Melanie Wellington

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Candida albicans morphogenesis is not required for macrophage interleukin 1β production
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    MBio 4:e00433-12. 2012
  2. ncbi request reprint Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    FEMS Immunol Med Microbiol 51:70-83. 2007
  3. pmc Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
  4. pmc A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis
    Arielle Butts
    Department of Chemistry, University of Rochester, Rochester, New York, USA
    Eukaryot Cell 12:278-87. 2013
  5. ncbi request reprint 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mycologia 98:393-8. 2006
  6. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
  7. pmc Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization
    Kristy Dolan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 53:3337-46. 2009
  8. pmc Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa
    Nadine E Van Alst
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 77:4446-54. 2009
  9. pmc Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:7228-31. 2003
  10. pmc Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Eukaryot Cell 13:329-40. 2014

Collaborators

Detail Information

Publications13

  1. pmc Candida albicans morphogenesis is not required for macrophage interleukin 1β production
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    MBio 4:e00433-12. 2012
    ..albicans...
  2. ncbi request reprint Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    FEMS Immunol Med Microbiol 51:70-83. 2007
    ..These data suggest that FcgammaR cooperates positively with antibody-independent recognition mechanisms in what may be a novel link between innate and adaptive immunity to C. albicans...
  3. pmc Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
    ..These studies indicate that live C. albicans actively suppresses ROS production in phagocytes in vitro, which may represent an important immune evasion mechanism...
  4. pmc A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis
    Arielle Butts
    Department of Chemistry, University of Rochester, Rochester, New York, USA
    Eukaryot Cell 12:278-87. 2013
    ..Taken together, these studies provide a foundation for the optimization of the antifungal properties of a set of pharmacologically attractive scaffolds for the development of novel anticryptococcal therapies...
  5. ncbi request reprint 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mycologia 98:393-8. 2006
    ..However most of the "pop-outs" acquired various chromosome alterations. Thus constructs exposed to 5-FOA should be examined for chromosome alterations or the use of 5-FOA should be avoided...
  6. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
    ..Collectively, our results show that Spx is a major stress gene regulator and is implicated in the pathophysiology of E. faecalis. The relationship of Spx to other oxidative stress regulators is also discussed...
  7. pmc Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization
    Kristy Dolan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 53:3337-46. 2009
    ..Taken together, these experiments indicate that the further study of compounds related to TAM as antifungal agents is warranted...
  8. pmc Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa
    Nadine E Van Alst
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 77:4446-54. 2009
    ..These data suggest that NO generated via nitrite reductase NirS contributes to the regulation of expression of selected virulence factors in P. aeruginosa PA14...
  9. pmc Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:7228-31. 2003
    ..Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen...
  10. pmc Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Eukaryot Cell 13:329-40. 2014
    ..This is the first example of a fungal pathogen triggering pyroptosis and indicates that C. albicans-mediated macrophage damage is not solely due to hypha-induced physical disruption of cellular integrity. ..
  11. ncbi request reprint 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans
    Melanie Wellington
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Yeast 22:57-70. 2005
    ..Our results indicate the necessity of electrokaryotyping of strains that have been exposed to 5-FOA, especially with studies of gene function and with DNA microarray assays...
  12. pmc Imaging morphogenesis of Candida albicans during infection in a live animal
    Soumya Mitra
    University of Rochester Medical Center, Department of Imaging Sciences, 601 Elmwood Avenue, Box 648, Rochester, New York 1462University of Rochester Medical Center, Department of Pediatrics, 601 Elmwood Avenue, Box 690, Rochester, New York 14642
    J Biomed Opt 15:010504. 2010
    ..This model system will allow us to gain significant new information about C. albicans pathogenesis through studies of host-C. albicans interactions in the native environment...
  13. ncbi request reprint Role of the 14-3-3 protein in carbon metabolism of the pathogenic yeast Candida albicans
    Ying Kai Wang
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA
    Yeast 21:685-702. 2004
    ..albicans essential gene BMH1 as a negative regulator of the utilization of secondary carbon source in yeast, which further substantiates the involvement of 14-3-3 proteins in diverse functions...