Gary L Wenk

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Inflammation and aging: can endocannabinoids help?
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Biomed Pharmacother 62:212-7. 2008
  2. ncbi request reprint The neural mechanisms underlying cholinergic cell death within the basal forebrain
    G L Wenk
    Arizona Research Laboratory, University of Arizona, Tucson 85724, USA
    Int J Dev Neurosci 16:729-35. 1998
  3. ncbi request reprint The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation
    G L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, 350 Life Sciences North Building, Tucson, AZ 85724, USA
    Neuroscience 125:769-76. 2004
  4. ncbi request reprint Neuropathologic changes in Alzheimer's disease
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, The University of Arizona, Tucson 85724, USA
    J Clin Psychiatry 64:7-10. 2003
  5. ncbi request reprint A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724, USA
    Eur J Pharmacol 453:319-24. 2002
  6. ncbi request reprint Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurochem 89:484-93. 2004
  7. ncbi request reprint Regional changes in the hippocampal density of AMPA and NMDA receptors across the lifespan of the rat
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ, USA
    Brain Res 885:1-5. 2000
  8. ncbi request reprint Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724, USA
    Eur J Pharmacol 402:77-85. 2000
  9. ncbi request reprint No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use
    G L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724, USA
    Life Sci 66:1079-83. 2000
  10. ncbi request reprint The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 121:719-29. 2003

Collaborators

Detail Information

Publications41

  1. pmc Inflammation and aging: can endocannabinoids help?
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Biomed Pharmacother 62:212-7. 2008
    ..The basis for the manipulation of the endocannabinoid system in the brain in combination with existing treatments for Alzheimer's disease will be discussed in this review...
  2. ncbi request reprint The neural mechanisms underlying cholinergic cell death within the basal forebrain
    G L Wenk
    Arizona Research Laboratory, University of Arizona, Tucson 85724, USA
    Int J Dev Neurosci 16:729-35. 1998
    ..This chapter will focus upon the NBM cholinergic system because this regions typically demonstrates a greater degree of cell loss with aging and AD...
  3. ncbi request reprint The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation
    G L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, 350 Life Sciences North Building, Tucson, AZ 85724, USA
    Neuroscience 125:769-76. 2004
    ..These results provide insight into the mechanism by which neuroinflammation may selectively target specific neural systems during the progression of Alzheimer's disease...
  4. ncbi request reprint Neuropathologic changes in Alzheimer's disease
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, The University of Arizona, Tucson 85724, USA
    J Clin Psychiatry 64:7-10. 2003
    ....
  5. ncbi request reprint A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724, USA
    Eur J Pharmacol 453:319-24. 2002
    ..Daily administration of the HCT1026 significantly reduced microglial activation and these effects were not attenuated by galantamine therapy...
  6. ncbi request reprint Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurochem 89:484-93. 2004
    ....
  7. ncbi request reprint Regional changes in the hippocampal density of AMPA and NMDA receptors across the lifespan of the rat
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ, USA
    Brain Res 885:1-5. 2000
    ....
  8. ncbi request reprint Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724, USA
    Eur J Pharmacol 402:77-85. 2000
    ..These results suggest that prostaglandins contribute to the degeneration of forebrain cholinergic neurons in Alzheimer's disease...
  9. ncbi request reprint No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use
    G L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724, USA
    Life Sci 66:1079-83. 2000
    ..Our in vitro data suggest that the clinical combination of memantine with a reversible AChE inhibitor should be a valuable pharmacotherapeutic approach to dementia...
  10. ncbi request reprint The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 121:719-29. 2003
    ..The results suggest that noradrenergic cell loss in Alzheimer's disease does not augment the consequences of the chronic neuroinflammation and does not enhance neurodegeneration of forebrain cholinergic neurons...
  11. ncbi request reprint Neuroprotection by novel antagonists at the NMDA receptor channel and glycineB sites
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724, USA
    Eur J Pharmacol 347:183-7. 1998
    ..Acute administration (i.p.) of MRZ 2/579, 2/570, 2/571 and 2/576 provided significant neuroprotection from NMDA...
  12. ncbi request reprint The nucleus basalis magnocellularis cholinergic system: one hundred years of progress
    G L Wenk
    Division of Neural Systems, Memory and Aging, Arizona Research Laboratories, University of Arizona, Tucson 85724, USA
    Neurobiol Learn Mem 67:85-95. 1997
    ....
  13. ncbi request reprint Rett syndrome: neurobiological changes underlying specific symptoms
    G L Wenk
    Department of Psychology, University of Arizona, Tucson 85724, USA
    Prog Neurobiol 51:383-91. 1997
    ..Overall, the clinical, biochemical and neuropathological data suggest that RS is a neurodevelopmental disorder that has its greatest effects upon a limited number of neural systems during the first few years of postnatal life...
  14. ncbi request reprint The influence of brain inflammation upon neuronal adenosine A2B receptors
    Susanna Rosi
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724, USA
    J Neurochem 86:220-7. 2003
    ..The results suggest that a therapy using an NO-releasing NSAID might significantly attenuate the processes that drive the pathology associated with AD and that this process may involve the activation of adenosine A2B receptors...
  15. ncbi request reprint Neuropathologic changes in Alzheimer's disease: potential targets for treatment
    Gary L Wenk
    Department of Psychology, Ohio State University, Columbus, OH 43210, USA
    J Clin Psychiatry 67:3-7; quiz 23. 2006
    ....
  16. ncbi request reprint Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat
    S Rosi
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 142:1303-15. 2006
    ..Combined, these findings suggest that low, therapeutically relevant doses of memantine delivered early in the development of neuroinflammation-influenced diseases may confer neural and cognitive protection...
  17. ncbi request reprint Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
    ..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
  18. pmc Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus
    Isabelle Bardou
    Department of Psychology, Ohio State University, Columbus, OH 43210, USA
    Neurobiol Aging 34:2293-301. 2013
    ..The duration- and age-dependent consequences of neuroinflammation might explain why human adults respond positively to anti-inflammatory therapies and aged humans do not. ..
  19. pmc Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats
    Yannick Marchalant
    Department of Psychology, Psychology Building, Ohio State University, Columbus, OH 43210, USA
    Neurobiol Aging 29:1894-901. 2008
    ..Stimulation of cannabinoid receptors may provide clinical benefits in age-related diseases that are associated with brain inflammation, such as Alzheimer's disease...
  20. ncbi request reprint Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses
    B Hauss-Wegrzyniak
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724, USA
    Exp Neurol 176:336-41. 2002
    ..Similar changes may underlie the temporal lobe pathology and dementia associated with AD...
  21. ncbi request reprint Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Aging 25:807-16. 2004
    ....
  22. pmc Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
    Y Marchalant
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, USA
    Neuroscience 144:1516-22. 2007
    ....
  23. doi request reprint Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem
    Isabelle Bardou
    Department of Psychology, The Ohio State University, Columbus, OH, USA Department of Neuroscience, The Ohio State University, Columbus, OH, USA
    Neurobiol Aging 35:1065-73. 2014
    ....
  24. pmc Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory
    Holly m Brothers
    Department of Psychology, Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA
    J Neuroimmune Pharmacol 8:1098-105. 2013
    ..Our findings highlight the therapeutic potential of reducing glutamatergic function upon memory impairment in neurodegenerative diseases associated with aging. ..
  25. doi request reprint Circadian phase in sleep-disturbed adolescents with a history of substance abuse: a pilot study
    Brant P Hasler
    Department of Psychology, University of Arizona, Box 210068, Tucson, AZ 85721, USA
    Behav Sleep Med 6:55-73. 2008
    ..However, circadian phase and its relationship to sleep may have sleep and behavioral consequences...
  26. ncbi request reprint Neuroprotection and selective vulnerability of neurons within the nucleus basalis magnocellularis
    G L Wenk
    Department of Psychology, 384 Life Sciences North, University of Arizona, Tucson 85724, USA
    Behav Brain Res 72:17-24. 1995
    ....
  27. ncbi request reprint Long-term estrogen therapy worsens the behavioral and neuropathological consequences of chronic brain inflammation
    L K Marriott
    Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson 85724, USA
    Behav Neurosci 116:902-11. 2002
    ..Results suggest that chronic ERT in postmenopausal women may exacerbate the memory impairment induced by the chronic neuroinflammation associated with AD...
  28. ncbi request reprint Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors
    C A Barnes
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North Building, Tucson, AZ 85724, USA
    Neuroscience 99:17-23. 2000
    ....
  29. ncbi request reprint Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B
    G L Wenk
    Arizona Research Laboratories, Department of Psychology, University of Arizona, Tucson, USA Internet
    Behav Brain Res 83:129-33. 1997
    ..Thus, memantine infusion at low doses leading to steady-state serum levels within a therapeutic range provides both neuroprotection and cognitive enhancement-an optimal combination for the treatment of neurodegenerative disorders...
  30. pmc Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:3446-52. 2011
    ..Furthermore, we provide evidence that pharmacological activation of α7 nicotinic acetylcholine receptors provide significant protection against ischemia-related cell death and inflammation within a clinically relevant time frame...
  31. ncbi request reprint Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle
    Beatrice Hauss-Wegrzyniak
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neurosci Lett 322:75-8. 2002
    ..Solutions that did not contain ascorbic acid were not associated with increased intraneuronal beta-amyloid immunoreactivity. The role of neprilysin in the deposition of beta-amyloid in AD brains remains undetermined...
  32. ncbi request reprint Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease
    S Rosi
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 134:671-6. 2005
    ..The present study suggests that DAPTA and other CCR5 antagonists may attenuate critical aspects of the neuroinflammation associated with Alzheimer's disease...
  33. ncbi request reprint Assessment of spatial memory using the T maze
    G L Wenk
    University of Arizona, Tucson, Arizona, USA
    Curr Protoc Neurosci . 2001
    ..e., on any day of testing). Finally, in the absence of food-deprivation, a simple T maze can be used as described to assess spontaneous alternation...
  34. ncbi request reprint Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    Paul T Jantzen
    Department of Pharmacology, Alzheimer s Research Laboratory, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 22:2246-54. 2002
    ..In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia...
  35. ncbi request reprint Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine
    Gary L Wenk
    Department Psychology and Neuroscience, Ohio State University, Ohio, USA
    Behav Pharmacol 17:411-24. 2006
    ....
  36. ncbi request reprint Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression
    Susanna Rosi
    Department of Neuroscience and Neurology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 25:723-31. 2005
    ..This activity-related alteration in Arc expression induced by neuroinflammation may contribute to the cognitive deficits found in diseases associated with inflammation, such as AD...
  37. ncbi request reprint The lowdown on Ginkgo biloba
    Paul E Gold
    University of Illinois at Urbana Champaign, USA
    Sci Am 288:86-91. 2003
  38. ncbi request reprint The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4457, USA
    CNS Drug Rev 9:275-308. 2003
    ....
  39. ncbi request reprint Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study
    Giancarlo Aldini
    Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    Life Sci 71:1487-500. 2002
    ..These data indicate that the NO molecule is not released from the parent drug within the brain...
  40. ncbi request reprint APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease
    Hafiz Mohmmad Abdul
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurosci Lett 368:148-50. 2004
    ..The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid peroxidation, independent of dietary cholesterol. These results are discussed with reference to proposed therapeutic strategies of AD...
  41. ncbi request reprint Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor
    Craige C Wrenn
    Laboratory of Behavioural Neuroscience, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Eur J Neurosci 19:1384-96. 2004
    ..The generally normal phenotype of GAL-R1 null mutants supports the use of this line for identification of the receptor subtypes that mediate the cognitive deficits produced by exogenous galanin...