Nathan V Welham

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosa
    Nathan V Welham
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 6:e17754. 2011
  2. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
  3. pmc Microarray-driven validation of reference genes for quantitative real-time polymerase chain reaction in a rat vocal fold model of mucosal injury
    Zhen Chang
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Anal Biochem 406:214-21. 2010
  4. pmc Reactive response of fibrocytes to vocal fold mucosal injury in rat
    Changying Ling
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Wound Repair Regen 18:514-23. 2010
  5. pmc Prospective multi-arm evaluation of surgical treatments for vocal fold scar and pathologic sulcus vocalis
    Nathan V Welham
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison Wisconsin, USA
    Laryngoscope 121:1252-60. 2011
  6. pmc Surgical method to create vocal fold injuries in mice
    Masaru Yamashita
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 118:131-8. 2009
  7. pmc Pulsed dye laser-induced inflammatory response and extracellular matrix turnover in rat vocal folds and vocal fold fibroblasts
    Ya Lin
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Lasers Surg Med 41:585-94. 2009
  8. pmc Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models
    Diane M Bless
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Curr Opin Otolaryngol Head Neck Surg 18:481-6. 2010
  9. pmc A rat excised larynx model of vocal fold scar
    Nathan V Welham
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Speech Lang Hear Res 52:1008-20. 2009
  10. pmc Proteomic analysis of a decellularized human vocal fold mucosa scaffold using 2D electrophoresis and high-resolution mass spectrometry
    Nathan V Welham
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Biomaterials 34:669-76. 2013

Collaborators

Detail Information

Publications28

  1. pmc Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosa
    Nathan V Welham
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 6:e17754. 2011
    ..The resulting vocal fold mucosa proteome was characterized by a wide range of cellular and extracellular proteins spanning 12 functional categories...
  2. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
    ..Morphological and ECM changes following vocal fold injury in the mouse were generally consistent with those reported in other animal models, particularly the rat, although wound repair in the mouse appears to occur at a faster rate...
  3. pmc Microarray-driven validation of reference genes for quantitative real-time polymerase chain reaction in a rat vocal fold model of mucosal injury
    Zhen Chang
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Anal Biochem 406:214-21. 2010
    ..The stable reference genes identified here are suitable for accurate normalization of target gene expression in vocal fold mucosal injury experiments...
  4. pmc Reactive response of fibrocytes to vocal fold mucosal injury in rat
    Changying Ling
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Wound Repair Regen 18:514-23. 2010
    ..Our newly reported antigen panel facilitating the direct characterization of fibrocytes via flow cytometry is a useful tool with the potential to facilitate improved study of this cell population...
  5. pmc Prospective multi-arm evaluation of surgical treatments for vocal fold scar and pathologic sulcus vocalis
    Nathan V Welham
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison Wisconsin, USA
    Laryngoscope 121:1252-60. 2011
    ..The purpose of this study was to compare the clinical effectiveness of type I thyroplasty, injection laryngoplasty, and graft implantation for the treatment of vocal fold scar and pathologic sulcus vocalis...
  6. pmc Surgical method to create vocal fold injuries in mice
    Masaru Yamashita
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 118:131-8. 2009
    ..The goal of this study was to develop a surgical method for the creation of vocal fold injuries in mice, as a precursor to the use of genetically engineered mouse models in the study of vocal fold wound healing and scar formation...
  7. pmc Pulsed dye laser-induced inflammatory response and extracellular matrix turnover in rat vocal folds and vocal fold fibroblasts
    Ya Lin
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Lasers Surg Med 41:585-94. 2009
    ..In this study, we examined the inflammatory and ECM modulating effects of PDL irradiation on normal vocal fold tissues and cultured vocal fold fibroblasts (VFFs)...
  8. pmc Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models
    Diane M Bless
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Curr Opin Otolaryngol Head Neck Surg 18:481-6. 2010
    ....
  9. pmc A rat excised larynx model of vocal fold scar
    Nathan V Welham
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Speech Lang Hear Res 52:1008-20. 2009
    ..To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar...
  10. pmc Proteomic analysis of a decellularized human vocal fold mucosa scaffold using 2D electrophoresis and high-resolution mass spectrometry
    Nathan V Welham
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Biomaterials 34:669-76. 2013
    ..This work has implications for the manufacturing of biologic scaffolds from any tissue or organ, as well as for prediction and monitoring of the scaffold-host interaction in vivo...
  11. pmc E-cadherin and transglutaminase-1 epithelial barrier restoration precedes type IV collagen basement membrane reconstruction following vocal fold mucosal injury
    Changying Ling
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 193:158-69. 2011
    ..These data may inform future efforts to optimize functional mucosal recovery postinjury and avoid undesirable events such as barrier compromise or epithelial metaplasia...
  12. pmc Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury
    Changying Ling
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Wound Repair Regen 18:89-97. 2010
    ..The sequential emergence of reactive cell populations following injury and subsequent reconstruction of the mucosa suggests their involvement in vocal fold tissue repair and scar formation processes...
  13. pmc Local vascularized flaps for augmentation of Reinke's space
    Seth H Dailey
    Department of Surgery Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Laryngoscope 121:S37-60. 2011
    ..We hypothesized that these specially designed vascularized flaps would remain viable once inset into the lamina propria, and that they would not disrupt rheologic, biomechanical, and histologic properties of the native vocal fold...
  14. ncbi Characterization of vocal fold scarring in a canine model
    Bernard Rousseau
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Laryngoscope 113:620-7. 2003
    ..The objective was to assess the histological and viscoelastic shear tissue properties of the scarred vocal fold lamina propria at 2 and 6 months postoperatively in a canine model...
  15. ncbi Growth factor therapy for vocal fold scarring in a canine model
    Shigeru Hirano
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 113:777-85. 2004
    ..From these data it is concluded that HGF has considerable potential in the treatment of vocal fold scarring...
  16. ncbi Vocal fatigue: current knowledge and future directions
    Nathan V Welham
    Department of Communicative Disorders, University of Wisconsin Madison, 53705, USA
    J Voice 17:21-30. 2003
    ..Third, research investigating the clinical and occupational manifestations of vocal fatigue is discussed. Fourth, directions for ongoing research in this area are offered...
  17. ncbi Tracking outcomes after phonosurgery for sulcus vocalis: a case report
    Nathan V Welham
    Department of Surgery, Division of Otolaryngology, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Voice 17:571-8. 2003
    ..This report reinforces the value of following patients until complete outcome stability...
  18. ncbi Characterization of chronic vocal fold scarring in a rabbit model
    Bernard Rousseau
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Voice 18:116-24. 2004
    ..Based on these results, a 6-month postoperative time frame is proposed for future studies of chronic vocal fold scarring using the rabbit animal model...
  19. ncbi Vocal fatigue in young trained singers across a solo performance: a preliminary study
    Nathan V Welham
    Department of Communicative Disorders, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Logoped Phoniatr Vocol 29:3-12. 2004
    ..Sound pressure level and pitch indices appeared more useful than perturbation indices in reflecting meaningful trends in vocal change...
  20. ncbi Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 117:227-38. 2008
    ..To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation...
  21. pmc Implantation of atelocollagen sheet for vocal fold scar
    Yo Kishimoto
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705 2275, USA
    Curr Opin Otolaryngol Head Neck Surg 18:507-11. 2010
    ..This article reviews recent advances in scaffold-based interventions for the treatment of vocal fold scarring, with a particular emphasis on atelocollagen sheet implantation in the vocal fold lamina propria...
  22. ncbi Voice handicap evaluation of patients with pathologic sulcus vocalis
    Nathan V Welham
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 116:411-7. 2007
    ..The purpose of this study was to characterize the psychosocial impact of dysphonia on patients with pathologic sulcus vocalis by use of the Voice Handicap Index (VHI)...
  23. pmc TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats
    Zhen Chang
    Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Dis Model Mech 7:83-91. 2014
    ..These experiments show that the TGF-β isoforms have distinct roles in VFM maintenance and repair, and that TGF-β3 redirects wound healing to improve VFM scar outcomes in vivo. ..
  24. ncbi Viscoelastic measurements of vocal folds using the linear skin rheometer
    Seth H Dailey
    Department of Surgery, University of Wisconsin School of Medicine, Division of Otolaryngology Head and Neck Surgery University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA
    J Voice 23:143-50. 2009
    ..The LSR should prove useful in the evaluation of vocal fold pliability for ex vivo and ultimately for in vivo applications...
  25. pmc Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection
    Nathan V Welham
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Proteomics 8:1933-44. 2008
    ....
  26. ncbi Chronic rhinosinusitis with nasal polyps: a proteomic analysis
    David C Upton
    Department of Surgery, Division of Otolaryngology University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
    Ann Otol Rhinol Laryngol 120:780-6. 2011
    ..The purpose of this study was to utilize the techniques of proteomics to investigate differences in protein abundance within the sinonasal mucosa of patients with CRSwNP compared to healthy controls...
  27. ncbi Inflammatory factor profiles one hour following vocal fold injury
    Nathan V Welham
    Division of Otolaryngology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 117:145-52. 2008
    ..The objective of this study was to characterize in vivo inflammatory factor and extracellular matrix (ECM) messenger RNA (mRNA) expression levels 1 hour after vocal fold injury...
  28. ncbi Aerodynamic, acoustic, and vibratory comparison of arytenoid adduction and adduction arytenopexy
    Justin McNamar
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Laryngoscope 118:552-8. 2008
    ..Adduction arytenopexy (AP) with thyroplasty provides improved physiologic placement of the vocal fold and therefore provides improved acoustic, aerodynamic, and vibratory function as compared with arytenoid adduction (AA) with thyroplasty...