Rebecca Wells

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
    Penelope C Georges
    Dept of Medicine, Univ of Pennsylvania School of Medicine, Philadelphia, PA 19104 6140, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1147-54. 2007
  2. ncbi request reprint Autocrine release of TGF-beta by portal fibroblasts regulates cell growth
    Rebecca G Wells
    The University of Pennsylvania School of Medicine, 600 CRB 6140, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    FEBS Lett 559:107-10. 2004
  3. ncbi request reprint The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis
    Rebecca G Wells
    Department of Medicine Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Gastroenterol 39:S158-61. 2005
  4. pmc Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
    Masayuki Uemura
    The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Biol Cell 16:4214-24. 2005
  5. ncbi request reprint Repetitive exposure to TGF-beta suppresses TGF-beta type I receptor expression by differentiated osteoblasts
    Kenneth K Kim
    Yale University School of Medicine, Department of Surgery, New Haven, CT 06520 8041, USA
    Gene 379:175-84. 2006
  6. pmc The portal fibroblast: not just a poor man's stellate cell
    Rebecca G Wells
    Departments of Medicine GI and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Gastroenterology 147:41-7. 2014
  7. pmc Cholangiocyte cilia are abnormal in syndromic and non-syndromic biliary atresia
    Andrew S Chu
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mod Pathol 25:751-7. 2012
  8. pmc Tissue mechanics and fibrosis
    Rebecca G Wells
    The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Biochim Biophys Acta 1832:884-90. 2013
  9. pmc Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
    Maryna Perepelyuk
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Physiol Gastrointest Liver Physiol 304:G605-14. 2013
  10. pmc Cellular sources of extracellular matrix in hepatic fibrosis
    Rebecca G Wells
    Department of Medicine Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6140, USA
    Clin Liver Dis 12:759-68, viii. 2008

Collaborators

  • Jonathan A Dranoff
  • Hong Fu
  • Frank Giordano
  • Matthew Raab
  • EUGENE SCOTT SWENSON
  • LINDA GREENBAUM
  • Paul Janmey
  • O Eickelberg
  • Thomas McCarthy
  • Masayuki Uemura
  • Penelope C Georges
  • Zhaodong Li
  • Marianna D A Gaca
  • Maryna Perepelyuk
  • Andrew S Chu
  • Abby L Olsen
  • Zina Meriden
  • Andrew Y Wang
  • Erick P Chan
  • Sara D Sackett
  • Emma E Furth
  • Jia Ji Hui
  • Kenneth K Kim
  • Michael Reiss
  • Chenghai Liu
  • Mitsuo Yamauchi
  • Masahiko Terajima
  • Pierre A Russo
  • Bridget Sackey
  • Steven A Bloomer
  • K Rajender Reddy
  • Theresa L Pasha
  • Kimberly A Forde
  • Reginald Hurtt
  • Karrie Brondell
  • Yan Gao
  • Klaus H Kaestner
  • Rosemarie Mick
  • Zoltan Gombos
  • Margaret E McCormick
  • Jean Sevigny
  • Weizhong Chang
  • Changhua Ji
  • Michael Centrella
  • Caren M Gundberg
  • Vincent F Vellucci

Detail Information

Publications21

  1. ncbi request reprint Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
    Penelope C Georges
    Dept of Medicine, Univ of Pennsylvania School of Medicine, Philadelphia, PA 19104 6140, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1147-54. 2007
    ..We suggest that increased liver stiffness may play an important role in initiating the early stages of fibrosis...
  2. ncbi request reprint Autocrine release of TGF-beta by portal fibroblasts regulates cell growth
    Rebecca G Wells
    The University of Pennsylvania School of Medicine, 600 CRB 6140, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    FEBS Lett 559:107-10. 2004
    ..Fibroblast growth factor (FGF)-2, but not platelet derived growth factor (PDGF), causes PF proliferation. These data suggest a mechanism whereby HSC eclipse PF as the dominant myofibroblast population in biliary fibrosis...
  3. ncbi request reprint The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis
    Rebecca G Wells
    Department of Medicine Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Gastroenterol 39:S158-61. 2005
    ....
  4. pmc Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
    Masayuki Uemura
    The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Biol Cell 16:4214-24. 2005
    ..We suggest that TGF-beta, signaling via Smad3, plays an important role in the morphological and functional maturation of hepatic myofibroblasts...
  5. ncbi request reprint Repetitive exposure to TGF-beta suppresses TGF-beta type I receptor expression by differentiated osteoblasts
    Kenneth K Kim
    Yale University School of Medicine, Department of Surgery, New Haven, CT 06520 8041, USA
    Gene 379:175-84. 2006
    ..This tightly controlled system may constitute a feedback loop to protect against TGF-beta excess, and impose important limitations that are required for the progression of events during skeletal growth, remodeling and repair...
  6. pmc The portal fibroblast: not just a poor man's stellate cell
    Rebecca G Wells
    Departments of Medicine GI and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Gastroenterology 147:41-7. 2014
    ..Understanding the functions of portal fibroblasts will require us to view them as more than just an alternative to hepatic stellate cells in fibrosis. ..
  7. pmc Cholangiocyte cilia are abnormal in syndromic and non-syndromic biliary atresia
    Andrew S Chu
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mod Pathol 25:751-7. 2012
    ..Although this may result from severe cholestasis or inflammation, it may also reflect common mechanistic pathways in different forms of BA and may have important implications for understanding the progression of the disease...
  8. pmc Tissue mechanics and fibrosis
    Rebecca G Wells
    The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Biochim Biophys Acta 1832:884-90. 2013
    ..This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease...
  9. pmc Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
    Maryna Perepelyuk
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Physiol Gastrointest Liver Physiol 304:G605-14. 2013
    ..These data suggest a model in which the liver is primed to respond quickly to injury, activating potential mechanical feed-forward mechanisms...
  10. pmc Cellular sources of extracellular matrix in hepatic fibrosis
    Rebecca G Wells
    Department of Medicine Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6140, USA
    Clin Liver Dis 12:759-68, viii. 2008
    ..The future challenge will be to define more explicitly the roles of these different fibrogenic cell populations in fibrosis in a disease-specific way...
  11. doi request reprint The role of matrix stiffness in regulating cell behavior
    Rebecca G Wells
    Department of Medicine Gastroenterology, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hepatology 47:1394-400. 2008
    ..Particular mention is made of data suggesting that cells of the liver are mechanosensitive, highlighting the potential importance of these findings in understanding the biology of normal and diseased liver...
  12. ncbi request reprint Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture
    Zhaodong Li
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hepatology 46:1246-56. 2007
    ....
  13. pmc Foxl1 is a marker of bipotential hepatic progenitor cells in mice
    Sara D Sackett
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hepatology 49:920-9. 2009
    ..These results demonstrate that the early Foxl1-Cre lineage cell gives rise to both cholangiocytes and hepatocytes after liver injury and suggest the potential for progenitor-portal fibroblast cell interactions...
  14. pmc Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet
    Rebecca G Wells
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sci Signal 1:pe13. 2008
    ..More broadly, the work suggests that matrix stiffness could regulate the equilibrium between storage and release of a host of matrix-bound growth factors...
  15. pmc Hepatic stellate cells require a stiff environment for myofibroblastic differentiation
    Abby L Olsen
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Physiol Gastrointest Liver Physiol 301:G110-8. 2011
    ..These findings suggest that alterations in liver stiffness are a key factor driving the progression of fibrosis...
  16. pmc Histologic predictors of fibrosis progression in liver allografts in patients with hepatitis C virus infection
    Zina Meriden
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 8:289-96, 296.e1-8. 2010
    ..Recurrent hepatitis C with ensuing fibrosis is the leading cause of liver allograft loss. We investigated whether histologic features in early posttransplant liver biopsies could predict the rate of fibrosis progression in this population...
  17. ncbi request reprint BMP-7: a new TGF-beta family member takes the stage in colitis treatment
    Rebecca G Wells
    The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Inflamm Bowel Dis 10:169. 2004
  18. ncbi request reprint Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells
    Jonathan A Dranoff
    Yale Univ School of Medicine, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 287:G417-24. 2004
    ..Because activation of P2Y receptors in activated HSC regulates procollagen-1 transcription, P2Y receptors may be an attractive target to prevent or treat liver fibrosis...
  19. ncbi request reprint Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
    Chenghai Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:11721-8. 2003
    ..These results demonstrate essential differences between TGF-beta-mediated signaling pathways in quiescent and in vitro transdifferentiated hepatic stellate cells...
  20. ncbi request reprint Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function
    Oliver Eickelberg
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    J Biol Chem 277:823-9. 2002
    ..Our data indicate that betaglycan can function as a potent inhibitor of TGF-beta signaling by a novel mechanism and provide support for an essential but complex role for proteoglycan co-receptors in growth factor signaling...

Research Grants18

  1. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca G Wells; Fiscal Year: 2010
    ....
  2. Betaglycan as a modulator of TGF-beta signaling in hepatoma
    Rebecca Wells; Fiscal Year: 2007
    ..They will also greatly increase our understanding of TGF-beta signaling in general, and will pave the way for in vivo studies of beta glycan. ..
  3. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca Wells; Fiscal Year: 2009
    ..This application proposes a new model to explain components of fibrosis progression, that, if supported by the experiments proposed here, would have significant implications for the understanding and treatment of fibrosis. ..
  4. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2001
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  5. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca Wells; Fiscal Year: 2009
    ....
  6. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca Wells; Fiscal Year: 2009
    ....
  7. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca Wells; Fiscal Year: 2007
    ....
  8. Betaglycan as a modulator of TGF-b signaling in hepatoma
    Rebecca Wells; Fiscal Year: 2006
    ..They will also greatly increase our understanding of TGF-beta signaling in general, and will pave the way for in vivo studies of beta glycan. ..
  9. Betaglycan as a modulator of TGF-b signaling in hepatoma
    Rebecca Wells; Fiscal Year: 2005
    ..They will also greatly increase our understanding of TGF-beta signaling in general, and will pave the way for in vivo studies of beta glycan. ..
  10. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2005
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  11. Betaglycan as a modulator of TGF-b signaling in hepatoma
    Rebecca Wells; Fiscal Year: 2004
    ..They will also greatly increase our understanding of TGF-beta signaling in general, and will pave the way for in vivo studies of beta glycan. ..
  12. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2004
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  13. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2002
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  14. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2003
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  15. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2002
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  16. TGF-beta, matrix, and myofibroblasts in hepatic fibrosis
    Rebecca Wells; Fiscal Year: 2009
    ....