Y Wen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Helicobacter pylori 5'ureB-sRNA, a cis-encoded antisense small RNA, negatively regulates ureAB expression by transcription termination
    Yi Wen
    Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    J Bacteriol 195:444-52. 2013
  2. ncbi request reprint Functional analysis of the promoter and chromosomal localization for human LEP503, a novel lens epithelium gene
    Y Wen
    The Membrane Biology Laboratory, Department of Physiology, School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Gene 269:61-71. 2001
  3. pmc The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, California 90073, USA
    J Bacteriol 191:449-60. 2009
  4. ncbi request reprint A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West Los Angeles VA Medical Center and UCLA, Los Angeles, CA 90073, USA
    Exp Eye Res 70:159-68. 2000
  5. pmc The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, USA
    J Bacteriol 189:2426-34. 2007
  6. pmc Involvement of the HP0165-HP0166 two-component system in expression of some acidic-pH-upregulated genes of Helicobacter pylori
    Yi Wen
    Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Bacteriol 188:1750-61. 2006
  7. pmc A cis-encoded antisense small RNA regulated by the HP0165-HP0166 two-component system controls expression of ureB in Helicobacter pylori
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, 11301 Wilshire Blvd, Bldg 113, Rm 324, Los Angeles, CA 90073, USA
    J Bacteriol 193:40-51. 2011
  8. ncbi request reprint Lens epithelial cell mRNA. I. Cloning and sequencing of a messenger RNA with a basic motif/leucine-rich domain specifically expressed in rat lens epithelial cells
    Y Wen
    Laboratory of Lens Molecular Biology, Doheny Eye Institute, Los Angeles, CA, USA
    Exp Eye Res 60:675-82. 1995
  9. ncbi request reprint Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West, Los Angeles VA Medical Center and UCLA, Los Angeles, California, 90073, USA
    Biochem Biophys Res Commun 258:713-21. 1999
  10. ncbi request reprint Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina
    Y Wen
    Department of Medicine, West Los Angeles VA Medical Center, California, USA
    J Biol Chem 273:2090-7. 1998

Collaborators

Detail Information

Publications42

  1. pmc Helicobacter pylori 5'ureB-sRNA, a cis-encoded antisense small RNA, negatively regulates ureAB expression by transcription termination
    Yi Wen
    Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    J Bacteriol 195:444-52. 2013
    ..With this mechanism, a limited amount of 5'ureB-sRNA is sufficient to regulate the relatively high level of ureAB transcript...
  2. ncbi request reprint Functional analysis of the promoter and chromosomal localization for human LEP503, a novel lens epithelium gene
    Y Wen
    The Membrane Biology Laboratory, Department of Physiology, School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Gene 269:61-71. 2001
    ..The LEP503 gene is mapped to human chromosome 1q22, the same location to which zonular pulverulent cataract was previously mapped...
  3. pmc The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, California 90073, USA
    J Bacteriol 191:449-60. 2009
    ....
  4. ncbi request reprint A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West Los Angeles VA Medical Center and UCLA, Los Angeles, CA 90073, USA
    Exp Eye Res 70:159-68. 2000
    ..These data suggest that the LEP503 may be an important lens epithelial cell gene involving the processes of epithelial cell differentiation...
  5. pmc The HP0165-HP0166 two-component system (ArsRS) regulates acid-induced expression of HP1186 alpha-carbonic anhydrase in Helicobacter pylori by activating the pH-dependent promoter
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, USA
    J Bacteriol 189:2426-34. 2007
    ....
  6. pmc Involvement of the HP0165-HP0166 two-component system in expression of some acidic-pH-upregulated genes of Helicobacter pylori
    Yi Wen
    Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Bacteriol 188:1750-61. 2006
    ..Regulation of these genes responds either to a decrease in the periplasmic pH alone (HP0165 dependent) or also to a decrease in the cytoplasmic pH (HP0165 independent)...
  7. pmc A cis-encoded antisense small RNA regulated by the HP0165-HP0166 two-component system controls expression of ureB in Helicobacter pylori
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, 11301 Wilshire Blvd, Bldg 113, Rm 324, Los Angeles, CA 90073, USA
    J Bacteriol 193:40-51. 2011
    ..The ability of the HP0165-HP0166 TCS to both increase and decrease ureB expression at low and high pHs, respectively, facilitates gastric habitation and colonization over the wide range of intragastric pHs experienced by the organism...
  8. ncbi request reprint Lens epithelial cell mRNA. I. Cloning and sequencing of a messenger RNA with a basic motif/leucine-rich domain specifically expressed in rat lens epithelial cells
    Y Wen
    Laboratory of Lens Molecular Biology, Doheny Eye Institute, Los Angeles, CA, USA
    Exp Eye Res 60:675-82. 1995
    ..Our data demonstrate that we have isolated a cDNA clone containing novel sequences specifically expressed in lens epithelial cells...
  9. ncbi request reprint Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West, Los Angeles VA Medical Center and UCLA, Los Angeles, California, 90073, USA
    Biochem Biophys Res Commun 258:713-21. 1999
    ....
  10. ncbi request reprint Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina
    Y Wen
    Department of Medicine, West Los Angeles VA Medical Center, California, USA
    J Biol Chem 273:2090-7. 1998
    ....
  11. pmc Acid-adaptive genes of Helicobacter pylori
    Yi Wen
    The Membrane Biology Laboratory, Department of Physiology and Medicine, University of California Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Infect Immun 71:5921-39. 2003
    ..These results suggest that H. pylori has evolved multifaceted acid-adaptive mechanisms enabling it to colonize the stomach that may be novel targets for eliminating infection...
  12. ncbi request reprint Expression of vascular endothelial growth factor mRNA in human preimplantation embryos derived from tripronuclear zygotes
    J Krussel
    Reproductive Immunology Laboratory, Department of Gynecology and Obstetrics, Stanford University Medical Center, California, Palo Alto, USA
    Fertil Steril 74:1220-6. 2000
    ..To detect the expression of vascular endothelial growth factor (VEGF) mRNA and/or secretion of VEGF protein by human preimplantation embryos...
  13. ncbi request reprint Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts
    J Gu
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, School of Medicine, MR 4 Building, Charlottesville, VA 22908, USA
    J Cell Physiol 186:357-65. 2001
    ..These results demonstrate for the first time that 12-LO activation can lead to apoptosis in fibroblasts, suggesting a role of 12-LO in leading to inflammatory mediated cellular damage...
  14. pmc Gene expression in vivo shows that Helicobacter pylori colonizes an acidic niche on the gastric surface
    David R Scott
    Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 104:7235-40. 2007
    ..0. Hence, the pH of the habitat of H. pylori on the surface of the stomach largely determines the regulation of these specific groups of genes...
  15. pmc Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4(+), is necessary for acid survival of Helicobacter pylori
    David R Scott
    Department of Physiology, David Geffen School of Medicine at UCLA, 405 Hilgard Ave, Los Angeles, California 90024, USA
    J Bacteriol 192:94-103. 2010
    ..Assembly of a pH-regulatory complex of active urease with UreI provides an advantage for periplasmic buffering...
  16. ncbi request reprint Gastric infection by Helicobacter pylori
    George Sachs
    Departments of Physiology and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Curr Gastroenterol Rep 11:455-61. 2009
    ..Continuing improvement of PPIs has led to the development of at least three candidate drugs with improved 24-hour acid control...
  17. pmc Antiretroviral therapy adherence among patients living with HIV/AIDS in Thailand
    Li Li
    Center for Community Health, Semel Institute, University of California, Los Angeles, California 90024, USA
    Nurs Health Sci 12:212-20. 2010
    ..Our findings underscore the critical importance of addressing these various challenges that can influence adherence to antiretroviral therapy...
  18. ncbi request reprint Acid acclimation by Helicobacter pylori
    George Sachs
    Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California Los Angeles, USA
    Physiology (Bethesda) 20:429-38. 2005
    ..1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach...
  19. ncbi request reprint Immunoreactive gonadotropin-releasing hormone expression in cycling human endometrium of fertile patients
    E M CasaƱ
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California, USA
    Fertil Steril 70:102-6. 1998
    ..To investigate the protein expression of GnRH in the endometrium of fertile patients throughout the menstrual cycle...
  20. pmc Genes of Helicobacter pylori regulated by attachment to AGS cells
    Nayoung Kim
    Department of Physiology and Medicine, Geffen School of Medicine, UCLA and VA Greater Los Angeles Health Care System, Los Angeles, California 90073, USA
    Infect Immun 72:2358-68. 2004
    ..The alteration of gene expression in H. pylori after adhesion to gastric cells in vitro suggests that changes in motility, outer membrane composition, and stress responses, among other changes, may be involved in gastric colonization...
  21. ncbi request reprint Urea transport in bacteria: acid acclimation by gastric Helicobacter spp
    G Sachs
    Department of Physiology, Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    J Membr Biol 212:71-82. 2006
    ..The finding also of upregulation of the two-component histidine kinase HP0165 and its response element HP0166, illustrates the complexity of the acid acclimation processes involved in gastric colonization by this pathogen...
  22. ncbi request reprint Lens epithelial cell mRNA, II. Expression of a mRNA encoding a lipid-binding protein in rat lens epithelial cells
    Y Wen
    Laboratory of Lens Molecular Biology, Doheny Eye Institute, Los Angeles, CA 90033, USA
    Gene 158:269-74. 1995
    ....
  23. doi request reprint International Transporter Consortium commentary on clinically important transporter polymorphisms
    K M Giacomini
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA
    Clin Pharmacol Ther 94:23-6. 2013
    ..Recommendations for incorporating studies of transporter polymorphisms in drug development are provided, along with the regulatory implications...
  24. ncbi request reprint The role of gonadotropin-releasing hormone in murine preimplantation embryonic development
    F Raga
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, California, USA
    Endocrinology 140:3705-12. 1999
    ..The deleterious effect of GnRH antagonist on embryo development was reversed by increasing concentrations of the agonist, as determined by the number of embryos reaching the blastocyst stage...
  25. ncbi request reprint Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein
    H Tu
    Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Virology 263:30-41. 1999
    ..These interactions provide a mechanism for membrane association of the HCV RNA replication complex and further suggest that NS5A is a part of the viral RNA replication complex...
  26. ncbi request reprint Monitoring of five sulfonamide antibacterial residues in milk by in-tube solid-phase microextraction coupled to high-performance liquid chromatography
    Yi Wen
    Department of Chemistry, Wuhan University, Wuhan 430072, People s Republic of China
    J Agric Food Chem 53:8468-73. 2005
    ..0 and <9.94%, respectively. The proposed method was proved to be robust in monitoring sulfadiazine, sulfamethazine, sulfamethoxazole, sulfamonomethoxine sodium, and sulfacetamide sodium residues in milk...
  27. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
    ..These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis...
  28. ncbi request reprint Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Brain Res 1008:147-54. 2004
    ..These studies also provide evidence that suppression of post-ischemic inflammation may play a critical role in estrogen-mediated neuroprotection...
  29. ncbi request reprint 17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats
    Ran Liu
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1060:55-61. 2005
    ..Our results suggest an important role of estrogens as multiple targeting protectants against ischemic stroke on cellular as well as vascular components of central nervous system...
  30. ncbi request reprint Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas, Health Science Center Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res 1009:1-8. 2004
    ....
  31. ncbi request reprint Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    Yi Wen
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:22684-92. 2004
    ....
  32. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
    ..Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly...
  33. ncbi request reprint Extraction of clenbuterol from urine using hydroxylated poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith microextraction followed by high-performance liquid chromatography determination
    Yi Wen
    Department of Chemistry, Wuhan University, Wuhan, China
    J Sep Sci 30:2874-80. 2007
    ..6-106%. The determination of CLB from one real sample including pretreatment, extraction, and analysis could be finished within 30 min...
  34. ncbi request reprint Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Brain Res 1022:30-8. 2004
    ..Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases...
  35. ncbi request reprint Inhibitory effects of antisense oligodeoxynucleotide on expression of vascular endothelia growth factor by human hepatocarcinoma cells
    Meng Biao Qiu
    Molecular Center, Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, China
    Hepatobiliary Pancreat Dis Int 3:552-7. 2004
    ..Inhibition of angiogenesis is considered a promising approach for cancer therapy, and treatments including administration of antisense drugs and RNA interference for the VEGF gene are geared to the suppression of tumor angiogenesis...
  36. ncbi request reprint Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
    ..Furthermore, a thorough examination of the effect of anesthesia-induced hypothermia on the risk and progression of AD is warranted...
  37. ncbi request reprint [Heteroplasmy: a common phenomenon of mitochondrial genome mutations in human tumor tissues]
    Duan Jun Tan
    Institute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing 100853, China
    Yi Chuan 27:44-8. 2005
    ..The main transfer forms of transition and transversion mutations are Hm-->Hm and Hm-->Ht respectively. Heteroplasmy is a common phenomenon in mitochondrial DNA somatic mutations of human tumors...
  38. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
    ..These results support the idea that kinases are involved in tauopathy progression and that kinase inhibitors may be effective therapeutically...
  39. ncbi request reprint Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
    Yi Wen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Biochim Biophys Acta 1772:473-83. 2007
    ..We conclude that Cdk5 may be the principal protein kinase responsible for tau hyperphosphorylation and may be a hallmark of the tauopathies in this stroke model...
  40. ncbi request reprint Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology
    James W Simpkins
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:233-42. 2005
    ....
  41. ncbi request reprint Identification and characterization of an interleukin-15 homologue from Tetraodon nigroviridis
    Wei Fang
    College of Life Sciences, Zhejiang University, Hangzhou 310012, People s Republic of China
    Comp Biochem Physiol B Biochem Mol Biol 143:335-43. 2006
    ..In addition, our analysis on another annotated T. nigroviridis IL-15 demonstrated that it may be a paralogue of IL-15. To differentiate it from the known IL-15s, we described it as IL-15x...
  42. ncbi request reprint Preparation and evaluation of hydroxylated poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolithic capillary for in-tube solid-phase microextraction coupled to high-performance liquid chromatography
    Yi Wen
    Department of Chemistry, Wuhan University, Wuhan 430072, China
    J Chromatogr A 1160:90-8. 2007
    ..Finally, the in-tube SPME-HPLC method, based on the developed monolithic capillary as the extraction media, was successfully applied to the determination of five polar organic contaminants in lake water...