Janet M Wenzlau

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. doi request reprint SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
  2. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
  3. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
  4. doi request reprint Identification of a major humoral epitope in Slc30A8 (ZnT8)
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:252-5. 2008
  5. pmc Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8
    Mylinh Dang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:6056-63. 2011
  6. ncbi request reprint Novel antigens in type 1 diabetes: the importance of ZnT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, 1775 North Ursula Court, Aurora, CO 80045, USA
    Curr Diab Rep 9:105-12. 2009
  7. doi request reprint New antigenic targets in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 15:315-20. 2008
  8. pmc Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado, USA
    Diabetes Care 35:1213-8. 2012
  9. pmc Mapping of conformational autoantibody epitopes in ZNT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:883-6. 2011
  10. doi request reprint Novel diabetes autoantibodies and prediction of type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Aurora, CO, 80045, USA
    Curr Diab Rep 13:608-15. 2013

Collaborators

Detail Information

Publications10

  1. doi request reprint SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
    ..We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D...
  2. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders...
  3. pmc A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 57:2693-7. 2008
    ..The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes...
  4. doi request reprint Identification of a major humoral epitope in Slc30A8 (ZnT8)
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:252-5. 2008
    ..9%) of ZnT8(+) sera. We conclude that the C-terminal domain of human ZnT8 contains at least two discrete epitopes, one of which is critically dependent upon the arginine residue at position 325...
  5. pmc Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8
    Mylinh Dang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:6056-63. 2011
    ....
  6. ncbi request reprint Novel antigens in type 1 diabetes: the importance of ZnT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, 1775 North Ursula Court, Aurora, CO 80045, USA
    Curr Diab Rep 9:105-12. 2009
    ..The incorporation of genetic and structural epitope analysis into ZnT8A determinations adds a further dimension to its diagnostic value and understanding of its role in the autoimmune disease process...
  7. doi request reprint New antigenic targets in type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 15:315-20. 2008
    ..We examine the hypothesis that the cell specificity and cellular localization of this granule membrane protein are significant factors in its contribution to the pathogenesis of these diseases...
  8. pmc Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado, USA
    Diabetes Care 35:1213-8. 2012
    ....
  9. pmc Mapping of conformational autoantibody epitopes in ZNT8
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:883-6. 2011
    ..The goal of the current study was to extend this analysis to identify non-polymorphic epitopes in ZnT8...
  10. doi request reprint Novel diabetes autoantibodies and prediction of type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Aurora, CO, 80045, USA
    Curr Diab Rep 13:608-15. 2013
    ..In this review, we summarize some of the salient properties of these targets that might contribute to their autoantigenicity and methods that have been used in attempts to identify new components of the humoral autoresponse. ..