Research Topics
Species | V P WerthSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototestingMichele L Lokitz
The University of Pennsylvania, Philadelphia, PA, USA
Photodermatol Photoimmunol Photomed 22:290-6. 2006....
Development of outcome measures for autoimmune dermatosesElizabeth Gaines
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Arch Dermatol Res 300:3-9. 2008..Finally, this review more closely looks at CLE, DM, and PV and addresses the recent and ongoing progress that has been made in the development of their outcome measures...
Multicenter randomized, double-blind, placebo-controlled, clinical trial of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgarisVictoria P Werth
Department of Dermatology, University of Pennsylvania, 2 Rhodes Pavilion, 3600 Spruce St, Philadelphia, PA 19119, USA
Arch Dermatol 144:25-32. 2008..To determine the efficacy of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris (PV)...- Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patientsAdam S Nabatian
Philadelphia Veterans Affairs Medical Center, 38th and Woodland Avenues, Philadelphia, PA 08901, USA
Arthritis Res Ther 14:R1. 2012.... - Impact of smoking in cutaneous lupus erythematosusEvan W Piette
Philadelphia VA Medical Center, Philadelphia, PA, USA
Arch Dermatol 148:317-22. 2012..To investigate cigarette smoking in cutaneous lupus erythematosus (CLE)... - IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor alpha from cultured skin fibroblasts and keratinocytesVictoria P Werth
Department of Dermatology, University of Pennsylvania and Philadelphia V A Hospital, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 120:116-22. 2003..Because tumor necrosis factor alpha is central to the pathogenesis of several photosensitive skin diseases and certain forms of immune suppression, interleukin-12 may have important physiologic, pathophysiologic, and therapeutic roles... - Medical dermatology: a view to the futureVictoria P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 126:528-9. 2006 - Photosensitivity in rheumatic diseasesVictoria P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Investig Dermatol Symp Proc 9:57-63. 2004..In the presence of specific MHC class I and II genes, antigen-presenting cells initiate a primary immune response that leads to cutaneous, and likely systemic, autoimmune disease... - Development of the CLASI as a tool to measure disease severity and responsiveness to therapy in cutaneous lupus erythematosusRachel Klein
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Dermatol 147:203-8. 2011..To determine how to use the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) to classify patients according to disease severity (mild, moderate, and severe) and to identify which patients respond to therapy... - Response to antimalarial agents in cutaneous lupus erythematosus: a prospective analysisAileen Y Chang
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
Arch Dermatol 147:1261-7. 2011..To demonstrate response to antimalarial agents in patients with cutaneous lupus erythematosus (CLE) using activity scores from the Cutaneous Lupus Erythematosus Disease Area and Severity Index, a validated outcome measure... - Ultraviolet irradiation induces the accumulation of chondroitin sulfate, but not other glycosaminoglycans, in human skinBenjamin Boegel Werth
Medical Research, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e14830. 2011..These molecules have important biologic functions and contribute to the cutaneous response to UV... - Cutaneous lupus: insights into pathogenesis and disease classificationVictoria P Werth
The University of Pennsylvania and the Philadelphia Veterans Administration Hospital, Department of Dermatology 19104, USA
Bull NYU Hosp Jt Dis 65:200-4. 2007..Scientific efforts are beginning to clarify the pathophysiologic differences between subsets of cutaneous LE, but there are clearly many areas of investigation needed to elucidate the complex mechanisms that culminate in cutaneous LE... - Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositisVictoria P Werth
Philadelphia V A Medical Center Department of Dermatology Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, PA 19104, USA
J Invest Dermatol 119:1394-9. 2002..Our model is that genetic polymorphisms leading to overproduction of apoptotic keratinocytes and then impaired clearance of these cells contribute to the pathogenesis of adult dermatomyositis, a photoinduced autoimmune skin disease... - Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesisVictoria P Werth
Philadelphia V A Medical Center, Department of Dermatology, University of Pennsylvania, USA
J Invest Dermatol 119:617-20. 2002..The differences in linkage with HLA-DR3, as well as several divergent clinical features, indicate that there are also fundamental mechanistic differences between dermatomyositis and subacute cutaneous lupus erythematosus... - Association of a promoter polymorphism of tumor necrosis factor-alpha with subacute cutaneous lupus erythematosus and distinct photoregulation of transcriptionV P Werth
The University of Pennsylvania, VA Hospital, Philadelphia, Pennsylvania, USA
J Invest Dermatol 115:726-30. 2000..Overall, our findings indicate a strong linkage between the -308A polymorphism and subacute systemic lupus erythematosus, which is likely to directly contribute to the photosensitivity of these patients... - Wavelength-specific synergy between ultraviolet radiation and interleukin-1 alpha in the regulation of matrix-related genes: mechanistic role for tumor necrosis factor-alphaV P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
J Invest Dermatol 113:196-201. 1999.... - Clinical manifestations of cutaneous lupus erythematosusVictoria P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia V A Hospital, 2 Rhoads Pavilion, 36th and Spruce Sts, Philadelphia, PA 19104, United States
Autoimmun Rev 4:296-302. 2005.... - Pathophysiology of cutaneous lupus erythematosusJulie H Lin
Department of Dermatology, University of Pennsylvania, 2 Rhoads Pavilion, Philadelphia, PA 19104, USA
Clin Rev Allergy Immunol 33:85-106. 2007..In addition, we consider the role and importance of humoral and cellular factors, synthesizing the current understanding of the pathophysiology of cutaneous lupus... - Dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgarisMichael R Heaphy
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA
Arch Dermatol 141:699-702. 2005..These data support the need for a prospective, randomized trial to confirm these findings... - TNF-alpha production in the skinM M Bashir
Department of Dermatology, University of Pennsylvania, 2, Rhodes Pavilion, 3600 Spruce Street, Philadelphia, PA, 19104, USA
Arch Dermatol Res 301:87-91. 2009..Keratinocyte-derived TNF-alpha is a component of the early induction phase of the inflammatory cascade... - Modification of the cutaneous dermatomyositis disease area and severity index, an outcome instrumentM Yassaee
Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, PA 19104 2676, USA
Br J Dermatol 162:669-73. 2010..A scoring system of skin disease severity in dermatomyositis known as the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) has been developed... - Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: a review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individualMichael Shapiro
Department of Dermatology, University of Pennsylvania Health System, Philadelphia V.A. Hospital, Philadelphia, PA 19104, USA
Int J Dermatol 43:87-94. 2004..An environmental agent present in the barn, coupled with springtime ultraviolet light, likely triggered the disease in this immunogenetically susceptible individual... - The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index scoreI Braunstein
Dermatology Section, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Br J Dermatol 166:971-5. 2012..Patients with SLE have increased IFN-regulated gene expression pointing towards a possible underlying genetic defect... - DermatomyositisM S Krathen
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19119, USA
Curr Dir Autoimmun 10:313-32. 2008..The seminal work regarding the pathogenesis of DM is reviewed and an update on the recent basic and molecular advances in the field is provided... - Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesisNicole Fett
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Am Acad Dermatol 64:217-28; quiz 229-30. 2011..The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction... - Combination antimalarials in the treatment of cutaneous dermatomyositis: a retrospective studyGina Charlene Ang
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, USA
Arch Dermatol 141:855-9. 2005.... - Update on morphea: part II. Outcome measures and treatmentNicole Fett
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Am Acad Dermatol 64:231-42; quiz 243-4. 2011..The most robust data in the treatment of morphea exists for methotrexate in combination with systemic steroids and ultraviolet A1... - Comparison of the reliability and validity of outcome instruments for cutaneous dermatomyositisR Q Klein
Department of Dermatology, School of Medicine, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA 19104, USA
Br J Dermatol 159:887-94. 2008..Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Dermatomyositis Skin Severity Index (DSSI) and Cutaneous Assessment Tool (CAT) skin indices have been developed as outcome instruments... - The Cutaneous Lupus Erythematosus Disease Activity and Severity Index: expansion for rheumatology and dermatologyM S Krathen
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Arthritis Rheum 59:338-44. 2008..To evaluate the validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) for use by rheumatologists via reliability testing, and to extend the validation for dermatologists... - Rheumatic manifestations of skin diseaseJennie T Clarke
Department of Dermatology, Penn State Hershey Medical Center, Hershey, USA
Curr Opin Rheumatol 22:78-84. 2010..Increasingly, studies are using the skin as a primary endpoint for evaluating therapies. This will review the current state of the art for the most common rheumatic skin diseases... - UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcriptionMuhammad M Bashir
Philadelphia V A Medical Center, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 129:994-1001. 2009..UVB with IL-1alpha did not enhance the half-life of TNF-alpha mRNA over that seen with UVB alone. In conclusion, TNF-alpha expression in primary keratinocytes is upregulated transcriptionally by UVB and IL-1alpha... - Ultraviolet-B recruits mannose-binding lectin into skin from non-cutaneous sourcesMichele L Lokitz
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Invest Dermatol 125:166-73. 2005..We hypothesize that MBL may facilitate non-inflammatory clearance of apoptotic debris in patients with photosensitive forms of DM... - Lack of correlation of skin thickness with bone density in patients receiving chronic glucocorticoidV P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
Arch Dermatol Res 290:388-93. 1998..The level of type I procollagen mRNA in skin from three GC-treated patients was 45% of the value in three age-matched controls. In conclusion, GCs cause statistically significant thinning of skin independently of the effects on bone... - Skin involvement and outcome measures in systemic autoimmune diseasesJ Albrecht
Department of Dermatology, University of Pennsylvania, Philadelphia, USA
Clin Exp Rheumatol 24:S52-9. 2006..The most typical skin manifestations are nodular lesions, which are commonly seen in BS and may be due to panniculitis [erythema nodosum (EN)-like lesions] or superficial thrombophlebitis... - Reliability and convergent validity of two outcome instruments for pemphigusMisha Rosenbach
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19119, USA
J Invest Dermatol 129:2404-10. 2009..Subset analysis suggests that for this population of mild-to-moderate disease activity, the PDAI captures more variability in cutaneous disease than the ABSIS... - Interstitial lung disease in classic and skin-predominant dermatomyositis: a retrospective study with screening recommendationsPamela A Morganroth
Department of Dermatology, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
Arch Dermatol 146:729-38. 2010..2) To compare the pulmonary abnormalities of patients with classic dermatomyositis and those with skin-predominant dermatomyositis... - Tumor necrosis factor inhibitor-associated dermatomyositisRachel Klein
Department of Medicine, Division of Rheumatology, University of Pennsylvania School of Medicine, Perelman Center for Advanced Medicine, First Floor South Pavilion, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
Arch Dermatol 146:780-4. 2010..Rarely have they been associated with dermatomyositis. The 4 cases reported herein indicate that TNF inhibitor use can be associated with either induction or exacerbation of dermatomyositis... - The cutaneous lupus erythematosus disease area and severity index: a responsive instrument to measure activity and damage in patients with cutaneous lupus erythematosusZuleika L Bonilla-Martinez
Department of Dermatology, University of Pennsylvania, 2 Rhodes Pavilion, 3600 Spruce St, Philadelphia, PA 19119, USA
Arch Dermatol 144:173-80. 2008..To assess the clinical responsiveness of the CLASI (Cutaneous Lupus Erythematosus [CLE] Disease Area and Severity Index)... - Preserving medical dermatology. A colleague lost, a call to arms, and a plan for battleV P Werth
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Dermatol Clin 19:583-92. 2001..Without an steady stream of young clinician-investigators focused on the many challenging problems in medical dermatology, dermatology will not exist as the specialty it is today... - Papulosquamous disorders of the elderlyA van Voorhees
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Geriatr Med 17:739-68, vii. 2001..Treatment often involves identifying underlying systemic causes, as well as specific approaches based on the diagnosis and severity of clinical presentation... - Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositisSherry H Hsiung
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Am Acad Dermatol 48:S11-4. 2003..Thus, it is important to consider the possibility of multicentric reticulohistiocytosis when evaluating a patient with the clinical diagnosis of dermatomyositis... - Modification to the approach of the diagnosis of mucous membrane pemphigoid: A case report and literature reviewErnesta Parisi
University of Pennsylvania, Department of Oral Medicine, Philadelphia, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:182-6. 2003..This case report illustrates a case of antiepiligrin MMP in a patient with an advanced cancer of the bladder... - Cutaneous lupus and the Cutaneous Lupus Erythematosus Disease Area and Severity Index instrumentRachel S Klein
Philadelphia VA Medical Center, Philadelphia, PA, USA
Rheum Dis Clin North Am 36:33-51, vii. 2010..It also describes the Cutaneous Lupus Erythematosus Disease Area and Severity Index, a novel clinical outcome instrument that quantifies cutaneous activity and damage in cutaneous lupus erythematosus... - The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): an outcome instrument for cutaneous lupus erythematosusJoerg Albrecht
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Invest Dermatol 125:889-94. 2005..96 (95% CI = 0.89 to 1.00) and for the damage score Sp was 0.99 (95% CI = 0.97-1.00). Clinical responsiveness needs to be evaluated in a prospective clinical trial, which is ongoing... - Number, characteristics, and classification of patients with dermatomyositis seen by dermatology and rheumatology departments at a large tertiary medical centerRhonda Q Klein
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Acad Dermatol 57:937-43. 2007..The current diagnostic criteria for dermatomyositis (DM) exclude patients without muscle involvement. As a result there is a paucity of research related to the complete spectrum of the disease... - Analysis of compact fluorescent lights for use by patients with photosensitive conditionsRachel S Klein
Philadelphia V A Hospital, and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 85:1004-10. 2009..01 to 15 mJ cm(-2). Because patients are exposed continually over long time frames, this could lead to significant cumulative damage. It would therefore be prudent for patients to use bulbs with the lowest UV irradiance... - The risk of ultraviolet radiation exposure from indoor lamps in lupus erythematosusRachel S Klein
Philadelphia V A Hospital, Philadelphia, PA 19104, United States
Autoimmun Rev 8:320-4. 2009..Therefore, it is possible that this chronic exposure could ultimately result in a significant accumulation of damage... - Cross-sectional analysis of a collaborative Web-based database for lupus erythematosus-associated skin lesions: prospective enrollment of 114 patientsSiamak Moghadam-Kia
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Arch Dermatol 145:255-60. 2009.... - Thalidomide in cutaneous lupus erythematosusMichelle T Pelle
Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Clin Dermatol 4:379-87. 2003..With appropriate control of drug access and close physician monitoring, thalidomide provides a needed therapeutic option for the treatment of refractory cases of cutaneous lupus erythematosus... - Management of cutaneous dermatomyositis: current therapeutic optionsRhonda D Quain
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Clin Dermatol 7:341-51. 2006.... - Pemphigus: a treatment updateSarah E Dick
Department of Dermatology, Philadelphia VA Medical Center, University of Pennsylvania, Philadelphia, PA, USA
Autoimmunity 39:591-9. 2006..Here we review the available treatment options and novel therapies for pemphigus and the supporting data... - Mycophenolate mofetil for interstitial lung disease in dermatomyositisPamela A Morganroth
Philadelphia VA Medical Center, University of Pennsylvania, USA
Arthritis Care Res (Hoboken) 62:1496-501. 2010..To report our experience using mycophenolate mofetil as first-line treatment for dermatomyositis-associated interstitial lung disease... - Cutaneous Mycobacterium haemophilum infection in iatrogenically immunocompromised patients without transplantationJason P Lott
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Acad Dermatol 59:139-42. 2008..haemophilum may arise in this patient population. Accordingly, we emphasize that a high index of suspicion is needed for diagnosis, which ultimately relies on skin biopsy, histopathologic examination, and culture... - Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis: a case series of nine patients and review of the literatureCamille E Introcaso
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Int J Dermatol 46:447-52. 2007..The only common exposure amongst patients is acute or chronic renal failure. The pathophysiology of the disease remains to be elucidated, and there is currently no consistently effective treatment for this unremitting disease... - Skin disorders with arthritisJoshua Levin
Department of Dermatology, University of Pennsylvania, PA 19104, USA
Best Pract Res Clin Rheumatol 20:809-26. 2006..This review will discuss the clinical presentation, both cutaneous and musculoskeletal, diagnosis and management of these disorders... - Darier's disease associated with an underlying neoplasm in combination with a nodular fibroproliferative diseaseKathryn L Dortzbach
Department of Dermatology, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
J Am Acad Dermatol 49:S237-9. 2003..We describe a 74-year-old man with metastatic carcinoma in whom fibroproliferative disease and an acquired variant of Darier's disease developed, both of which may have been paraneoplastic processes... - Improvement in dermatomyositis rash associated with the use of antiestrogen medicationDanya Sereda
Section of Dermatology,
Arch Dermatol 142:70-2. 2006..Further investigation into the use of antiestrogen therapy in DM is merited to evaluate long-term risks and benefits... - Quality of life and disease severity in a cutaneous lupus erythematosus pilot studyElizabeth Gaines
Arch Dermatol 144:1061-2. 2008 - Consensus statement on definitions of disease, end points, and therapeutic response for pemphigusDedee F Murrell
Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
J Am Acad Dermatol 58:1043-6. 2008..These should assist in development of consistent reporting of outcomes in future studies... - Activation of autoimmunity following use of immunostimulatory herbal supplementsAlice N Lee
Section of Dermatology, University of Chicago, IL, USA
Arch Dermatol 140:723-7. 2004..Increased production of TNF-alpha may play a role, although more research is needed to clarify the mechanisms of such phenomena... - Development of the CLASI as an outcome instrument for cutaneous lupus erythematosusJoerg Albrecht
Department of Medicine, Division of Dermatology, John Stroger Jr Hospital of Cook County, Chicago, Illinois, USA
Dermatol Ther 20:93-101. 2007.... - The cutaneous lupus disease activity and severity index as a validated outcome measure for cutaneous lupus erythematosus: comment on the article by Stamm et alMichael Krathen
Arthritis Rheum 59:601-2. 2008
Research Grants
- PATIENT-ORIENTED RESEARCH IN SKIN AUTOMMUNE DISEASEVictoria Werth; Fiscal Year: 2005..This K24 translational grant is intended to permit the P.I. greater time to focus on patient-based scientific studies and will provide an infrastructure for Dr. Werth to pursue and mentor in POR. ..