A Wells

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Epidermal growth factor receptor-mediated motility in fibroblasts
    A Wells
    Department of Pathology, University of Alabama at Birmingham, and Birmingham VA Medical Center, 35294 0007, USA
    Microsc Res Tech 43:395-411. 1998
  2. ncbi request reprint EGF receptor
    A Wells
    Department of Pathology, University of Alabama, Birmingham 35294 0007, USA
    Int J Biochem Cell Biol 31:637-43. 1999
  3. ncbi request reprint Tumor invasion as dysregulated cell motility
    J Kassis
    Department of Pathology, University of Pittsburgh and Pittsburgh VAMC, 713 Scaife Hall, Pittsburgh, PA 15261, USA
    Semin Cancer Biol 11:105-17. 2001
  4. pmc Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
    C S Swindle
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Cell Biol 154:459-68. 2001
  5. pmc Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin
    C C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, PA 15213, USA
    Br J Cancer 96:1246-52. 2007
  6. pmc Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline
    C Yates
    Department of Pathology, University of Pittsburgh, and Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Br J Cancer 92:366-75. 2005
  7. ncbi request reprint Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling
    A Glading
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 276:23341-8. 2001
  8. ncbi request reprint A role for phospholipase C-gamma-mediated signaling in tumor cell invasion
    J Kassis
    Birmingham Veterans Administration Medical Center, Department of Pathology, University of Alabama at Birmingham, 35294 0007, USA
    Clin Cancer Res 5:2251-60. 1999
  9. ncbi request reprint PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors
    C R Shepard
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 26:3020-6. 2007
  10. pmc Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
    S E Wheeler
    Department of Pathology, University of Pittsburgh, S711 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, USA
    Br J Cancer 111:2342-50. 2014

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Epidermal growth factor receptor-mediated motility in fibroblasts
    A Wells
    Department of Pathology, University of Alabama at Birmingham, and Birmingham VA Medical Center, 35294 0007, USA
    Microsc Res Tech 43:395-411. 1998
    ..Our model postulates that many biochemical pathways will be shared between chemokinetic and haptokinetic motility but that select pathways will be activated only during RPTK-enhanced motility...
  2. ncbi request reprint EGF receptor
    A Wells
    Department of Pathology, University of Alabama, Birmingham 35294 0007, USA
    Int J Biochem Cell Biol 31:637-43. 1999
    ..Thus, EGFR and its downstream signaling molecules' are targets for therapeutic interventions in wound repair and cancer...
  3. ncbi request reprint Tumor invasion as dysregulated cell motility
    J Kassis
    Department of Pathology, University of Pittsburgh and Pittsburgh VAMC, 713 Scaife Hall, Pittsburgh, PA 15261, USA
    Semin Cancer Biol 11:105-17. 2001
    ....
  4. pmc Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
    C S Swindle
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Cell Biol 154:459-68. 2001
    ..These data identify a new class of "insoluble" growth factor ligands and a novel mode of activation for growth factor receptors...
  5. pmc Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin
    C C Yates
    Department of Pathology, University of Pittsburgh, Pittsburgh VAMC, PA 15213, USA
    Br J Cancer 96:1246-52. 2007
    ..We conclude that the term epithelial-mesenchymal transition only summarises the transient downregulation of E-cadherin for invasion with re-expression of E-cadherin being a physiological consequence of metastatic seeding...
  6. pmc Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline
    C Yates
    Department of Pathology, University of Pittsburgh, and Pittsburgh VAMC, Pittsburgh, PA 15261, USA
    Br J Cancer 92:366-75. 2005
    ..The ability of Cetrorelix to downregulate EGFR signalling and subsequently reverse the antiadhesiveness found in metastatic prostate cancer highlights a novel potential target for therapeutic strategies...
  7. ncbi request reprint Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling
    A Glading
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 276:23341-8. 2001
    ....
  8. ncbi request reprint A role for phospholipase C-gamma-mediated signaling in tumor cell invasion
    J Kassis
    Birmingham Veterans Administration Medical Center, Department of Pathology, University of Alabama at Birmingham, 35294 0007, USA
    Clin Cancer Res 5:2251-60. 1999
    ..In all situations, the inhibition of PLCgamma signaling did not decrease mitogenic signaling. Thus, the motility-associated PLCgamma signaling pathway is a generalizable rate-limiting step for tumor cell progression...
  9. ncbi request reprint PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors
    C R Shepard
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 26:3020-6. 2007
    ..In conclusion, abrogation of the PLCgamma signaling pathway can limit the metastatic potential of carcinomas...
  10. pmc Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
    S E Wheeler
    Department of Pathology, University of Pittsburgh, S711 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, USA
    Br J Cancer 111:2342-50. 2014
    ..Existing model systems of dormancy are limited as they do not recapitulate human metastatic dormancy without exogenous manipulations and are unable to query early events of micrometastases...
  11. ncbi request reprint Kinetic and spectroscopic evidence for three actomyosin:ADP states in smooth muscle
    S S Rosenfeld
    Department of Neurology, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 275:25418-26. 2000
    ....
  12. ncbi request reprint Cytokine mRNA expression and serum cortisol evaluation during murine lung inflammation induced by Mycobacterium tuberculosis
    J K Actor
    Department of Pathology, University of Texas Houston Medical School, Texas 77030, USA
    Comb Chem High Throughput Screen 3:343-51. 2000
    ..The high constitutive serum cortisol in the A/J mice may therefore contribute to establishment of an environment counter-productive to initiation of protective Th1 cell and granulomatous responses...