W V Welshons
Affiliation: University of Missouri
- Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposureWade V Welshons
Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
Endocrinology 147:S56-69. 2006....
- Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activityWade V Welshons
Department of Veterinary Biomedical Sciences, Columbia, MO, USA
Environ Health Perspect 111:994-1006. 2003....
- Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in miceW V Welshons
Department of Veterinary Biomedical Sciences, University of Missouri Columbia 65211, USA
Toxicol Ind Health 15:12-25. 1999..The studies and strategies we describe are important in developing criteria for a tiered testing system for the detection of estrogenic chemicals as well as endocrine-disrupting chemicals with different modes of action...
- Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high dosesF S vom Saal
Division of Biological Sciences, University of Missouri Columbia, 65211, USA
Proc Natl Acad Sci U S A 94:2056-61. 1997..For both estradiol and DES, prostate weight first increased then decreased with dose, resulting in an inverted-U dose-response relationship...
- Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cellsCatherine A Richter
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 115:902-8. 2007....
- A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behaviorF S vom Saal
Division of Biological Sciences, University of Missouri, Columbia 65211, USA
Toxicol Ind Health 14:239-60. 1998..A new approach to studying physiologically relevant doses of environmental endocrine disruptors is discussed, particularly with regard to the development of the reproductive organs, the brain, and behavior...
- Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol AFrederick S vom Saal
Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Environ Res 100:50-76. 2006..We discuss the importance of appropriate controls in toxicological research and that positive controls are required to determine whether conclusions from experiments that report no significant effects are valid or false...
- The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol AFrederick S vom Saal
Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
Birth Defects Res A Clin Mol Teratol 73:140-5. 2005....
- No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female miceJulia A Taylor
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
Reprod Toxicol 25:169-76. 2008..Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration...
- Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiolCatherine A Peterson
Department of Nutritional Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Ann Nutr Metab 52:48-57. 2008..Our aim was to determine the skeletal, reproductive, and serum estradiol (E(2))/estrogenic activity response of consuming naturally-occurring soy protein-associated IF during peripuberty...
- Commercial animal feed: variability in estrogenic activity and effects on body weight in miceFrederick S vom Saal
Division of Biological Sciences, University of Missouri--Columbia, Columbia, Missouri 65211, USA
Birth Defects Res A Clin Mol Teratol 73:474-5. 2005
- Gender, exercise training, and eNOS expression in porcine skeletal muscle arteriesM Harold Laughlin
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
J Appl Physiol 95:250-64. 2003..relative to human men, the male pig is not biologically estrogenized by high levels of E2 reported by RIA, whereas in female pigs E2 levels are lower than in the blood of human women...
- Estrogen modulation of baroreflex function in conscious miceJaya Pamidimukkala
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, USA
Am J Physiol Regul Integr Comp Physiol 284:R983-9. 2003..These data support the hypothesis that estrogen facilitates baroreflex function in female mice and suggest that ANG II-mediated acute blunting of baroreflex regulation of heart rate may be sex dependent...
- Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiolK A Thayer
Department of Biological Sciences, University of Missouri Columbia, Columbia, Missouri, USA
Hum Reprod 16:988-96. 2001..These findings are consistent with prior studies showing that prenatal exposure of mice to very low doses of a number of oestrogenic chemicals can alter the adult male reproductive system without causing gross external malformations...
- Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 miceRachel L Ruhlen
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 116:322-8. 2008..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
- Bisphenol A is released from used polycarbonate animal cages into water at room temperatureKembra L Howdeshell
Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
Environ Health Perspect 111:1180-7. 2003..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages...
- Lipoproteins during the estrous cycle in swineYing Liu
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO, USA
Metabolism 53:140-1. 2004..These results suggest that lipoprotein concentrations fluctuate during the estrous cycle of swine, with high E2 concentrations associated with elevated lipoprotein concentrations...
- Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanoparticlesRavi Shukla
Department of Radiology, University of Missouri Columbia, MO 65212, USA
Small 4:1425-36. 2008..The overall strategy described herein for the generation of gold nanoparticles meets all 12 principles of green chemistry, as no "man-made" chemicals, other than the gold salts, are used in the green nanotechnological process...
- Basis of melengestrol acetate action as a progestinGeorge A Perry
Department of Animal Science, 160 Animal Science Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA
Domest Anim Endocrinol 28:147-61. 2005....
- Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissuesBrian J Philips
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
Biochemistry 43:6698-708. 2004..The extensive biochemical characterization of this binding protein indicates that this protein may be a receptor, and thus may mediate ERalpha/beta-independent effects of catechol estrogens and their metabolites...
- Transcription factor accessibility and histone acetylation of the progesterone receptor gene differs between parental MCF-7 cells and a subline that has lost progesterone receptor expressionXiaojie Xu
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 1300 University Avenue, MSC 5250, Madison, WI 53706, USA
Gene 328:143-51. 2004..We speculate that the histone acetylation level at this site may be a marker for chromatin structure that affects the access of transcription factors to the whole promoter...
- Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007
- Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the publicFrederick S vom Saal
Toxicology 212:244-52, author reply 253-4. 2005
- Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancerYu-Wei Leu
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 64:8184-92. 2004..The results imply, for the first time, the significance of epigenetic regulation on ERalpha target genes, providing new direction for research in this classical signaling pathway...
- Human exposure to bisphenol A (BPA)Laura N Vandenberg
Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
Reprod Toxicol 24:139-77. 2007..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
- Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivityYukun Cui
Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
Cancer Res 64:9199-208. 2004..We propose that the hypersensitive ERalpha mutant breast cancer phenotype involves an integration of coupled acetylation and phosphorylation events by upstream signaling molecules...
- Estrogen receptor expression and sensitivity to paclitaxel in breast cancerMichele K Dougherty
Lombardi Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC, USA
Cancer Biol Ther 3:460-7. 2004..These data suggest that measurements of tumor proliferation may provide more accurate predictive markers for the benefits of adjuvant paclitaxel than ERalpha analysis...
- Estrogen receptors in membrane lipid rafts and signal transduction in breast cancerDiana C Márquez
UCLA School of Medicine, Department of Medicine, Division of Hematology Oncology, Los Angeles, CA 90095 1678, USA
Mol Cell Endocrinol 246:91-100. 2006..Thus, nuclear and lipid raft ER derive from the same transcript, and extranuclear ER co-localizes with HER receptors in membrane signaling domains that modulate downstream nuclear events leading to cell growth...