Affiliation: University of Georgia
Vaidyanathan K, Wells L. Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes. J Biol Chem. 2014;289:34466-71 pubmed publisher
..We will also summarize potential causal roles for the O-GlcNAc modification in complications associated with diabetes. ..
Durning S, Flanagan Steet H, Prasad N, Wells L. O-Linked Î²-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells. J Biol Chem. 2016;291:2107-18 pubmed publisher
..These findings implicate the O-GlcNAc modification as a potential mechanism for hyperglycemic-regulated gene expression in the beta cell. ..
Selvan N, George S, Serajee F, Shaw M, Hobson L, Kalscheuer V, et al
. O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling. J Biol Chem. 2018;293:10810-10824 pubmed publisher
Teo C, El Karim E, Wells L. Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin. Glycobiology. 2016;26:1198-1208 pubmed publisher
Halmo S, Singh D, Patel S, Wang S, Edlin M, Boons G, et al
. Protein O-Linked Mannose Î²-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of Î±-Dystroglycan. J Biol Chem. 2017;292:2101-2109 pubmed publisher
Vaidyanathan K, Niranjan T, Selvan N, Teo C, May M, Patel S, et al
. Identification and characterization of a missense mutation in the O-linked ?-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability. J Biol Chem. 2017;292:8948-8963 pubmed publisher
Webster D, Teo C, Sun Y, Wloga D, Gay S, Klonowski K, et al
. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev Biol. 2009;9:28 pubmed publisher
..O-GlcNAc modifies the transcription factor Spiel ohne grenzen/Pou5f1 and may regulate its activity. ..
Wells L, Kreppel L, Comer F, Wadzinski B, Hart G. O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem. 2004;279:38466-70 pubmed
Sheikh M, Wells L. Whoa man! Unexpected protein O-mannosylation pathways in mammals. J Biol Chem. 2017;292:11599-11600 pubmed publisher
..In an effort to explore those roles, a new study now serendipitously uncovers the existence of an alternative pathway to the well-described POMT (protein O-mannosyltransferase) family of O-mannosyltransferases. ..