarray analysis reveals novel gene expression changes associated with erectile dysfunction in diabetic rats
    Chris J Sullivan
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Physiol Genomics 23:192-205. 2005
    ..Overall, this study broadens the scope of candidate genes and pathways that may be relevant to the pathophysiology of diabetes-induced ED as well as highlights the potential complexity of this disorder...
  33. ncbi request reprint The relationship among lower urinary tract symptoms, prostate specific antigen and erectile dysfunction in men with benign prostatic hyperplasia: results from the proscar long-term efficacy and safety study
    Sung Hyun Paick
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104, USA
    J Urol 173:903-7. 2005
    ....
  34. ncbi request reprint The penile implant for erectile dysfunction
    John J Mulcahy
    Department of Urology, Indiana University, Indianapolis, IN, USA
    J Sex Med 1:98-109. 2004
    ..Although they are the least chosen and most invasive treatment option, they have the highest satisfaction rate of all available ED options and provide a predictable and reliable result...

Research Grants11

  1. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    HUNTER contact WESSELLS; Fiscal Year: 2010
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..
  2. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    Hunter Wessells; Fiscal Year: 2009
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..
  3. Immortalized Human Cavernosal Endothelial Cells
    Hunter Wessells; Fiscal Year: 2005
    ..abstract_text> ..
  4. Neural Melanocortin Signaling and Erectile Function
    Hunter Wessells; Fiscal Year: 2005
    ..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..
  5. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2004
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  6. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    HUNTER contact WESSELLS; Fiscal Year: 2010
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..