Research Topics
| J S WernerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Night vision in the elderly: consequences for seeing through a "blue filtering" intraocular lensJ S Werner
Department of Ophthalmology and Vision Science, Section of Neurobiology, University of California Davis, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Br J Ophthalmol 89:1518-21. 2005..01 log unit. It is thus improbable that a difference in scotopic vision between observers with the Natural and Conventional IOLs could be reliably detected using broadband stimuli...- Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathiesJ S Werner
Department of Ophthalmology and Vision Science, Davis Eye Center, University of California, Davis, CA, USA
Eye (Lond) 25:279-89. 2011..These results demonstrate that nonglaucomatous and glaucomatous optic neuropathies are associated with outer retinal changes following long-term inner retinal pathology... - Senescence of foveal and parafoveal cone sensitivities and their relations to macular pigment densityJ S Werner
Department of Ophthalmology, University of California, Davis Medical Center, Sacramento 95817, USA
J Opt Soc Am A Opt Image Sci Vis 17:1918-32. 2000..However, because this result is independent of age, it is interpreted as being due to local gain changes resulting from differential filtering of incident light by the macular pigment between the fovea and the parafovea... - Spherical aberration yielding optimum visual performance: evaluation of intraocular lenses using adaptive optics simulationJohn S Werner
University of California Davis Eye Center, Department of Ophthalmology and Vision Science, University of California, Davis Medical Center, Sacramento, California 95817, USA
J Cataract Refract Surg 35:1229-33. 2009..To evaluate the influence of spherical aberration on contrast sensitivity using adaptive optics... - Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea planaMichael F Marmor
Department of Ophthalmology, Stanford University Medical Center, 300 Pasteur Dr, Room A 157, Stanford, CA 94305 5308, USA
Arch Ophthalmol 126:907-13. 2008..To elucidate the visual significance of the foveal pit by measuring foveal architecture and function and to reassess use of the term foveal hypoplasia (as visual acuity can vary among patients who lack a pit)... - Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: correlation between macular morphology and visual functionS Pilli
Department of Ophthalmology and Vision Science, University of California, Davis Eye Center, Sacramento, CA 95817, USA
Eye (Lond) 25:775-83. 2011.... - High resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferationSteven N Truong
Department of Ophthalmology and Vision Science, University of California, Davis Medical Center, USA
Retina 27:915-25. 2007.... - Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensionsRobert J Zawadzki
Department of Ophthalmology and Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California Davis, Sacramento 95817, USA
J Opt Soc Am A Opt Image Sci Vis 24:1373-83. 2007..Finally, examples of microscopic retinal structures that are acquired with the University of California Davis AO-OCT system are presented... - Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusenStacey S Choi
Department of Ophthalmology and Vision Science, University of California at Davis, Sacramento, California 95817, USA
J Neuroophthalmol 28:120-5. 2008..New technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic disc drusen... - Spatial profile of contours inducing long-range color assimilationFrédéric Devinck
Section of Neurobiology, Physiology and Behavior, Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California, USA
Vis Neurosci 23:573-7. 2006..This research suggests that luminance-dependent chromatic mechanisms mediate the WCE and that these mechanisms are sensitive to differences in the two spatial profiles of the pattern contours only when they are wide... - Photoreceptor counting and montaging of en-face retinal images from an adaptive optics fundus cameraBai Xue
Department of Ophthalmology and Vision Science, University of California Davis, Sacramento 95817, USA
J Opt Soc Am A Opt Image Sci Vis 24:1364-72. 2007..Our algorithms do not require spatial regularity in cone packing and are, therefore, useful for counting cones in diseased retinas, as demonstrated for eyes with Stargardt's macular dystrophy and retinitis pigmentosa... - Spatial dependence of color assimilation by the watercolor effectFrédéric Devinck
Section of Neurobiology, Physiology and Behavior, Department of Ophthalmology and Vision Science, University of California, Davis, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Perception 35:461-8. 2006..These results demonstrate that chromatic aberration may account, in part, for color assimilation over small, but not large, surface areas... - In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual functionStacey S Choi
Department of Ophthalmology and Vision Science, University of California Davis, Sacramento 95817, USA
Invest Ophthalmol Vis Sci 47:2080-92. 2006..To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy... - Aging and blur adaptationSarah L Elliott
Department of Ophthalmology and Vision Science, Department of Psychology, University of California, Davis, CA, USA
J Vis 7:8. 2007..The neural processes mediating adaptation to blur thus appear to remain largely intact with aging... - Adaptation of a support vector machine algorithm for segmentation and visualization of retinal structures in volumetric optical coherence tomography data setsRobert J Zawadzki
University of California, Davis, California 95817, USA
J Biomed Opt 12:041206. 2007..Our software has been tested successfully in clinical settings for its efficacy in assessing 3D retinal structures in healthy as well as diseased cases. Our tool facilitates diagnosis and treatment monitoring of retinal diseases... - Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correctionRobert J Zawadzki
Vision Science and Advanced Retinal Imaging Laboratory VSRI, Department of Ophthalmology and Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Opt Express 16:8126-43. 2008..The combination of improved micron-scale 3D resolution, and reduced speckle size and contrast were found to significantly improve visibility of microscopic structures in the retina... - Role of high-order aberrations in senescent changes in spatial visionSarah L Elliott
Department of Ophthalmology and Vision Science, University of California, Davis, CA 95817, USA
J Vis 9:24.1-16. 2009..These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision... - Error budget analysis for an adaptive optics optical coherence tomography systemJulia W Evans
Department of Ophthalmology and Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California, Davis, Sacramento, CA 95817, USA
Opt Express 17:13768-84. 2009..We also discuss the scaling of error sources for different subjects and the need to improve the robustness of the system by addressing subject variability... - High-resolution Fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degenerationSusanna S Park
Department of Ophthalmology and Vision Science, Davis Medical Center, University of California, Sacramento, California 95817, USA
Invest Ophthalmol Vis Sci 51:4200-6. 2010..To investigate the use of high-resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVMs) associated with exudative age-related macular degeneration (eAMD)... - Age-related changes in contrast gain related to the M and P pathwaysSarah L Elliott
Department of Ophthalmology and Vision Science, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
J Vis 10:4.1-15. 2010..Results indicate that both M and P pathways undergo age-related changes, but functional losses appear greater for the P pathway under the conditions tested... - Changes in cellular structures revealed by ultra-high resolution retinal imaging in optic neuropathiesStacey S Choi
Department of Ophthalmology and Vision Science, 4860 Y Street, University of California Davis, Sacramento, CA 95817, USA
Invest Ophthalmol Vis Sci 49:2103-19. 2008..To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities... - The watercolor effect: quantitative evidence for luminance-dependent mechanisms of long-range color assimilationFrédéric Devinck
Section of Neurobiology, Physiology and Behavior, Department of Ophthalmology and Visual Science, University of California, Davis, 4860 Y Street, Suite 2400 Sacramento, CA 95817, USA
Vision Res 45:1413-24. 2005..The results support the hypothesis that the WCE is mediated by luminance-dependent mechanisms of long-range color assimilation... - Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics in patients with large drusenChristina Gerth
Department of Ophthalmology and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, USA
Arch Ophthalmol 121:1404-14. 2003.... - Multifocal electroretinogram: age-related changes for different luminance levelsChristina Gerth
Department of Ophthalmology, Section of Neurobiology, Physiology and Behavior, University of California Davis, 4860 Y Street, Suite 2400, Sacramento, CA 95817, USA
Graefes Arch Clin Exp Ophthalmol 240:202-8. 2002..m(-2)). The relative contribution of optical and neural factors to senescent change in response was evaluated... - Long-term renormalization of chromatic mechanisms following cataract surgeryPeter B Delahunt
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California Davis, 95817, USA
Vis Neurosci 21:301-7. 2004..The shifts in the achromatic point occur over a number of months and appear to occur independently of the fellow eye... - Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomographyRobert J Zawadzki
Vision Science and Advanced Retinal Imaging Laboratory VSRI, Department of Ophthalmology and Vision Science, University of California Davis, 4860 Y Street, Suite 2400, Sacramento, California 95817, USA
Opt Express 17:4084-94. 2009..Additionally, we explored the utility of Interactive Science Publishing by linking all presented AO-OCT datasets with the OSA ISP software... - mfERG response dynamics of the aging retinaChristina Gerth
Department of Ophthalmology, University of California, Davis, Sacramento, California 95817, USA
Invest Ophthalmol Vis Sci 44:4443-50. 2003..To determine age-related changes in retinal response dynamics derived from multifocal electroretinograms (mfERGs)... - High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repairAllison J Smith
Department of Ophthalmology and Vision Science, University of California Davis Medical Center, Sacramento, California, USA
Ophthalmology 115:1923-9. 2008.... - Color naming, lens aging, and grue: what the optics of the aging eye can teach us about color languageJoseph L Hardy
Department of Ophthalmology, University of California, 4860 Y St, Suite 2400, Sacramento, CA 95817, USA
Psychol Sci 16:321-7. 2005..Color naming for stimuli that were nominally green, blue-green, or blue was virtually identical for older and younger observers who viewed the same (unfiltered) stimuli. Our results are inconsistent with the lens-brunescence hypothesis... - Clinical application of rapid serial fourier-domain optical coherence tomography for macular imagingSuhail Alam
Department of Ophthalmology and Vision Science, University of California-Davis, Sacramento, California 95817, USA
Ophthalmology 113:1425-31. 2006.... 
Illusory color & the brain. Novel illusions suggest that the brain does not separate perception of color from perception of form and depthJohn S Werner
University of California, Davis, USA
Sci Am 296:90-5. 2007- Senescence of human multifocal electroretinogram components: a localized approachRadouil T Tzekov
Department of Ophthalmology, University of California-Davis, Suite 2400, 4860 Y Street, Sacramento, CA 95817, USA
Graefes Arch Clin Exp Ophthalmol 242:549-60. 2004..Information about changes in discrete retinal areas with age should make the mfERG more useful in quantitatively monitoring progression of retinal disease... - Illusory spreading of watercolorFrédéric Devinck
Section of Neurobiology, Physiology and Behavior, Department of Ophthalmology and Vision Science, University of California, Davis, CA, USA
J Vis 6:625-33. 2006..Our data suggest that the WCE depends critically upon the particular spatiochromatic arrangement in the display, with the relative chromatic contrast between the inducing contours being particularly important... - Cone-mediated multifocal electroretinogram in age-related macular degeneration: progression over a long-term follow-upChristina Gerth
Department of Ophthalmology and Vision Sciences and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, USA
Arch Ophthalmol 124:345-52. 2006..To evaluate the progression of change in the cone-driven multifocal electroretinogram (mfERG) responses in patients previously identified as having high-risk, soft drusen 63 mum or greater... - Senescence of spatial chromatic contrast sensitivity. II. Matching under natural viewing conditionsPeter B Delahunt
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California, Davis Medical Center, Sacramento, California 95817, USA
J Opt Soc Am A Opt Image Sci Vis 22:60-7. 2005..The results suggest that the perception of relative contrasts across spatial frequencies is stable with age... - Senescence of spatial chromatic contrast sensitivity. I. Detection under conditions controlling for optical factorsJoseph L Hardy
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California, Davis Medical Center, Sacramento, California 95817, USA
J Opt Soc Am A Opt Image Sci Vis 22:49-59. 2005..When stimuli were equated at the retina, the age-related difference in thresholds for S-varying stimuli was reduced. Both optical and neural factors contribute to these age-related losses in spatial chromatic contrast sensitivity... - Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patientsChristine Schupp
Department of Ophthalmology, School of Medicine, University of California, Davis, USA
Am J Clin Nutr 79:1045-52. 2004..The clinical implications of low plasma concentrations of carotenoids in CF are yet to be clarified... - Aging and the saturation of colors. 2. Scaling of color appearanceJ M Kraft
Department of Psychology, University of California, Santa Barbara 93106, USA
J Opt Soc Am A Opt Image Sci Vis 16:231-5. 1999.... - Senescent changes in parafoveal color appearance: saturation as a function of stimulus areaHolger Knau
Department of Ophthalmology, University of California, Davis, Sacramento 95817, USA
J Opt Soc Am A Opt Image Sci Vis 19:208-14. 2002..The data were modeled by using an impulse-response function (i.e., Naka-Rushton equation) so that perceptive fields could be compared to electrophysiological measures of receptive fields or dendritic fields of retinal and cortical cells... - Aging and the saturation of colors. 1. Colorimetric purity discriminationJ M Kraft
Department of Psychology, University of California, Santa Barbara 93106, USA
J Opt Soc Am A Opt Image Sci Vis 16:223-30. 1999..The model and the data indicate similar age-related losses of sensitivity in the two channels, perhaps secondary to receptorial sensitivity losses... - Variety of genotypes in males diagnosed as dichromatic on a conventional clinical anomaloscopeMaureen Neitz
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226 4812, USA
Vis Neurosci 21:205-16. 2004.... - Topography of the chromatic pattern-onset VEPChristina Gerth
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California Davis, CA, USA
J Vis 3:171-82. 2003..Our method for recording chromatic multifocal pattern-onset VEPs holds promise for clinical application to detect and monitor early retinal and optic nerve changes related to aging and disease... - Photopigment optical density of the human foveola and a paradoxical senescent increase outside the foveaAgnes B Renner
Department of Ophthalmology and Section of Neurobiology, Physiology and Behavior, University of California, Davis, Sacramento, CA 95817, USA
Vis Neurosci 21:827-34. 2004..Over the 70-year age range of our participants, the perifoveal M- and L-cones showed a 14% increase in capacity to absorb photons despite a 30% decrease in visual sensitivity over the same period... - Senescence of the temporal impulse response to a luminous pulseKeizo Shinomori
Department of Information Systems Engineering, Kochi University of Technology, 185 Miyanokuchi, Tosayamada town, Kami gun, Kochi 782 8502, Japan
Vision Res 43:617-27. 2003..The data suggest that the human visual system generally maintains a stable speed of response to a flash until at least about 80 years of age, even while there are senescent reductions in response signal amplitude... - The watercolor effect: a new principle of grouping and figure-ground organizationBaingio Pinna
Facolta di Lettere e Filosofia, Universita di Sassari, Piazza Conte di Moriana, 8, Sassari I 07100, Italy
Vision Res 43:43-52. 2003..These findings show that the watercolor effect induced by the edge could be an independent factor, different from the classical Gestalt factors of figure-ground organization... - Anomalous induction of brightness and surface qualities: a new illusion due to radial lines and chromatic ringsBaingio Pinna
A G Hirnforschung, Universitat Freiburg, Hansastrasse 9, D 79104 Freiburg, Germany
Perception 32:1289-305. 2003.... - Retinal morphological changes of patients with X-linked retinoschisis evaluated by Fourier-domain optical coherence tomographyChristina Gerth
Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Arch Ophthalmol 126:807-11. 2008..To investigate the retinal microstructure and lamination of patients affected with X-linked retinoschisis (XLRS) using high-resolution imaging modalities... - The effect of senescence on orientation discrimination and mechanism tuningPeter B Delahunt
Posit Science Corporation, San Francisco, CA 94104, USA
J Vis 8:5.1-9. 2008..This implies a model of orientation processing that allows the adult visual system to maintain consistent and reliable orientation information at the network and ultimately the perceptual level... - Evidence against age-related enlargements of ganglion cell receptive field centers under scotopic conditionsBrooke E Schefrin
Department of Psychology, University of Colorado, Boulder, CO 80309-0345, USA
Vision Res 44:423-8. 2004..This result is inconsistent with proposed age-related enlargements of ganglion cell receptive field centers under scotopic conditions... - Flashing anomalous color contrastBaingio Pinna
, AG Hirnforschung, Freiburg, Germany
Vis Neurosci 21:365-72. 2004..The stimulus properties inducing the illusion suggest that flashing anomalous color contrast may be based on asynchronous interactions among multiple visual pathways... - Impulse response of an S-cone pathway in the aging visual systemKeizo Shinomori
Department of Information Systems Engineering, Kochi University of Technology, Kami-city, Kochi 782-8502, Japan
J Opt Soc Am A Opt Image Sci Vis 23:1570-7. 2006..The results demonstrated significant age-related losses in IRF amplitude, but the latency (time to peak) of the IRF was stable with age... - Visualization of lipofuscin accumulation in Stargardt macular dystrophy by high-resolution Fourier-domain optical coherence tomographyChristina Gerth
Department of Ophthalmology, University ot Toronto and Hospital for Sick Children, ON, Canada
Arch Ophthalmol 125:575. 2007 - Nonlinearities in color coding: compensating color appearance for the eye's spectral sensitivityYoko Mizokami
Department of Psychology, University of Nevada, Reno, Reno, NV 89557, USA
J Vis 6:996-1007. 2006.... - Unveiling the foveal blue scotoma through an afterimageSvein Magnussen
Brain Research Unit, University of Freiburg, Hansastrasse 9, D-79104 Freiburg, Germany
Vision Res 44:377-83. 2004..The results support the hypothesis of an active post-receptoral process for filling-in of chromatic scotomas... - Retinal morphology in patients with BBS1 and BBS10 related Bardet-Biedl Syndrome evaluated by Fourier-domain optical coherence tomographyChristina Gerth
Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ont, Canada M5G 1X8
Vision Res 48:392-9. 2008..This is the first report of in-vivo micro-structural analysis of retinal layers in patients with BBS. Mutations in different BBS genes seem to be associated with similar micro-structural changes in retinal layers... - The impulse response of S-cone pathways in detection of increments and decrementsKeizo Shinomori
Department of Information Systems Engineering, Kochi University of Technology, Kami city, Koichi, Japan
Vis Neurosci 25:341-7. 2008..These results were used to derive the temporal contrast sensitivity for human observers of putative ON- and OFF-channels carrying signals from S-cones... - Characteristics of the normative database for the Humphrey matrix perimeterAndrew John Anderson
Discoveries in Sight, Devers Eye Institute, Portland, Oregon, USA
Invest Ophthalmol Vis Sci 46:1540-8. 2005..The finding of a spatially nonuniform difference in sensitivity between left and right eyes is attributable to light-adaptation differences between the eyes. This effect is accounted for in the perimeter's normative database...
Research Grants
- Ophthalmic Imaging Using Adaptive Optics and OCTJohn S Werner; Fiscal Year: 2010..These advanced imaging techniques will be deployed for evaluating the changes in the retina and optic nerve resulting from novel therapies for rescuing retinal layers from the leading causes of blindness. ..
- Ophthalmic Imaging Using Adaptive Optics and OCTJohn Werner; Fiscal Year: 2007..abstract_text> ..
- TRAINING PROGRAM IN VISION SCIENCEJohn Werner; Fiscal Year: 2007..All trainees will be engaged in vision science research that will be presented at national meetings and submitted to peer- reviewed journals. Postdoctoral training will have a strong emphasis on achieving independent research funding. ..
- OPTICAL AND NEURAL CHANGES IN THE AGING VISUAL SYSTEMJohn Werner; Fiscal Year: 2007..Fortype specifications, see ¿on page6.) RESEARCH GRANT TABLE OF CONTENTS ¿ . i PageNumbers Face Page .,4 1 Description, ..
- Ophthalmic Imaging Using Adaptive Optics and OCTJohn Werner; Fiscal Year: 2009..These advanced imaging techniques will be deployed for evaluating the changes in the retina and optic nerve resulting from novel therapies for rescuing retinal layers from the leading causes of blindness. ..