Sally Wenzel

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Dupilumab in persistent asthma with elevated eosinophil levels
    Sally Wenzel
    Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    N Engl J Med 368:2455-66. 2013
  2. pmc Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset
    John M Coleman
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC UPSOM, Pittsburgh, PA 15213, USA
    Thorax 67:1061-6. 2012
  3. doi request reprint Tissue-based and bronchoalveolar lavage-based biomarkers in asthma
    Sally E Wenzel
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Asthma Institute, University of Pittsburgh Medical Center, Montefiore Hospital, PA 15213, USA
    Immunol Allergy Clin North Am 32:401-11. 2012
  4. doi request reprint Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous features
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pulmonary Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 186:501-7. 2012
  5. doi request reprint Asthma phenotypes: the evolution from clinical to molecular approaches
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 18:716-25. 2012
  6. doi request reprint Severe asthma: from characteristics to phenotypes to endotypes
    S Wenzel
    Department of Medicine, Pulmonary, Allergy and Critical Care Medicine Division, Asthma Institute at UPMC UPSOM, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Exp Allergy 42:650-8. 2012
  7. doi request reprint A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    Sally E Wenzel
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 179:549-58. 2009
  8. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
  9. ncbi request reprint Severe asthma: lessons from the Severe Asthma Research Program
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:14-21; quiz 22-3. 2007
  10. pmc Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
    Raed A Dweik
    Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 181:1033-41. 2010

Detail Information

Publications60

  1. doi request reprint Dupilumab in persistent asthma with elevated eosinophil levels
    Sally Wenzel
    Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    N Engl J Med 368:2455-66. 2013
    ....
  2. pmc Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset
    John M Coleman
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC UPSOM, Pittsburgh, PA 15213, USA
    Thorax 67:1061-6. 2012
    ..However, the epithelial and bronchoalveolar lavage (BAL) cell expression of these chemokines in relation to asthma severity and eosinophilic phenotypes has not been addressed...
  3. doi request reprint Tissue-based and bronchoalveolar lavage-based biomarkers in asthma
    Sally E Wenzel
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Asthma Institute, University of Pittsburgh Medical Center, Montefiore Hospital, PA 15213, USA
    Immunol Allergy Clin North Am 32:401-11. 2012
    ..Although some biomarkers may only be associated with disease, it is also likely that some may be mechanistically involved. Some of these biomarkers may then also become targets for specific treatment...
  4. doi request reprint Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous features
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pulmonary Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 186:501-7. 2012
    ..Although it is increasingly recognized as consisting of numerous heterogenous phenotypes, their immunopathology, particularly in the distal airways and interstitium, remains poorly described...
  5. doi request reprint Asthma phenotypes: the evolution from clinical to molecular approaches
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 18:716-25. 2012
    ....
  6. doi request reprint Severe asthma: from characteristics to phenotypes to endotypes
    S Wenzel
    Department of Medicine, Pulmonary, Allergy and Critical Care Medicine Division, Asthma Institute at UPMC UPSOM, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Exp Allergy 42:650-8. 2012
    ..Moving forward, this integration of genetics, biology and clinical characteristics should substantially enhance our ability to effectively treat complex heterogeneous diseases, such as severe asthma...
  7. doi request reprint A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    Sally E Wenzel
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 179:549-58. 2009
    ..The treatment effect of golimumab, a human monoclonal antibody against tumor necrosis factor (TNF)-alpha, in severe persistent asthma is unknown...
  8. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  9. ncbi request reprint Severe asthma: lessons from the Severe Asthma Research Program
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:14-21; quiz 22-3. 2007
    ..Future studies will specifically evaluate the role of inflammatory/oxidative processes, infection, genetics, and the distal lung in the pathogenesis of severe asthma...
  10. pmc Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
    Raed A Dweik
    Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 181:1033-41. 2010
    ..Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more reactive, at-risk asthma phenotype...
  11. pmc Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program
    Christy Gamble
    University of Pittsburgh, USA
    J Allergy Clin Immunol 126:1149-56.e1. 2010
    ..Biologic factors are known to contribute to asthma severity. It is unknown whether these factors differentially contribute to asthma severity in black compared with white subjects...
  12. pmc Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function
    Weimin Liu
    Division of Allergy and Immunology, Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Mol Cell Biol 30:1783-99. 2010
    ..Thus, we have developed a cellular model of sustained ERK1/2 activation, which may provide a mechanistic understanding of self-sustained biological processes in chronic illnesses such as asthma...
  13. ncbi request reprint The safety and efficacy of zileuton controlled-release tablets as adjunctive therapy to usual care in the treatment of moderate persistent asthma: a 6-month randomized controlled study
    Sally Wenzel
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Asthma 44:305-10. 2007
    ..These elevations typically occurred (81.8%) during the first 3 months of exposure and most resolved within 21 days after discontinuation...
  14. ncbi request reprint Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    Sally Wenzel
    University of Pittsburgh, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA
    Lancet 370:1422-31. 2007
    ..Our aim was to assess the therapeutic effect of pitrakinra, an interleukin-4 variant that targets allergic Th2 inflammation by potently inhibiting the binding of interleukin 4 and interleukin 13 to interleukin-4Ralpha receptor complexes...
  15. doi request reprint Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways
    Weimin Liu
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:893-902.e2. 2008
    ..Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown...
  16. pmc IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes
    Silvana Balzar
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:855-62. 2007
    ..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes...
  17. doi request reprint The role of cytokines in chronic rhinosinusitis with nasal polyps
    Bradley A Otto
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Curr Opin Otolaryngol Head Neck Surg 16:270-4. 2008
    ..Chronic rhinosinusitis with nasal polyps is generally characterized by eosinophilic infiltration and a Th2-biased cytokine profile. However, the mechanisms that lead to nasal polyps are not clear...
  18. pmc Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 179:782-90. 2009
    ..IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown...
  19. pmc Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program
    Silvana Balzar
    University of Pittsburgh Asthma Institute at UPMC University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 183:299-309. 2011
    ..Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity...
  20. ncbi request reprint Physiologic and pathologic abnormalities in severe asthma
    Sally Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Chest Med 27:29-40, v. 2006
    ..Recent studies suggest that response to therapy in severe asthma may depend on the phenotype...
  21. ncbi request reprint Improvements in distal lung function correlate with asthma symptoms after treatment with oral montelukast
    Monica Kraft
    Department of Medicine, Duke University Medical Center, MSBR M201D, Durham, NC 27710, USA
    Chest 130:1726-32. 2006
    ..We hypothesized that treatment with montelukast, an oral cysteinyl-leukotriene receptor antagonist, would improve both proximal and distal lung physiology in patients with mild asthma...
  22. pmc Role of insulin-like growth factor binding protein-3 in allergic airway remodeling
    Kristen L Veraldi
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 180:611-7. 2009
    ....
  23. ncbi request reprint Increased TGF-beta2 in severe asthma with eosinophilia
    Silvana Balzar
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 115:110-7. 2005
    ..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities...
  24. ncbi request reprint Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13
    John Trudeau
    Department of Medicine, Division of Pulmonary, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:1446-54. 2006
    ....
  25. ncbi request reprint Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
    ..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product...
  26. pmc Pulmonary function abnormalities in HIV-infected patients during the current antiretroviral therapy era
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 182:790-6. 2010
    ..The prevalence and exact phenotype of pulmonary abnormalities in the current era are unknown. In addition, these abnormalities may be underdiagnosed...
  27. ncbi request reprint Tissue and BAL based biomarkers in asthma
    June Y Zhang
    Allergy Immunology Section, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Immunol Allergy Clin North Am 27:623-32; vi. 2007
    ..Efforts are to compare tissue and lavage biomarkers with less invasive measures, such as sputum, serum, or exhaled breath, to improve the treatment and management of asthma...
  28. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  29. ncbi request reprint Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study
    June H Lee
    Genentech, Inc, 1 DNA Way, MS 453B, South San Francisco, CA 94080, USA
    Chest 132:1882-9. 2007
    ..A better understanding is needed regarding factors associated with persistent airway obstruction; this study was performed to determine demographic and clinical characteristics associated with persistent airflow limitation...
  30. ncbi request reprint Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    Christina Miranda
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 113:101-8. 2004
    ..Asthma is a heterogeneous process, yet little is understood regarding phenotypes...
  31. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  32. ncbi request reprint Gender differences in IgE-mediated allergic asthma in the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study
    June H Lee
    Genentech, Inc, South San Francisco, California 94080, USA
    J Asthma 43:179-84. 2006
    ....
  33. ncbi request reprint Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004
    Leonardo Fabbri
    Medical, Oncological, and Radiological Sciences, University of Modena, Modena, Italy
    Am J Respir Crit Care Med 171:686-98. 2005
  34. ncbi request reprint Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both?
    Sally E Wenzel
    Am J Respir Crit Care Med 170:579-80. 2004
  35. pmc Regional fibroblast heterogeneity in the lung: implications for remodeling
    Chakradhar Kotaru
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 173:1208-15. 2006
    ..Whether differing fibrotic capacities of fibroblasts from these two regions contribute to this variability is unknown...
  36. pmc Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma
    Suzy A A Comhair
    Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Am J Respir Crit Care Med 172:306-13. 2005
    ....
  37. ncbi request reprint Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006
    ....
  38. ncbi request reprint Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
    ..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9...
  39. ncbi request reprint Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages
    Mai Lan N Huynh
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:972-9. 2005
    ..Clearance of apoptotic cells is crucial to the resolution of inflammation and development of fibrosis, but the process is not well understood in normal or diseased human lungs...
  40. ncbi request reprint Asthma: defining of the persistent adult phenotypes
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Lancet 368:804-13. 2006
    ..This Review analyses some of the methods that have been used to define asthma phenotypes and proposes an integrated method of classification to improve our understanding of these phenotypes...
  41. ncbi request reprint The role of leukotrienes in asthma
    Sally E Wenzel
    National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
    Prostaglandins Leukot Essent Fatty Acids 69:145-55. 2003
    ..While an anti-inflammatory effect is suggested, longer-term, earlier intervention, studies are needed to determine whether these compounds will have any effect on the natural history of the disease...
  42. pmc Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
    Am J Pathol 165:1097-106. 2004
    ..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation...
  43. ncbi request reprint Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts
    XiuXia Zhou
    National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Cell Physiol 288:C435-42. 2005
    ..Although IL-13 induced activation of PI3K-Akt, the activation did not contribute to the synergy observed with TGF-beta1 plus IL-13 in TIMP-1 expression and in fact may dampen it. The mechanisms behind the synergy remain to be determined...
  44. ncbi request reprint Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Med 112:627-33. 2002
    ....
  45. ncbi request reprint Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids
    Meghan Cundall
    Department of Medicine, National Jewish Center and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1064-71. 2003
    ..Matrix metalloproteinase (MMP)-9 levels are increased in bronchoalveolar lavage (BAL) fluid from patients with severe asthma on high doses of glucocorticoids (GCs)...
  46. ncbi request reprint TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 169:4613-9. 2002
    ..These results support the concept that interactions of innate and adaptive immune systems may be important in promoting the tissue eosinophilia of asthma, particularly in those with more severe disease...
  47. ncbi request reprint Ensuring quality in pharmaceutical studies
    Sally E Wenzel
    Am J Respir Crit Care Med 168:1010-1; author reply 1011-2. 2003
  48. ncbi request reprint Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation
    Raweewan Hoontrakoon
    Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 26:404-12. 2002
    ..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation...
  49. ncbi request reprint Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy
    Michael O Daines
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 119:375-83. 2007
    ..Despite the critical role of allergens in the pathogenesis of these disorders, little is known about how allergens modulate the immune response. IL-13 receptor alpha2 (IL-13Ralpha2) is a decoy receptor for IL-13...
  50. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  51. ncbi request reprint Recent asthma exacerbations: a key predictor of future exacerbations
    Mary K Miller
    Genentech, Inc, South San Francisco, CA 94080, USA
    Respir Med 101:481-9. 2007
    ..The objective of this analysis was to investigate whether patients with severe or difficult-to-treat asthma who experienced recent severe asthma exacerbations are at increased risk of future asthma exacerbations...
  52. ncbi request reprint Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?
    Sally E Wenzel
    Am J Respir Crit Care Med 174:364-5. 2006
  53. ncbi request reprint Asthma in older adults: observations from the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study
    Raymond G Slavin
    Department of Internal Medicine, Division of Allergy and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Ann Allergy Asthma Immunol 96:406-14. 2006
    ..More than 280 pulmonologist and allergist sites across the United States participated...
  54. ncbi request reprint A profile of U.S. asthma centers, 2006
    Ashley F Sullivan
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Allergy Asthma Immunol 99:419-23. 2007
    ..Asthma is a significant public health problem that results in 1.8 million annual emergency department (ED) visits. Many ED visits may be prevented with specialized asthma care...
  55. ncbi request reprint Update in asthma 2005
    Sally E Wenzel
    National Jewish Medical and Research Center for Immunology, Denver, Colorado, USA
    Am J Respir Crit Care Med 173:698-706. 2006
  56. ncbi request reprint Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Narbeth, PA 19072, USA
    J Allergy Clin Immunol 116:1249-55. 2005
    ..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy...
  57. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  58. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  59. ncbi request reprint Severity assessment in asthma: An evolving concept
    Mary K Miller
    Genentech, Inc, South San Francisco, CA 94080, USA
    J Allergy Clin Immunol 116:990-5. 2005
    ..Thus, the accuracy of such assessments is essential for proper clinical management. The consistency of asthma severity assessment in patients with difficult-to-treat disease is unknown...
  60. ncbi request reprint Characterization of autopsy-proven fatal asthma patients in São Paulo, Brazil
    Thais Mauad
    Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
    Rev Panam Salud Publica 23:418-23. 2008
    ..3%) deaths took place outside a hospital. We conclude that this population shares characteristics of severe or poorly controlled asthma, low educational and socioeconomic levels, and lack of medical care and of inhaled steroid use...

Research Grants35

  1. Th2 effects on eicosanoid pathways: implications for altered innate responses
    Sally Wenzel; Fiscal Year: 2007
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
  2. Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
    Sally E Wenzel; Fiscal Year: 2010
    ..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..
  3. TGF-beta2 and IL-4Ralpha Pathway Interactions in Asthma
    Sally Wenzel; Fiscal Year: 2007
    ..abstract_text> ..
  4. TGF-beta2 and IL-4Ralpha Pathway Interactions in Asthma
    Sally Wenzel; Fiscal Year: 2009
    ..abstract_text> ..
  5. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
  6. Amplification of IL-4Ralpha signaling pathways in human airways through 15 LO1
    Sally E Wenzel; Fiscal Year: 2010
    ..Finally, these interactions open up new opportunities for innovative molecular approaches to drug development. ..
  7. LEUKOTRIENE B4 IN GLUCOCORTOCOID INSENSITIVE ASTHMA
    Sally Wenzel; Fiscal Year: 1999
    ....
  8. TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIR
    Sally Wenzel; Fiscal Year: 2002
    ..abstract_text> ..
  9. TGF-BETA AND 15 HETE IN POORLY STEROID RESPONSIVE ASTHMA
    Sally Wenzel; Fiscal Year: 2004
    ..abstract_text> ..
  10. IL-13, MYOFIBROBLASTS & ELASTIC RECOIL IN SEVERE ASTHMA
    Sally Wenzel; Fiscal Year: 2005
    ..Completing these studies in both asthma and emphysema should offer new targets for the treatment and prevention of severe obstructive lung diseases. ..
  11. Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
    Sally E Wenzel; Fiscal Year: 2010
    ..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..