S R Wersinger

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Sexually dimorphic processing of somatosensory and chemosensory inputs to forebrain luteinizing hormone-releasing hormone neurons in mated ferrets
    S R Wersinger
    Department of Biology, Boston University, Massachusetts 02215, USA
    Endocrinology 138:1121-9. 1997
  2. ncbi request reprint Sexually dimorphic activation of midbrain tyrosine hydroxylase neurons after mating or exposure to chemosensory cues in the ferret
    S R Wersinger
    Department of Biology, Boston University, Massachusetts 02215, USA
    Biol Reprod 56:1407-14. 1997
  3. ncbi request reprint Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 32:176-83. 1997
  4. ncbi request reprint Dopamine activates masculine sexual behavior independent of the estrogen receptor alpha
    S R Wersinger
    University of Virginia, Department of Biology, Charlottesville, Virginia 22903, USA
    J Neurosci 20:4248-54. 2000
  5. ncbi request reprint Oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice
    S R Wersinger
    Department of Biology, Neuroscience Program, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
    J Neuroendocrinol 12:103-10. 2000
  6. ncbi request reprint Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Endocrine 11:137-43. 1999
  7. ncbi request reprint Sex with knockout models: behavioral studies of estrogen receptor alpha
    E F Rissman
    Department of Biology, Neuroscience Graduate Program, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 835:80-90. 1999
  8. ncbi request reprint Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 31:232-43. 1997
  9. ncbi request reprint Effects of female pheromones on gonadotropin-releasing hormone gene expression and luteinizing hormone release in male wild-type and oestrogen receptor-alpha knockout mice
    A C Gore
    Fishberg Research Center for Neurobiology, Kastor Neurobiology of Aging Laboratories and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neuroendocrinol 12:1200-4. 2000
  10. ncbi request reprint Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    Section on Neural Gene Expression, NIMH, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:975-84. 2002

Detail Information

Publications13

  1. ncbi request reprint Sexually dimorphic processing of somatosensory and chemosensory inputs to forebrain luteinizing hormone-releasing hormone neurons in mated ferrets
    S R Wersinger
    Department of Biology, Boston University, Massachusetts 02215, USA
    Endocrinology 138:1121-9. 1997
    ..These results suggest that the sex dimorphism in mating-induced LH secretion reflects a sex difference in the central processing of genital-somatosensory stimuli and possibly of chemosensory inputs as well...
  2. ncbi request reprint Sexually dimorphic activation of midbrain tyrosine hydroxylase neurons after mating or exposure to chemosensory cues in the ferret
    S R Wersinger
    Department of Biology, Boston University, Massachusetts 02215, USA
    Biol Reprod 56:1407-14. 1997
    ..These activated TH-IR neurons in the MOB are most likely dopaminergic. Their role in the neural response to mating is currently unknown...
  3. ncbi request reprint Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 32:176-83. 1997
    ..However, it is clear that the ER alpha plays a key role in the expression of masculine sexual behavior and in the regulation of androgen receptors in a neuronal cell population involved in the display of motivated behaviors...
  4. ncbi request reprint Dopamine activates masculine sexual behavior independent of the estrogen receptor alpha
    S R Wersinger
    University of Virginia, Department of Biology, Charlottesville, Virginia 22903, USA
    J Neurosci 20:4248-54. 2000
    ..Moreover, dopamine can activate sexual behavior via a mechanism that either acts on an ER other than ERalpha or via an estrogen-independent pathway...
  5. ncbi request reprint Oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice
    S R Wersinger
    Department of Biology, Neuroscience Program, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
    J Neuroendocrinol 12:103-10. 2000
    ..Responses to female pheromones do not require ERalpha. However, normal male sexual performance requires the ERalpha gene...
  6. ncbi request reprint Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Endocrine 11:137-43. 1999
    ..Although E2 can exert negative feedback effects on LH release in both males and females by actions at the ERalpha, the androgen receptor plays the primary physiological role in the male mouse...
  7. ncbi request reprint Sex with knockout models: behavioral studies of estrogen receptor alpha
    E F Rissman
    Department of Biology, Neuroscience Graduate Program, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 835:80-90. 1999
    ..Based on these data we hypothesize that ERalpha mediates many of the effects of estrogen on sexual behavior, learning, and memory...
  8. ncbi request reprint Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 31:232-43. 1997
    ....
  9. ncbi request reprint Effects of female pheromones on gonadotropin-releasing hormone gene expression and luteinizing hormone release in male wild-type and oestrogen receptor-alpha knockout mice
    A C Gore
    Fishberg Research Center for Neurobiology, Kastor Neurobiology of Aging Laboratories and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neuroendocrinol 12:1200-4. 2000
    ..Thus, this neuroendocrine response is regulated by a steroid receptor other than ERalpha and does not require alterations in GnRH mRNA expression...
  10. ncbi request reprint Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
    S R Wersinger
    Section on Neural Gene Expression, NIMH, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:975-84. 2002
    ..We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries...
  11. pmc The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
    W S Young
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 49, Room 5A56, Bethesda, MD 20892 4483, USA
    Neuroscience 143:1031-9. 2006
    ..Finally, ISHH and RT-PCR showed expression of the Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters...
  12. ncbi request reprint Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression
    S R Wersinger
    Department of Psychology, University at Buffalo, SUNY, Buffalo, NY 14260, USA
    Genes Brain Behav 6:540-51. 2007
    ..However, the olfactory deficits observed in the Avpr1a(-/-) mice suggest that Avp and Avpr1a drugs may affect behavior, in part, by modulation of chemosensory systems...
  13. pmc Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice
    S R Wersinger
    Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
    Genes Brain Behav 6:653-60. 2007
    ..We hypothesize that Avpr1b plays an important role in the central processing that couples the detection and perception of social cues (which appears normal) with the appropriate behavioral response...