Research Topics
Genomes and Genes | S WelleSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
What statisticians should know about microarray gene expression technologyStephen Welle
Functional Genomics Center, University of Rochester, Rochester, NY, USA
Methods Mol Biol 972:1-13. 2013..This information may give data analysts a better appreciation of the technical sources of variability in the data and the importance of minimizing such variability by normalization methods or exclusion of aberrant arrays...
Gene expression profile of aging in human muscleStephen Welle
University of Rochester Medical Center, Rochester, New York 14642, USA
Physiol Genomics 14:149-59. 2003..We conclude that in human skeletal muscle the expression of many genes tends to increase or decrease between the third and seventh decades. The changes are modest when averaged over all of the cells in the tissue...- Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old womenStephen Welle
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Exp Gerontol 39:369-77. 2004..More than 100 genes involved in energy metabolism were expressed at lower levels in older muscle. In general, these results support previous observations on the differences in gene expression profiles between younger and older men... - Myofibrillar protein synthesis in myostatin-deficient miceStephen Welle
Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 290:E409-15. 2006..Thus the increased protein synthesis and RNA content per muscle in myostatin-deficient mice cannot be explained entirely by an increased number of myonuclei... - Muscle growth after postdevelopmental myostatin gene knockoutStephen Welle
Department of Medicine, University of Rochester, Rochester, NY, USA
Am J Physiol Endocrinol Metab 292:E985-91. 2007..We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass... 
Sex-related differences in gene expression in human skeletal muscleStephen Welle
Department of Medicine, University of Rochester, Rochester, New York, USA
PLoS ONE 3:e1385. 2008..7-fold, P<0.001) and ACVR2B (1.7-fold, P<0.03). If these sex-related differences in mRNA expression lead to reduced IGF-1 activity and increased myostatin activity, they could contribute to the sex difference in muscle size...- Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature miceStephen Welle
University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 296:E567-72. 2009..Reversal of the inhibition of myofibrillar synthesis with an anti-myostatin antibody is not dependent on mTOR activation... - Skeletal muscle gene expression after myostatin knockout in mature miceStephen Welle
Department of Medicine, University of Rochester, Rochester, New York, USA
Physiol Genomics 38:342-50. 2009.... - Relation between extent of myostatin depletion and muscle growth in mature miceStephen Welle
Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 297:E935-40. 2009..These data suggest that anabolic therapies based on reducing the concentration of active myostatin will be effective only if a very large proportion of the myostatin is removed or inactivated... - Effect of postdevelopmental myostatin depletion on myofibrillar protein metabolismStephen Welle
Department of Medicine, Division of Endocrinology and Metabolism, University of Rochester, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 300:E993-E1001. 2011..These data indicate that maintenance of the muscle hypertrophy caused by loss of myostatin is mediated by increased protein synthesis per muscle fiber rather than suppression of proteolysis... - Reduced amount of mitochondrial DNA in aged human muscleStephen Welle
Departments of Medicine, Pharmacology and Physiology, and Neurology, University of Rochester, Rochester, New York 14642, USA
J Appl Physiol 94:1479-84. 2003..We conclude that the lower concentration of mitochondrial mRNAs in older muscle can be explained by a reduced concentration of mtDNA... - Computational method for reducing variance with Affymetrix microarraysStephen Welle
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
BMC Bioinformatics 3:23. 2002..Six HG-U95A arrays that probed mRNA from young (21-31 yr old) human muscle were compared with six arrays that probed mRNA from older (62-77 yr old) muscle... - Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old menStephen Welle
University of Rochester Medical Center, Endocrinology, P O Box 693, 601 Elmwood Avenue, Rochester, NY 14642, USA
Exp Gerontol 37:833-9. 2002..We conclude that IGF-1 gene expression in muscle tends to decline with normal aging. The functional significance is uncertain... - High-abundance mRNAs in human muscle: comparison between young and oldS Welle
Departments of Medicine, Pharmacology and Physiology, and Neurology, University of Rochester, Rochester, New York 14642, USA
J Appl Physiol 89:297-304. 2000..These data suggest that some of the phenotypic changes in senescent muscle may be related to altered gene transcription... - Gene transcript profiling in aging researchStephen Welle
University of Rochester, Rochester, NY 14642, USA
Exp Gerontol 37:583-90. 2002..In this review, these issues are discussed with a focus on two methods for profiling mRNAs--serial analysis of gene expression (SAGE) and DNA arrays... - Stimulation of myofibrillar synthesis by exercise is mediated by more efficient translation of mRNAS Welle
Department of Medicine, University of Rochester, Rochester, New York 14620, USA
J Appl Physiol 86:1220-5. 1999..These data suggest that the stimulation of myofibrillar synthesis by resistance exercise is mediated by more efficient translation of mRNA... - Senescence-related changes in gene expression in muscle: similarities and differences between mice and menS Welle
Departments of Medicine, Pharmacology and Physiology, Neurology, Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
Physiol Genomics 5:67-73. 2001..There was no evidence that older human muscle has increased expression of the stress response genes that are increased in old murine muscle... - Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophyR J Osborne
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8673, USA
Neurology 68:569-77. 2007..Previous work has suggested that muscle degeneration in FSHD results from increased expression of genes proximal to the deletion, including FRG1... - Inventory of high-abundance mRNAs in skeletal muscle of normal menS Welle
University of Rochester, Rochester, New York 14642 USA
Genome Res 9:506-13. 1999..The database can be used as a reference for investigations of alterations in gene expression associated with conditions that influence muscle function, such as muscular dystrophies, aging, and exercise... - Cellular and molecular basis of age-related sarcopeniaStephen Welle
Department of Medicine, University of Rochester, Rochester, New York 14642, USA
Can J Appl Physiol 27:19-41. 2002..Many genes are differentially expressed in young and old muscle, but additional research is needed to determine which of these genes have a significant role in the pathogenesis or adaptation to sarcopenia... - Expression of elongation factor-1 alpha and S1 in young and old human skeletal muscleS Welle
University of Rochester, New York, USA
J Gerontol A Biol Sci Med Sci 52:B235-9. 1997..However, we cannot exclude the possibility that the activity of these proteins declines during senescence due to post-translational modifications... - Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophyRobert J Osborne
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Hum Mol Genet 18:1471-81. 2009.... - Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell modelsXiaodong Li
Departments of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
J Mol Endocrinol 40:211-29. 2008..These findings suggest that the ERE-dependent pathway is a required signaling route for E(2)-ERbeta to induce cellular responses... - Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1John D Lueck
Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 292:C1291-7. 2007.... - Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasisChristian Meyer
Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Endocrinol Metab 282:E419-27. 2002..We postulate that increases in postprandial renal glucose release may play a role in facilitating efficient liver glycogen repletion by permitting substantial suppression of hepatic glucose release... - Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetesChristian Meyer
Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
Am J Physiol Endocrinol Metab 287:E1049-56. 2004..The latter may provide an explanation for the renal glycogen accumulation characteristic of diabetes mellitus as well as a mechanism by which hyperglycemia may lead to diabetic nephropathy... - Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimensHans J Woerle
Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
Diabetes 52:918-25. 2003.... - Molecular fingerprints of inflammatory myopathiesCharles A Thornton
Neurology 59:1128-9. 2002
Research Grants
- CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLEStephen Welle; Fiscal Year: 2003..abstract_text> ..
- Muscle protein synthesis and gene expression in myostatin-deficient miceStephen Welle; Fiscal Year: 2007..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
- Muscle protein synthesis and gene expression in myostatin-deficient miceStephen Welle; Fiscal Year: 2009..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
- Muscle protein synthesis and gene expression in myostatin-deficient miceStephen L Welle; Fiscal Year: 2010..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..