Research Topics
Genomes and GenesSpecies | Robert C WelshSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptomsRobert C Welsh
Department of Radiology, Basic Radiological Sciences Division, University Hospital of Michigan, Ann Arbor, Michigan 48109 0553, USA
J Magn Reson Imaging 26:541-51. 2007..To investigate the source of significant difference in apparent diffusion coefficient (ADC) between patients with acute symptoms of neuropsychiatric (NP) systematic lupus erythematosus (SLE) (NPSLE) and normal controls...
Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in schizophreniaRobert C Welsh
Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0553, USA
Schizophr Bull 36:713-22. 2010..These data support a disruption model of the thalamocortical network and are consistent with a disconnection hypothesis of schizophrenia...- Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networksRebecca K Sripada
Departments of Psychology, University of Michigan, Ann Arbor, Michigan, USA
Psychosom Med 74:904-11. 2012..This might be linked to aberrations in large-scale networks subserving the detection of salient stimuli (i.e., the salience network [SN]) and stimulus-independent, internally focused thought (i.e., the default mode network [DMN])... - Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorderEmily R Stern
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 69:583-91. 2011..While OCD has been associated with an increased neural response to errors, the influence of motivational factors on this effect remains poorly understood... - Altered function and connectivity of the medial frontal cortex in pediatric obsessive-compulsive disorderKate Dimond Fitzgerald
Department of Psychiatry, Medical School, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 68:1039-47. 2010..We tested whether hyperactive MFC-based performance monitoring function relates to altered MFC connectivity within task control and default mode networks in pediatric patients... - Medial frontal hyperactivity in reality distortionStephan F Taylor
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48109 5765, USA
Biol Psychiatry 61:1171-8. 2007..The amygdala interacts with MPFC, also carries out socioemotional processing, and has been implicated in schizophrenia; thus, we also tested the hypothesis that patients would exhibit aberrant amygdala activity... - The impact of serotonin transporter (5-HTTLPR) genotype on the development of resting-state functional connectivity in children and adolescents: a preliminary reportJillian Lee Wiggins
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 59:2760-70. 2012..This preliminary report expands our understanding of the genetic influences on the development of large-scale brain connectivity and lays down the foundation for future research and replication of the results with a larger sample... - Social appraisal in chronic psychosis: role of medial frontal and occipital networksStephan F Taylor
Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Rd, Ann Arbor MI 48109 2700, USA
J Psychiatr Res 45:526-38. 2011.... - Diffusion-weighted and diffusion tensor imaging in fibromyalgia patients: a prospective study of whole brain diffusivity, apparent diffusion coefficient, and fraction anisotropy in different regions of the brain and correlation with symptom severityPia C Sundgren
Department of Radiology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0030, USA
Acad Radiol 14:839-46. 2007 - Medial frontal cortex activity and loss-related responses to errorsStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 26:4063-70. 2006..The findings support the hypothesis that the rostral extent of the MFC (rACC) processes loss-related responses to errors, and individual differences may account for some of the reported variation of error-related foci in the MFC... - Age differences in callosal contributions to cognitive processesBrett W Fling
School of Kinesiology, University of Michigan, Ann Arbor, MI, USA
Neuropsychologia 49:2564-9. 2011..Thus, while the capability for interhemispheric interactions, as inferred from callosal size, may provide performance benefits for older adults, this capacity alone does not assure protection from general performance decline... - Topographic analysis of individual activation patterns in medial frontal cortex in schizophreniaEmily R Stern
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
Hum Brain Mapp 30:2146-56. 2009.... - No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorderMichael C Hsu
Department of Physical Medicine and Rehabilitation, University of Michigan Chronic Pain and Fatigue Research Center, 24 Frank Lloyd Wright Drive, Lobby M, PO Box 385, Ann Arbor, MI 48106, USA
Pain 143:262-7. 2009..470, p<.001). No other significant clusters were found on ROI-based analysis. Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain... - Self-related neural response to tailored smoking-cessation messages predicts quittingHannah Faye Chua
Health Behavior and Health Education, University of Michigan, Ann Arbor, Michigan, USA
Nat Neurosci 14:426-7. 2011..We found that increases in activation in self-related processing regions, particularly dorsomedial prefrontal cortex, to tailored messages predicted quitting during a 4-month follow-up... - The development of performance-monitoring function in the posterior medial frontal cortexKate Dimond Fitzgerald
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48104, USA
Neuroimage 49:3463-73. 2010..To characterize the development of pMFC-based performance monitoring functions, we segregated interference and error-processing, while statistically controlling for performance... - Updating beliefs for a decision: neural correlates of uncertainty and underconfidenceEmily R Stern
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:8032-41. 2010.... - Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorderKate Dimond Fitzgerald
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109-0118, USA
Biol Psychiatry 57:287-94. 2005..Activity in this region was positively correlated with symptom severity in the patients. CONCLUSIONS: Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD... 
Prechemotherapy alterations in brain function in women with breast cancerBernadine Cimprich
School of Nursing, The University of Michigan, Ann Arbor, MI, USA
J Clin Exp Neuropsychol 32:324-31. 2010..Results indicate compromised cognitive functioning before any chemotherapy and raise key questions for further research...- Neural correlates of social and nonsocial emotions: An fMRI studyJennifer C Britton
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109
Neuroimage 31:397-409. 2006..Overall, these findings highlight that sociality has a key role in processing emotional valence, which may have implications for patient populations with social and emotional deficits... - Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorderRebecca K Sripada
Department of Psychology and Psychiatry, University of Michigan, Ann Arbor, MI, USA
J Psychiatry Neurosci 37:241-9. 2012..However, few studies have examined patterns of connectivity at rest in individuals with PTSD, a potentially powerful method for illuminating brain network structure... - Habituation of rostral anterior cingulate cortex to repeated emotionally salient picturesK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Ann Arbor, MI, USA
Neuropsychopharmacology 28:1344-50. 2003..These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation... - 'Do I like this person?' A network analysis of midline cortex during a social preference taskAshley C Chen
Neuroscience Program, University of Michigan, USA
Neuroimage 51:930-9. 2010.... - Differential callosal contributions to bimanual control in young and older adultsBrett W Fling
University of Michigan, 401 Washtenaw Ave, Ann Arbor, MI 48109 2214, USA
J Cogn Neurosci 23:2171-85. 2011..Further, the differential age-related involvement of transcallosal pathways reported here raises new questions about the role of the CC in bimanual control... - Neural correlates of message tailoring and self-relatedness in smoking cessation programmingHannah Faye Chua
Department of Health Behavior and Health Education, University of Michigan, 300 North Ingalls Street, Ann Arbor, MI 48109 0471, USA
Biol Psychiatry 65:165-8. 2009..However, little is known about the brain responses of smokers when they receive tailored smoking cessation messages... - A multiple-plane approach to measure the structural properties of functionally active regions in the human cortexXin Wang
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 49:3075-85. 2010..These results support the use of novel approaches for combined analysis of functional and structural neuroimaging... - Differentiation of recurrent brain tumor versus radiation injury using diffusion tensor imaging in patients with new contrast-enhancing lesionsPia C Sundgren
Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI 48109 0030, USA
Magn Reson Imaging 24:1131-42. 2006.... - Decision-related loss: regret and disappointmentHannah Faye Chua
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 47:2031-40. 2009.... - Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youthKate Dimond Fitzgerald
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
J Child Psychol Psychiatry 49:986-94. 2008..Developmental neuroimaging studies of response inhibition have found pMFC activation, but the possible contribution of error-related activation during inhibitory processing has not been well studied in youth... - Exogenous glucocorticoids decrease subgenual cingulate activity evoked by sadnessKeith D Sudheimer
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 38:826-45. 2013.... - Accumbens functional connectivity during reward mediates sensation-seeking and alcohol use in high-risk youthBarbara J Weiland
Department of Psychiatry, The University of Michigan, Ann Arbor, MI, United States Addiction Research Center, The University of Michigan, Ann Arbor, MI, United States Electronic address
Drug Alcohol Depend 128:130-9. 2013..Differences in accumbens connectivity with attention/motor/default networks, rather than control systems, may influence the reward system's role in vulnerability for substance abuse... - Aging and the neural correlates of successful picture encoding: frontal activations compensate for decreased medial-temporal activityAngela H Gutchess
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
J Cogn Neurosci 17:84-96. 2005..Because the analyses included only the unique activations associated with remembered items, these data suggest that prefrontal regions could serve a compensatory role for declines in medial-temporal activations with age... - A functional neuroimaging study of motivation and executive functionStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0118, USA
Neuroimage 21:1045-54. 2004..Areas of overlap and interaction may integrate information about value, or they may represent a general effect of motivation increasing neural effort... - Resting state cortico-cerebellar functional connectivity networks: a comparison of anatomical and self-organizing map approachesJessica A Bernard
Department of Psychology, University of Michigan, Ann Arbor MI, USA
Front Neuroanat 6:31. 2012..Additionally, driving the analyses from the cerebellum is key to determining the complete picture of functional connectivity within the structure... - Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI studyK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0118, USA
Biol Psychiatry 53:211-5. 2003..CONCLUSIONS: Our findings demonstrate that individual behavioral data are useful in improving detection of activation in block-design functional imaging studies... - Cultural differences in neural function associated with object processingAngela H Gutchess
University of Michigan, Ann Arbor, USA
Cogn Affect Behav Neurosci 6:102-9. 2006..These results suggest that cultural experiences subtly direct neuralactivity, particularly for focal objects, at an early stage of scene encoding... - Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthoodBarbara J Weiland
Department of Psychiatry, The University of Michigan, Ann Arbor, 48109, USA
Alcohol Clin Exp Res 36:1355-64. 2012..Cortical-striatal connectivity has been proposed to underlie adaptive switches between cautious and risky behaviors... - Clinical applications of diffusion tensor imagingQian Dong
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109-0030, USA
J Magn Reson Imaging 19:6-18. 2004..This review describes the clinical utility of diffusion tensor imaging, including the basic principles of the technique, acquisition, data analysis, and the major clinical applications... - The Relationship between Depressive Symptoms, Disease State, and Cognition in Amyotrophic Lateral SclerosisLaura Jelsone-Swain
Department of Radiology, University of Michigan Ann Arbor, MI, USA
Front Psychol 3:542. 2012..Collectively, it is suggested that translational advances in psychological intervention for those with CI and depression become emphasized in future research... - Using a self-organizing map algorithm to detect age-related changes in functional connectivity during rest in autism spectrum disordersJillian Lee Wiggins
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Brain Res 1380:187-97. 2011..These findings indicate that SOM is a complementary method for calculating connectivity in a clinical population. Additionally, adolescents with ASD have a different developmental trajectory of the default network compared to controls... - Sustained activation of the hippocampus in response to fearful faces in schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 57:1011-9. 2005..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia... - Neural correlates of individual ratings of emotional salience: a trial-related fMRI studyK Luan Phan
Department of Psychiatry and Behvioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
Neuroimage 21:768-80. 2004..The findings highlight both overlapping and segregated neural representations of intrinsic value and personal relevance during the appraisal of emotional stimuli... - Working memory for complex scenes: age differences in frontal and hippocampal activationsDenise C Park
The Beckman Institute, University of Illinois at Urbana Champaign 61801, USA
J Cogn Neurosci 15:1122-34. 2003..Thus, we demonstrate qualitatively different engagement of both frontal and hippocampal structures in older adults in a working memory task, despite behavioral equivalence... - Does fitness level modulate the cardiovascular hemodynamic response to exercise?Michael K Stickland
Faculty of Physiucal Education and Recreation, University of Alberta, Edmonton, Canada
J Appl Physiol 100:1895-901. 2006.... - Decreased neural specialization in old adults on a working memory taskDoris Payer
Department of Psychology, The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Neuroreport 17:487-91. 2006..Results provided evidence for less specialization of faces and houses in older adults than in younger adults, while the middle and inferior frontal cortex showed increased activation in elders compared with the young... - Guideline adjudicated fibrinolytic failure: incidence, findings, and management in a contemporary clinical trialChristopher E Buller
University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
Am Heart J 155:121-7. 2008..We sought to describe the frequency of fibrinolytic failure (rescue eligibility) as well as the patient characteristics associated with rescue eligibility, rescue referral, and PCI...