Research Topics
Genomes and Genes | Sally WenzelSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onsetJohn M Coleman
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC UPSOM, Pittsburgh, PA 15213, USA
Thorax 67:1061-6. 2012..However, the epithelial and bronchoalveolar lavage (BAL) cell expression of these chemokines in relation to asthma severity and eosinophilic phenotypes has not been addressed...- Tissue-based and bronchoalveolar lavage-based biomarkers in asthmaSally E Wenzel
Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Asthma Institute, University of Pittsburgh Medical Center, Montefiore Hospital, PA 15213, USA
Immunol Allergy Clin North Am 32:401-11. 2012..Although some biomarkers may only be associated with disease, it is also likely that some may be mechanistically involved. Some of these biomarkers may then also become targets for specific treatment... - Asthmatic granulomatosis: a novel disease with asthmatic and granulomatous featuresSally E Wenzel
University of Pittsburgh Asthma Institute at University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pulmonary Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Respir Crit Care Med 186:501-7. 2012..Although it is increasingly recognized as consisting of numerous heterogenous phenotypes, their immunopathology, particularly in the distal airways and interstitium, remains poorly described... - Asthma phenotypes: the evolution from clinical to molecular approachesSally E Wenzel
University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Nat Med 18:716-25. 2012.... - Severe asthma: from characteristics to phenotypes to endotypesS Wenzel
Department of Medicine, Pulmonary, Allergy and Critical Care Medicine Division, Asthma Institute at UPMC UPSOM, University of Pittsburgh, Pittsburgh, PA 15213, USA
Clin Exp Allergy 42:650-8. 2012..Moving forward, this integration of genetics, biology and clinical characteristics should substantially enhance our ability to effectively treat complex heterogeneous diseases, such as severe asthma... 
IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expressionSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 175:570-6. 2007..However, an effect on exacerbations and tissue inflammation has not been shown...
Severe asthma: lessons from the Severe Asthma Research ProgramSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Allergy Clin Immunol 119:14-21; quiz 22-3. 2007..Future studies will specifically evaluate the role of inflammatory/oxidative processes, infection, genetics, and the distal lung in the pathogenesis of severe asthma...- A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthmaSally E Wenzel
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 179:549-58. 2009..The treatment effect of golimumab, a human monoclonal antibody against tumor necrosis factor (TNF)-alpha, in severe persistent asthma is unknown... - Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthmaRaed A Dweik
Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 181:1033-41. 2010..Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more reactive, at-risk asthma phenotype... - Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research ProgramChristy Gamble
University of Pittsburgh, USA
J Allergy Clin Immunol 126:1149-56.e1. 2010..Biologic factors are known to contribute to asthma severity. It is unknown whether these factors differentially contribute to asthma severity in black compared with white subjects... - Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial functionWeimin Liu
Division of Allergy and Immunology, Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Mol Cell Biol 30:1783-99. 2010..Thus, we have developed a cellular model of sustained ERK1/2 activation, which may provide a mechanistic understanding of self-sustained biological processes in chronic illnesses such as asthma... - Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studiesSally Wenzel
University of Pittsburgh, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA
Lancet 370:1422-31. 2007..Our aim was to assess the therapeutic effect of pitrakinra, an interleukin-4 variant that targets allergic Th2 inflammation by potently inhibiting the binding of interleukin 4 and interleukin 13 to interleukin-4Ralpha receptor complexes... - Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airwaysWeimin Liu
Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 121:893-902.e2. 2008..Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown... - The safety and efficacy of zileuton controlled-release tablets as adjunctive therapy to usual care in the treatment of moderate persistent asthma: a 6-month randomized controlled studySally Wenzel
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Asthma 44:305-10. 2007..These elevations typically occurred (81.8%) during the first 3 months of exposure and most resolved within 21 days after discontinuation... - Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research ProgramSilvana Balzar
University of Pittsburgh Asthma Institute at UPMC University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 183:299-309. 2011..Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity... - Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cellsJinming Zhao
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 179:782-90. 2009..IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown... - The role of cytokines in chronic rhinosinusitis with nasal polypsBradley A Otto
Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Curr Opin Otolaryngol Head Neck Surg 16:270-4. 2008..Chronic rhinosinusitis with nasal polyps is generally characterized by eosinophilic infiltration and a Th2-biased cytokine profile. However, the mechanisms that lead to nasal polyps are not clear... - IgE expression pattern in lung: relation to systemic IgE and asthma phenotypesSilvana Balzar
Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
J Allergy Clin Immunol 119:855-62. 2007..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes... - Physiologic and pathologic abnormalities in severe asthmaSally Wenzel
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Clin Chest Med 27:29-40, v. 2006..Recent studies suggest that response to therapy in severe asthma may depend on the phenotype... - Improvements in distal lung function correlate with asthma symptoms after treatment with oral montelukastMonica Kraft
Department of Medicine, Duke University Medical Center, MSBR M201D, Durham, NC 27710, USA
Chest 130:1726-32. 2006..We hypothesized that treatment with montelukast, an oral cysteinyl-leukotriene receptor antagonist, would improve both proximal and distal lung physiology in patients with mild asthma... - Role of insulin-like growth factor binding protein-3 in allergic airway remodelingKristen L Veraldi
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 180:611-7. 2009.... - Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblastsXiuXia Zhou
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Allergy Clin Immunol 119:1388-97. 2007..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product... - Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13John Trudeau
Department of Medicine, Division of Pulmonary, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 117:1446-54. 2006.... - Increased TGF-beta2 in severe asthma with eosinophiliaSilvana Balzar
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
J Allergy Clin Immunol 115:110-7. 2005..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities... - Pulmonary function abnormalities in HIV-infected patients during the current antiretroviral therapy eraMatthew R Gingo
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 182:790-6. 2010..The prevalence and exact phenotype of pulmonary abnormalities in the current era are unknown. In addition, these abnormalities may be underdiagnosed... - Tissue and BAL based biomarkers in asthmaJune Y Zhang
Allergy Immunology Section, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Immunol Allergy Clin North Am 27:623-32; vi. 2007..Efforts are to compare tissue and lavage biomarkers with less invasive measures, such as sputum, serum, or exhaled breath, to improve the treatment and management of asthma... - Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004Leonardo Fabbri
Medical, Oncological, and Radiological Sciences, University of Modena, Modena, Italy
Am J Respir Crit Care Med 171:686-98. 2005 - Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammationChristina Miranda
National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 113:101-8. 2004..CONCLUSIONS: Differentiating severe asthma by age at onset and presence or absence of eosinophils identifies phenotypes of asthma, which could benefit subsequent genetic and therapeutic studies... - Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component... - Phenotypes in asthma: useful guides for therapy, distinct biological processes, or both?Sally E Wenzel
Am J Respir Crit Care Med 170:579-80. 2004 - Regional fibroblast heterogeneity in the lung: implications for remodelingChakradhar Kotaru
National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
Am J Respir Crit Care Med 173:1208-15. 2006..Whether differing fibrotic capacities of fibroblasts from these two regions contribute to this variability is unknown... - Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repairSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 111:1345-52. 2003..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9... - Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptomsSilvana Balzar
National Jewish Medical and Research Center, Denver, CO 80206, USA
Int Arch Allergy Immunol 140:96-102. 2006.... - Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:405-13. 2007..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important... - Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthmaSuzy A A Comhair
Department of Pathology, Cleveland Clinic Foundation, OH 44195, USA
Am J Respir Crit Care Med 172:306-13. 2005.... - Gender differences in IgE-mediated allergic asthma in the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) studyJune H Lee
Genentech, Inc, South San Francisco, California 94080, USA
J Asthma 43:179-84. 2006.... - Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophagesMai Lan N Huynh
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
Am J Respir Crit Care Med 172:972-9. 2005..Clearance of apoptotic cells is crucial to the resolution of inflammation and development of fibrosis, but the process is not well understood in normal or diseased human lungs... - Asthma: defining of the persistent adult phenotypesSally E Wenzel
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Lancet 368:804-13. 2006..This Review analyses some of the methods that have been used to define asthma phenotypes and proposes an integrated method of classification to improve our understanding of these phenotypes... - Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR studyJune H Lee
Genentech, Inc, 1 DNA Way, MS 453B, South San Francisco, CA 94080, USA
Chest 132:1882-9. 2007..A better understanding is needed regarding factors associated with persistent airway obstruction; this study was performed to determine demographic and clinical characteristics associated with persistent airflow limitation... - Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblastsXiuXia Zhou
National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Am J Physiol Cell Physiol 288:C435-42. 2005..Although IL-13 induced activation of PI3K-Akt, the activation did not contribute to the synergy observed with TGF-beta1 plus IL-13 in TIMP-1 expression and in fact may dampen it. The mechanisms behind the synergy remain to be determined... - Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthmaHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
Am J Pathol 165:1097-106. 2004..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation... - Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoidsMeghan Cundall
Department of Medicine, National Jewish Center and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 112:1064-71. 2003..22). Peripheral blood neutrophil MMP-9 protein was not affected by GCs. CONCLUSIONS: BAL neutrophils contribute to BAL fluid MMP-9 protein and activity and are poorly inhibited by GCs... - Ensuring quality in pharmaceutical studiesSally E Wenzel
Am J Respir Crit Care Med 168:1010-1; author reply 1011-2. 2003 - The role of leukotrienes in asthmaSally E Wenzel
National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
Prostaglandins Leukot Essent Fatty Acids 69:145-55. 2003..While an anti-inflammatory effect is suggested, longer-term, earlier intervention, studies are needed to determine whether these compounds will have any effect on the natural history of the disease... - TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblastsSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Immunol 169:4613-9. 2002..These results support the concept that interactions of innate and adaptive immune systems may be important in promoting the tissue eosinophilia of asthma, particularly in those with more severe disease... - Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulinSally E Wenzel
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Med 112:627-33. 2002..Larger-scale studies are needed... - Recent asthma exacerbations: a key predictor of future exacerbationsMary K Miller
Genentech, Inc, South San Francisco, CA 94080, USA
Respir Med 101:481-9. 2007..The objective of this analysis was to investigate whether patients with severe or difficult-to-treat asthma who experienced recent severe asthma exacerbations are at increased risk of future asthma exacerbations... - Characterization of autopsy-proven fatal asthma patients in São Paulo, BrazilThais Mauad
Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
Rev Panam Salud Publica 23:418-23. 2008..3%) deaths took place outside a hospital. We conclude that this population shares characteristics of severe or poorly controlled asthma, low educational and socioeconomic levels, and lack of medical care and of inhaled steroid use... - Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergyMichael O Daines
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 119:375-83. 2007..Despite the critical role of allergens in the pathogenesis of these disorders, little is known about how allergens modulate the immune response. IL-13 receptor alpha2 (IL-13Ralpha2) is a decoy receptor for IL-13... - Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?Sally E Wenzel
Am J Respir Crit Care Med 174:364-5. 2006 - Asthma in older adults: observations from the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) studyRaymond G Slavin
Department of Internal Medicine, Division of Allergy and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Ann Allergy Asthma Immunol 96:406-14. 2006..More than 280 pulmonologist and allergist sites across the United States participated... - Severe asthma in adults: what are the important questions?Pascal Chanez
INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
J Allergy Clin Immunol 119:1337-48. 2007..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies... - Update in asthma 2005Sally E Wenzel
National Jewish Medical and Research Center for Immunology, Denver, Colorado, USA
Am J Respir Crit Care Med 173:698-706. 2006 - Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthmaPhilip E Silkoff
National Jewish Medical and Research Center, Narbeth, PA 19072, USA
J Allergy Clin Immunol 116:1249-55. 2005..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy... - A profile of U.S. asthma centers, 2006Ashley F Sullivan
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Ann Allergy Asthma Immunol 99:419-23. 2007..Asthma is a significant public health problem that results in 1.8 million annual emergency department (ED) visits. Many ED visits may be prevented with specialized asthma care... - Severity assessment in asthma: An evolving conceptMary K Miller
Genentech, Inc, South San Francisco, CA 94080, USA
J Allergy Clin Immunol 116:990-5. 2005..Thus, the accuracy of such assessments is essential for proper clinical management. The consistency of asthma severity assessment in patients with difficult-to-treat disease is unknown... - Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activationRaweewan Hoontrakoon
Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Cell Mol Biol 26:404-12. 2002..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation... - Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthmaAnna Planagumà
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 178:574-82. 2008..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation... - Alterations of the arginine metabolome in asthmaAbigail Lara
Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 178:673-81. 2008..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
Research Grants
- Th2 effects on eicosanoid pathways: implications for altered innate responsesSally Wenzel; Fiscal Year: 2007..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
- Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe AsthmaSally E Wenzel; Fiscal Year: 2010..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..
- TGF-beta2 and IL-4Ralpha Pathway Interactions in AsthmaSally Wenzel; Fiscal Year: 2007..abstract_text> ..
- TGF-beta2 and IL-4Ralpha Pathway Interactions in AsthmaSally Wenzel; Fiscal Year: 2009..abstract_text> ..
- Th2 effects on eicosanoid pathways: implications for altered innate responses inSally E Wenzel; Fiscal Year: 2010..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
- Amplification of IL-4Ralpha signaling pathways in human airways through 15 LO1Sally E Wenzel; Fiscal Year: 2010..Finally, these interactions open up new opportunities for innovative molecular approaches to drug development. ..
- LEUKOTRIENE B4 IN GLUCOCORTOCOID INSENSITIVE ASTHMASally Wenzel; Fiscal Year: 1999....
- TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIRSally Wenzel; Fiscal Year: 2002..abstract_text> ..
- TGF-BETA AND 15 HETE IN POORLY STEROID RESPONSIVE ASTHMASally Wenzel; Fiscal Year: 2004..abstract_text> ..
- IL-13, MYOFIBROBLASTS & ELASTIC RECOIL IN SEVERE ASTHMASally Wenzel; Fiscal Year: 2005..Completing these studies in both asthma and emphysema should offer new targets for the treatment and prevention of severe obstructive lung diseases. ..
- Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe AsthmaSally E Wenzel; Fiscal Year: 2010..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..