W V Welshons

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
  2. pmc Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity
    Wade V Welshons
    Department of Veterinary Biomedical Sciences, Columbia, MO, USA
    Environ Health Perspect 111:994-1006. 2003
  3. ncbi request reprint Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice
    W V Welshons
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia 65211, USA
    Toxicol Ind Health 15:12-25. 1999
  4. pmc Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
    F S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, 65211, USA
    Proc Natl Acad Sci U S A 94:2056-61. 1997
  5. pmc Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells
    Catherine A Richter
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 115:902-8. 2007
  6. ncbi request reprint A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior
    F S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Toxicol Ind Health 14:239-60. 1998
  7. ncbi request reprint Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 100:50-76. 2006
  8. ncbi request reprint The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:140-5. 2005
  9. pmc No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice
    Julia A Taylor
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Reprod Toxicol 25:169-76. 2008
  10. doi request reprint Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiol
    Catherine A Peterson
    Department of Nutritional Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Ann Nutr Metab 52:48-57. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
    ....
  2. pmc Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity
    Wade V Welshons
    Department of Veterinary Biomedical Sciences, Columbia, MO, USA
    Environ Health Perspect 111:994-1006. 2003
    ....
  3. ncbi request reprint Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice
    W V Welshons
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia 65211, USA
    Toxicol Ind Health 15:12-25. 1999
    ..The studies and strategies we describe are important in developing criteria for a tiered testing system for the detection of estrogenic chemicals as well as endocrine-disrupting chemicals with different modes of action...
  4. pmc Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
    F S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, 65211, USA
    Proc Natl Acad Sci U S A 94:2056-61. 1997
    ..For both estradiol and DES, prostate weight first increased then decreased with dose, resulting in an inverted-U dose-response relationship...
  5. pmc Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells
    Catherine A Richter
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 115:902-8. 2007
    ....
  6. ncbi request reprint A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior
    F S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Toxicol Ind Health 14:239-60. 1998
    ..A new approach to studying physiologically relevant doses of environmental endocrine disruptors is discussed, particularly with regard to the development of the reproductive organs, the brain, and behavior...
  7. ncbi request reprint Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 100:50-76. 2006
    ..We discuss the importance of appropriate controls in toxicological research and that positive controls are required to determine whether conclusions from experiments that report no significant effects are valid or false...
  8. ncbi request reprint The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:140-5. 2005
    ....
  9. pmc No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice
    Julia A Taylor
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Reprod Toxicol 25:169-76. 2008
    ..Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration...
  10. doi request reprint Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiol
    Catherine A Peterson
    Department of Nutritional Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Ann Nutr Metab 52:48-57. 2008
    ..Our aim was to determine the skeletal, reproductive, and serum estradiol (E(2))/estrogenic activity response of consuming naturally-occurring soy protein-associated IF during peripuberty...
  11. ncbi request reprint Commercial animal feed: variability in estrogenic activity and effects on body weight in mice
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:474-5. 2005
  12. ncbi request reprint Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries
    M Harold Laughlin
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 95:250-64. 2003
    ..relative to human men, the male pig is not biologically estrogenized by high levels of E2 reported by RIA, whereas in female pigs E2 levels are lower than in the blood of human women...
  13. ncbi request reprint Estrogen modulation of baroreflex function in conscious mice
    Jaya Pamidimukkala
    Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, USA
    Am J Physiol Regul Integr Comp Physiol 284:R983-9. 2003
    ..These data support the hypothesis that estrogen facilitates baroreflex function in female mice and suggest that ANG II-mediated acute blunting of baroreflex regulation of heart rate may be sex dependent...
  14. ncbi request reprint Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol
    K A Thayer
    Department of Biological Sciences, University of Missouri Columbia, Columbia, Missouri, USA
    Hum Reprod 16:988-96. 2001
    ..These findings are consistent with prior studies showing that prenatal exposure of mice to very low doses of a number of oestrogenic chemicals can alter the adult male reproductive system without causing gross external malformations...
  15. pmc Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice
    Rachel L Ruhlen
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 116:322-8. 2008
    ..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
  16. pmc Bisphenol A is released from used polycarbonate animal cages into water at room temperature
    Kembra L Howdeshell
    Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
    Environ Health Perspect 111:1180-7. 2003
    ..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages...
  17. ncbi request reprint Lipoproteins during the estrous cycle in swine
    Ying Liu
    Department of Nutritional Sciences, University of Missouri Columbia, Columbia, MO, USA
    Metabolism 53:140-1. 2004
    ..These results suggest that lipoprotein concentrations fluctuate during the estrous cycle of swine, with high E2 concentrations associated with elevated lipoprotein concentrations...
  18. doi request reprint Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanoparticles
    Ravi Shukla
    Department of Radiology, University of Missouri Columbia, MO 65212, USA
    Small 4:1425-36. 2008
    ..The overall strategy described herein for the generation of gold nanoparticles meets all 12 principles of green chemistry, as no "man-made" chemicals, other than the gold salts, are used in the green nanotechnological process...
  19. ncbi request reprint Basis of melengestrol acetate action as a progestin
    George A Perry
    Department of Animal Science, 160 Animal Science Research Center, University of Missouri Columbia, Columbia, MO 65211, USA
    Domest Anim Endocrinol 28:147-61. 2005
    ....
  20. ncbi request reprint Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues
    Brian J Philips
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    Biochemistry 43:6698-708. 2004
    ..The extensive biochemical characterization of this binding protein indicates that this protein may be a receptor, and thus may mediate ERalpha/beta-independent effects of catechol estrogens and their metabolites...
  21. ncbi request reprint Transcription factor accessibility and histone acetylation of the progesterone receptor gene differs between parental MCF-7 cells and a subline that has lost progesterone receptor expression
    Xiaojie Xu
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 1300 University Avenue, MSC 5250, Madison, WI 53706, USA
    Gene 328:143-51. 2004
    ..We speculate that the histone acetylation level at this site may be a marker for chromatin structure that affects the access of transcription factors to the whole promoter...
  22. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  23. ncbi request reprint Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the public
    Frederick S vom Saal
    Toxicology 212:244-52, author reply 253-4. 2005
  24. ncbi request reprint Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer
    Yu Wei Leu
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:8184-92. 2004
    ..The results imply, for the first time, the significance of epigenetic regulation on ERalpha target genes, providing new direction for research in this classical signaling pathway...
  25. ncbi request reprint Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
    ..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
  26. ncbi request reprint Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity
    Yukun Cui
    Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
    Cancer Res 64:9199-208. 2004
    ..We propose that the hypersensitive ERalpha mutant breast cancer phenotype involves an integration of coupled acetylation and phosphorylation events by upstream signaling molecules...
  27. ncbi request reprint Estrogen receptor expression and sensitivity to paclitaxel in breast cancer
    Michele K Dougherty
    Lombardi Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
    Cancer Biol Ther 3:460-7. 2004
    ..These data suggest that measurements of tumor proliferation may provide more accurate predictive markers for the benefits of adjuvant paclitaxel than ERalpha analysis...
  28. ncbi request reprint Estrogen receptors in membrane lipid rafts and signal transduction in breast cancer
    Diana C Márquez
    UCLA School of Medicine, Department of Medicine, Division of Hematology Oncology, Los Angeles, CA 90095 1678, USA
    Mol Cell Endocrinol 246:91-100. 2006
    ..Thus, nuclear and lipid raft ER derive from the same transcript, and extranuclear ER co-localizes with HER receptors in membrane signaling domains that modulate downstream nuclear events leading to cell growth...