S Welle

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice
    Kerri Burgess
    Endocrinology and Metabolism Division, Department of Medicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e17090. 2011
  2. doi request reprint What statisticians should know about microarray gene expression technology
    Stephen Welle
    Functional Genomics Center, University of Rochester, Rochester, NY, USA
    Methods Mol Biol 972:1-13. 2013
  3. ncbi request reprint Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Exp Gerontol 39:369-77. 2004
  4. ncbi request reprint Myofibrillar protein synthesis in myostatin-deficient mice
    Stephen Welle
    Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E409-15. 2006
  5. ncbi request reprint Muscle growth after postdevelopmental myostatin gene knockout
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Am J Physiol Endocrinol Metab 292:E985-91. 2007
  6. pmc Sex-related differences in gene expression in human skeletal muscle
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, New York, USA
    PLoS ONE 3:e1385. 2008
  7. pmc Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice
    Stephen Welle
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 296:E567-72. 2009
  8. pmc Skeletal muscle gene expression after myostatin knockout in mature mice
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, New York, USA
    Physiol Genomics 38:342-50. 2009
  9. pmc Relation between extent of myostatin depletion and muscle growth in mature mice
    Stephen Welle
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 297:E935-40. 2009
  10. pmc Effect of postdevelopmental myostatin depletion on myofibrillar protein metabolism
    Stephen Welle
    Department of Medicine, Division of Endocrinology and Metabolism, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 300:E993-E1001. 2011

Collaborators

Detail Information

Publications29

  1. pmc Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice
    Kerri Burgess
    Endocrinology and Metabolism Division, Department of Medicine, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e17090. 2011
    ..Myostatin depletion also attenuated hepatic steatosis and accumulation of fat in muscle tissue. We conclude that blocking myostatin signaling after maturity can attenuate some of the adverse effects of a high-fat diet...
  2. doi request reprint What statisticians should know about microarray gene expression technology
    Stephen Welle
    Functional Genomics Center, University of Rochester, Rochester, NY, USA
    Methods Mol Biol 972:1-13. 2013
    ..This information may give data analysts a better appreciation of the technical sources of variability in the data and the importance of minimizing such variability by normalization methods or exclusion of aberrant arrays...
  3. ncbi request reprint Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Exp Gerontol 39:369-77. 2004
    ..More than 100 genes involved in energy metabolism were expressed at lower levels in older muscle. In general, these results support previous observations on the differences in gene expression profiles between younger and older men...
  4. ncbi request reprint Myofibrillar protein synthesis in myostatin-deficient mice
    Stephen Welle
    Department of Medicine in the Center for Aging and developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E409-15. 2006
    ..Thus the increased protein synthesis and RNA content per muscle in myostatin-deficient mice cannot be explained entirely by an increased number of myonuclei...
  5. ncbi request reprint Muscle growth after postdevelopmental myostatin gene knockout
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Am J Physiol Endocrinol Metab 292:E985-91. 2007
    ..We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass...
  6. pmc Sex-related differences in gene expression in human skeletal muscle
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, New York, USA
    PLoS ONE 3:e1385. 2008
    ..7-fold, P<0.001) and ACVR2B (1.7-fold, P<0.03). If these sex-related differences in mRNA expression lead to reduced IGF-1 activity and increased myostatin activity, they could contribute to the sex difference in muscle size...
  7. pmc Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice
    Stephen Welle
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 296:E567-72. 2009
    ..Reversal of the inhibition of myofibrillar synthesis with an anti-myostatin antibody is not dependent on mTOR activation...
  8. pmc Skeletal muscle gene expression after myostatin knockout in mature mice
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, New York, USA
    Physiol Genomics 38:342-50. 2009
    ....
  9. pmc Relation between extent of myostatin depletion and muscle growth in mature mice
    Stephen Welle
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 297:E935-40. 2009
    ..These data suggest that anabolic therapies based on reducing the concentration of active myostatin will be effective only if a very large proportion of the myostatin is removed or inactivated...
  10. pmc Effect of postdevelopmental myostatin depletion on myofibrillar protein metabolism
    Stephen Welle
    Department of Medicine, Division of Endocrinology and Metabolism, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 300:E993-E1001. 2011
    ..These data indicate that maintenance of the muscle hypertrophy caused by loss of myostatin is mediated by increased protein synthesis per muscle fiber rather than suppression of proteolysis...
  11. ncbi request reprint Gene expression profile of aging in human muscle
    Stephen Welle
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Physiol Genomics 14:149-59. 2003
    ..We conclude that in human skeletal muscle the expression of many genes tends to increase or decrease between the third and seventh decades. The changes are modest when averaged over all of the cells in the tissue...
  12. ncbi request reprint Reduced amount of mitochondrial DNA in aged human muscle
    Stephen Welle
    Departments of Medicine, Pharmacology and Physiology, and Neurology, University of Rochester, Rochester, New York 14642, USA
    J Appl Physiol (1985) 94:1479-84. 2003
    ..We conclude that the lower concentration of mitochondrial mRNAs in older muscle can be explained by a reduced concentration of mtDNA...
  13. ncbi request reprint Gene transcript profiling in aging research
    Stephen Welle
    University of Rochester, Rochester, NY 14642, USA
    Exp Gerontol 37:583-90. 2002
    ..In this review, these issues are discussed with a focus on two methods for profiling mRNAs--serial analysis of gene expression (SAGE) and DNA arrays...
  14. pmc Computational method for reducing variance with Affymetrix microarrays
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    BMC Bioinformatics 3:23. 2002
    ..Six HG-U95A arrays that probed mRNA from young (21-31 yr old) human muscle were compared with six arrays that probed mRNA from older (62-77 yr old) muscle...
  15. ncbi request reprint Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old men
    Stephen Welle
    University of Rochester Medical Center, Endocrinology, P O Box 693, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Gerontol 37:833-9. 2002
    ..We conclude that IGF-1 gene expression in muscle tends to decline with normal aging. The functional significance is uncertain...
  16. ncbi request reprint High-abundance mRNAs in human muscle: comparison between young and old
    S Welle
    Departments of Medicine, Pharmacology and Physiology, and Neurology, University of Rochester, Rochester, New York 14642, USA
    J Appl Physiol (1985) 89:297-304. 2000
    ..These data suggest that some of the phenotypic changes in senescent muscle may be related to altered gene transcription...
  17. ncbi request reprint Stimulation of myofibrillar synthesis by exercise is mediated by more efficient translation of mRNA
    S Welle
    Department of Medicine, University of Rochester, Rochester, New York 14620, USA
    J Appl Physiol (1985) 86:1220-5. 1999
    ..These data suggest that the stimulation of myofibrillar synthesis by resistance exercise is mediated by more efficient translation of mRNA...
  18. ncbi request reprint Senescence-related changes in gene expression in muscle: similarities and differences between mice and men
    S Welle
    Departments of Medicine, Pharmacology and Physiology, Neurology, Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    Physiol Genomics 5:67-73. 2001
    ..There was no evidence that older human muscle has increased expression of the stress response genes that are increased in old murine muscle...
  19. ncbi request reprint Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy
    R J Osborne
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8673, USA
    Neurology 68:569-77. 2007
    ..Previous work has suggested that muscle degeneration in FSHD results from increased expression of genes proximal to the deletion, including FRG1...
  20. pmc Inventory of high-abundance mRNAs in skeletal muscle of normal men
    S Welle
    University of Rochester, Rochester, New York 14642 USA
    Genome Res 9:506-13. 1999
    ..The database can be used as a reference for investigations of alterations in gene expression associated with conditions that influence muscle function, such as muscular dystrophies, aging, and exercise...
  21. ncbi request reprint Cellular and molecular basis of age-related sarcopenia
    Stephen Welle
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Can J Appl Physiol 27:19-41. 2002
    ..Many genes are differentially expressed in young and old muscle, but additional research is needed to determine which of these genes have a significant role in the pathogenesis or adaptation to sarcopenia...
  22. ncbi request reprint Expression of elongation factor-1 alpha and S1 in young and old human skeletal muscle
    S Welle
    University of Rochester, New York, USA
    J Gerontol A Biol Sci Med Sci 52:B235-9. 1997
    ..However, we cannot exclude the possibility that the activity of these proteins declines during senescence due to post-translational modifications...
  23. pmc Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy
    Robert J Osborne
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Mol Genet 18:1471-81. 2009
    ....
  24. pmc Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models
    Xiaodong Li
    Departments of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    J Mol Endocrinol 40:211-29. 2008
    ..These findings suggest that the ERE-dependent pathway is a required signaling route for E(2)-ERbeta to induce cellular responses...
  25. ncbi request reprint Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1
    John D Lueck
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 292:C1291-7. 2007
    ....
  26. ncbi request reprint Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 282:E419-27. 2002
    ..We postulate that increases in postprandial renal glucose release may play a role in facilitating efficient liver glycogen repletion by permitting substantial suppression of hepatic glucose release...
  27. ncbi request reprint Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 287:E1049-56. 2004
    ..The latter may provide an explanation for the renal glycogen accumulation characteristic of diabetes mellitus as well as a mechanism by which hyperglycemia may lead to diabetic nephropathy...
  28. ncbi request reprint Molecular fingerprints of inflammatory myopathies
    Charles A Thornton
    Neurology 59:1128-9. 2002
  29. ncbi request reprint Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes 52:918-25. 2003
    ....

Research Grants8

  1. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2000
    ..abstract_text> ..
  2. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2001
    ..abstract_text> ..
  3. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2002
    ..abstract_text> ..
  4. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2003
    ..abstract_text> ..
  5. Muscle protein synthesis and gene expression in myostatin-deficient mice
    Stephen Welle; Fiscal Year: 2007
    ..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
  6. Muscle protein synthesis and gene expression in myostatin-deficient mice
    Stephen Welle; Fiscal Year: 2009
    ..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
  7. Muscle protein synthesis and gene expression in myostatin-deficient mice
    Stephen L Welle; Fiscal Year: 2010
    ..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..