Research Topics
| Nathan V WelhamSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosaNathan V Welham
Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
PLoS ONE 6:e17754. 2011..The resulting vocal fold mucosa proteome was characterized by a wide range of cellular and extracellular proteins spanning 12 functional categories...- Morphological and extracellular matrix changes following vocal fold injury in miceMasaru Yamashita
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Cells Tissues Organs 192:262-71. 2010..Morphological and ECM changes following vocal fold injury in the mouse were generally consistent with those reported in other animal models, particularly the rat, although wound repair in the mouse appears to occur at a faster rate... - Microarray-driven validation of reference genes for quantitative real-time polymerase chain reaction in a rat vocal fold model of mucosal injuryZhen Chang
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Anal Biochem 406:214-21. 2010..The stable reference genes identified here are suitable for accurate normalization of target gene expression in vocal fold mucosal injury experiments... - Reactive response of fibrocytes to vocal fold mucosal injury in ratChangying Ling
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
Wound Repair Regen 18:514-23. 2010..Our newly reported antigen panel facilitating the direct characterization of fibrocytes via flow cytometry is a useful tool with the potential to facilitate improved study of this cell population... - Prospective multi-arm evaluation of surgical treatments for vocal fold scar and pathologic sulcus vocalisNathan V Welham
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison Wisconsin, USA
Laryngoscope 121:1252-60. 2011..The purpose of this study was to compare the clinical effectiveness of type I thyroplasty, injection laryngoplasty, and graft implantation for the treatment of vocal fold scar and pathologic sulcus vocalis... - Pulsed dye laser-induced inflammatory response and extracellular matrix turnover in rat vocal folds and vocal fold fibroblastsYa Lin
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Lasers Surg Med 41:585-94. 2009..In this study, we examined the inflammatory and ECM modulating effects of PDL irradiation on normal vocal fold tissues and cultured vocal fold fibroblasts (VFFs)... - Surgical method to create vocal fold injuries in miceMasaru Yamashita
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ann Otol Rhinol Laryngol 118:131-8. 2009..The goal of this study was to develop a surgical method for the creation of vocal fold injuries in mice, as a precursor to the use of genetically engineered mouse models in the study of vocal fold wound healing and scar formation... - Characterization of vocal fold scar formation, prophylaxis, and treatment using animal modelsDiane M Bless
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
Curr Opin Otolaryngol Head Neck Surg 18:481-6. 2010.... - A rat excised larynx model of vocal fold scarNathan V Welham
University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Speech Lang Hear Res 52:1008-20. 2009..To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar... - E-cadherin and transglutaminase-1 epithelial barrier restoration precedes type IV collagen basement membrane reconstruction following vocal fold mucosal injuryChangying Ling
Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Cells Tissues Organs 193:158-69. 2011..These data may inform future efforts to optimize functional mucosal recovery postinjury and avoid undesirable events such as barrier compromise or epithelial metaplasia... - Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injuryChangying Ling
Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
Wound Repair Regen 18:89-97. 2010..The sequential emergence of reactive cell populations following injury and subsequent reconstruction of the mucosa suggests their involvement in vocal fold tissue repair and scar formation processes... - Local vascularized flaps for augmentation of Reinke's spaceSeth H Dailey
Department of Surgery Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Laryngoscope 121:S37-60. 2011..We hypothesized that these specially designed vascularized flaps would remain viable once inset into the lamina propria, and that they would not disrupt rheologic, biomechanical, and histologic properties of the native vocal fold... 
Characterization of vocal fold scarring in a canine modelBernard Rousseau
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, USA
Laryngoscope 113:620-7. 2003..The objective was to assess the histological and viscoelastic shear tissue properties of the scarred vocal fold lamina propria at 2 and 6 months postoperatively in a canine model...- Growth factor therapy for vocal fold scarring in a canine modelShigeru Hirano
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA
Ann Otol Rhinol Laryngol 113:777-85. 2004..From these data it is concluded that HGF has considerable potential in the treatment of vocal fold scarring... - Vocal fatigue: current knowledge and future directionsNathan V Welham
Department of Communicative Disorders, University of Wisconsin Madison, 53705, USA
J Voice 17:21-30. 2003..Third, research investigating the clinical and occupational manifestations of vocal fatigue is discussed. Fourth, directions for ongoing research in this area are offered... - Tracking outcomes after phonosurgery for sulcus vocalis: a case reportNathan V Welham
Department of Surgery, Division of Otolaryngology, University of Wisconsin Madison, Madison, Wisconsin, USA
J Voice 17:571-8. 2003..This report reinforces the value of following patients until complete outcome stability... - Characterization of chronic vocal fold scarring in a rabbit modelBernard Rousseau
Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
J Voice 18:116-24. 2004..Based on these results, a 6-month postoperative time frame is proposed for future studies of chronic vocal fold scarring using the rabbit animal model... - Vocal fatigue in young trained singers across a solo performance: a preliminary studyNathan V Welham
Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Logoped Phoniatr Vocol 29:3-12. 2004..Sound pressure level and pitch indices appeared more useful than perturbation indices in reflecting meaningful trends in vocal change... - Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblastsXinhong Lim
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ann Otol Rhinol Laryngol 117:227-38. 2008..To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation... - Implantation of atelocollagen sheet for vocal fold scarYo Kishimoto
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705 2275, USA
Curr Opin Otolaryngol Head Neck Surg 18:507-11. 2010..This article reviews recent advances in scaffold-based interventions for the treatment of vocal fold scarring, with a particular emphasis on atelocollagen sheet implantation in the vocal fold lamina propria... - Voice handicap evaluation of patients with pathologic sulcus vocalisNathan V Welham
Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ann Otol Rhinol Laryngol 116:411-7. 2007..The purpose of this study was to characterize the psychosocial impact of dysphonia on patients with pathologic sulcus vocalis by use of the Voice Handicap Index (VHI)... - Viscoelastic measurements of vocal folds using the linear skin rheometerSeth H Dailey
Department of Surgery, University of Wisconsin School of Medicine, Division of Otolaryngology Head and Neck Surgery University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA
J Voice 23:143-50. 2009..The LSR should prove useful in the evaluation of vocal fold pliability for ex vivo and ultimately for in vivo applications... - Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injectionNathan V Welham
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Proteomics 8:1933-44. 2008.... - Proteomic analysis of a decellularized human vocal fold mucosa scaffold using 2D electrophoresis and high-resolution mass spectrometryNathan V Welham
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Biomaterials 34:669-76. 2013..This work has implications for the manufacturing of biologic scaffolds from any tissue or organ, as well as for prediction and monitoring of the scaffold-host interaction in vivo... - Chronic rhinosinusitis with nasal polyps: a proteomic analysisDavid C Upton
Department of Surgery, Division of Otolaryngology University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
Ann Otol Rhinol Laryngol 120:780-6. 2011..The purpose of this study was to utilize the techniques of proteomics to investigate differences in protein abundance within the sinonasal mucosa of patients with CRSwNP compared to healthy controls... - Inflammatory factor profiles one hour following vocal fold injuryNathan V Welham
Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ann Otol Rhinol Laryngol 117:145-52. 2008..The objective of this study was to characterize in vivo inflammatory factor and extracellular matrix (ECM) messenger RNA (mRNA) expression levels 1 hour after vocal fold injury... - Aerodynamic, acoustic, and vibratory comparison of arytenoid adduction and adduction arytenopexyJustin McNamar
Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Laryngoscope 118:552-8. 2008..Adduction arytenopexy (AP) with thyroplasty provides improved physiologic placement of the vocal fold and therefore provides improved acoustic, aerodynamic, and vibratory function as compared with arytenoid adduction (AA) with thyroplasty...