MICHAEL WELTE

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint How Brain Fat Conquers Stress
    Michael A Welte
    Department of Biology, University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Cell 163:269-70. 2015
  2. doi request reprint Expanding roles for lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Curr Biol 25:R470-81. 2015
  3. pmc As the fat flies: The dynamic lipid droplets of Drosophila embryos
    Michael A Welte
    Department of Biology University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Biochim Biophys Acta 1851:1156-85. 2015
  4. pmc Novel isoforms of the transport regulator klar
    Dae Hwan Kim
    Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS ONE 8:e55070. 2013
  5. pmc Targeting the motor regulator Klar to lipid droplets
    Yanxun V Yu
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    BMC Cell Biol 12:9. 2011
  6. doi request reprint Bidirectional transport: matchmaking for motors
    Michael A Welte
    University of Rochester, Department of Biology, 317 Hutchison Hall, Rochester, NY 14627, USA
    Curr Biol 20:R410-3. 2010
  7. doi request reprint Fat on the move: intracellular motion of lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Biochem Soc Trans 37:991-6. 2009
  8. ncbi request reprint Proteins under new management: lipid droplets deliver
    Michael A Welte
    Rosenstiel Biomedical Research Center and Department of Biology, 415 South Street, Waltham, MA 02454, USA
    Trends Cell Biol 17:363-9. 2007
  9. ncbi request reprint Regulation of lipid-droplet transport by the perilipin homolog LSD2
    Michael A Welte
    Rosenstiel Biomedical Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Curr Biol 15:1266-75. 2005
  10. pmc Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar
    Yi Guo
    Rosenstiel Biomedical Research Center, Brandeis University, Waltham, MA 02454, USA
    Mol Biol Cell 16:1406-16. 2005

Research Grants

Collaborators

Detail Information

Publications12

  1. doi request reprint How Brain Fat Conquers Stress
    Michael A Welte
    Department of Biology, University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Cell 163:269-70. 2015
    ..In Drosophila larvae, lipid droplets in glia allow neuronal stem cells to keep proliferating under hypoxic conditions. Protection likely involves sequestering vulnerable membrane lipids away from reactive oxygen species...
  2. doi request reprint Expanding roles for lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Curr Biol 25:R470-81. 2015
    ..As the cell biology and biochemistry of lipid droplets become increasingly well understood, the next few years should yield many new mechanistic insights into these novel functions of lipid droplets. ..
  3. pmc As the fat flies: The dynamic lipid droplets of Drosophila embryos
    Michael A Welte
    Department of Biology University of Rochester, RC Box 270211, 317 Hutchison Hall, Rochester, NY 14627, USA Electronic address
    Biochim Biophys Acta 1851:1156-85. 2015
    ....
  4. pmc Novel isoforms of the transport regulator klar
    Dae Hwan Kim
    Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS ONE 8:e55070. 2013
    ..Our analysis identifies novel forms of the Klar protein and provides new tools for functionally dissecting the complex klar locus...
  5. pmc Targeting the motor regulator Klar to lipid droplets
    Yanxun V Yu
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    BMC Cell Biol 12:9. 2011
    ..Although the LD domain is necessary and sufficient for droplet targeting in cultured cells, lack of specific reagents had made it previously impossible to analyze its role in vivo...
  6. doi request reprint Bidirectional transport: matchmaking for motors
    Michael A Welte
    University of Rochester, Department of Biology, 317 Hutchison Hall, Rochester, NY 14627, USA
    Curr Biol 20:R410-3. 2010
    ..In bidirectional transport, opposing motors frequently require each other for full activity. A new study suggests that mechanical coupling between motors is the key to this reciprocal activation...
  7. doi request reprint Fat on the move: intracellular motion of lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Biochem Soc Trans 37:991-6. 2009
    ..This review summarizes the current understanding of where, why and how lipid droplets move...
  8. ncbi request reprint Proteins under new management: lipid droplets deliver
    Michael A Welte
    Rosenstiel Biomedical Research Center and Department of Biology, 415 South Street, Waltham, MA 02454, USA
    Trends Cell Biol 17:363-9. 2007
    ..The implications of this emerging role of lipid droplets include regulated inactivation of proteins, prevention of toxic protein aggregates and localized delivery of signaling molecules...
  9. ncbi request reprint Regulation of lipid-droplet transport by the perilipin homolog LSD2
    Michael A Welte
    Rosenstiel Biomedical Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Curr Biol 15:1266-75. 2005
    ..To identify factors regulating this transport, we biochemically purified droplets from individual phases and used 2D gel analysis to search for proteins whose amount on droplets changes as motion changes...
  10. pmc Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar
    Yi Guo
    Rosenstiel Biomedical Research Center, Brandeis University, Waltham, MA 02454, USA
    Mol Biol Cell 16:1406-16. 2005
    ..Such isoform variation may be a general strategy for adapting a common regulatory mechanism to specifically control motion and positioning of multiple organelles...
  11. ncbi request reprint Bidirectional transport along microtubules
    Michael A Welte
    Rosenstiel Biomedical Research Center and Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Curr Biol 14:R525-37. 2004
    ..These analyses will likely provide insight into motor cooperation in general...

Research Grants1

  1. Lipid droplets as sites for protein sequestration
    MICHAEL WELTE; Fiscal Year: 2008
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