JOHN WEMMIE

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Neurobiology of panic and pH chemosensation in the brain
    John A Wemmie
    Department of Psychiatry, Interdisciplinary Graduate Program in Neuroscience, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Dialogues Clin Neurosci 13:475-83. 2011
  2. ncbi request reprint Acid-sensing ion channels: advances, questions and therapeutic opportunities
    John A Wemmie
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Trends Neurosci 29:578-86. 2006
  3. ncbi request reprint Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning
    John A Wemmie
    Department of Psychiatry, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 23:5496-502. 2003
  4. ncbi request reprint The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
    John A Wemmie
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
    Neuron 34:463-77. 2002
  5. ncbi request reprint Stomatin modulates gating of acid-sensing ion channels
    Margaret P Price
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Biol Chem 279:53886-91. 2004
  6. ncbi request reprint Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit
    Matthew W Coryell
    Neuroscience Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Biol Psychiatry 62:1140-8. 2007
  7. pmc Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)
    Alesia M Hruska-Hageman
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, U S A
    Biochem J 361:443-50. 2002
  8. ncbi request reprint Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons
    Candice C Askwith
    Department of Internal Medicine, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:18296-305. 2004
  9. pmc cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1
    A Soren Leonard
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 100:2029-34. 2003
  10. pmc Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses
    Matthew W Coryell
    Neuroscience Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 28:13738-41. 2008

Collaborators

Detail Information

Publications31

  1. pmc Neurobiology of panic and pH chemosensation in the brain
    John A Wemmie
    Department of Psychiatry, Interdisciplinary Graduate Program in Neuroscience, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Dialogues Clin Neurosci 13:475-83. 2011
    ..These observations suggest that a key to better understanding of panic disorder may He in more knowledge of brain pH regulation and pH-sensitive receptors...
  2. ncbi request reprint Acid-sensing ion channels: advances, questions and therapeutic opportunities
    John A Wemmie
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Trends Neurosci 29:578-86. 2006
    ..Here, we briefly review advances in our understanding of ASICs, their potential contributions to disease, and the possibility for their therapeutic modification...
  3. ncbi request reprint Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning
    John A Wemmie
    Department of Psychiatry, Neuroscience Graduate Program, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 23:5496-502. 2003
    ..These studies suggest that ASIC1 is distributed to regions supporting high levels of synaptic plasticity and contributes to the neural mechanisms of fear conditioning...
  4. ncbi request reprint The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
    John A Wemmie
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
    Neuron 34:463-77. 2002
    ..These results identify ASIC as a key component of acid-activated currents and implicate these currents in processes underlying synaptic plasticity, learning, and memory...
  5. ncbi request reprint Stomatin modulates gating of acid-sensing ion channels
    Margaret P Price
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Biol Chem 279:53886-91. 2004
    ..Our findings indicate that modulation of DEG/ENaC channels by stomatin-like proteins is evolutionarily conserved and may have important implications for mammalian nociception and mechanosensation...
  6. ncbi request reprint Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit
    Matthew W Coryell
    Neuroscience Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Biol Psychiatry 62:1140-8. 2007
    ..Previous studies indicated that the acid sensing ion channel ASIC1a influences fear behavior in conditioning paradigms. However, these differences may have resulted from an ASIC1a effect on learning, memory, or the expression of fear...
  7. pmc Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)
    Alesia M Hruska-Hageman
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, U S A
    Biochem J 361:443-50. 2002
    ..These data suggest that PICK1 binds ASIC and BNC1 via its PDZ domain. This interaction may be important for the localization and/or function of these channels in both the central and peripheral nervous systems...
  8. ncbi request reprint Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons
    Candice C Askwith
    Department of Internal Medicine, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:18296-305. 2004
    ..These findings indicate that the absolute and relative amounts of ASIC subunits determine the amplitude and properties of hippocampal H(+)-gated currents and therefore may contribute to normal physiology and pathophysiology...
  9. pmc cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1
    A Soren Leonard
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 100:2029-34. 2003
    ..Thus, the ASIC1 C terminus contains two sites that influence its binding to PICK1. Regulation of this interaction by phosphorylation provides a mechanism to control the cellular localization of ASIC1...
  10. pmc Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses
    Matthew W Coryell
    Neuroscience Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 28:13738-41. 2008
    ..Furthermore, this work illustrates a strategy for identifying discrete brain regions where specific genes contribute to complex behaviors...
  11. pmc Seizure termination by acidosis depends on ASIC1a
    Adam E Ziemann
    Medical Scientist Training Program, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Neurosci 11:816-22. 2008
    ..Our results identify ASIC1a as an important element in seizure termination when brain pH falls and suggest both a molecular mechanism for how the brain stops seizures and new therapeutic strategies...
  12. pmc Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior
    John A Wemmie
    Department of Psychiatry, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:3621-6. 2004
    ..These data raise the possibility that ASIC1a and H(+)-gated currents may contribute to the development of abnormal fear and to anxiety disorders in humans...
  13. pmc ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury
    Roxanne Y Walder
    Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 11:210-8. 2010
    ..A-317567 was effective in reversing hyperalgesia in these animals, suggesting the potential of ASICs as therapeutic targets for muscle inflammatory pain...
  14. pmc Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines
    Xiang ming Zha
    Howard Hughes Medical Institute, and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 103:16556-61. 2006
    ..The results provide insight into how protons influence brain function and how they may contribute to pathophysiology...
  15. pmc Stereotactic atlas-based depth electrode localization in the human amygdala
    Hiroyuki Oya
    Department of Neurosurgery, University of Iowa, Iowa City, IA 52241 1061, USA
    Stereotact Funct Neurosurg 87:219-28. 2009
    ..The amygdala complex is a case in point, in that it consists of multiple histologically defined subnuclei with different functional characteristics...
  16. pmc The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction
    Mikael K Schnizler
    Howard Hughes Medical Institute and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 284:2697-705. 2009
    ..These findings suggest that alpha-actinins may link ASIC1a to a macromolecular complex in the postsynaptic membrane where it regulates ASIC1a activity...
  17. ncbi request reprint Impaired motor performance and learning in glia maturation factor-knockout mice
    Ramon Lim
    Department of Neurology Division of Neurochemistry and Neurobiology, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Brain Res 1024:225-32. 2004
    ..The structural abnormality in GMF-null mice explained their impaired ability for both motor performance and motor learning...
  18. ncbi request reprint ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons
    Jinghui Xie
    Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurophysiol 89:2459-65. 2003
    ..The presence of several ASIC subunits, the diversity of FMRFamide-related peptides, and the distinct effects on H(+)-gated currents suggest the possibility of substantial complexity in modulation of current in DRG sensory neurons...
  19. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
    ..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
  20. pmc Amygdala volume correlates positively with fearfulness in normal healthy girls
    Ellen A A van der Plas
    University of Iowa Neuroscience Program, Department of Psychiatry, University of Iowa Carver College of Medicine, 200 Hawkins Drive, W285 GH, Iowa City, Iowa 52242, USA
    Soc Cogn Affect Neurosci 5:424-31. 2010
    ..Given the role of enlarged amygdala volume in pathology, these findings may indicate that variation in amygdala morphology marks susceptibility to internalizing disorders...
  21. ncbi request reprint Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, 1 242 Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Pain 106:229-39. 2003
    ..Therefore, interfering with ASIC3 might be of benefit in treatment or prevention of chronic hyperalgesia...
  22. pmc The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior
    Adam E Ziemann
    Medical Scientist Training Program, Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cell 139:1012-21. 2009
    ..They also give a molecular explanation for how rising CO(2) concentrations elicit intense fear and provide a foundation for dissecting the bases of anxiety and panic disorders...
  23. pmc Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior
    Matthew W Coryell
    Neuroscience Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 29:5381-8. 2009
    ..These data are consistent with clinical studies emphasizing the importance of the amygdala in mood regulation, and suggest that ASIC1a antagonists may effectively combat depression...
  24. pmc Acid-sensing ion channels: A new target for pain and CNS diseases
    Kathleen A Sluka
    University of Iowa, Iowa City, 52242, USA
    Curr Opin Drug Discov Devel 12:693-704. 2009
    ..However, the development of pharmaceuticals that target ASICs and are suitable for clinical use remains an obstacle. This review provides an update on ASICs and their potential for therapeutic modification in pain and CNS diseases...
  25. ncbi request reprint Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors
    Gumei Liu
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 25:9321-7. 2005
    ..Together, our proof-of-principal experiments suggest a unique and efficient manner for treating the global CNS deficits in LSD patients...
  26. pmc Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits
    Xiang ming Zha
    Howard Hughes Medical Institute and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:3573-8. 2009
    ..They also suggest a mechanism by which the redox state can dynamically regulate membrane protein activity by forming intracellular bridges...
  27. pmc Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine
    Ana Recober
    Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 29:8798-804. 2009
    ..Moreover, they validate CGRP hypersensitive mice as a tool for exploring the neurobiology and novel therapies for migraine and other disorders involving photophobia...
  28. ncbi request reprint Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  29. ncbi request reprint Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    Manuel A Friese
    Medical Research Council Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nat Med 13:1483-9. 2007
    ..In addition, adoptive transfer of T cells from wild-type mice did not affect the protection mediated by Asic1 disruption. These results suggest that ASIC1 blockers could provide neuroprotection in multiple sclerosis...
  30. ncbi request reprint The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function
    Amanda J Page
    Nerve Gut Research Laboratroy, Hanson Institute, Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Gastroenterology 127:1739-47. 2004
    ..We examined the influence of the DEG/ENaC channel ASIC1 on gastrointestinal mechanosensory function, on gastric emptying, and on fecal output. We also compared its role in gastrointestinal and somatic sensory function...
  31. pmc Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 24:8678-89. 2004
    ..Our studies suggest that Zn2+ may play an important role in a negative feedback system for preventing overexcitation of neurons during normal synaptic transmission and ASIC1a-mediated excitotoxicity in pathological conditions...

Research Grants4

  1. Inhibition of seizures and neuron excitability by acid-sensing ion channels
    JOHN WEMMIE; Fiscal Year: 2007
    ..These studies have the potential to foster the development of Asic1a antagonists as a novel therapeutic approach to seizures. ..
  2. Modeling CO2-evoked fear in mice: role of acid-sensing ion channels
    John A Wemmie; Fiscal Year: 2010
    ..This proposal models CO2- evoked anxiety and panic in mice and suggests that understanding CO2-sensitivity has broad implications, including novel molecular pathways underlying anxiety disorders and new treatment targets. ..