Alan Wells

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway
    Akihiro Iwabu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:14551-60. 2004
  2. pmc α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13921. 2010
  3. pmc STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
    W Zhou
    Laboratory and Pathology Service, Pittsburgh VAMC, PA, USA
    Br J Cancer 95:164-71. 2006
  4. ncbi request reprint PKCδ Regulates Force Signaling during VEGF/CXCL4 Induced Dissociation of Endothelial Tubes
    Joshua Jamison
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e93968. 2014
  5. pmc Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin
    C C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, PA 15213, USA
    Br J Cancer 96:1246-52. 2007
  6. pmc The dormancy dilemma: quiescence versus balanced proliferation
    Alan Wells
    Department of Pathology and Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 73:3811-6. 2013
  7. pmc Targeting tumor cell motility as a strategy against invasion and metastasis
    Alan Wells
    Department of Pathology, University of Pittsburgh and Pittsburgh VAHS, Pittsburgh, PA 15213, USA
    Trends Pharmacol Sci 34:283-9. 2013
  8. ncbi request reprint Laboratory medicine: a view to the future of diagnostics and training
    Alan Wells
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15217, USA
    Rinsho Byori 60:312-20. 2012
  9. pmc Growth factor regulation of proliferation and survival of multipotential stromal cells
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 USA
    Stem Cell Res Ther 1:32. 2010
  10. ncbi request reprint Counterpoint: developing a clinical pathology curriculum to meet current and future needs
    Alan Wells
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Chem 52:971-2. 2006

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway
    Akihiro Iwabu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:14551-60. 2004
    ..Hence, we identify here a new pathway helping to govern cell motility, with PLC signaling playing a role in activation of PKCdelta to promote the acute phase of EGF-induced MLC activation...
  2. pmc α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13921. 2010
    ..Interestingly, ACTN4 is phosphorylated upon growth factor stimulation, and this loosens its interaction with actin...
  3. pmc STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
    W Zhou
    Laboratory and Pathology Service, Pittsburgh VAMC, PA, USA
    Br J Cancer 95:164-71. 2006
    ..These findings suggest a molecular basis for the STAT3 dependence of EGFR-mediated prostate tumour progression...
  4. ncbi request reprint PKCδ Regulates Force Signaling during VEGF/CXCL4 Induced Dissociation of Endothelial Tubes
    Joshua Jamison
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e93968. 2014
    ..This study suggests that growth factor regulation of PKCδ may be involved in CXCL4-mediated dissociation of endothelial cords. ..
  5. pmc Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin
    C C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, PA 15213, USA
    Br J Cancer 96:1246-52. 2007
    ..We conclude that the term epithelial-mesenchymal transition only summarises the transient downregulation of E-cadherin for invasion with re-expression of E-cadherin being a physiological consequence of metastatic seeding...
  6. pmc The dormancy dilemma: quiescence versus balanced proliferation
    Alan Wells
    Department of Pathology and Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 73:3811-6. 2013
    ..As such, a greater emphasis on developing diagnostics and therapeutics for quiescent carcinomas is needed...
  7. pmc Targeting tumor cell motility as a strategy against invasion and metastasis
    Alan Wells
    Department of Pathology, University of Pittsburgh and Pittsburgh VAHS, Pittsburgh, PA 15213, USA
    Trends Pharmacol Sci 34:283-9. 2013
    ..In this context, the cellular phenotype will also be discussed because the modes of migration are dictated by quantitative and physical aspects of the cell motility machinery...
  8. ncbi request reprint Laboratory medicine: a view to the future of diagnostics and training
    Alan Wells
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15217, USA
    Rinsho Byori 60:312-20. 2012
    ....
  9. pmc Growth factor regulation of proliferation and survival of multipotential stromal cells
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 USA
    Stem Cell Res Ther 1:32. 2010
    ..The present review looks at the effect of and downstream signaling of various growth factors on proliferation and survival in MSCs...
  10. ncbi request reprint Counterpoint: developing a clinical pathology curriculum to meet current and future needs
    Alan Wells
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Chem 52:971-2. 2006
  11. ncbi request reprint Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis
    Alan Wells
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA 15213, USA
    Front Biosci (Landmark Ed) 16:815-37. 2011
    ..Finally, we will describe a new mode of discerning the balance between epithelioid and mesenchymal movement...
  12. pmc E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas
    Alan Wells
    Department of Pathology, Pittsburgh VA Medical Center and University of Pittsburgh, 3550 Terrace St, Scaife Hall, S 713, Pittsburgh, PA 15261, USA
    Clin Exp Metastasis 25:621-8. 2008
    ....
  13. ncbi request reprint The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: an overview
    Alan Wells
    Department Pathology, University of Pittsburgh, Scaife 713, Pittsburgh, PA 15213, USA
    Clin Lab Med 27:229-40; abstract v. 2007
    ..Furthermore, this pathologist must be steeped in the skills required for lifelong learning and adaptation...
  14. pmc m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate
    Ludovic Leloup
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:33549-66. 2010
    ..The phosphorylation of m-calpain by ERK and PKA by growth factors and chemokines, respectively, act in cells to regulate the enzyme only indirectly by controlling its redistribution...
  15. pmc Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling
    Anand Krishnan V Iyer
    Department of Pathology, University of Pittsburgh, Pittsburgh, Penssylvania 15261, USA
    J Cell Physiol 214:504-12. 2008
    ..This work extends the signaling paradigm of EGFL repeat being presented in a restricted fashion as part of the extracellular matrix...
  16. pmc Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway
    Kenichi Tamama
    Department of Pathology, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Stem Cells Dev 17:897-908. 2008
    ..This approach has obvious implications for cell therapeutics and tissue engineering of hollow visceral organs such as blood vessels...
  17. pmc The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Int J Biochem Cell Biol 45:1051-63. 2013
    ..These findings suggest that the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum...
  18. pmc Expression of myopodin induces suppression of tumor growth and metastasis
    Ling Jing
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Pathol 164:1799-806. 2004
    ..All these results support the hypothesis that myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells...
  19. pmc Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor
    Cecelia C Yates
    Department of Pathology, University of Pittsburgh and Pittsburgh VAMC, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 171:484-95. 2007
    ..These studies establish a pathophysiologic role for CXCR3 and its ligand during wound repair...
  20. ncbi request reprint DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling
    Asmaa Mamoune
    Department of Pathology, University of Pittsburgh, PA 15261, USA
    Exp Cell Res 299:91-100. 2004
    ..Herein, a number of key molecules whose expression levels are interrelated, including both EGFR and uPAR, are required but none are sufficient in the absence of other keys molecules in promoting tumor progression...
  21. ncbi request reprint Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression
    Clayton Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Adv Cancer Res 97:225-46. 2007
    ..It also circumvents current limitations in assays to assess early events in metastasis, and provides new approaches to study molecular events during tumor progression...
  22. pmc Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring
    Cecelia C Yates
    University of Pittsburgh, Department of Pathology, Pittsburgh, PA 15261, USA
    Am J Pathol 176:1743-55. 2010
    ....
  23. doi request reprint Pericyte regulation of vascular remodeling through the CXC receptor 3
    Richard J Bodnar
    From the Department of Pathology R J B, M E B, A W and Department of Bioengineering W C W C, University of Pittsburgh, PA and Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA R J B, M E B, A W
    Arterioscler Thromb Vasc Biol 33:2818-29. 2013
    ..To understand the role, if any, played by pericytes in the regulation of newly formed vessels during angiogenesis. In this study, we investigate whether pericytes regulate the number of nascent endothelial tubes...
  24. pmc Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:2591-600. 2010
    ..These results suggest that EGF regulates the actin binding activity of ACTN4 by inducing tyrosyl-directed phosphorylation...
  25. pmc Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C
    Jelena Grahovac
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    J Invest Dermatol 133:210-20. 2013
    ..Our findings suggest that melanoma-derived TNCEGFL exert a role in melanoma invasion by modulating ROCK signaling and cell migration...
  26. ncbi request reprint EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness
    Jareer Kassis
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA, USA
    Int J Cancer 99:644-51. 2002
    ..Instead, we found that the EBV-infected cells presented increased focal adhesion kinase (FAK) phosphorylation. These findings suggest a role for integrin-mediated signaling in promoting EBV-associated invasiveness...
  27. ncbi request reprint Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells
    Sourabh Kharait
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 343:848-56. 2006
    ..Thus, we conclude that PKCdelta inhibition can limit migration and invasion of prostate cancer cells...
  28. pmc Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion
    Qian Wu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Cancer 11:3. 2012
    ..While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively with cancer progression though the molecular basis remains unclear...
  29. ncbi request reprint Breast cancer--response rates to chemotherapeutic agents studied in vitro
    Paul Kornblith
    Precision Therapeutics, Inc, 2516 Jane Street, Pittsburgh, PA 15203, USA
    Anticancer Res 23:3405-11. 2003
    ..The biological efficacy of, and spectrum of action of, agents used in treatment of breast cancer are important issues in therapy planning...
  30. pmc Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh, Scaife Hall, S 711, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Mol Cell Biol 26:5481-96. 2006
    ....
  31. pmc Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility
    Beatrice B Yaroslavskiy
    Department of Pathology, University of Pittsburgh, Veteran s Affairs Medical Center, Pittsburgh, PA 15243, USA
    J Cell Sci 120:2884-94. 2007
    ..We conclude that NO-induced motility in osteoclasts requires regulated Ca(2+) release, which activates mu-calpain. This occurs via the Ins(1,4,5)P(3)R1...
  32. ncbi request reprint Extracellular matrix signaling through growth factor receptors during wound healing
    Kien T Tran
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Wound Repair Regen 12:262-8. 2004
    ..We provide a model framework for further studies into this emerging class of signals...
  33. doi request reprint Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model
    Cecelia C Yates
    Department of Pathology and McGowan Institute for Regenerative Medicine, University of Pittsburgh and Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Cell Transplant 21:919-31. 2012
    ..These suggest that the major determinant of healing versus scarring lies with the nature of the matrix. These findings have intriguing implications for rational cellular interventions aimed at promoting wound healing via cell therapy...
  34. pmc Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells
    Yong Ho Bae
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 107:21547-52. 2010
    ..In summary, this study uncovers a unique biological consequence of profilin1-phosphoinositide interaction, thus providing direct evidence of profilin1's regulation of cell migration independent of its actin-related activity...
  35. ncbi request reprint Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 63:5629-35. 2003
    ..Tumors expressed higher levels of phosphorylated PLCgamma-1 compared with normal adjacent mucosa (P = 0.05). Thus, PLCgamma-1 may mediate invasion and metastasis downstream of EGFR in HNSCC...
  36. ncbi request reprint Gene expression patterns in isolated keloid fibroblasts
    Latha Satish
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Wound Repair Regen 14:463-70. 2006
    ..We also report for the first time that a few tumor-related genes are overexpressed in keloid fibroblasts...
  37. pmc Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 31:104-16. 2013
    ..Our results suggest that MSCs and differentiating osteoblasts need protective signals to survive in the inflammatory wound milieu and that tEGF can serve this function...
  38. ncbi request reprint Calpain-2 as a target for limiting prostate cancer invasion
    Asmaa Mamoune
    Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cancer Res 63:4632-40. 2003
    ..Taken together, these results strongly suggest that epigenetic activation of calpain plays an important role in the invasion of human prostate cancer and that it can be targeted to reduce tumor progression...
  39. pmc Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins
    Yong Ho Bae
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Cell Physiol 219:354-64. 2009
    ..Our findings for the first time highlight a possible mechanism of how reduced expression of a pro-migratory molecule like Pfn1 could actually promote motility of breast cancer cells...
  40. ncbi request reprint Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar
    Priya Krishna
    University of Pittsburgh Voice Center, Department of Otolaryngology, PA 15213, USA
    Otolaryngol Head Neck Surg 135:937-45. 2006
    ..To investigate hepatocyte growth factor (HGF) primed fibroblasts and decorin application on skin and vocal fold fibroblasts in vitro and in vivo in rabbit vocal fold scar model...
  41. ncbi request reprint Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity
    Anand Krishnan V Iyer
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 211:748-58. 2007
    ..This transient interaction with the receptor on the cell surface is in marked contrast to other EGFR ligands which cause EGFR transit through, and signaling from intracellular locales in addition to cell surface signaling...
  42. ncbi request reprint Motility signaled from the EGF receptor and related systems
    Alan Wells
    Department of Pathology, University of Pittsburgh, PA, USA
    Methods Mol Biol 327:159-77. 2006
    ..Herein we describe methods that measure the overall motility and its parameters as well as the biophysical processes extension, de-adhesion/retraction, and contraction...
  43. pmc IP-10 induces dissociation of newly formed blood vessels
    Richard J Bodnar
    Pittsburgh Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    J Cell Sci 122:2064-77. 2009
    ..This is the first direct evidence for an extracellular signaling mechanism through CXCR3 that causes the dissociation of newly formed blood vessels followed by cell death...
  44. pmc Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain
    Latha Satish
    Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Cell Biol 25:1922-41. 2005
    ..This is also the first demonstration of differential activation of the two ubiquitous calpain isoforms in the same cell by different signals...
  45. pmc Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC
    Kenichi Tamama
    Department of Pathology, The Ohio State University, Columbus, OH 43210, USA
    J Biomed Biotechnol 2010:795385. 2010
    ..Tethered EGF can also be utilized to direct MSC towards osteogenic lineage both in vitro and in vivo...
  46. ncbi request reprint Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA 15213, USA
    Oncogene 24:5897-904. 2005
    ..The CCR7-mediated pathway in metastatic SCCHN cells functions independently of EGFR signal transduction and therefore may represent an additional target for therapeutic intervention to prevent tumor progression and metastasis...
  47. ncbi request reprint Motility is rate-limiting for invasion of bladder carcinoma cell lines
    Jareer Kassis
    Pathology and Laboratory Medicine Service, Pittsburgh VAMC and Department of Pathology, University of Pittsburgh, S713 Scaife, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Int J Biochem Cell Biol 34:762-75. 2002
    ..These results demonstrate that one interventional target for limiting invasion is not necessarily an individual motility pathway but rather cell migration per se...
  48. ncbi request reprint Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways
    Latha Satish
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Wound Repair Regen 12:183-92. 2004
    ..Thus, the blunted migratory response to EGF noted in keloid fibroblasts appears due to limited activation of two important biochemical switches for cell motility...
  49. pmc Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways
    Hanshuang Shao
    Department of Pathology, University of Pittsburgh, and Department of Pathology, Pittsburgh VAMC, Pittsburgh, Pennsylvania 15261, USA
    Wound Repair Regen 16:551-8. 2008
    ..These findings indicate that EGF receptor activation provides survival response against staurosporine-induced apoptosis through signal pathways of PI3K and Rac, which then may prevent the activation of caspase-3...
  50. pmc The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Tissue Eng Part A 19:1972-83. 2013
    ..This matrix component is proposed to supplement MSC delivery on the scaffolds to provide a survival advantage against death upon in vivo implantation. ..
  51. ncbi request reprint Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
    Stephen Y Lai
    Department of Otolaryngology Head and Neck Surgery, The Eye and Ear Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Oncogene 24:4442-9. 2005
    ..Increased levels of EPO and EPOR in lymph node metastases as compared to primary tumors from HNSCC patients further support the role of EPO/EPOR in HNSCC disease progression and metastasis...
  52. pmc Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility
    Sourabh Kharait
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    BMC Syst Biol 1:9. 2007
    ....
  53. pmc Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking
    Timothy Travers
    Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biophys J 104:705-15. 2013
    ..Collectively, these studies provide a starting point for understanding the role of external cues in regulating ACTN4, with different phenotypes resulting from changes in the multidomain assembly of the protein...
  54. ncbi request reprint Growth factor-induced cell motility in tumor invasion
    Alan Wells
    Department of Pathology, Pittsburgh VAMC, PA 15261, USA
    Acta Oncol 41:124-30. 2002
    ..These represent novel and potentially selective targets for drug development. Future advances in the imaging of tumors in animals and ex vivo organ culture systems should provide additional new targets...
  55. pmc ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair
    Cecelia C Yates
    Department of Pathology, University of Pittsburgh and Pittsburgh Veteran s Administration Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 173:643-52. 2008
    ..We conclude that IP-9 is a key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis...
  56. pmc Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells
    Tuhin Das
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Cell Physiol 218:436-43. 2009
    ..These findings may provide mechanistic insights underlying at least some of the tumor-suppressive properties of Pfn1...
  57. pmc Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3
    Cecelia C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Wound Repair Regen 17:34-41. 2009
    ..These studies further establish the emerging signaling network that involves the CXCR3 chemokine receptor and its ligands as a key regulator of wound repair...
  58. ncbi request reprint Skin wound healing and scarring: fetal wounds and regenerative restitution
    Cecelia C Yates
    Department of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania
    Birth Defects Res C Embryo Today 96:325-33. 2012
    ..Herein, we propose that matrix can be controlled via cellular therapy to resemble a fetal-like matrix that will result in reduced scarring...
  59. ncbi request reprint Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility
    Jeffrey Chou
    Department of Pathology, University of Pittsburgh, 713 Scaife Street, Pittsburgh, PA 15261, USA
    Int J Biochem Cell Biol 34:776-90. 2002
    ..Together these data suggest a model of PIP(2) hydrolysis at the leading edge causing a localized release of PIP(2)-binding proteins-particularly gelsolin-that drives cytoskeletal rearrangement and protrusion...
  60. ncbi request reprint Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors
    Robert L Ochs
    Precision Therapeutics, Inc, 2516 Jane Street, Pittsburgh, Pennsylvania 15203, USA
    In Vitro Cell Dev Biol Anim 39:63-70. 2003
    ..These data also provide proof that malignant tumor cells, derived from a diverse number of human solid tumors, can be isolated and grown in primary cell culture...
  61. pmc Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
    Yvonne L Chao
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Cancer 9:179. 2010
    ....
  62. ncbi request reprint Directional motility induced by epidermal growth factor requires Cdc42
    Jeffrey Chou
    Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Cell Res 287:47-56. 2003
    ..We conclude that Cdc42 controls cell polarity, likely in part, through its binding to active PLCgamma...
  63. pmc The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models
    Cecelia C Yates
    Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Biomaterials 28:3977-86. 2007
    ..These preclinical studies show that the anti-microbial polymer gel not only supports but also accelerates healing of bacterially contaminated wounds...
  64. pmc PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling
    Joshua Jamison
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e77434. 2013
    ..Therefore, we investigated whether the membrane localization of PKCδ mediates the transcellular contractility of fibroblasts...
  65. ncbi request reprint Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair
    Latha Satish
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Invest Dermatol 120:1110-7. 2003
    ..This provides for a model whereby redifferentiated basal keratinocytes could limit fibroblast repopulation of the dermis underlying healed wounds while simultaneously promoting re-epithelialization of the remaining provisional wound...
  66. pmc Modeling boundary conditions for balanced proliferation in metastatic latency
    Donald P Taylor
    Department of Bioengineering, University of Pittsburgh and Taylor Allderdice High School, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 19:1063-70. 2013
    ..To examine the boundary parameters for balanced proliferation, we conducted in silico modeling...
  67. pmc CSR1 suppresses tumor growth and metastasis of prostate cancer
    Guoying Yu
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Pathol 168:597-607. 2006
    ..The present findings suggest that CSR1 is a potent tumor sup-pressor gene...
  68. doi request reprint Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance
    Yvonne Chao
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Exp Metastasis 29:39-50. 2012
    ....
  69. pmc IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain
    Richard J Bodnar
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261 0001, USA
    Circ Res 98:617-25. 2006
    ..This provides a means by which late wound repair signals limit the angiogenesis driven early in the wound response process...
  70. pmc Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells
    Zhijie Ding
    Department of Bioengineering, University of Pittsburgh, PA, USA
    Exp Cell Res 315:2963-73. 2009
    ..Together, these experimental data demonstrate that Pfn1 regulates VEC migration, invasion and capillary morphogenesis through its interaction with both actin and proline-rich ligands...
  71. doi request reprint The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring
    Priya Krishna
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Laryngoscope 120:2247-57. 2010
    ....
  72. ncbi request reprint Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity
    Kien T Tran
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Cell Res 289:359-67. 2003
    ..These data support a model in which, near senescence, dermal fibroblasts become resistant to EGFR-mediated stimuli by a combination of receptor downregulation and increased signal attenuation...
  73. ncbi request reprint Cutting to the chase: calpain proteases in cell motility
    Angela Glading
    Dept of Pathology, University of Pittsburgh VAMC, PA 15261, USA
    Trends Cell Biol 12:46-54. 2002
    ..Armed with this knowledge, the precise roles of calpains in inflammation, wound repair and tumor progression can be ascertained and offer novel therapeutic targets...
  74. ncbi request reprint Calpain proteases in cell adhesion and motility
    Alan Wells
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int Rev Cytol 245:1-16. 2005
    ....
  75. pmc Matrix control of scarring
    Cecelia C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Mol Life Sci 68:1871-81. 2011
    ..This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations...
  76. pmc Proteomic analysis of laser microdissected melanoma cells from skin organ cultures
    Brian L Hood
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    J Proteome Res 9:3656-63. 2010
    ..This concordance demonstrates the value of SOCs for conducting proteomic investigations of the melanoma microenvironment...
  77. pmc Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL
    Allison C Sharrow
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15243, USA
    Exp Cell Res 314:297-308. 2008
    ..Cell-cell communication was maintained in serum starvation, which may model response to acute injury, but was sensitive to TNFs. These inflammatory agents mediated selective, reversible removal of connexin43 from cell processes...
  78. pmc Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain
    Hidenori Shiraha
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Cell Biol 22:2716-27. 2002
    ..These data point to a novel mechanism of negative control of calpain activation, direct phosphorylation by PKA...
  79. ncbi request reprint Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells
    Kenichi Tamama
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 24:686-95. 2006
    ..These findings suggest that EGFR ligands could be used for ex vivo expansion and direction of BMMSCs...
  80. ncbi request reprint Attraction or repulsion: a matter of individual taste?
    Alan Wells
    Department of Pathology and Pittsburgh Veterans Administration Medical Center, PA, USA
    Sci STKE 2004:pe47. 2004
    ..There are precedents for all three scenarios, but which one proves true will define the window of opportunity for regulating cell migration...
  81. ncbi request reprint Phospholipase C-gamma1 in tumor progression
    Alan Wells
    Pathology and Laboratory Service, Pittsburgh VAMC, Pennsylvania, USA
    Clin Exp Metastasis 20:285-90. 2003
    ..This has focused attention on initiators of signaling cascades that regulate tumor migration. In this effort, one molecule, phospholipase C-gamma 1 (PLCgamma), has been shown to function as a key molecular switch...
  82. ncbi request reprint Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling
    Alan Wells
    Department of Pathology, Pittsburgh VAMC and University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Cancer Res 8:1251-7. 2002
    ..One possible mechanism was suggested by LHRH receptors triggering phospholipase-C (PLC) to activate protein kinase C (PKC) because PKC activation limits EGFR tyrosine kinase activity by phosphorylating EGFR at threonine 654...
  83. ncbi request reprint Feasibility assessment of a chemoresponse assay to predict pathologic response in neoadjuvant chemotherapy for breast cancer patients
    Zhibao Mi
    Precision Therapeutics, Inc, Pittsburgh, PA 15203, USA
    Anticancer Res 28:1733-40. 2008
    ..For chemosensitivity and resistance assays to be clinically useful in predicting patient outcome, they should require small amounts of tissue and be highly reproducible and reliable...
  84. ncbi request reprint Absence of inhibition of cutaneous wound healing in mice by oral doxycycline
    Patricia A Hebda
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Wound Repair Regen 11:373-9. 2003
    ..These data suggest that wound healing studies incorporating transgene expression can utilize tet-on/tet-off regulation of gene expression without interference from doxycycline...
  85. pmc Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix
    Ranjith Babu
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, S 713 Pittsburgh, PA 15261, USA
    Biomaterials 27:4304-14. 2006
    ..In conclusion, silver ions can serve dual functions of catalyzing gelation and providing anti-microbial properties to a biocompatible polymer...
  86. ncbi request reprint Signalling shortcuts: cell-surface receptors in the nucleus?
    Alan Wells
    Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 3:697-702. 2002
    ....
  87. ncbi request reprint Pituitary glycoprotein hormone receptors in non-endocrine organs
    Harry C Blair
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Trends Endocrinol Metab 18:227-33. 2007
    ..Studies of the multiple roles of the glycoprotein hormone receptors are likely to uncover novel endocrine functions and axes, and highlight the potential of these receptors as novel therapeutic targets...
  88. ncbi request reprint In vitro responses of ovarian cancers to platinums and taxanes
    Paul Kornblith
    Precision Therapeutics, Inc, 2516 Jane Street, Pittsburgh, PA 15203, USA
    Anticancer Res 23:543-8. 2003
    ..These in vitro responses compare favorably to published in vivo clinical response rates. The current study serves to demonstrate how an in vitro predictive assay can be used as a surrogate for clinical therapeutic challenge...
  89. pmc Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion
    Hiroshi Nozawa
    Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cancer Res 14:4336-44. 2008
    ..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion...
  90. ncbi request reprint Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal
    Brian R Smith
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Hum Pathol 37:934-68. 2006
    ..This curriculum is presented as a potentially helpful outline for use by pathology residency training programs...
  91. ncbi request reprint Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts
    Kirsty D Smith
    Biological Engineering Division, 56 341 MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Exp Cell Res 312:1970-82. 2006
    ..Our findings have thus identified key signals downstream of EGFR, which integrate in a complex manner to generate and transmit contractile forces to yield matrix deformation...
  92. ncbi request reprint Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells
    Vivian H Fan
    Departments of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Stem Cells 25:1241-51. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  93. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
    ..Our experimental findings here represent, to our knowledge, discovery of a previously undescribed set of balances of cell and matrix properties that govern the ability of tumor cells to migration in 3D environments...
  94. ncbi request reprint EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation
    Elizabeth J Joslin
    Department of Biological Engineering, MIT, Cambridge, MA 02139, USA
    J Cell Sci 120:3688-99. 2007
    ..Thus, in our mammary epithelial cell system, migration and proliferation are differentially sensitive to the mode of EGF ligand presentation...
  95. ncbi request reprint Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells
    Bart S Hendriks
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biol Chem 280:6157-69. 2005
    ....
  96. ncbi request reprint Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal
    Brian R Smith
    Dept of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Am J Clin Pathol 125:S3-37. 2006
    ..This curriculum is presented as a potentially helpful outline for use by pathology residency training programs...
  97. ncbi request reprint Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal
    Brian R Smith
    Yale University, New Haven, CT 06520 8035, USA
    Clin Chem 52:917-49. 2006
    ..This curriculum is presented as a potentially helpful outline for use by pathology residency training programs...
  98. ncbi request reprint Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model
    Kulasekaran S Priya
    Biomaterials Division, Central Leather Research Institute, Adyar, Chennai, India
    Wound Repair Regen 12:618-25. 2004
    ..In short, we demonstrate a salutary action of the CA extract on wound healing, and suggest that this may be due to mitogenic and motogenic promotion of dermal fibroblasts...
  99. ncbi request reprint Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation
    Fred D Allen
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Wound Repair Regen 10:67-76. 2002
    ..Countervailing processes that down-regulate calpain activation can, accordingly, direct the transition of cell function from locomotion to matrix contraction...
  100. pmc Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis
    Douglas A Lauffenburger
    Biological Engineering Division, Biology Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biophys J 84:3499-500. 2003
  101. ncbi request reprint The challenge of training pathologists in the 21st century
    Alan Wells
    Hum Pathol 37:932-3. 2006

Research Grants23

  1. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2010
    ..abstract_text> ..
  2. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2001
    ..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
  3. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2009
    ..These studies will define molecular bases for spatial restriction of receptor signaling and resultant biophysical responses, offering promise for design of 'smart' scaffolds for tissue engineering to support tissue function. ..
  4. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2005
    ..The completion of these investigations will yield a model of dermal skin repair in which key extracellular and intracellular molecules are identified that can be targeted to either increase healing or limit scarring. ..
  5. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2009
    ..These investigations will define key extracellular and intracellular molecules that are potential targets for rationally designed interventions to promote normal wound healing and limit scarring. ..
  6. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2006
    ..This will enable the design of'smart scaffolds for cell and tissue engineering directing the synthesis of both the matrix and the vascular bed that is reauired to sunnort tissue function. ..
  7. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2005
    ..This will enable the design of'smart scaffolds for cell and tissue engineering directing the synthesis of both the matrix and the vascular bed that is reauired to sunnort tissue function. ..
  8. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2010
    ..These studies will define molecular bases for spatial restriction of receptor signaling and resultant biophysical responses, offering promise for design of 'smart'scaffolds for tissue engineering to support tissue function. ..
  9. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2004
    ..This will enable the design of'smart scaffolds for cell and tissue engineering directing the synthesis of both the matrix and the vascular bed that is reauired to sunnort tissue function. ..
  10. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2003
    ..The completion of these investigations will yield a model of dermal skin repair in which key extracellular and intracellular molecules are identified that can be targeted to either increase healing or limit scarring. ..
  11. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2010
    ..abstract_text> ..
  12. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2010
    ..These investigations will define key extracellular and intracellular molecules that are potential targets for rationally designed interventions to promote normal wound healing and limit scarring. ..
  13. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2011
    ..These studies will define molecular bases for spatial restriction of receptor signaling and resultant biophysical responses, offering promise for design of 'smart'scaffolds for tissue engineering to support tissue function. ..
  14. Spatial Segregation of Cell Functioning During Motility
    Alan Wells; Fiscal Year: 2007
    ..This will enable the design of'smart scaffolds for cell and tissue engineering directing the synthesis of both the matrix and the vascular bed that is reauired to sunnort tissue function. ..
  15. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2006
    ..The completion of these investigations will yield a model of dermal skin repair in which key extracellular and intracellular molecules are identified that can be targeted to either increase healing or limit scarring. ..
  16. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2005
    ..The completion of these investigations will yield a model of dermal skin repair in which key extracellular and intracellular molecules are identified that can be targeted to either increase healing or limit scarring. ..
  17. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2004
    ..The completion of these investigations will yield a model of dermal skin repair in which key extracellular and intracellular molecules are identified that can be targeted to either increase healing or limit scarring. ..
  18. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2003
    ..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
  19. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2002
    ..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
  20. FIBROBLAST CELL MOTILITY IN WOUND HEALING
    Alan Wells; Fiscal Year: 1999
    ..That decreased wound healing in aging is, in part, due to decreased motility response of fibroblasts secondary to decreased signal transduction of the motility pathway. ..
  21. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2000
    ..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..